当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE期刊下所有文献 > P7 peptides targeting bFGF sensitize colorectal cancer cells to CPT-11.

P7 peptides targeting bFGF sensitize colorectal cancer cells to CPT-11.

Abstract：

:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potential target for improving the sensitivity of tumor cells to chemotherapeutic agents. In this study, we first demonstrate that a novel bFGF antagonist, peptide P7, previously isolated by phage display technology, reversed bFGF-induced resistance to irinotecan hydrochloride (CPT-11), and counteracted the anti-apoptotic effects of bFGF on CPT-11-treated HT-29 cells. Further experiments indicated that the inhibition of Akt activation, the suppression of bFGF internalization, the increase in the Bax to Bcl-2 ratio and the downregulation of cytokeratin 8 (CK8) by P7 may contribute to the counteracting of the anti-apoptotic effects of bFGF, and further reversal of bFGF-induced resistance to CPT-11. Our results suggest that peptide P7 may have therapeutic potential in CRC as a sensitizer to chemotherapeutic agents by targeting bFGF.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

doi

10.3892/ijmm.2013.1547

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

194-200

issue

1

eissn

1107-3756

issn

1791-244X

journal_volume

33

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE文献大全
  • Chrysobalanus icaco L. extract for antiangiogenic potential observation.

    abstract：:Angiogenesis is an important process in several physiological situations and it is also implicated in the development of some diseases such as diabetes and cancer. This study investigated the antiangiogenic potential of Chrysobalanus icaco methanol extract in the chicken embrionary tissue. Clinical trials for cancer t...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.5.6.667

    authors： Alves De Paulo S,Teruszkin Balassiano I,Henriques Silva N,Oliveira Castilho R,Coelho Kaplan MA,Currie Cabral M,da Costa Carvalho MG

    更新日期：2000-06-01 00:00:00

  • MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase.

    abstract：:A variety of microRNAs (miRNAs) have been reported to be significantly be involved in the regulation of vascular smooth muscle cell (VSMC) proliferation, which is an essential process for the formation of atherosclerotic plaque. The objective of the present study was to explore the role of microRNA-155 (miR-155) in th...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2181

    authors： Zhang J,Zhao F,Yu X,Lu X,Zheng G

    更新日期：2015-06-01 00:00:00

  • Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock.

    abstract：:Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage foll...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Toth B,Schwacha MG,Kuebler JF,Bland KI,Wang P,Chaudrya IH

    更新日期：2003-03-01 00:00:00

  • The calcium-sensing receptor and vitamin D receptor expression in tertiary hyperparathyroidism.

    abstract：:The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. All of these elements control calcium homeostasis, which is crucial for many physiological processes. Thus, impairment of the upstream component ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Grzela T,Chudzinski W,Lasiecka Z,Niderla J,Wilczynski G,Gornicka B,Wasiutynski A,Durlik M,Boszczyk A,Brawura-Biskupski-Samaha R,Dziunycz P,Milewski L,Lazarczyk M,Lazarczyk M,Nawrot I

    更新日期：2006-05-01 00:00:00

  • A new method for the quantification of aortic calcification by three-dimensional micro-computed tomography.

    abstract：:To gain a better understanding of the mechanisms that underpin aortic calcification, rodent models have been previously utilised. Regions of calcium and phosphate deposition are commonly visualised using labor-intensive two-dimensional histomorphometric techniques. In this study, we developed a novel micro-computed to...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1490

    authors： Huesa C,Millán JL,van 't Hof RJ,MacRae VE

    更新日期：2013-11-01 00:00:00

  • ERK activation induced by selenium treatment significantly downregulates beta/gamma-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M.

    abstract：:Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease....

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000211

    authors： Yim SY,Chae KR,Shim SB,Hong JT,Park JY,Lee CY,Son HJ,Sheen YY,Hwang DY

    更新日期：2009-07-01 00:00:00

  • Sox2 promotes tumor aggressiveness and epithelial‑mesenchymal transition in tongue squamous cell carcinoma.

    abstract：:Tongue squamous cell carcinoma (TSCC) is highly malignant and poorly differentiated, resulting in a high frequency of local recurrence and distant metastases. Sox2 (Sry‑box2), an important factor in embryonic development and cell differentiation, has been shown to associate with malignant phenotypes and epithelial‑mes...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3742

    authors： Liu X,Qiao B,Zhao T,Hu F,Lam AK,Tao Q

    更新日期：2018-09-01 00:00:00

  • Poly-ε-caprolactone composite scaffolds for bone repair.

    abstract：:Synthetic biomaterials combined with cells and osteogenic factors represent a promising approach for the treatment of a number of orthopedic diseases, such as bone trauma and congenital malformations. To guarantee optimal biological properties, bone substitutes are prepared with a 3D structure and porosity grade funct...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1954

    authors： Di Liddo R,Paganin P,Lora S,Dalzoppo D,Giraudo C,Miotto D,Tasso A,Barbon S,Artico M,Bianchi E,Parnigotto PP,Conconi MT,Grandi C

    更新日期：2014-12-01 00:00:00

  • Computational modeling of the potential interactions of the proteasome beta5 subunit and catechol-O-methyltransferase-resistant EGCG analogs.

    abstract：:(-)-Epigallocatechin gallate [(-)-EGCG] has been implicated in cancer chemoprevention and has been shown as an inhibitor of tumor proteasomal chymotrypsin-like activity in vitro and in vivo. However, EGCG is subjected to rapid biotransforming modifications such as methylation by catechol-Omicron-methyltransferase (COM...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000454

    authors： Kanwar J,Mohammad I,Yang H,Huo C,Chan TH,Dou QP

    更新日期：2010-08-01 00:00:00

  • Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer.

    abstract：:Heparanase is an enzyme that degrades extracellular glycoprotein to release heparan sulfate molecules. CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration. Production of CD44v3 and expression of heparanase were detected by immunohistochemistry and in situ hy...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kuniyasu H,Chihara Y,Kubozoe T,Takahashi T

    更新日期：2002-09-01 00:00:00

  • Serological markers for detection of cancer (Review).

    abstract：:We reviewed the effectiveness of commercial serological markers for the early detection of cancer and monitoring cancer patients. Parameters, such as specificity and variability of tumor markers were compared with a new approach for cancer detection which was recently developed in our laboratory. We demonstrate that t...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：10.3892/ijmm.7.5.547

    authors： Zusman I,Ben-Hur H

    更新日期：2001-05-01 00:00:00

  • The influence of angiotensin converting enzyme inhibitors on lipid peroxidation in sera and aorta of rabbits in diet-induced hypercholesterolemia.

    abstract：:In hypercholesterolemia increased lipid and lipoprotein peroxidation occurs. The renin-angiotensin system plays an important role in atherogenesis. Angiotensin II induces smooth muscle cells proliferation and stimulates oxidation of LDL particles and foam cell accumulation. Inhibition of ang II production leads to dec...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.6.5.591

    authors： Wojakowski W,Gminski J,Siemianowicz K,Goss M,Machalski M

    更新日期：2000-11-01 00:00:00

  • Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α.

    abstract：:Atherosclerosis is a chronic inflammatory disease in the vessel, and inflammatory cytokines play an important role in the inflammatory process of atherosclerosis. A high level of free fatty acids (FFAs) produced in lipid metabolism disorders are known to participate in the formation of atherosclerosis through multiple...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1942

    authors： Wu D,Liu J,Pang X,Wang S,Zhao J,Zhang X,Feng L

    更新日期：2014-12-01 00:00:00

  • Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits.

    abstract：:The aim of the present study was to investigate the biological activity of 20 essential oils (EOs) derived from herbal plants and citrus fruits. The in vitro anti-allergic and anti-inflammatory activities of these oils were investigated, and the EO which was found to have the strongest activity of the 20 EOs examined,...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1720

    authors： Mitoshi M,Kuriyama I,Nakayama H,Miyazato H,Sugimoto K,Kobayashi Y,Jippo T,Kuramochi K,Yoshida H,Mizushina Y

    更新日期：2014-06-01 00:00:00

  • The Irish paradigm on the natural progression of hepatitis C virus infection: an investigation in a homogeneous patient population infected with HCV 1b (review).

    abstract：:The aetiological agent of chronic hepatitis C is the hepatitis C virus. The hepatitis C virus is spread by parenteral transmission of body fluids, primarily blood or blood products. In 1989, after more than a decade of research, HCV was isolated and characterised. The hepatitis C viral genome is a positive-sense, sing...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Fanning LJ

    更新日期：2002-02-01 00:00:00

  • Black rice (Oryza sativa L.) extract modulates ultraviolet-induced expression of matrix metalloproteinases and procollagen in a skin cell model.

    abstract：:Exposure of the skin to ultraviolet (UV) radiation causes extracellular matrix (ECM) collapse in the dermis, owing to an increase in matrix metalloproteinase (MMP) production in both the epidermis and dermis, and a decrease in type I collagen expression in the dermis. Recently, black rice (Oryza sativa L.) was reporte...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3508

    authors： Han M,Bae JS,Ban JJ,Shin HS,Lee DH,Chung JH

    更新日期：2018-05-01 00:00:00

  • Experimental postoperative adjuvant chemotherapy by UFT using primary tumor amputation model.

    abstract：:We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC) primary tumors on the hind foot pad grew palpable, they were amputated on two different days. In experiment (A) (earlier amputation model), micrometastases were det...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.5.4.357

    authors： Uchida J,Sato K,Okabe H,Saito H,Nakano K,Fujioka A,Takechi T,Takeda S,Unemi N,Fukushima M

    更新日期：2000-04-01 00:00:00

  • The antitumor activity screening of chemical constituents from Camellia nitidissima Chi.

    abstract：:Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3502

    authors： Hou X,Du H,Yang R,Qi J,Huang Y,Feng S,Wu Y,Lin S,Liu Z,Jia AQ,Yuan S,Sun L

    更新日期：2018-05-01 00:00:00

  • Functions of the bone morphogenetic protein signaling pathway through microRNAs (review).

    abstract：:MicroRNAs (miRNAs or miRs) have emerged as key regulators of gene expression in essential cellular processes, such as cell growth, differentiation and development. Recent findings have established that the levels of miRNAs are modulated by cell signaling mechanisms, including the bone morphogenetic protein (BMP) signa...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：10.3892/ijmm.2015.2060

    authors： Hata A,Kang H

    更新日期：2015-03-01 00:00:00

  • Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells.

    abstract：:Laminarin, found in marine brown algae, is used as a carbohydrate reserve for phytoplankton; however, it is also used in traditional Chinese medicine, and has been shown to have several biological activities, including anticancer activities. In this study, we examined the mechanisms through which laminarin from Lamina...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1409

    authors： Park HK,Kim IH,Kim J,Nam TJ

    更新日期：2013-08-01 00:00:00

  • An adenosine A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation.

    abstract：:Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the activation of microglia, however, the underlying mechanisms remain elusive. Thus, t...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3546

    authors： Huang W,Bai S,Zuo X,Tang W,Chen P,Chen X,Wang G,Wang H,Xie P

    更新日期：2018-06-01 00:00:00

  • MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.

    abstract：:Non-alcoholic steatohepatitis (NASH) is one of the most common causes of chronic liver disease and is considered to be a causative factor of cryptogenic cirrhosis and hepatocellular carcinoma. microRNAs (miRNAs) are small non-coding RNAs that negatively regulate messenger RNA (mRNA). Recently, it was demonstrated that...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2092

    authors： Katsura A,Morishita A,Iwama H,Tani J,Sakamoto T,Tatsuta M,Toyota Y,Fujita K,Kato K,Maeda E,Nomura T,Miyoshi H,Yoneyama H,Himoto T,Fujiwara S,Kobara H,Mori H,Niki T,Ono M,Hirashima M,Masaki T

    更新日期：2015-04-01 00:00:00

  • Expression of BMP7 in cervical cancer and inhibition of epithelial‑mesenchymal transition by BMP7 knockdown in HeLa cells.

    abstract：:The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical cancer HeLa cells and the possible mechanism involved. Immunohistochemistry was us...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4519

    authors： Sun R,Guan H,Liu W,Liang J,Wang F,Li C

    更新日期：2020-05-01 00:00:00

  • Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27.

    abstract：:Selenium is an essential trace element and has shown chemopreventive or therapeutic activities on human solid cancers; however, whether it has anticancer effects on leukemia has not yet been elucidated. The present study was designed to determine the role of selenium on HL-60 human promyelocytic leukemia cells. We fou...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1854

    authors： Wu S,Bao Y,Ma D,Zi Y,Yang C,Yang M,Xing M,Yang W

    更新日期：2014-10-01 00:00:00

  • Study on autologous blood transfusion in hemodialysis patients.

    abstract：:The storage period of autologous blood of hemodialysis (HD) patients was investigated with focus on the red blood cell life span. Healthy subjects, HD patients administered recombinant human erythropoietin (rHuEPO) preparation at 4,500 units/week and at 9,000 units/week were classified into 3 groups, respectively. Blo...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Tsuchida K,Nakatani T,Sugimura K,Yoshimura R,Takemoto Y

    更新日期：2003-02-01 00:00:00

  • Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells.

    abstract：:High-fidelity maintenance of genomic integrity in eukaryotes is ensured by cell cycle checkpoints and DNA repair. The checkpoint kinase, Chk2, has been implicated in both of these responses. In response to DNA damage, Chk2 is initially phosphorylated at Thr-68, which leads to its full activation. The fully activated C...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Liang X,Reed E,Yu JJ

    更新日期：2006-05-01 00:00:00

  • The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB.

    abstract：:Inflammation and remodeling play a role in the pathogenesis of pulmonary arterial hypertension (PAH). Nuclear factor-κB (NF-κB) and nuclear factor of activated T cells-1 (NFAT-1) participate in inflammation and remodeling in a number of diseases. As a tryptophan hydroxylase inhibitor, 4-chloro-DL-phenylalanine (PCPA) ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3001

    authors： Bai Y,Li ZX,Wang HL,Lian GC,Wang Y

    更新日期：2017-07-01 00:00:00

  • Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells.

    abstract：:The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression of oncogenic Ras. However, the ability of HDAC inhibitors to regulate the apoptotic pathway in human breast cancer cells is still not completely understood. In this study, the anti-proliferative e...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Park H,Im JY,Kim J,Choi WS,Kim HS

    更新日期：2008-03-01 00:00:00

  • Triticum aestivum sprout-derived polysaccharide exerts hepatoprotective effects against ethanol-induced liver damage by enhancing the antioxidant system in mice.

    abstract：:Triticum aestivum sprout-derived polysaccharide (TASP) has anti-diabetic properties, but no information is available in regards to its protective effect against ethanol-induced hepatic injury. This study aimed to investigate the mechanism behind the protective role of TASP against ethanol-induced liver injury in vivo....

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3095

    authors： Nepali S,Ki HH,Lee JH,Cha JY,Lee YM,Kim DK

    更新日期：2017-10-01 00:00:00

  • Inhibitory effect of lactoperoxidase-generated hypothiocyanite upon black pigmented anaerobe growth.

    abstract：:This study aimed to evaluate the in vitro effect of lactoperoxidase with or without its substrates (hydrogen peroxide, thiocyanate) on the growth of 4 different black pigmented anaerobe (BPA) strains associated with the development and progress of periodontal diseases: Porphyromonas gingivalis ATCC 33277, Prevotella i...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Fadel M,Courtois P

    更新日期：2001-07-01 00:00:00