Proinflammatory circulating molecules in peripheral arterial disease.

abstract：:A previous study has revealed that oxidized low‑density lipoprotein (oxLDL)/β2‑glycoprotein I (β2GPI)/anti‑β2‑glycoprotein I (anti‑β2GPI), an immune complex, is able to activate the Toll‑like receptor 4 (TLR4)/nuclear factor κβ (NF‑κβ) inflammatory signaling pathway in macrophages, and consequently enhance foam cell f...

journal_title：International journal of molecular medicine

authors： Wang T,Ouyang H,Zhou H,Xia L,Wang X,Wang T

更新日期：2018-10-01 00:00:00

abstract：:The effect of interferon-alpha (IFN) for chronic myeloid leukemia (CML) in the chronic phase (CP) was retrospectively evaluated in comparison with that of busulfan (BU) or hydroxyurea (HU) given alone. Among 107 patients diagnosed with CML between 1982 and 1997, 72 CP cases evaluable for long-term follow-up included 1...

journal_title：International journal of molecular medicine

authors： Itoh T,Tamura S,Takemoto Y,Kakishita E

更新日期：1999-12-01 00:00:00

abstract：:Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studi...

journal_title：International journal of molecular medicine

authors： Chen T,Yang P,Jia Y

更新日期：2021-03-01 00:00:00

abstract：:Decreased skeletal muscle capillarization is considered to significantly contribute to the development of pulmonary cachexia syndrome (PCS) and progressive muscle wasting in several chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). It is unclear to which extent the concurrent prese...

journal_title：International journal of molecular medicine

authors： Basic VT,Jacobsen A,Sirsjö A,Abdel-Halim SM

更新日期：2014-07-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

journal_title：International journal of molecular medicine

authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

更新日期：2003-12-01 00:00:00

abstract：:Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis. In this study, we examined the in vitro and in vivo mechanisms of the traditional Vietnamese herb Zanthoxylum avicennae on the inhibition of HA22T human hepatocellular carcinoma cell ...

journal_title：International journal of molecular medicine

authors： Dung TD,Chang HC,Binh TV,Lee MR,Tsai CH,Tsai FJ,Kuo WW,Chen LM,Huang CY

更新日期：2012-06-01 00:00:00

abstract：:The current study aimed to clarify the role of nucleolin in the phenotypic transformation of vascular smooth muscle cells (VSMCs) and to preliminarily explore its underlying mechanism. The spatial and temporal expression patterns of nucleolin, and the effects of angiotensin II (Ang II) on the expression of VSMC phenot...

journal_title：International journal of molecular medicine

authors： Fang L,Zhang PF,Wang KK,Xiao ZL,Yang M,Yu ZX

更新日期：2019-04-01 00:00:00

abstract：:The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was investigated and it was demonstrated that transforming growth factor‑β1 (TGF‑β1) s...

journal_title：International journal of molecular medicine

authors： Liu Z,Kuang W,Zhou Q,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:The adaptive response of skeletal muscle fibres depends on a variety of biological factors including loading conditions and neuromuscular activity. An extreme type of atrophy-inducing change in contractile activity is represented by the physical disconnection between the motor nerve and its respective fibre unit. Sinc...

journal_title：International journal of molecular medicine

authors： Donoghue P,Ribaric S,Moran B,Cebasek V,Erzen I,Ohlendieck K

更新日期：2004-06-01 00:00:00

abstract：:Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The prese...

journal_title：International journal of molecular medicine

authors： Song F,Liu J,Feng Y,Jin Y

更新日期：2020-09-01 00:00:00

abstract：:betaA25-35, a neurotoxic fragment of the Alzheimer beta-amyloid peptide (betaA), acts as a strong inducer of pro-inflammatory cytokines, such as interleukin (IL)-1 and IL-6, in glial cells. Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha an...

journal_title：International journal of molecular medicine

authors： Eriksson G,Zetterström M,Cortes Toro V,Bartfai T,Iverfeldt K

更新日期：1998-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been studied in a number of diseases. However, the roles of circRNAs in hypoxic‑ischemic brain damage (HIBD) remains unknown. In the present study, high throughput sequencing was used to profile altered circRNAs in HIBD rats. A total of 66 circRNAs were identified to be differentially exp...

journal_title：International journal of molecular medicine

authors： Jiang L,Li H,Fan Z,Zhao R,Xia Z

更新日期：2019-04-01 00:00:00

abstract：:There is clinical evidence that patients with heart failure and concomitant iron deficiency have increased skeletal muscle fatigability and impaired exercise tolerance. It was expected that a skeletal muscle cell line subjected to different degrees of iron availability and/or concomitant hypoxia would demonstrate chan...

journal_title：International journal of molecular medicine

authors： Kobak K,Kasztura M,Dziegala M,Bania J,Kapuśniak V,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2018-05-01 00:00:00

abstract：:ACSL3 is a member of the long chain acyl-CoA synthetase (ACSL) family that consists of 5 isozymes responsible for cellular fatty acid metabolism in various tissues in an isozyme-specific manner. Our previous studies have demonstrated that expression of ACSL3 mRNA and protein in liver was specifically increased after f...

journal_title：International journal of molecular medicine

authors： Wu M,Cao A,Dong B,Liu J

更新日期：2011-05-01 00:00:00

abstract：:Recent studies have suggested that calcium‑activated potassium channel (KCa) agonists increase the proportion of mouse embryonic stem cell‑derived cardiomyocytes and promote the differentiation of pacemaker cells. In the present study, it was hypothesized that adipose‑derived stem cells (ADSCs) can differentiate into ...

journal_title：International journal of molecular medicine

authors： Yang M,Zhao Q,Zhao H,Yang A,Wang F,Wang X,Tang Y,Huang C

更新日期：2019-12-01 00:00:00

abstract：:Aromatic turmerone (ar-turmerone) has been reported to have a cytotoxic effect on L-1210 and HL-60 cells. In the present study, we investigated the anticancer responses and immune activities in implanted tumor cells. Our study found that ar-turmerone inhibited the increase in the nu...

journal_title：International journal of molecular medicine

authors： Kim D,Suh Y,Lee H,Lee Y

更新日期：2013-02-01 00:00:00

abstract：:Mutations in the known predisposing breast cancer genes BRCA1 and BRCA2 account for only a small proportion (<10%) of breast cancer families in the Stockholm region of Sweden. This study aims to identify novel predisposing genes in non-BRCA1/BRCA2 breast cancer families. We have employed comparative genomic hybridizat...

journal_title：International journal of molecular medicine

authors： Maguire P,Holmberg K,Kost-Alimova M,Imreh S,Skoog L,Lindblom A

更新日期：2005-07-01 00:00:00

abstract：:Influenza is the most common infectious disease and is caused by influenza A virus (IAV) infection. Hemagglutinin (HA) is an important viral protein of influenza A and is a major component of current IAV vaccines. The side effects associated with IAV vaccination are well studied; however, the HA‑induced immunopatholog...

journal_title：International journal of molecular medicine

authors： Li Y,Hu H,Qi Z,Sun J,Li Y,Feng Q,Guo C,Wang H,Zhao P,Liu Y,Zhao X,Wang G,Zhang H,Liu L,Hu J

更新日期：2018-03-01 00:00:00

abstract：:The deletion mutation of exon 4 in surfactant protein C (SP-C), a lung surfactant protein, has been identified in parent-child cases of familial interstitial pneumonia. It has been shown that this mutation induces endoplasmic reticulum (ER) stress. Synoviolin is an E3 ubiquitin ligase that is localized to the ER and i...

journal_title：International journal of molecular medicine

authors： Nakajima F,Aratani S,Fujita H,Yagishita N,Ichinose S,Makita K,Setoguchi Y,Nakajima T

更新日期：2015-01-01 00:00:00

abstract：:Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-κB pathway; therefore, suppression of TLR4/NF-κB signaling has become a prom...

journal_title：International journal of molecular medicine

authors： Lan L,Tao J,Chen A,Xie G,Huang J,Lin J,Peng J,Chen L

更新日期：2013-01-01 00:00:00

abstract：:Clinical evidence suggests that healing is faster and almost scarless at an early neonatal age in comparison with that in adults. In this study, the phenotypes of neonatal and adult dermal fibroblasts and keratinocytes (nestin, smooth muscle actin, keratin types 8, 14 and 19, and fibronectin) were compared. Furthermor...

journal_title：International journal of molecular medicine

authors： Mateu R,Živicová V,Krejčí ED,Grim M,Strnad H,Vlček Č,Kolář M,Lacina L,Gál P,Borský J,Smetana K Jr,Dvořánková B

更新日期：2016-10-01 00:00:00

abstract：:This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL...

journal_title：International journal of molecular medicine

authors： Heo JC,Nam SH,Nam DY,Kim JG,Lee KG,Yeo JH,Yoon CS,Park CH,Lee SH

更新日期：2010-09-01 00:00:00

abstract：:Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue generates irreversible damage to the myocardium, which is termed 'cardiac ischemia‑reperfusion (IR) injury'. Due to the large number of mito...

journal_title：International journal of molecular medicine

authors： Marin W,Marin D,Ao X,Liu Y

更新日期：2021-02-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. Findings indicate that Alzheimer disease (AD) and vascular dementia (VaD) may have common risk factors and/or pathogene...

journal_title：International journal of molecular medicine

authors： Folin M,Baiguera S,Conconi MT,Di Liddo R,De Carlo E,Parnigotto PP,Nussdorfer GG

更新日期：2004-10-01 00:00:00

abstract：:We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene...

journal_title：International journal of molecular medicine

authors： Chen X,Zhu C,Ji C,Zhao Y,Zhang C,Chen F,Gao C,Zhu J,Qian L,Guo X

更新日期：2010-03-01 00:00:00

abstract：:Inflammation and remodeling play a role in the pathogenesis of pulmonary arterial hypertension (PAH). Nuclear factor-κB (NF-κB) and nuclear factor of activated T cells-1 (NFAT-1) participate in inflammation and remodeling in a number of diseases. As a tryptophan hydroxylase inhibitor, 4-chloro-DL-phenylalanine (PCPA) ...

journal_title：International journal of molecular medicine

authors： Bai Y,Li ZX,Wang HL,Lian GC,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:The inhibition of elements of the plasminogen activator system [urokinase (uPA), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)] plays an important role in human diseases. PAI-1 is overexpressed in obesity and diabetes, and the inhibition of this protein has been postulated to allevia...

journal_title：International journal of molecular medicine

authors： Jankun J,Kondray V,Skrzypczak-Jankun E

更新日期：2013-05-01 00:00:00

abstract：:This study examined the mechanism for the anti-cancer effects of histone deacetylase (HDAC) inhibitor trichostatin A (TsA) in H-ras-transformed human breast epithelial (MCF10A-ras) cells. The effects of TsA on anti-cancer effects of MCF10A-ras cells were determined by measuring the level of cell cycle regulator expres...

journal_title：International journal of molecular medicine

authors： Park H,Lee YJ,Kim TH,Lee J,Yoon S,Choi WS,Myung CS,Kim HS

更新日期：2008-11-01 00:00:00

abstract：:Thioredoxin (TRX), which is a stress-inducible protein with redox-active disulfide structures, has various biological activities by regulating DNA binding of transcription factors in cells. In Graves' disease that is among the common diseases of the thyroid, endogenous stresses that are induced by excess thyroid hormo...

journal_title：International journal of molecular medicine

authors： Kihara M,Kontani K,Yamauchi A,Miyauchi A,Nakamura H,Yodoi J,Yokomise H

更新日期：2005-05-01 00:00:00

abstract：:A tight relationship has been revealed between cellular microRNAs (miRNAs) and the course of hepatitis C virus (HCV) replication in human hepatoma cells. Although the detection of the antigenomic HCV RNA strand in peripheral blood mononuclear cells (PBMCs) has provided evidence for viral replication in PBMCs, no repor...

journal_title：International journal of molecular medicine

authors： Grek M,Piekarska A,Bartkowiak J,Fendler W,Kuydowicz J,Wroblewski P,Paradowski M,Sidorkiewicz M

更新日期：2011-11-01 00:00:00