Focal cortical dysplasia: Molecular disturbances and clinicopathological classification (Review).

abstract：:It is now well established that immune effector mechanisms contribute to cardiac dysfunction in several heart diseases, including myocarditis and the associated dilated cardiomyopathy, heart transplant rejection and Chagas' disease. These and other pathologies, in which cellular immunity plays an important role, contr...

journal_title：International journal of molecular medicine

authors： Binah O

更新日期：2000-07-01 00:00:00

abstract：:S100A4, one of the tandemly arranged S100 genes at chromosome 1q21, has been suggested to play a functional role in cell motility and invasiveness of tumor cell growth. We investigated the expression of S100A4 and the in vitro invasiveness of 4 human bile duct adenocarcinoma cell lines by the Matrigel assay. S100A4 wa...

journal_title：International journal of molecular medicine

authors： Katayama N,Murao S,Ajiki T,Kitazawa S,Onoyama H,Kuroda Y,Maeda S

更新日期：2000-11-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL), which involves the blood and bone marrow, is the most common type of cancer in children younger than 5 years of age. Previous studies have investigated the effects of centipedegrass extract (CGE), which is mainly composed of maysin and its derivatives, and have demonstrated that it ...

journal_title：International journal of molecular medicine

authors： Bai HW,Badaboina S,Park CH,Choi BY,Na YH,Chung BY

更新日期：2015-02-01 00:00:00

abstract：:Peripheral arterial disease (PAD) affects about 5% of the elderly population in the western world. It has been reported that PAD is associated with elevated plasma levels of the inflammatory markers. The goal of this review is to describe which proinflammatory molecules may play a role in PAD development, C-reactive p...

journal_title：International journal of molecular medicine

authors： Signorelli SS,Mazzarino MC,Spandidos DA,Malaponte G

更新日期：2007-09-01 00:00:00

abstract：:The isolation of rare cells, such as fetal nucleated red blood cells and trophoblasts, from maternal blood for non-invasive prenatal diagnosis is a new field of research exhibiting several difficulties since this strategy requires unresolved basic technological protocols for a successful outcome. However, several achi...

journal_title：International journal of molecular medicine

authors： Borgatti M,Bianchi N,Mancini I,Feriotto G,Gambari R

更新日期：2008-01-01 00:00:00

abstract：:The storage period of autologous blood of hemodialysis (HD) patients was investigated with focus on the red blood cell life span. Healthy subjects, HD patients administered recombinant human erythropoietin (rHuEPO) preparation at 4,500 units/week and at 9,000 units/week were classified into 3 groups, respectively. Blo...

journal_title：International journal of molecular medicine

authors： Tsuchida K,Nakatani T,Sugimura K,Yoshimura R,Takemoto Y

更新日期：2003-02-01 00:00:00

abstract：:Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

journal_title：International journal of molecular medicine

authors： Grässel S,Ahmed N,Göttl C,Grifka J

更新日期：2009-06-01 00:00:00

abstract：:Group B streptococci (GBS) are the most common cause of pneumonia and sepsis during the neonatal period. However, the pathogenesis of invasive infection is poorly understood. We investigated the ability of GBS grown at 37 degrees C and 40 degrees C to adhere and invade human umbilical vein endothelial cells (HUVECs) a...

journal_title：International journal of molecular medicine

authors： Freitas Lione VO,Bittencourt Dos Santos MH,Ulisses Carvalho TM,Hirata R Jr,Mattos-Guaraldi AL,Arruda Mortara R,Nagao PE

更新日期：2010-10-01 00:00:00

abstract：:A microarray analysis of an animal model with experimental sepsis induced by caecal ligation and puncture revealed that the level of microRNA‑195 (miR‑195) was upregulated. However, to the best of our knowledge, the role of miR‑195 in sepsis remains unknown. The present study investigated the effect of miR‑195 on apop...

journal_title：International journal of molecular medicine

authors： Yuan T,Zhang L,Yao S,Deng SY,Liu JQ

更新日期：2020-02-01 00:00:00

abstract：:15-Deoxy-∆(12,14)-prostaglandin J(2) (15d-PGJ(2)), a peroxisome proliferator-activated receptor γ ligand, has been reported to have antiproliferative activity in certain types of cancer. The purpose of this study was to elucidate the effect of 15d-PGJ(2) on endometrial cancer cells, as well as the mechanism of action....

journal_title：International journal of molecular medicine

authors： Li H,Narahara H

更新日期：2013-04-01 00:00:00

abstract：:Motility is a requirement for a number of biological processes, including embryonic development, neuronal development, immune responses, cancer progression and wound healing. Specific to wound healing is the migration of endothelial cells, fibroblasts and other key cellular players into the wound space. Aberrations in...

journal_title：International journal of molecular medicine

authors： Bosanquet DC,Ye L,Harding KG,Jiang WG

更新日期：2014-07-01 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is associated with psychological stress. However, the full landscape of IBS‑related epigenetic factors remains unveiled and needs to be elucidated. The water‑avoidance stress (WAS) method was used to induce a rat IBS model. Each rat was monitore...

journal_title：International journal of molecular medicine

authors： Zhu S,Min L,Guo Q,Li H,Yu Y,Zong Y,Wang L,Li P,Gu J,Zhang S

更新日期：2018-11-01 00:00:00

abstract：:Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage foll...

journal_title：International journal of molecular medicine

authors： Toth B,Schwacha MG,Kuebler JF,Bland KI,Wang P,Chaudrya IH

更新日期：2003-03-01 00:00:00

abstract：:Decreased skeletal muscle capillarization is considered to significantly contribute to the development of pulmonary cachexia syndrome (PCS) and progressive muscle wasting in several chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). It is unclear to which extent the concurrent prese...

journal_title：International journal of molecular medicine

authors： Basic VT,Jacobsen A,Sirsjö A,Abdel-Halim SM

更新日期：2014-07-01 00:00:00

abstract：:The introduction of bortezomib has resulted in a paradigm shift in the treatment of multiple myeloma (MM) and has contributed to the improved survival of patients with MM. Inevitably, resistance to therapy develops, and thus the clinical efficacy of bortezomib is hampered by drug resistance. The oncogene B-cell‑specif...

journal_title：International journal of molecular medicine

authors： Wu SQ,Xu ZZ,Niu WY,Huang HB,Zhan R

更新日期：2014-08-01 00:00:00

abstract：:Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained ...

journal_title：International journal of molecular medicine

authors： Le HTT,Cho YC,Cho S

更新日期：2018-03-01 00:00:00

abstract：:An effective therapeutic strategy for suppressing liver fibrosis development should improve the overall prognosis of patients with chronic liver diseases. Despite efforts to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic treatments for humans. An alternative strategy may be to employ a ...

journal_title：International journal of molecular medicine

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Shirai Y,Yoshii J,Yanase K,Fukui H

更新日期：2011-07-01 00:00:00

abstract：:Regucalcin is a Ca2+-binding protein which plays a regulatory role in liver cell functions related to Ca2+. In this study we have cloned and characterized cDNA for regucalcin from human liver and human hepatoma cell line Hep G2 by screening and rapid amplification of cDNA ends (RACE). The nucleotide sequences of the c...

journal_title：International journal of molecular medicine

authors： Misawa H,Yamaguchi M

更新日期：2000-03-01 00:00:00

abstract：:To assess effects of Celecoxib, selective cyclo-oxygenase (COX)-2 inhibitor, on matrix synthesis by chondrocytes under mechanical stress in vitro. Chondrocytes from 7-day-old rat articular cartilage were cultured. Cyclic mechanical stress (0.5 Hz, 7% elongation) was loaded using a Flexercell strain unit in the presenc...

journal_title：International journal of molecular medicine

authors： Iimoto S,Watanabe S,Takahashi T,Shimizu A,Yamamoto H

更新日期：2005-12-01 00:00:00

abstract：:There is clinical evidence that patients with heart failure and concomitant iron deficiency have increased skeletal muscle fatigability and impaired exercise tolerance. It was expected that a skeletal muscle cell line subjected to different degrees of iron availability and/or concomitant hypoxia would demonstrate chan...

journal_title：International journal of molecular medicine

authors： Kobak K,Kasztura M,Dziegala M,Bania J,Kapuśniak V,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2018-05-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. Howe...

journal_title：International journal of molecular medicine

authors： Xiao J,Wang R,Zhou W,Cai X,Ye Z

更新日期：2021-01-01 00:00:00

abstract：:The number of regulatory T cells (Treg cells) and the expression of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1; also known as CD39) and 5'-ectonucleotidase (NT5E; also known as CD73) on the Treg cell surface are increased during sepsis. In this study, to determine the factors leading to the high expressi...

journal_title：International journal of molecular medicine

authors： Bao R,Shui X,Hou J,Li J,Deng X,Zhu X,Yang T

更新日期：2016-09-01 00:00:00

abstract：:In our previous study, the proliferation rate of esophageal squamous cell carcinoma cell lines, which poorly expressed p21Waf1, was found to be regulated by p21Waf1 gene transfection using adenovirus vector. In the present study, in order to examine the effect of p21Waf1 gene therapy in esophageal cancer, we used gene...

journal_title：International journal of molecular medicine

authors： Tanaka Y,Fujii T,Yamana H,Kato S,Morimatsu M,Shirouzu K

更新日期：2004-10-01 00:00:00

abstract：:The ectromelia virus (ECTV) is a mouse specific Orthopoxvirus that causes lethal infection in some mouse strains. ECTV infection of these mouse strains has been used as a valuable model for understanding the interplay between Orthopoxvirus species and their hosts, including variola virus in humans. Although poxviruses...

journal_title：International journal of molecular medicine

authors： Cheng W,Jia H,Wang X,He X,Jin Q,Cao J,Jing Z

更新日期：2018-08-01 00:00:00

abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

journal_title：International journal of molecular medicine

authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

更新日期：2018-07-01 00:00:00

abstract：:Studies have shown that an overproduction of mitochondrial reactive oxygen species (ROS) is an initiating cause in the pathogenesis of diabetic complications. However, uncoupling protein 2 (UCP2) can protect retinal vascular endothelial cells from damage by inhibiting the overproduction of mitochondrial ROS, although ...

journal_title：International journal of molecular medicine

authors： He Y,Wang N,Shen Y,Zheng Z,Xu X

更新日期：2014-05-01 00:00:00

abstract：:A series of emodin analogues have been demonstrated to exhibit potent antiproliferative activity in three human epidermal growth factor receptor 2 (HER2)‑overexpressing cell lines. However, in docking simulations, not all of these emodin analogues docked into the HER2 protein binding site. As the epidermal growth fact...

journal_title：International journal of molecular medicine

authors： Chen KC,Juang SH,Lien JC

更新日期：2019-03-01 00:00:00

abstract：:The development of angiogenesis within a tumor brings on a sequence of extremely complex molecular events. We have developed a methodology which enables a wide set of biological parameters to be quantitatively determined in the field of anti-angiogenesis pharmacology. This methodology which includes a video cell track...

journal_title：International journal of molecular medicine

authors： Farinelle S,Dehauwer C,Darro F,Decaestecker C,Fontaine J,Pasteels JL,Van Ham P,Atassi G,Kiss R

更新日期：1998-11-01 00:00:00

abstract：:Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that ...

journal_title：International journal of molecular medicine

authors： Nakajima K,Wu G,Takeyama N,Sakudo A,Sugiura K,Yukawa M,Onodera T

更新日期：2009-07-01 00:00:00

abstract：:Periplaneta americana extracts (PAEs) play a crucial role in skin wound healing. However, their molecular effects and signaling pathways in regenerating tissues and cells are not clear. In this study, we refined the PAE from Periplaneta americana to investigate the mechanisms underlying skin wound healing. The human k...

journal_title：International journal of molecular medicine

authors： Song Q,Xie Y,Gou Q,Guo X,Yao Q,Gou X

更新日期：2017-08-01 00:00:00