The calcium-sensing receptor and vitamin D receptor expression in tertiary hyperparathyroidism.

abstract：:Myocardial ischemic injury results from severe impairment of the coronary blood supply and may lead to metabolic and ultrastructural changes, thereby causing irreversible damage. MicroRNA (miR)‑20b‑5p has been demonstrated to be involved in malignancies of the breast, colorectum, stomach, blood and oropharynx. The pre...

journal_title：International journal of molecular medicine

authors： Liang ZG,Yao H,Xie RS,Gong CL,Tian Y

更新日期：2018-08-01 00:00:00

abstract：:Thioredoxin (TRX), which is a stress-inducible protein with redox-active disulfide structures, has various biological activities by regulating DNA binding of transcription factors in cells. In Graves' disease that is among the common diseases of the thyroid, endogenous stresses that are induced by excess thyroid hormo...

journal_title：International journal of molecular medicine

authors： Kihara M,Kontani K,Yamauchi A,Miyauchi A,Nakamura H,Yodoi J,Yokomise H

更新日期：2005-05-01 00:00:00

abstract：:We have previously reported that the calcium-sensing receptor (CaSR) plays an important role in modulating lipid metabolism under low calcium conditions. The aim of this study was to identify possible regulators of CaSR and the mechanisms of action of CaSR in obese individuals. Subcutaneous fat samples were obtained f...

journal_title：International journal of molecular medicine

authors： He Y,Perry B,Bi M,Sun H,Zhao T,Li Y,Sun C

更新日期：2013-08-01 00:00:00

abstract：:Peritoneal fibrosis is a major complication of continuous ambulatory peritoneal dialysis (CAPD). The present study tested the hypothesis that ADP-ribose polymerase-1 (PARP-1) may play a role in peritoneal epithelial-mesenchymal transition and fibrosis under high glucose conditions. High glucose (126 mmol/l)-induced pe...

journal_title：International journal of molecular medicine

authors： Lei P,Jiang Z,Zhu H,Li X,Su N,Yu X

更新日期：2012-03-01 00:00:00

abstract：:Inflammatory genes serve a crucial role in the pathogenesis of inflammation‑associated tumors. However, as recent studies have mainly focused on the effects of single inflammatory genes on colorectal cancer (CRC), but not on the global interactions between genes, the underlying mechanisms between inflammatory genes and...

journal_title：International journal of molecular medicine

authors： Jiang H,Dong L,Gong F,Gu Y,Zhang H,Fan D,Sun Z

更新日期：2018-07-01 00:00:00

abstract：:To characterize the changes in global gene expression in the livers of H1/siRNAinsulin-CMV/hIDE transgenic (Tg) mice in response to the reduced bioavailability of insulin, total RNA extracted from the livers of 20-week-old Tg and non-Tg mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide ...

journal_title：International journal of molecular medicine

authors： Jee S,Hwang D,Seo S,Kim Y,Kim C,Kim B,Shim S,Lee S,Sin J,Bae C,Lee B,Jang M,Kim M,Yim S,Jang I,Cho J,Chae K

更新日期：2007-12-01 00:00:00

abstract：:Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell ...

journal_title：International journal of molecular medicine

authors： Dung TD,Chang HC,Binh TV,Lee MR,Tsai CH,Tsai FJ,Kuo WW,Chen LM,Huang CY

更新日期：2012-06-01 00:00:00

abstract：:The treatment of locoregional recurrence (LRR) of head and neck squamous cell carcinoma (HNSCC) often requires a combination of surgery, radiation therapy and/or chemotherapy. Survival outcomes are poor and the treatment outcomes are morbid. Cold atmospheric plasma (CAP) is an ionized gas produced at room temperature ...

journal_title：International journal of molecular medicine

authors： Guerrero-Preston R,Ogawa T,Uemura M,Shumulinsky G,Valle BL,Pirini F,Ravi R,Sidransky D,Keidar M,Trink B

更新日期：2014-10-01 00:00:00

abstract：:There is much interest in precise functions of amino acids on mammalian growth and development. Some of amino acids play important roles in the control of gene expression by controlling the initiation phase of mRNA translation. The signal induced by leucine or arginine may stimulate cell growth. On the other hand, the...

journal_title：International journal of molecular medicine

authors： Naomoto Y,Yamatsuji T,Shigemitsu K,Ban H,Nakajo T,Shirakawa Y,Motok T,Kobayashi M,Gunduz M,Tanaka N

更新日期：2005-08-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into the circulation, has been recognized as a marker of bone metabolism. It ha...

journal_title：International journal of molecular medicine

authors： Kondo A,Otsuka T,Kato K,Matsushima-Nishiwaki R,Kuroyanagi G,Mizutani J,Tokuda H,Kozawa O

更新日期：2013-06-01 00:00:00

abstract：:Acute Achilles tendon (AT) rupture is a common injury with a comparatively high complication rate. Presently, surgical treatments compete with nonoperative treatment modalities. The aim of this study was to elucidate the possible beneficial effects of short-term combinatory application of growth factors on tendon heal...

journal_title：International journal of molecular medicine

authors： Konerding MA,Arlt F,Wellmann A,Li V,Li W

更新日期：2010-02-01 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) remains unknown. It has been suggested that luminal factors such as the microflora, short chain fatty acids (SCFAs), food antigens and so on play important roles in the disease progression. Many reports have revealed alterations in the SCFA and organic acid concentr...

journal_title：International journal of molecular medicine

authors： Araki Y,Andoh A,Fujiyama Y,Itoh A,Bamba T

更新日期：2002-06-01 00:00:00

abstract：:The effect of interferon-alpha (IFN) for chronic myeloid leukemia (CML) in the chronic phase (CP) was retrospectively evaluated in comparison with that of busulfan (BU) or hydroxyurea (HU) given alone. Among 107 patients diagnosed with CML between 1982 and 1997, 72 CP cases evaluable for long-term follow-up included 1...

journal_title：International journal of molecular medicine

authors： Itoh T,Tamura S,Takemoto Y,Kakishita E

更新日期：1999-12-01 00:00:00

abstract：:Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genomic DNA from the members o...

journal_title：International journal of molecular medicine

authors： Horiuchi T,Tsukamoto H,Mitoma H,Miyagawa H,Tamimoto Y,Yoshizawa S,Harada M,Hayashi K,Hashimura C,Oribe M,Okamura S

更新日期：2004-11-01 00:00:00

abstract：:Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study i...

journal_title：International journal of molecular medicine

authors： Pei W,Zou Y,Wang W,Wei L,Zhao Y,Li L

更新日期：2018-12-01 00:00:00

abstract：:We describe a novel spontaneous autosomal recessive mutation, cervelet-4 (crv4), which arose in a BALB/c strain. Mice homozygous for the mutation exhibit principally a reduced body size, a congenital neurological phenotype characterized by ataxic gait and intention tremor, with no gross anomalies observed in brain or ...

journal_title：International journal of molecular medicine

authors： Conti V,Aghaie A,Cilli M,Martin N,Caridi G,Musante L,Candiano G,Castagna M,Fairen A,Ravazzolo R,Guenet JL,Puliti A

更新日期：2006-10-01 00:00:00

abstract：:The spindle checkpoint proteins (SCPs), which sense the existence of misaligned sister chromatids during mitosis and meiosis, are essential for cell proliferation and differentiation. Therefore, the role of SCPs in carcinogenesis is gaining increased attention. In this study, we ana...

journal_title：International journal of molecular medicine

authors： Liao S,Deng D,Hu X,Wang W,Li L,Li W,Zhou J,Xu G,Meng L,Wang S,Ma D

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of microRNA (miR)‑142‑3p on neuropathic pain caused by sciatic nerve injury in chronic compression injury (CCI) rats, and further investigate its mechanism. Rat experiments were divided into four parts in the study. In the first part, the rats were divided in...

journal_title：International journal of molecular medicine

authors： Li X,Wang S,Yang X,Chu H

更新日期：2021-02-01 00:00:00

abstract：:Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage foll...

journal_title：International journal of molecular medicine

authors： Toth B,Schwacha MG,Kuebler JF,Bland KI,Wang P,Chaudrya IH

更新日期：2003-03-01 00:00:00

abstract：:The development of new osteoconductive bone substitute materials is expected in medicine. In this study, we attempted to produce new hydroxylapatite (HAP)/collagen (Col) composites using two HAP particles of different sizes and porcine type I collagen. The two HAP particles were either nano-sized (40 nm in average dia...

journal_title：International journal of molecular medicine

authors： Hatakeyama W,Taira M,Chosa N,Kihara H,Ishisaki A,Kondo H

更新日期：2013-12-01 00:00:00

abstract：:The uptake of D-[3H]mannoheptulose by isolated pancreatic islets was recently proposed as a tool to assess the relative contribution of insulin-producing cells to the total mass of the islets. In the present study, the uptake of the tritiated heptose over 60 min incubation at 37 degrees C was about 21% lower in islets...

journal_title：International journal of molecular medicine

authors： Sener A,Ladriere L,Malaisse WJ

更新日期：2001-08-01 00:00:00

abstract：:The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation s...

journal_title：International journal of molecular medicine

authors： Alric C,Pecher C,Schanstra JP,Bascands JL,Girolami JP

更新日期：2000-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and a key element in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Moreover, it is a negative regulator of autophagy and acts as a central regulator in cell growth. For the treatment of cancer, mTOR is a nove...

journal_title：International journal of molecular medicine

authors： Cai Y,Xia Q,Su Q,Luo R,Sun Y,Shi Y,Jiang W

更新日期：2013-04-01 00:00:00

abstract：:Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma cell lines. The expression of these molecules has been also characterized in human normal ti...

journal_title：International journal of molecular medicine

authors： Takebayashi Y,Nakayama K,Fujioka T,Kanzaki A,Mutho M,Uchida T,Miyazaki K,Ito M,Fukumoto M

更新日期：2001-04-01 00:00:00

abstract：:To assess effects of Celecoxib, selective cyclo-oxygenase (COX)-2 inhibitor, on matrix synthesis by chondrocytes under mechanical stress in vitro. Chondrocytes from 7-day-old rat articular cartilage were cultured. Cyclic mechanical stress (0.5 Hz, 7% elongation) was loaded using a Flexercell strain unit in the presenc...

journal_title：International journal of molecular medicine

authors： Iimoto S,Watanabe S,Takahashi T,Shimizu A,Yamamoto H

更新日期：2005-12-01 00:00:00

abstract：:Although endogenous digitalis‑like factor (EDLF) is associated with the development of various physical disorders, the role in preeclampsia remains unclear. This study investigated the effects of EDLF on vascular endothelial cell damage in patients with preeclampsia and the potential mechanisms. From July 2014 to July...

journal_title：International journal of molecular medicine

authors： Peng M,Yang M,Ding Y,Yu L,Deng Y,Lai W,Hu Y

更新日期：2018-02-01 00:00:00

abstract：:We examined the P16 expression by immunohistochemical stain and detected the methylation by methylation specific polymerase chain reaction (MSP) in 48 primary oral squamous cell carcinoma (SCC) tissues. The results showed that 20/48 (41.7%) of cancerous tissues had CpG methylation around the promoter region, but 8/48 ...

journal_title：International journal of molecular medicine

authors： Huang MJ,Yeh KT,Shih HC,Wang YF,Lin TH,Chang JY,Shih MC,Chang JG

更新日期：2002-11-01 00:00:00

abstract：:Intralesional injection of bleomycin‑A5 (BLE‑A5) is a novel treatment for nasal polyps. Our previous study clarified that BLE‑A5 could induce nasal polyp‑derived fibroblast (NPDF) apoptosis in nasal polyps. However, the detailed mechanisms are still unclear. The present study aimed to determine the effects of BLE‑A5 o...

journal_title：International journal of molecular medicine

authors： Wu F,Ma Y,Wang J,Ou H,Dang H,Zheng Y,Tian P,Zou H

更新日期：2021-01-01 00:00:00

abstract：:Congenital heart disease (CHD), the most prevalent birth defect in humans worldwide, is still a leading non‑infectious cause of infant morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of CHD, and more than 50 genes have been linked to various types...

journal_title：International journal of molecular medicine

authors： Pan Y,Geng R,Zhou N,Zheng GF,Zhao H,Wang J,Zhao CM,Qiu XB,Yang YQ,Liu XY

更新日期：2015-04-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen exerts an effective thera...

journal_title：International journal of molecular medicine

authors： Yao L,Chen H,Wu Q,Xie K

更新日期：2019-09-01 00:00:00