Impact of combinatory growth factor application on rabbit Achilles tendon injury with operative versus conservative treatment: a pilot study.

abstract：:The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via...

journal_title：International journal of molecular medicine

authors： Fan X,Yan K,Meng Q,Sun R,Yang X,Yuan D,Li F,Deng H

更新日期：2019-07-01 00:00:00

abstract：:The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pat...

journal_title：International journal of molecular medicine

authors： Mignini F,Sabbatini M,Mattioli L,Cosenza M,Artico M,Cavallotti C

更新日期：2014-06-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common malignant tumors in males globally. Its progression imposes a heavy burden on patients; however, the expression profile of circular (circ)RNAs in BC progression remains unclear. This study explored changes in circRNA expression during BC progression by sequencing different...

journal_title：International journal of molecular medicine

authors： Li W,Li Y,Sun Z,Zhou J,Cao Y,Ma W,Xie K,Yan X

更新日期：2019-11-01 00:00:00

abstract：:A number of cell-penetrating peptides (CPPs) have been reported, but their transduction efficiencies are too low to be used as intracellular carriers for therapeutic purposes. We conducted a comprehensive search to find novel CPPs using an in vitro virus (IVV) library, which presented random peptides consisting of 15 ...

journal_title：International journal of molecular medicine

authors： Kamide K,Nakakubo H,Uno S,Fukamizu A

更新日期：2010-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and con...

journal_title：International journal of molecular medicine

authors： Bianchi E,Scarinci F,Ripandelli G,Feher J,Pacella E,Magliulo G,Gabrieli CB,Plateroti R,Plateroti P,Mignini F,Artico M

更新日期：2013-01-01 00:00:00

abstract：:In the present study, human umbilical cord-derived mesenchymal stem cells (hUMSCs) were investigated for their potential to be induced to differentiate in vitro into neuron-like cells by monosialoteterahexosyl ganglioside (GM1). Mononuclear cells obtained from umbilical cords from women with full-term pregnancies whos...

journal_title：International journal of molecular medicine

authors： Nan C,Shi Y,Zhao Z,Ma S,Liu J,Yan D,Song G,Liu H

更新日期：2015-10-01 00:00:00

abstract：:White blood cell (WBC) count is considered a prognostic risk factor in acute myeloid leukemia. As density of leukemic cells increases, the cytotoxic activity of certain anticancer drugs, such as vincristine and doxorubicin, progressively decreases. In this study, we investigated the cell density-dependent induction of...

journal_title：International journal of molecular medicine

authors： Navrátilová J,Jungová P,Vanhara P,Preisler J,Kanicky V,Smarda J

更新日期：2009-11-01 00:00:00

abstract：:ABCA3 is a surfactant lipid transporter in the limiting membrane of lamellar bodies in alveolar type II cells. Mutations in the ATP-binding cassette, sub-family A (ABC1), member 3 (ABCA3) gene cause respiratory distress syndrome in newborns, and chronic interstitial lung disease in children and adults. ABCA3 belongs t...

journal_title：International journal of molecular medicine

authors： Frixel S,Lotz-Havla AS,Kern S,Kaltenborn E,Wittmann T,Gersting SW,Muntau AC,Zarbock R,Griese M

更新日期：2016-08-01 00:00:00

abstract：:We determined whether the expression of VEGF-A and -C and their receptors, Flt-1 and Flt-4, are associated with primary tumor size, regional lymph node metastasis, distant metastasis and prognosis in patients with tongue carcinoma. The expression of VEGF-A and -C, and their receptors, Flt-1 and Flt-4, in biopsy specim...

journal_title：International journal of molecular medicine

authors： Tanigaki Y,Nagashima Y,Kitamura Y,Matsuda H,Mikami Y,Tsukuda M

更新日期：2004-09-01 00:00:00

abstract：:The adhesion of monocytes to human umbilical vein endothelial cells (HUVECs) plays a crucial role in the initiation of atherosclerosis. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are two important molecules involved in the adhesion of monocytes to HUVECs. Previous studies...

journal_title：International journal of molecular medicine

authors： Wang Y,Cao J,Fan Y,Xie Y,Xu Z,Yin Z,Gao L,Wang C

更新日期：2016-06-01 00:00:00

abstract：:Paeonol (2'-hydroxy-4'-methoxyacetophenone) is an active component isolated from the root of Paeonia Suffruticosa Andrews. We previously found that paeonol inhibited vascular cell adhesion molecule-1 (VCAM‑1) expression, and thus may be useful for the prevention and treatment of rabbit atherosclerosis (AS); however, t...

journal_title：International journal of molecular medicine

authors： Yuan X,Chen J,Dai M

更新日期：2016-12-01 00:00:00

abstract：:After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and Allison Piovesan, are located at DIMES at the University of Florence (fourth af...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-08-01 00:00:00

abstract：:Abnormal gap junction communication (GJC) has been associated with carcinogenesis. We investigated the role of endothelial cell GJC and connexin 43 (Cx43), the main gap junction protein in these cells, during tumour cell extravasation. GJC was determined by the ability of cells to transfer Lucifer yellow, to neighbour...

journal_title：International journal of molecular medicine

authors： Cai J,Jiang WG,Mansel RE

更新日期：1998-01-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

journal_title：International journal of molecular medicine

authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

更新日期：2014-06-01 00:00:00

abstract：:The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), plays an important role in angiotension II (Ang II)-induced hypertensive renal injury associated with pro-inflammatory responses, tubular functional damage and cellular apoptosis. In this study, we report on the role of LOX-1 in Ang II-induced oxidat...

journal_title：International journal of molecular medicine

authors： Xu Y,Ruan S,Xie H,Lin J

更新日期：2010-11-01 00:00:00

abstract：:About 80% of short children are not deficient in endogenous growth hormone (GH) and termed idiopathic short stature (ISS). The causes of impaired growth in children with ISS are various. Short stature and low insulin-like growth factor-I (IGF-I) concentration despite normal to high GH concentration suggest impaired GH...

journal_title：International journal of molecular medicine

authors： Takahashi Y,Chihara K

更新日期：1998-09-01 00:00:00

abstract：:Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucus secretion, which can lead to chronic and obstinate asthma and can obstruct pulmonary function. In this study, the effects of Bangpungtongseong-san water extract (BPTS) on ...

journal_title：International journal of molecular medicine

authors： Lee MY,Shin IS,Jeon WY,Shin N,Shin HK

更新日期：2014-04-01 00:00:00

abstract：:Recently, naringin (NAR; 4',5,7-trihydroxyflavanone-7-rhamnoglucoside) has been shown to have cardioprotective properties. However, the specific mechanisms underlying its cardioprotective effects remain unclear. In this study, we aimed to investigate the cardioprotective effects of NAR and the possible underlying mole...

journal_title：International journal of molecular medicine

authors： Huang H,Wu K,You Q,Huang R,Li S,Wu K

更新日期：2013-08-01 00:00:00

abstract：:Neuropathic pain is one of most intense types of chronic pain. Numerous studies investigating neuropathic pain have described the critical involvement of microglia in the spinal cord. Previous studies have indicated that activation of large conductance Ca2+‑activated K+ (BK) channels contributes to microglial activati...

journal_title：International journal of molecular medicine

authors： Imari K,Harada Y,Zhang J,Mori Y,Hayashi Y

更新日期：2019-10-01 00:00:00

abstract：:Peripheral arterial disease (PAD) affects about 5% of the elderly population in the western world. It has been reported that PAD is associated with elevated plasma levels of the inflammatory markers. The goal of this review is to describe which proinflammatory molecules may play a role in PAD development, C-reactive p...

journal_title：International journal of molecular medicine

authors： Signorelli SS,Mazzarino MC,Spandidos DA,Malaponte G

更新日期：2007-09-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is one of the most important causes of drug-resistant epilepsy in paediatric patients, particularly in those below the age of 3. Even though over 40 years have passed since the first description of the entity by Taylor, the exact mechanisms causing these cortical abnormalities remain une...

journal_title：International journal of molecular medicine

authors： Siedlecka M,Grajkowska W,Galus R,Dembowska-Bagińska B,Jóźwiak J

更新日期：2016-11-01 00:00:00

abstract：:Celastrol, a natural biologically active compound isolated from Tripterygium wilfordii Hook F root extracts, has been shown to possess antitumor properties and therefore, is an interesting candidate for the development of novel chemotherapeutic cancer agents. In this study, we have demonstrated that Celastrol is a pot...

journal_title：International journal of molecular medicine

authors： Huang L,Zhang Z,Zhang S,Ren J,Zhang R,Zeng H,Li Q,Wu G

更新日期：2011-03-01 00:00:00

abstract：:The aim of the present study was to investigate the role of the angiotensin-converting enzyme (ACE)2-angiotensin‑(Ang)-(1-7)-Mas axis in the pathogenesis of pancreatitis and the association between this axis and the p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor (NF-κB) signaling pathway in pancreatic ...

journal_title：International journal of molecular medicine

authors： Yu X,Cui L,Hou F,Liu X,Wang Y,Wen Y,Chi C,Li C,Liu R,Yin C

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important regulatory role during adipogenesis, and have been studied extensively in this regard. Specifically, the switch between the differentiation of mesenchymal stem cells (MSCs) towards adipogenic vs. osteogenic lineages is regulated by miR-204 which controls the expression of R...

journal_title：International journal of molecular medicine

authors： He H,Chen K,Wang F,Zhao L,Wan X,Wang L,Mo Z

更新日期：2015-06-01 00:00:00

abstract：:Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine ...

journal_title：International journal of molecular medicine

authors： Seya T,Nomura M,Murakami Y,Begum NA,Matsumoto M,Nagasawa S

更新日期：1998-05-01 00:00:00

abstract：:Reineckia carnea has been used to treat several diseases in folk remedies. RCE-4 has been isolated from several plants of the family Liliaceae, but its biological activity has not yet been reported. In the present study, we found that RCE-4 exhibited potent cytotoxicity to the teste...

journal_title：International journal of molecular medicine

authors： Wang G,Huang W,He H,Fu X,Wang J,Zou K,Chen J

更新日期：2013-01-01 00:00:00

abstract：:It is known that cancers develop by a multi-step process. Normal cells are first immortalized, and then transformed into tumorigenic cells. Normal human cells are very rarely immortalized, but once they are, they are relatively easily transformed into tumorigenic cells. This indicates that the immortalization step pla...

journal_title：International journal of molecular medicine

authors： Katayama B,Sakaguchi M,Li JW,Pu H,Inoue Y,Namba M

更新日期：1998-11-01 00:00:00

abstract：:To characterize the changes in global gene expression in the livers of H1/siRNAinsulin-CMV/hIDE transgenic (Tg) mice in response to the reduced bioavailability of insulin, total RNA extracted from the livers of 20-week-old Tg and non-Tg mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide ...

journal_title：International journal of molecular medicine

authors： Jee S,Hwang D,Seo S,Kim Y,Kim C,Kim B,Shim S,Lee S,Sin J,Bae C,Lee B,Jang M,Kim M,Yim S,Jang I,Cho J,Chae K

更新日期：2007-12-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2), a multifunctional member of the transforming growth factor (TGF)-beta, superfamily, has powerful osteoinductive effects and causes cell cycle arrest in a variety of transformed cell lines. We have observed BMP-2-induced inhibition of cell proliferation in an androgen-dependent hum...

journal_title：International journal of molecular medicine

authors： Tomari K,Kumagai T,Shimizu T,Takeda K

更新日期：2005-02-01 00:00:00