The influence of Celecoxib on matrix synthesis by chondrocytes under mechanical stress in vitro.

abstract：:Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine ...

journal_title：International journal of molecular medicine

authors： Seya T,Nomura M,Murakami Y,Begum NA,Matsumoto M,Nagasawa S

更新日期：1998-05-01 00:00:00

abstract：:Laminarin, found in marine brown algae, is used as a carbohydrate reserve for phytoplankton; however, it is also used in traditional Chinese medicine, and has been shown to have several biological activities, including anticancer activities. In this study, we examined the mechanisms through which laminarin from Lamina...

journal_title：International journal of molecular medicine

authors： Park HK,Kim IH,Kim J,Nam TJ

更新日期：2013-08-01 00:00:00

abstract：:Epidemiological studies have indicated that increased consumption of cruciferous vegetables is associated with a statistically significant reduction in the risk for cancers. The major bioactive agent in these vegetables is a class of sulfur-containing glycosides called glucosinolates. Isothiocyanates, derivatives of g...

journal_title：International journal of molecular medicine

authors： Jadhav U,Ezhilarasan R,Vaughn SF,Berhow MA,Mohanam S

更新日期：2007-03-01 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology and pathogenesis remain poorly understood. The aberrant expression of T lymphocytes plays an essential role in the progression of UC. This study aimed to evaluate the expression profile of circulating Th17, Th1 and Tc1 cells in...

journal_title：International journal of molecular medicine

authors： Dong Z,Du L,Xu X,Yang Y,Wang H,Qu A,Qu X,Wang C

更新日期：2013-04-01 00:00:00

abstract：:Needle biopsy is widely used to obtain specimens for physiological, anatomical and biochemical studies of skeletal muscle (SM). We optimized a procedure which we termed tiny percutaneous needle biopsy (TPNB), to efficiently gather good numbers of human satellite cells and single dissociated fibers for the functional s...

journal_title：International journal of molecular medicine

authors： Pietrangelo T,D'Amelio L,Doria C,Mancinelli R,Fulle S,Fanò G

更新日期：2011-03-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:Acute necrotizing pancreatitis (ANP) is a common severe critical illness with a high mortality rate. Resveratrol, a polyphenol compound derived from various plants such as grape skin, peanut, berry and veratrum, exhibits multiple biological activities, especially potent anti‑inflammatory activity, but its effect on AN...

journal_title：International journal of molecular medicine

authors： Wang N,Zhang F,Yang L,Zou J,Wang H,Liu K,Liu M,Zhang H,Xiao X,Wang K

更新日期：2017-08-01 00:00:00

abstract：:A previous study has revealed that oxidized low‑density lipoprotein (oxLDL)/β2‑glycoprotein I (β2GPI)/anti‑β2‑glycoprotein I (anti‑β2GPI), an immune complex, is able to activate the Toll‑like receptor 4 (TLR4)/nuclear factor κβ (NF‑κβ) inflammatory signaling pathway in macrophages, and consequently enhance foam cell f...

journal_title：International journal of molecular medicine

authors： Wang T,Ouyang H,Zhou H,Xia L,Wang X,Wang T

更新日期：2018-10-01 00:00:00

abstract：:Intralesional injection of bleomycin‑A5 (BLE‑A5) is a novel treatment for nasal polyps. Our previous study clarified that BLE‑A5 could induce nasal polyp‑derived fibroblast (NPDF) apoptosis in nasal polyps. However, the detailed mechanisms are still unclear. The present study aimed to determine the effects of BLE‑A5 o...

journal_title：International journal of molecular medicine

authors： Wu F,Ma Y,Wang J,Ou H,Dang H,Zheng Y,Tian P,Zou H

更新日期：2021-01-01 00:00:00

abstract：:The underground parts of Nardostachys chinensis (N. chinensis), which belongs the genus Valerianaceae, have been used as sedative and analgesic agents in traditional Korean medicine for centuries. The mitogen-activated protein kinases (MAPKs) are serine/threonine kinases involved in the regulation of various cellular ...

journal_title：International journal of molecular medicine

authors： Ju SM,Kang JG,Pae HO,Lee GS,Kim WS,Lyu YS,Jeon BH

更新日期：2014-03-01 00:00:00

abstract：:Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bon...

journal_title：International journal of molecular medicine

authors： Moon PD,Kim MH,Oh HA,Nam SY,Han NR,Jeong HJ,Kim HM

更新日期：2015-08-01 00:00:00

abstract：:The overexpression of interleukin-8 (IL-8) is closely associated with poor tumor differentiation, metastasis and tumor progression. This study aimed to examine the effects and mechanisms of action of SN38 (a metabolite of the camptothecin derivative, CPT-11) on IL-8 expression in HCT8 cells, using ELISA, CCK-8 and wes...

journal_title：International journal of molecular medicine

authors： Zhang L,Lou WH,Xu XF,Wu W,Rong YF,Jin DY

更新日期：2017-01-01 00:00:00

abstract：:It was previously shown that total saponins extracted from Aralia taibaiensis (sAT) have potent antioxidant activities for treating diabetes mellitus and attenuate d-galactose-induced aging. Since diabetes mellitus and aging are closely associated with cardiac dysfunction, particularly ischemic heart disease, sAT may ...

journal_title：International journal of molecular medicine

authors： Yan J,Duan J,Wu X,Guo C,Yin Y,Zhu Y,Hu T,Wei G,Wen A,Xi M

更新日期：2015-12-01 00:00:00

abstract：:Berberine (BBR) is a botanical alkaloid that has been reported to have effects in cardiovascular diseases; however, the mechanisms involved are not yet fully understood. In the present study, the protective effects of BBR were evaluated, and the underlying molecular mechanisms were investigated. The effects of a combi...

journal_title：International journal of molecular medicine

authors： Chi L,Peng L,Pan N,Hu X,Zhang Y

更新日期：2014-10-01 00:00:00

abstract：:We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene...

journal_title：International journal of molecular medicine

authors： Chen X,Zhu C,Ji C,Zhao Y,Zhang C,Chen F,Gao C,Zhu J,Qian L,Guo X

更新日期：2010-03-01 00:00:00

abstract：:Studies have shown that an overproduction of mitochondrial reactive oxygen species (ROS) is an initiating cause in the pathogenesis of diabetic complications. However, uncoupling protein 2 (UCP2) can protect retinal vascular endothelial cells from damage by inhibiting the overproduction of mitochondrial ROS, although ...

journal_title：International journal of molecular medicine

authors： He Y,Wang N,Shen Y,Zheng Z,Xu X

更新日期：2014-05-01 00:00:00

abstract：:Antigen presenting cells, especially the antigen presenting dendritic cells (DC) in the tissue, regulate the magnitude of antigen-specific immune response. A role of impaired and narrowly focused specific immune response has been implicated in the pathogenesis of chronic hepatitis due to hepatitis B virus and hepatiti...

journal_title：International journal of molecular medicine

authors： Abe M,Kajino K,Akbar SM,Yamamura K,Onji M,Hino O

更新日期：2002-01-01 00:00:00

abstract：:Human interleukin-15 (hIL15) exerts anticancer effects through the activities of lymphokine-activated killer (LAK) cells. However, its short half-life hinders its clinical application. Recombinant adeno-associated virus serotype 2 (rAAV2) is used for hIL15 gene transfer vectors, bec...

journal_title：International journal of molecular medicine

authors： Yiang GT,Chou PL,Tsai HF,Chen LA,Chang WJ,Yu YL,Wei CW

更新日期：2012-05-01 00:00:00

abstract：:Dynamin-related peptide 1 (Drpl)-mediated mitochondrial fission is an important process associated with cardiac dysfunction under different pathological conditions. The aim of the present study was to investigate the expression of Drpl during inflammatory myocardial injury. Sprague‑Dawley rats were treated intraperito...

journal_title：International journal of molecular medicine

authors： Shen YL,Shi YZ,Chen GG,Wang LL,Zheng MZ,Jin HF,Chen YY

更新日期：2018-04-01 00:00:00

abstract：:Sprouty (SPRY) was first identified in a genetic screen in Drosophila to be an antagonist of fibroblast growth factor (FGF) and epidermal growth factor (EGF) signaling, seemingly by inhibiting the Ras/MAP kinase pathway. During large scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel splice ...

journal_title：International journal of molecular medicine

authors： Wang L,Ji C,Wu H,Xu J,Wu Q,Dai J,Yin G,Ye X,Gu S,Xie Y,Mao Y

更新日期：2003-11-01 00:00:00

abstract：:Although the upregulation of enhancer of zeste homolog 2 (EZH2) expression and downregulation of long non-coding RNA (lncRNA) LET expression are known to be associated with cell apoptosis and proliferation, little is known about the interaction of EZH2 with lncRNA LET. The present study aimed to investigate the intera...

journal_title：International journal of molecular medicine

authors： Zheng W,Yu A

更新日期：2018-04-01 00:00:00

abstract：:Inflammatory genes serve a crucial role in the pathogenesis of inflammation‑associated tumors. However, as recent studies have mainly focused on the effects of single inflammatory genes on colorectal cancer (CRC), but not on the global interactions between genes, the underlying mechanisms between inflammatory genes and...

journal_title：International journal of molecular medicine

authors： Jiang H,Dong L,Gong F,Gu Y,Zhang H,Fan D,Sun Z

更新日期：2018-07-01 00:00:00

abstract：:Dextromethorphan is a widely used anti-tussive drug with non-competitive antagonistic effects on excitatory amino acid receptors of the N-methyl-D-aspartate (NMDA) type. This study examined the effect of daily dextromethorphan administration on gene expression in rat brain hippocampus and cortex regions using Rat 5K c...

journal_title：International journal of molecular medicine

authors： Lee KH,Ahn JI,Yu DH,Koh HC,Kim SH,Yang BH,Lee YS,Lee YS

更新日期：2003-05-01 00:00:00

abstract：:Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around the TMJ is involved in the pathogenesis of inflammatory diseases, inc...

journal_title：International journal of molecular medicine

authors： Yokota S,Chosa N,Kyakumoto S,Kimura H,Ibi M,Kamo M,Satoh K,Ishisaki A

更新日期：2017-04-01 00:00:00

abstract：:We report on the in silico-initiated cloning and molecular characterization of CTXN3 (cortexin 3), a new human gene that was specifically expressed in the kidney and brain due to tissue-specific alternative exon 1 usage, on chromosome 5q23.2 using digital gene expression displayer (DGED) and a novel in silico cloning ...

journal_title：International journal of molecular medicine

authors： Wang HT,Chang JW,Guo Z,Li BG

更新日期：2007-10-01 00:00:00

abstract：:The direction of mesenchymal stem cell (MSC) differentiation is regulated by stimulation with various growth factors and cytokines. We recently established MSC lines, [transforming growth factor-β (TGF-β)-responsive SG‑2 cells, bone morphogenetic protein (BMP)-responsive SG‑3 cells, and TGF-β/BMP-non-responsive SG‑5 c...

journal_title：International journal of molecular medicine

authors： Igarashi Y,Chosa N,Sawada S,Kondo H,Yaegashi T,Ishisaki A

更新日期：2016-04-01 00:00:00

abstract：:Oral squamous cell carcinomas (OSCCs), a major public health problem worldwide, are the most common neoplasms of the head and neck. The most important prognostic indicator for patients with OSCC is metastasis to cervical lymph nodes or distant organs. Galectin-9 is correlated with cellular adhesion and aggregation in ...

journal_title：International journal of molecular medicine

authors： Kasamatsu A,Uzawa K,Nakashima D,Koike H,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2005-08-01 00:00:00

abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

journal_title：International journal of molecular medicine

authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

更新日期：2012-02-01 00:00:00

abstract：:Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease....

journal_title：International journal of molecular medicine

authors： Yim SY,Chae KR,Shim SB,Hong JT,Park JY,Lee CY,Son HJ,Sheen YY,Hwang DY

更新日期：2009-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by areas of inflammation, demyelination and axonal damage. The etiology of MS is multifactorial with an interaction between genetic, environmental and geographical factors. The objective of this study was to review the physiopathology and the genetic polym...

journal_title：International journal of molecular medicine

authors： Kallaur AP,Kaimen-Maciel DR,Morimoto HK,Watanabe MA,Georgeto SM,Reiche EM

更新日期：2011-10-01 00:00:00