Identification of a trypsinogen activity stimulating factor produced by pancreatic cancer cells: its role in tumor invasion and metastasis.

abstract：:The transcription factor, forkhead box protein M1 (FoxM1), and the tyrosine kinase receptor, human epidermal growth factor receptor-2 (Her-2), are aberrantly expressed in a number of human malignancies, and are closely associated with the development of cancer. However, their regulatory mechanisms and their involvemen...

journal_title：International journal of molecular medicine

authors： Qi W,Li X,Zhang Y,Yao R,Qiu W,Tang D,Liang J

更新日期：2014-06-01 00:00:00

abstract：:Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid and has been shown to exhibit a diversity of pharmacological properties, including antimicrobial and anticancer activiti...

journal_title：International journal of molecular medicine

authors： Hua F,Li CH,Chen XG,Liu XP

更新日期：2018-06-01 00:00:00

abstract：:Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons. Nerve growth fact...

journal_title：International journal of molecular medicine

authors： Ohta M,Chosa N,Kyakumoto S,Yokota S,Okubo N,Nemoto A,Kamo M,Joh S,Satoh K,Ishisaki A

更新日期：2018-09-01 00:00:00

abstract：:Elastofibroma is a rare, benign, slow-growing degenerative pseudotumor that typically occurs in the subscapular region and has been considered a peculiar fibroblastic proliferation with accumulation of abnormal elastic fibers. Very little is known about the cytogenetic and molecular genetic changes in elastofibroma. I...

journal_title：International journal of molecular medicine

authors： Nishio JN,Iwasaki H,Ohjimi Y,Ishiguro M,Koga T,Isayama T,Naito M,Kikuchi M

更新日期：2002-09-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Sprouty (SPRY) was first identified in a genetic screen in Drosophila to be an antagonist of fibroblast growth factor (FGF) and epidermal growth factor (EGF) signaling, seemingly by inhibiting the Ras/MAP kinase pathway. During large scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel splice ...

journal_title：International journal of molecular medicine

authors： Wang L,Ji C,Wu H,Xu J,Wu Q,Dai J,Yin G,Ye X,Gu S,Xie Y,Mao Y

更新日期：2003-11-01 00:00:00

abstract：:The opioid growth factor (OGF) is a constitutively expressed negative growth regulator whose action is mediated by the OGF receptor (OGFr). The OGF-OGFr axis tonically regulates the growth of human squamous cell carcinoma of the head and neck (SCCHN). To examine the repercussions of amplifying OGFr in SCCHN, construct...

journal_title：International journal of molecular medicine

authors： McLaughlin PJ,Verderame MF,Hankins JL,Zagon IS

更新日期：2007-03-01 00:00:00

abstract：:The anti-cancer and cancer-preventive effects of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] are well documented by a variety of studies, including epidemiological, cell culture, animal, and clinical studies. While (-)-EGCG remains the most potent polyphenol in green tea, it is very unst...

journal_title：International journal of molecular medicine

authors： Landis-Piwowar KR,Kuhn DJ,Wan SB,Chen D,Chan TH,Dou QP

更新日期：2005-04-01 00:00:00

abstract：:CDH1, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinoma...

journal_title：International journal of molecular medicine

authors： Ling ZQ,Li P,Ge MH,Zhao X,Hu FJ,Fang XH,Dong ZM,Mao WM

更新日期：2011-05-01 00:00:00

abstract：:Congenital heart disease (CHD), the most prevalent birth defect in humans worldwide, is still a leading non‑infectious cause of infant morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of CHD, and more than 50 genes have been linked to various types...

journal_title：International journal of molecular medicine

authors： Pan Y,Geng R,Zhou N,Zheng GF,Zhao H,Wang J,Zhao CM,Qiu XB,Yang YQ,Liu XY

更新日期：2015-04-01 00:00:00

abstract：:We aimed to explore the anti-inflammatory effects of total alkaloids inRubus alceifolius Poir [corrected]. (TARAP) on non-alcoholic fatty liver disease, and to investigate the possible molecular mechanisms. A rodent non-alcoholic fatty liver disease (NAFLD) model was established by administration of a modified high-fa...

journal_title：International journal of molecular medicine

authors： Zhao J,Zheng H,Liu Y,Lin J,Zhong X,Xu W,Hong Z,Peng J

更新日期：2013-04-01 00:00:00

abstract：:The advanced glycation end‑product (AGE)‑receptor for AGE (RAGE) axis induces transforming growth factor‑β (TGF‑β) expression, cell hypertrophy and increases extracellular matrices that are indicated in the pathogenesis of diabetic nephropathy (DN). RAGE binds to numerous ligands besides AGE, including S100B. In the p...

journal_title：International journal of molecular medicine

authors： Chuang CT,Guh JY,Lu CY,Chen HC,Chuang LY

更新日期：2015-02-01 00:00:00

abstract：:The ZNF268 gene was originally isolated from an early human embryo cDNA library. Several different transcripts have been isolated for the ZNF268 gene and developmental expression studies suggest that ZNF268 plays a role in the development of human fetal liver and the differentiation of blood cells. In our effort to st...

journal_title：International journal of molecular medicine

authors： Shao H,Zhu C,Zhao Z,Guo M,Qiu H,Liu H,Wang D,Xue L,Gao L,Sun C,Li W

更新日期：2006-09-01 00:00:00

abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...

journal_title：International journal of molecular medicine

authors： Wang J,Cui M,Sun F,Zhou K,Fan B,Qiu JH,Chen FQ

更新日期：2020-04-01 00:00:00

abstract：:Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resve...

journal_title：International journal of molecular medicine

authors： Sun X,Fu P,Xie L,Chai S,Xu Q,Zeng L,Wang X,Jiang N,Sang M

更新日期：2021-01-01 00:00:00

abstract：:DNA microarrays, which are among the most popular genomic tools, are widely applied in biology and medicine. Boutique arrays, which are small, spotted, dedicated microarrays, constitute an inexpensive alternative to whole-genome screening methods. The data extracted from each microarray-based experiment must be transf...

journal_title：International journal of molecular medicine

authors： Uszczyńska B,Zyprych-Walczak J,Handschuh L,Szabelska A,Kaźmierczak M,Woronowicz W,Kozłowski P,Sikorski MM,Komarnicki M,Siatkowski I,Figlerowicz M

更新日期：2013-09-01 00:00:00

abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

journal_title：International journal of molecular medicine

authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

更新日期：2012-02-01 00:00:00

abstract：:miR-30a is situated on chromosome 6q.13 and is produced by an intronic transcriptional unit. However, its role in regulating the apoptosis, invasion and metastasis of breast cancer cells is not yet fully understood. The aim of this study was to research the biological function of miR‑30a and its direct target gene in ...

journal_title：International journal of molecular medicine

authors： Zhang HD,Jiang LH,Sun DW,Li J,Tang JH

更新日期：2017-10-01 00:00:00

abstract：:When treating glaucoma, excessive scar tissue reactions reduce the postoperative survival rate of the filtering bleb. Accumulating evidence has demonstrated that the proliferation, migration and extracellular matrix (ECM) synthesis of fibroblasts are important molecular mechanisms underlying scar formation. Recent evi...

journal_title：International journal of molecular medicine

authors： Sun L,Dong Y,Zhao J,Yin Y,Tong B,Zheng Y,Xin H

更新日期：2018-03-01 00:00:00

abstract：:Celastrol, a natural biologically active compound isolated from Tripterygium wilfordii Hook F root extracts, has been shown to possess antitumor properties and therefore, is an interesting candidate for the development of novel chemotherapeutic cancer agents. In this study, we have demonstrated that Celastrol is a pot...

journal_title：International journal of molecular medicine

authors： Huang L,Zhang Z,Zhang S,Ren J,Zhang R,Zeng H,Li Q,Wu G

更新日期：2011-03-01 00:00:00

abstract：:Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMAC1 were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become...

journal_title：International journal of molecular medicine

authors： Wang NM,Chang JG

更新日期：1999-05-01 00:00:00

abstract：:Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by...

journal_title：International journal of molecular medicine

authors： Zhu H,Cao W,Zhao P,Wang J,Qian Y,Li Y

更新日期：2018-12-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common malignant tumors in males globally. Its progression imposes a heavy burden on patients; however, the expression profile of circular (circ)RNAs in BC progression remains unclear. This study explored changes in circRNA expression during BC progression by sequencing different...

journal_title：International journal of molecular medicine

authors： Li W,Li Y,Sun Z,Zhou J,Cao Y,Ma W,Xie K,Yan X

更新日期：2019-11-01 00:00:00

abstract：:Xuebijing injection (XBJ) has long been used to treat infectious diseases in China. The therapeutic effect of XBJ is probably associated with anti-inflammatory effects. However, the precise mechanisms responsible for the effects of XBJ remain unknown. The present study was conducted in order to evaluate the protective...

journal_title：International journal of molecular medicine

authors： Liu MW,Liu R,Wu HY,Zhang W,Xia J,Dong MN,Yu W,Wang Q,Xie FM,Wang R,Huang YQ,Qian CY

更新日期：2016-11-01 00:00:00

abstract：:The circulating concentrations of triglycerides, high density lipoprotein (HDL)‑cholesterol, and low density lipoprotein (LDL)‑cholesterol have a substantial genetic component, and the heritability of early‑onset dyslipidemia might be expected to be higher compared with late‑onset forms. In the present study, exome‑wi...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Oguri M,Horibe H,Fujimaki T,Yasukochi Y,Takeuchi I,Sakuma J

更新日期：2019-01-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) are a major cause of hearing loss. In this study, we performed a systematic mutational screening of the 12S rRNA, tRNA Ser(UCN), tRNA Lys and tRNA Leu(UUR) genes in 227 unrelated patients with nonsyndromic hearing impairment for the first time in a Korean population. We found two...

journal_title：International journal of molecular medicine

authors： Bae JW,Lee KY,Choi SY,Lee SH,Park HJ,Kim UK

更新日期：2008-08-01 00:00:00

abstract：:A substantial increase in NADH production, arising from accelerated glycolysis, occurs in cardiac hypertrophy and this raises the question of how the NADH is oxidised. We have addressed this problem by reconstructing appropriate mitochondrial shuttles in vitro, using mitochondria from the left ventricles of both normo...

journal_title：International journal of molecular medicine

authors： Atlante A,Seccia TM,De Bari L,Marra E,Passarella S

更新日期：2006-07-01 00:00:00

abstract：:The adhesion of monocytes to human umbilical vein endothelial cells (HUVECs) plays a crucial role in the initiation of atherosclerosis. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are two important molecules involved in the adhesion of monocytes to HUVECs. Previous studies...

journal_title：International journal of molecular medicine

authors： Wang Y,Cao J,Fan Y,Xie Y,Xu Z,Yin Z,Gao L,Wang C

更新日期：2016-06-01 00:00:00

abstract：:The response of living cells to change in cell environment depends on the action of second messenger molecules. The two second messenger molecules cAMP and Ca2+ regulate a large number of eukaryotic cellular events. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1) is one of the key enzymes involved in ...

journal_title：International journal of molecular medicine

authors： Sharma RK,Das SB,Lakshmikuttyamma A,Selvakumar P,Shrivastav A

更新日期：2006-07-01 00:00:00

abstract：:Cartilage tissue engineering plays an important role in the generation of grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. Dedifferentiated cells produce matrix of less quality, and the molecular basis is still not well understood. Theref...

journal_title：International journal of molecular medicine

authors： Goessler UR,Bieback K,Bugert P,Naim R,Schafer C,Sadick H,Hormann K,Riedel F

更新日期：2005-10-01 00:00:00