Gene and protein expression profile of naive and osteo-chondrogenically differentiated rat bone marrow-derived mesenchymal progenitor cells.

abstract：:p107 protein, a member of the retinoblastoma family protein, suppresses growth promotion in cancer cells. We have already reported evidence that calpain, a calcium dependent protease is involved in the cleavage of p107 protein. We show here that p107 protein can also be a substrate for ubiquitination. A negative growt...

journal_title：International journal of molecular medicine

authors： Jang JS,Choi YH

更新日期：1999-11-01 00:00:00

abstract：:The tumor microenvironment is thought to affect malignant transformation and tumor progression. The histone methyltransferase, enhancer of zeste homologue 2 (EZH2), has recently been suggested to play a critical role in the tumorigenesis of several types of human cancer. The aim of this study was to investigate the ef...

journal_title：International journal of molecular medicine

authors： Xu L,Deng Q,Pan Y,Peng M,Wang X,Song L,Xiao M,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:GATA binding protein 3 (GATA3) is a key molecule regulating the balance in the ratio of type 1 helper T (Th1) cells to type 2 helper T (Th2) cells, which is thought to be indicative of the pathogenesis of allergic diseases such as asthma and atopic dermatitis. The aim of this study was to investigate the role of GATA3...

journal_title：International journal of molecular medicine

authors： Bae CJ,Lee JW,Shim SB,Jee SW,Lee SH,Woo JM,Lee CK,Hwang DY

更新日期：2011-08-01 00:00:00

abstract：:Non‑alcoholic fatty liver disease (NAFLD) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress and lipotoxicity. The present study aimed to elucidate the effect of Quaking 5 (QKI 5) as mediated by Sirtuin 1 (SIRT1) on triglyceride (TG) synthesis in the liver of an NAFLD mouse model. A hi...

journal_title：International journal of molecular medicine

authors： Zhang W,Sun Y,Liu W,Dong J,Chen J

更新日期：2019-03-01 00:00:00

abstract：:Akt1/protein kinase Bα (Akt1/PKBα) is a downstream mediator of the insulin signaling system. In this study we explored mechanism(s) for its role in burn injury. Akt1/PKBα in liver extracts from mice with burn injury fed with (2H7)-L-Leu was immunoprecipitated and isolated with SDS-PAGE. Two tryptic peptides, one in th...

journal_title：International journal of molecular medicine

authors： Lu XM,Tompkins RG,Fischman AJ

更新日期：2012-03-01 00:00:00

abstract：:Neuropathic pain is a condition characterized by unpleasant sensory and emotional experiences associated with a number of diseases or injuries affecting the sensory system through various mechanisms. In this study, we focused on the impact of chronic neuropathic pain on the microglial state and hippocampal neurogenesi...

journal_title：International journal of molecular medicine

authors： Tyrtyshnaia A,Manzhulo I,Kipryushina Y,Ermolenko E

更新日期：2019-05-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of atherosclerosis by promoting vascular smooth muscle cell (VSMC) growth, migration, apoptosis, adhesion and the secretion of matrix components. The osteogenic differentiation of VSMCs is essential in the development of vascular calcif...

journal_title：International journal of molecular medicine

authors： Huang J,Huang H,Wu M,Li J,Xie H,Zhou H,Liao E,Peng Y

更新日期：2013-08-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:It is known that cancers develop by a multi-step process. Normal cells are first immortalized, and then transformed into tumorigenic cells. Normal human cells are very rarely immortalized, but once they are, they are relatively easily transformed into tumorigenic cells. This indicates that the immortalization step pla...

journal_title：International journal of molecular medicine

authors： Katayama B,Sakaguchi M,Li JW,Pu H,Inoue Y,Namba M

更新日期：1998-11-01 00:00:00

abstract：:In the present study, we aimed to explore the effect of environmental endocrine disruptors (EEDs) on sexual differentiation in androgen receptor (AR)-/-, AR+/- and AR+/+ male mice. By using a Cre-loxP conditional knockout strategy, we generated AR knockout mice. By mating flox-AR female mice with AR-Cre male mice, the...

journal_title：International journal of molecular medicine

authors： Liu D,Shen L,Tao Y,Kuang Y,Cai L,Wang D,He M,Tong X,Zhou S,Sun J,Shi C,Wang C,Wu Y

更新日期：2015-02-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and con...

journal_title：International journal of molecular medicine

authors： Bianchi E,Scarinci F,Ripandelli G,Feher J,Pacella E,Magliulo G,Gabrieli CB,Plateroti R,Plateroti P,Mignini F,Artico M

更新日期：2013-01-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:Sevoflurane (Sevo) is one of the most frequently used volatile anesthetic agents in surgical oncology and has various effects on tumors, including inhibiting tumor growth, recurrence, and metastases; however, the molecular mechanisms are unknown. This study tried to investigate the influence of Sevo on hepatocellular ...

journal_title：International journal of molecular medicine

authors： Cao Y,Lv W,Ding W,Li J

更新日期：2020-07-01 00:00:00

abstract：:Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The prese...

journal_title：International journal of molecular medicine

authors： Song F,Liu J,Feng Y,Jin Y

更新日期：2020-09-01 00:00:00

abstract：:Cardiac fibroblast (CF) proliferation and transformation into myofibroblasts play important roles in cardiac fibrosis during pathological myocardial remodeling. In this study, we demonstrate that hepatocyte growth factor (HGF), an antifibrotic factor in the process of pulmonary, renal and liver fibrosis, is a negative...

journal_title：International journal of molecular medicine

authors： Yi X,Li X,Zhou Y,Ren S,Wan W,Feng G,Jiang X

更新日期：2014-08-01 00:00:00

abstract：:The aim of the present study was to examine the protective effect of caveolin‑1 (Cav‑1) in the penehyclidine hydrochloride (PHC)‑based inhibition of lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in vivo and in vitro, in addition to the potential underlying mechanisms. In vivo, an ALI rat model was establish...

journal_title：International journal of molecular medicine

authors： Wu X,Kong Q,Xia Z,Zhan L,Duan W,Song X

更新日期：2019-05-01 00:00:00

abstract：:Congenital bicuspid aortic valve (BAV) represents the most common type of cardiac birth defect affecting 0.4‑2% of the general population, and accounts for a markedly increased incidence of life‑threatening complications, including valvulopathy and aortopathy. Accumulating evidence has demonstrated the genetic basis o...

journal_title：International journal of molecular medicine

authors： Wang J,Abhinav P,Xu YJ,Li RG,Zhang M,Qiu XB,Di RM,Qiao Q,Li XM,Huang RT,Xue S,Yang YQ

更新日期：2019-04-01 00:00:00

abstract：:Oral squamous cell carcinomas (OSCCs), a major public health problem worldwide, are the most common neoplasms of the head and neck. The most important prognostic indicator for patients with OSCC is metastasis to cervical lymph nodes or distant organs. Galectin-9 is correlated with cellular adhesion and aggregation in ...

journal_title：International journal of molecular medicine

authors： Kasamatsu A,Uzawa K,Nakashima D,Koike H,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2005-08-01 00:00:00

abstract：:Trypsinogen/trypsin is one of the major serine proteases and is produced by pancreatic acinar cells. Tumor-associated trypsinogen (TAT) has been reported to be produced by several cancer cell lines. The biological roles and activation mechanisms of both TAT and pancreatic acinar trypsinogen (PAT) have not been elucida...

journal_title：International journal of molecular medicine

authors： Uchima Y,Sawada T,Nishihara T,Umekawa T,Ohira M,Ishikawa T,Nishino H,Hirakawa K

更新日期：2003-12-01 00:00:00

abstract：:Recent studies have suggested that calcium‑activated potassium channel (KCa) agonists increase the proportion of mouse embryonic stem cell‑derived cardiomyocytes and promote the differentiation of pacemaker cells. In the present study, it was hypothesized that adipose‑derived stem cells (ADSCs) can differentiate into ...

journal_title：International journal of molecular medicine

authors： Yang M,Zhao Q,Zhao H,Yang A,Wang F,Wang X,Tang Y,Huang C

更新日期：2019-12-01 00:00:00

abstract：:Aberrant DNA methylation on CpG islands is one of the most consistent epigenetic changes in human cancers, and the methylation process is catalyzed by DNA methyltransferase (DNMT). We evaluated i) the mRNA levels of three DNMTs; DNMT1, DNMT3a and DNMT3b, in 25 hepatocellular carcinomas (HCCs), in their corresponding n...

journal_title：International journal of molecular medicine

authors： Oh BK,Kim H,Park HJ,Shim YH,Choi J,Park C,Park YN

更新日期：2007-07-01 00:00:00

abstract：:Noise-induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. It has been demonstrated that hair cell loss in the auditory end organ may account for the majority of ear pathological conditions. Previous studies have indicated that histone deacetylases (HDACs) play an important...

journal_title：International journal of molecular medicine

authors： Wen LT,Wang J,Wang Y,Chen FQ

更新日期：2015-08-01 00:00:00

abstract：:In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

journal_title：International journal of molecular medicine

authors： Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

更新日期：2018-06-01 00:00:00

abstract：:DNA microarrays, which are among the most popular genomic tools, are widely applied in biology and medicine. Boutique arrays, which are small, spotted, dedicated microarrays, constitute an inexpensive alternative to whole-genome screening methods. The data extracted from each microarray-based experiment must be transf...

journal_title：International journal of molecular medicine

authors： Uszczyńska B,Zyprych-Walczak J,Handschuh L,Szabelska A,Kaźmierczak M,Woronowicz W,Kozłowski P,Sikorski MM,Komarnicki M,Siatkowski I,Figlerowicz M

更新日期：2013-09-01 00:00:00

abstract：:The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathwa...

journal_title：International journal of molecular medicine

authors： Yin M,Shen Z,Yang L,Zheng W,Song H

更新日期：2019-05-01 00:00:00

abstract：:Abnormal gap junction communication (GJC) has been associated with carcinogenesis. We investigated the role of endothelial cell GJC and connexin 43 (Cx43), the main gap junction protein in these cells, during tumour cell extravasation. GJC was determined by the ability of cells to transfer Lucifer yellow, to neighbour...

journal_title：International journal of molecular medicine

authors： Cai J,Jiang WG,Mansel RE

更新日期：1998-01-01 00:00:00

abstract：:Determination of CD34+ cells was performed in bone marrow and G-CSF mobilised peripheral blood samples. We adopted three different protocols of analysis: the Milan/Mulhouse protocol, the ISHAGE guidelines for CD34+ cell determination and our own protocol based upon the use of PAINT-A-GATEPRO software analysis program....

journal_title：International journal of molecular medicine

authors： Venditti A,Buccisano F,Del Poeta G,Battaglia A,Tamburini A,Bruno A,Adorno G,Caravita T,Santinelli S,Del Moro B,Epiceno AM,Ballatore G,Amadori S

更新日期：1998-01-01 00:00:00

abstract：:Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genomic DNA from the members o...

journal_title：International journal of molecular medicine

authors： Horiuchi T,Tsukamoto H,Mitoma H,Miyagawa H,Tamimoto Y,Yoshizawa S,Harada M,Hayashi K,Hashimura C,Oribe M,Okamura S

更新日期：2004-11-01 00:00:00

abstract：:Hepatic glucose production is promoted by forkhead box O1 (FoxO1) under conditions of insulin resistance. The overactivity of cannabinoid receptor type 1 (CB1R) partly causes increased liver fat deposits and metabolic dysfunction in obese rodents by decreasing mitochondrial function. The aim of the present study was t...

journal_title：International journal of molecular medicine

authors： Chen CC,Lee TY,Kwok CF,Hsu YP,Shih KC,Lin YJ,Ho LT

更新日期：2016-03-01 00:00:00

abstract：:Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study i...

journal_title：International journal of molecular medicine

authors： Pei W,Zou Y,Wang W,Wei L,Zhao Y,Li L

更新日期：2018-12-01 00:00:00