S100B is required for high glucose-induced pro-fibrotic gene expression and hypertrophy in mesangial cells.

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:Geranylgeranylacetone (GGA) has recently been reported to have a protective effect against ischemic, injurious and apoptotic stress in several tissues. The aim of this study was to determine the effect of GGA on colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. Colitis was induced by intrarectal i...

journal_title：International journal of molecular medicine

authors： Ohkawara T,Nishihira J,Takeda H,Katsurada T,Kato K,Yoshiki T,Sugiyama T,Asaka M

更新日期：2006-02-01 00:00:00

abstract：:Synthetic biomaterials combined with cells and osteogenic factors represent a promising approach for the treatment of a number of orthopedic diseases, such as bone trauma and congenital malformations. To guarantee optimal biological properties, bone substitutes are prepared with a 3D structure and porosity grade funct...

journal_title：International journal of molecular medicine

authors： Di Liddo R,Paganin P,Lora S,Dalzoppo D,Giraudo C,Miotto D,Tasso A,Barbon S,Artico M,Bianchi E,Parnigotto PP,Conconi MT,Grandi C

更新日期：2014-12-01 00:00:00

abstract：:Our objectives were to determine whether heme oxygenase-1 is a second messenger for prolactin-mediated angiogenesis. Endothelial cell proliferation and angiogenesis assay demonstrated that cell number and capillary formation were increased by prolactin (10 and 25 ng/ml). Both protein synthesis and mRNA analysis confir...

journal_title：International journal of molecular medicine

authors： Malaguarnera L,Pilastro MR,Quan S,Ghattas MH,Yang L,Mezentsev AV,Kushida T,Abraham NG,Kappas A

更新日期：2002-10-01 00:00:00

abstract：:After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and Allison Piovesan, are located at DIMES at the University of Florence (fourth af...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-08-01 00:00:00

abstract：:Apoptosis plays a critical role in the pathogenesis of chronic myocardial ischemia (CMI) and heart failure (HF). Endoplasmic reticulum stress (ERS) is one of the newly defined signaling pathways which initiate apoptosis. Previous studies have shown that ERS-associated apoptosis is involved in the pathogenesis of HF in...

journal_title：International journal of molecular medicine

authors： Xin W,Li X,Lu X,Niu K,Cai J

更新日期：2011-04-01 00:00:00

abstract：:Annexin A9 (ANXA9), a member of annexin family, has been reported be associated with colorectal cancer (CRC) carcinogenesis. However, the clinical significance of ANXA9 in CRC, particularly its correlation to invasion and metastasis remains ambiguous. The aim of the present study was to investigate the significance of...

journal_title：International journal of molecular medicine

authors： Yu S,Bian H,Gao X,Gui L

更新日期：2018-04-01 00:00:00

abstract：:It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) alleviated liver fibrosis. We investigated whether BMSCs transfected with human matrix metalloproteinase 1 (BMSCs/MMP1) would improve their therapeutic effect in liver fibrosis induced by carbon tetrachloride (CCl4) in rats. BMSCs were transf...

journal_title：International journal of molecular medicine

authors： Du C,Jiang M,Wei X,Qin J,Xu H,Wang Y,Zhang Y,Zhou D,Xue H,Zheng S,Zeng W

更新日期：2018-06-01 00:00:00

abstract：:Metformin, a widely prescribed antidiabetic drug, has previously been shown to lower the risk of certain types of cancer, including that of breast cancer, and to improve prognosis. Its anticancer effects, which are mediated by the activation of AMP-activated protein kinase (AMPK), have become notable. The Sonic hedgeh...

journal_title：International journal of molecular medicine

authors： Fan C,Wang Y,Liu Z,Sun Y,Wang X,Wei G,Wei J

更新日期：2015-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a common age-associated neurodegenerative disorder. To date, stem cell transplantation therapy has been developed to replace lost or damaged neural cells in PD patients, in whom dopaminergic neuron cells are lost. Here, we show that CD44+ human amniotic fluid cells (HuAFCs) can be induced t...

journal_title：International journal of molecular medicine

authors： Liu T,Guo L,Liu Z,Huang Y,Cheng W

更新日期：2011-11-01 00:00:00

abstract：:To gain a better understanding of the mechanisms that underpin aortic calcification, rodent models have been previously utilised. Regions of calcium and phosphate deposition are commonly visualised using labor-intensive two-dimensional histomorphometric techniques. In this study, we developed a novel micro-computed to...

journal_title：International journal of molecular medicine

authors： Huesa C,Millán JL,van 't Hof RJ,MacRae VE

更新日期：2013-11-01 00:00:00

abstract：:Although efavirenz (EFV) is efficacious as an antiretroviral therapy when combined with other antiretroviral drugs, it may cause adverse clinical effects, including skin and mucosal eruptions, central nervous system complications, hepatotoxicity, renal failure and pulmonary complications. The present study investigate...

journal_title：International journal of molecular medicine

authors： Dong Q,Oh JE,Yi JK,Kim RH,Shin KH,Mitsuyasu R,Park NH,Kang MK

更新日期：2013-06-01 00:00:00

abstract：:Epidemiological studies have indicated that increased consumption of cruciferous vegetables is associated with a statistically significant reduction in the risk for cancers. The major bioactive agent in these vegetables is a class of sulfur-containing glycosides called glucosinolates. Isothiocyanates, derivatives of g...

journal_title：International journal of molecular medicine

authors： Jadhav U,Ezhilarasan R,Vaughn SF,Berhow MA,Mohanam S

更新日期：2007-03-01 00:00:00

abstract：:Van der Woude syndrome (VWS) is the most common autosomal dominant disorder with characteristic lip pits and clefts of the lip and/or palate (CL/P). The interferon regulatory factor 6 gene (IRF6) has been recently identified as the gene mutated in patients with VWS. Here, we report two novel mutations of IRF6 in two u...

journal_title：International journal of molecular medicine

authors： Kim Y,Park JY,Lee TJ,Yoo HW

更新日期：2003-10-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominantly inherited cancer syndrome (OMIM 131100), with tumours in several endocrine glands. In 1997 the responsible tumour suppressor gene was identified and recently it was shown that menin, its encoded protein, represses JunD-activated gene expression. Al...

journal_title：International journal of molecular medicine

authors： Roijers JF,Apel T,Neumann HP,Arnim UV,Lips CJ,Hoppener JW

更新日期：2000-06-01 00:00:00

abstract：:Although diabetes mellitus has been recognized as a risk factor for chronic kidney disease (CKD), genetic factors for predisposition to CKD in individuals with diabetes mellitus remain elucidated. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD among individuals with...

journal_title：International journal of molecular medicine

authors： Yoshida T,Kato K,Yokoi K,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nishigaki Y,Suzuki T,Nozawa Y,Yamada Y

更新日期：2009-04-01 00:00:00

abstract：:We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC) primary tumors on the hind foot pad grew palpable, they were amputated on two different days. In experiment (A) (earlier amputation model), micrometastases were det...

journal_title：International journal of molecular medicine

authors： Uchida J,Sato K,Okabe H,Saito H,Nakano K,Fujioka A,Takechi T,Takeda S,Unemi N,Fukushima M

更新日期：2000-04-01 00:00:00

abstract：:Survivin is a novel apoptosis inhibitor. Its gene is related to the baculovirus gene, which is believed to play a crucial role in fetal development and in cancer. We attempted to determine the expression of survivin in both thyroid goiter and carcinoma tissues, and to evaluate its prognostic value in human thyroid dis...

journal_title：International journal of molecular medicine

authors： Chen Z,Liu N,Zhu G,Dralle H,Hoang-Vu C

更新日期：2012-09-01 00:00:00

abstract：:Acute Achilles tendon (AT) rupture is a common injury with a comparatively high complication rate. Presently, surgical treatments compete with nonoperative treatment modalities. The aim of this study was to elucidate the possible beneficial effects of short-term combinatory application of growth factors on tendon heal...

journal_title：International journal of molecular medicine

authors： Konerding MA,Arlt F,Wellmann A,Li V,Li W

更新日期：2010-02-01 00:00:00

abstract：:One of the most aggressive human malignancies, anaplastic thyroid carcinoma (ATC), has an extremely poor prognosis that may be explained by its genomic instability. We hypothesized that the very rapid cell turnover observed in ATC might accelerate telomere shortening and chromosomal instability associated with tumor c...

journal_title：International journal of molecular medicine

authors： Kammori M,Onoda N,Nakamura K,Izumiyama N,Ogisawa K,Kurabayashi R,Ogawa T,Kaminishi M,Poon SS,Takubo K

更新日期：2006-07-01 00:00:00

abstract：:Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requireme...

journal_title：International journal of molecular medicine

authors： Wang Z,Wang N,Liu X,Wang Q,Xu B,Liu P,Zhu H,Chen J,Situ H,Lin Y

更新日期：2018-01-01 00:00:00

abstract：:A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect...

journal_title：International journal of molecular medicine

authors： Sancho V,Nuche B,Arnés L,Cancelas J,González N,Díaz-Miguel M,Martín-Duce A,Valverde I,Villanueva-Peñacarrillo ML

更新日期：2007-06-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the clearance of pathogens. In the present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C...

journal_title：International journal of molecular medicine

authors： Bian H,Li F,Wang W,Zhao Q,Gao S,Ma J,Li X,Ren W,Qin C,Qi J

更新日期：2017-11-01 00:00:00

abstract：:The number of regulatory T cells (Treg cells) and the expression of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1; also known as CD39) and 5'-ectonucleotidase (NT5E; also known as CD73) on the Treg cell surface are increased during sepsis. In this study, to determine the factors leading to the high expressi...

journal_title：International journal of molecular medicine

authors： Bao R,Shui X,Hou J,Li J,Deng X,Zhu X,Yang T

更新日期：2016-09-01 00:00:00

abstract：:Angioplasty is a principal treatment for occlusive vascular disease but 30-50% of patients show a restenosis of the vessel. There is no clinical effective therapy for this disease. It has been demonstrated, in animal models, that various drugs such as NO-donor, plasminogen inhibitor tranexamic acid and MMP (matrix met...

journal_title：International journal of molecular medicine

authors： Indolfi C,Stabile E,Perrino C,Chiariello M

更新日期：1998-08-01 00:00:00

abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

journal_title：International journal of molecular medicine

authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

更新日期：2001-03-01 00:00:00

abstract：:Living donor liver transplantation (LDLT) requires ischemia/reperfusion (I/R), which can cause early graft injury. However, the detailed mechanism of I/R injury remains unknown. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme catabolism and results in the production of iro...

journal_title：International journal of molecular medicine

authors： Matsumi J,Morimatsu H,Matsusaki T,Kaku R,Shimizu H,Takahashi T,Yagi T,Matsumi M,Morita K

更新日期：2012-02-01 00:00:00

abstract：:CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

journal_title：International journal of molecular medicine

authors： Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

更新日期：2008-02-01 00:00:00

abstract：:Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma cell lines. The expression of these molecules has been also characterized in human normal ti...

journal_title：International journal of molecular medicine

authors： Takebayashi Y,Nakayama K,Fujioka T,Kanzaki A,Mutho M,Uchida T,Miyazaki K,Ito M,Fukumoto M

更新日期：2001-04-01 00:00:00

abstract：:We have previously reported that the calcium-sensing receptor (CaSR) plays an important role in modulating lipid metabolism under low calcium conditions. The aim of this study was to identify possible regulators of CaSR and the mechanisms of action of CaSR in obese individuals. Subcutaneous fat samples were obtained f...

journal_title：International journal of molecular medicine

authors： He Y,Perry B,Bi M,Sun H,Zhao T,Li Y,Sun C

更新日期：2013-08-01 00:00:00