Inhibitory effect of lactoperoxidase-generated hypothiocyanite upon black pigmented anaerobe growth.

abstract：:Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

journal_title：International journal of molecular medicine

authors： Grässel S,Ahmed N,Göttl C,Grifka J

更新日期：2009-06-01 00:00:00

abstract：:An early insulin regimen ameliorates glucotoxicity but also lipotoxicity in type 2 diabetes; however, the underlying mechanism remains elusive. In the present study, we investigated the role of mitochondria in lipid regulation following early insulin administration in insulin-resistant skeletal muscle cells. Male C57B...

journal_title：International journal of molecular medicine

authors： Tang W,Tang S,Wang H,Ge Z,Zhu D,Bi Y

更新日期：2017-12-01 00:00:00

abstract：:Arachidin-1 [trans-4-(3-methyl-1-butenyl)-3,5,3',4'-tetrahydroxystilbene] is a polyphenol produced by peanut kernels during germination. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory effect of arachidin-1 in endothelial cells (ECs). The results of cell adhesion and west...

journal_title：International journal of molecular medicine

authors： Chen LG,Zhang YQ,Wu ZZ,Hsieh CW,Chu CS,Wung BS

更新日期：2018-01-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:It is abundantly clear that tumor-derived parathyroid hormone-related protein (PTHrP), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are central contributors in promoting osteolytic process of breast carcinoma bone metastasis. Forcusing on this molecular basis, the study was undertak...

journal_title：International journal of molecular medicine

authors： Zheng X,Kang W,Liu H,Guo S

更新日期：2018-06-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMCs) are involved in all stages of the progression of human atherosclerosis (AS). MicroRNAs (miRNAs or miRs) are non‑coding, small RNAs that regulate gene expression at the post‑transcriptional level through translational repression or messenger RNA (mRNA) decay. Recently, a variety of ...

journal_title：International journal of molecular medicine

authors： Yu X,Li Z

更新日期：2014-10-01 00:00:00

abstract：:Telomerase activity and hTERT mRNA expression are upregulated in colorectal cancer. Whether they are inherent in colorectal adenomas, premalignant lesions to cancer, however, remains to be elucidated. We examined telomerase activity by the fluorescence-based telomeric repeat amplification protocol method and analyzed ...

journal_title：International journal of molecular medicine

authors： Kanamaru T,Tanaka K,Kotani J,Ueno K,Yamamoto M,Idei Y,Hisatomi H,Takeyama Y

更新日期：2002-08-01 00:00:00

abstract：:Prostate-specific antigen (PSA) has been used clinically as a marker for the diagnosis and staging of prostate cancer due to its specific expression in prostate epithelial cells. In addition to its medical importance, its complex hormonal and tissue-specific regulation makes it an attractive model to study gene regula...

journal_title：International journal of molecular medicine

authors： Willis RA,Wei C,Turner MJ,Callahan BP,Pugh AE,Barth RK,Lord EM,Frelinger JG

更新日期：1998-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that control key genes involved in fatty acid metabolism and energy homeostasis. Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma. As...

journal_title：International journal of molecular medicine

authors： Kannisto K,Chibalin A,Glinghammar B,Zierath JR,Hamsten A,Ehrenborg E

更新日期：2006-01-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:A wide range of therapeutic options exists for the treatment of keloids, all of which have their own strengths; however, a high risk of side‑effects and frequent recurrence remains. Therefore, the present study aimed to identify improved therapeutic approaches or drugs for the treatment of keloids. Ginsenoside Rg3 (Rg...

journal_title：International journal of molecular medicine

authors： Tang M,Bian W,Cheng L,Zhang L,Jin R,Wang W,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology with considerable morbidity and mortality. Seeking informative diagnostic markers with greater clinical significance is essential for the early diagnosis of IPF. microRNAs (miRNAs or miRs) have emerged as novel serum diagnostic biomarkers for various...

journal_title：International journal of molecular medicine

authors： Li P,Li J,Chen T,Wang H,Chu H,Chang J,Zang W,Wang Y,Ma Y,Du Y,Zhao G,Zhang G

更新日期：2014-06-01 00:00:00

abstract：:Manumycin was reported to have inhibitory effect on farnesyltransferase by competing with the farnesyl pyrophosphate substrate. It exhibited different antiproliferative activity in human hepatocellular carcinoma HepG2 cells, primary cultured human cardiac muscle cells and human liver cells (CLC). HepG2 cells overexpre...

journal_title：International journal of molecular medicine

authors： Zhou JM,Zhu XF,Pan QC,Liao DF,Li ZM,Liu ZC

更新日期：2003-06-01 00:00:00

abstract：:microRNAs (miRNAs) are important both in early cardiogenesis and in the process of heart maturation. The aim of this study was to determine the stage-specific expression of miRNAs in human fetal heart in order to identify valuable targets for further study of heart defects. Affymetrix microarrays were used to obtain m...

journal_title：International journal of molecular medicine

authors： Zhou J,Dong X,Zhou Q,Wang H,Qian Y,Tian W,Ma D,Li X

更新日期：2014-05-01 00:00:00

abstract：:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potentia...

journal_title：International journal of molecular medicine

authors： Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

更新日期：2014-01-01 00:00:00

abstract：:Porphyra yezoensis (P. yezoensis) is the most noteworthy red alga and is mainly consumed in China, Japan and Korea. In the present study, the effects of a P. yezoensis peptide (PY‑PE) on cell proliferation and the associated signaling pathways were examined in IEC‑6 rat intestinal epithelial cells. First, the MTS assa...

journal_title：International journal of molecular medicine

authors： Lee MK,Kim IH,Choi YH,Nam TJ

更新日期：2015-02-01 00:00:00

abstract：:Excessive preadipocyte differentiation/adipogenesis is closely linked to the development of obesity. LY3009120 is a pan‑Raf kinase inhibitor and is known for its anticancer activities. In the present study, the effect of LY3009120 on 3T3‑L1 cell adipogenesis was investigated. The differentiation of 3T3‑L1 preadipocyte...

journal_title：International journal of molecular medicine

authors： Yang SM,Park YK,Kim JI,Lee YH,Lee TY,Jang BC

更新日期：2018-12-01 00:00:00

abstract：:Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. Transforming growth factor-β1 (TGF-β1) signaling has been considered as a trigger causally contributing to pathological cardiac hypertrophy. Asiatic acid (AA) is a triterpenoid compound extracted from Centella asiatica and exhibits a variety of...

journal_title：International journal of molecular medicine

authors： Si L,Xu J,Yi C,Xu X,Wang F,Gu W,Zhang Y,Wang X

更新日期：2014-08-01 00:00:00

abstract：:17β-estradiol (17β-E2) is a steroid hormone that is known to exert effects on blood glucose homeostasis. The G protein‑coupled estrogen receptor (GPER) has been identified as a non-genomic estrogenic receptor, and is involved in numerous physiological processes, including cell survival, energy provision and metabolism...

journal_title：International journal of molecular medicine

authors： Zhang L,Zhao Y,Guo L

更新日期：2018-05-01 00:00:00

abstract：:Caveolin, the essential structural component of caveolae, serves as a scaffolding protein onto which signaling molecules are assembled, and functions as a negative regulator for signal transduction. Caveolin-1 and -2 are expressed in most cell types, but are not expressed in normal blood cells and cell lines. We previ...

journal_title：International journal of molecular medicine

authors： Tsuji Y,Hatanaka M,Maeda T,Seya T,Takenaka H,Shimizu A

更新日期：2005-11-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators of gene expression during tumorigenesis. The downregulation of microRNA-9 (miR-9) has been reported in ovarian serous carcinoma (OSC), indicating a role for miR-9 in this type of cancer. In this study, we investigated the biological significance of miR-9 in OSC in vitro. Usi...

journal_title：International journal of molecular medicine

authors： Tang H,Yao L,Tao X,Yu Y,Chen M,Zhang R,Xu C

更新日期：2013-08-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:The overexpression of interleukin-8 (IL-8) is closely associated with poor tumor differentiation, metastasis and tumor progression. This study aimed to examine the effects and mechanisms of action of SN38 (a metabolite of the camptothecin derivative, CPT-11) on IL-8 expression in HCT8 cells, using ELISA, CCK-8 and wes...

journal_title：International journal of molecular medicine

authors： Zhang L,Lou WH,Xu XF,Wu W,Rong YF,Jin DY

更新日期：2017-01-01 00:00:00

abstract：:Electrical activity of beta-cells and cytosolic Ca2+ concentration ([Ca2+]i) were monitored in mouse pancreatic islets exposed to the pentaacetate esters of alpha-D-glucose, beta-D-galactose and beta-L-glucose, all tested at 1.7 mM concentration. In the presence of 5 mM D-glucose, alpha-D-glucose pentaacetate induced ...

journal_title：International journal of molecular medicine

authors： Pomares R,Ropero AB,Sánchez-Andrés JV,Nadal A,Soria B,Malaisse WJ

更新日期：1999-01-01 00:00:00

abstract：:Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that ...

journal_title：International journal of molecular medicine

authors： Nakajima K,Wu G,Takeyama N,Sakudo A,Sugiura K,Yukawa M,Onodera T

更新日期：2009-07-01 00:00:00

abstract：:Currently, several therapeutic approaches including surgery, chemotherapy, and radiation therapy are available for the treatment of endometrial cancer. However, endometrial cancer cells may survive, resulting in relapse of the disease, and ultimately causing demise of the patient. Hepsin is a cell surface-expressed ch...

journal_title：International journal of molecular medicine

authors： Nakamura K,Takamoto N,Abarzua F,Hongo A,Kodama J,Nasu Y,Kumon H,Hiramatsu Y

更新日期：2008-09-01 00:00:00

abstract：:The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. The myocardial I/R model was established using C57BL/J6 mice. Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. Commercial kits were used ...

journal_title：International journal of molecular medicine

authors： Zhou Y,Li KS,Liu L,Li SL

更新日期：2020-06-01 00:00:00

abstract：:The ZNF268 gene was originally isolated from an early human embryo cDNA library. Several different transcripts have been isolated for the ZNF268 gene and developmental expression studies suggest that ZNF268 plays a role in the development of human fetal liver and the differentiation of blood cells. In our effort to st...

journal_title：International journal of molecular medicine

authors： Shao H,Zhu C,Zhao Z,Guo M,Qiu H,Liu H,Wang D,Xue L,Gao L,Sun C,Li W

更新日期：2006-09-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a rare aggressive type of B-cell non-Hodgkin's lymphoma. Response to chemotherapy tends to be short and virtually all patients sooner or later relapse. The prognosis of relapsed patients is extremely poor. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered o...

journal_title：International journal of molecular medicine

authors： Pospisilova J,Vit O,Lorkova L,Klanova M,Zivny J,Klener P,Petrak J

更新日期：2013-05-01 00:00:00

abstract：:We have recently demonstrated the antiproliferative and apoptotic activities of herbal traditional Chinese medicines, including the analomous fruit extract of Gleditsia sinensis, the fresh juice of Scutellaria barbata and the warmed water extract of Radix Sophorae Tonkinensis on a series of human carcinoma cells. Here...

journal_title：International journal of molecular medicine

authors： Lau FY,Chui CH,Gambari R,Kok SH,Kan KL,Cheng GY,Wong RS,Teo IT,Cheng CH,Wan TS,Chan AS,Tang JC

更新日期：2005-12-01 00:00:00