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Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells.

Abstract：

:Laminarin, found in marine brown algae, is used as a carbohydrate reserve for phytoplankton; however, it is also used in traditional Chinese medicine, and has been shown to have several biological activities, including anticancer activities. In this study, we examined the mechanisms through which laminarin from Laminaria digitata induces apoptosis in HT-29 colon cancer cells, as well as the involvement of the ErbB signaling pathway. Cell viability assay revealed that laminarin induced cell death in a dose-dependent manner. Cell cycle analysis revealed that laminarin increased the percentage of cells in the sub-G1 and G2-M phase. Western blot analysis demonstrated that laminarin inhibited the heregulin-stimulated phosphorylation of ErbB2. A decrease in cellular proliferation was also observed; this was found to be dependent on ErbB, which activates c-Jun N-terminal kinase. These findings demonstrate the important role of the epidermal growth factor receptor in colon cancer tumorigenesis, and suggest the potential of laminarin as a bio-functional food with anticancer effects on human colon cancer.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Park HK,Kim IH,Kim J,Nam TJ

doi

10.3892/ijmm.2013.1409

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

291-5

issue

2

eissn

1107-3756

issn

1791-244X

journal_volume

32

pub_type

杂志文章

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