Transcription factor E2-2 inhibits the proliferation of endothelial progenitor cells by suppressing autophagy.

abstract：:The adaptive response of skeletal muscle fibres depends on a variety of biological factors including loading conditions and neuromuscular activity. An extreme type of atrophy-inducing change in contractile activity is represented by the physical disconnection between the motor nerve and its respective fibre unit. Sinc...

journal_title：International journal of molecular medicine

authors： Donoghue P,Ribaric S,Moran B,Cebasek V,Erzen I,Ohlendieck K

更新日期：2004-06-01 00:00:00

abstract：:Graves' ophthalmopathy (GO) is considered to be an organ-specific autoimmune disease. However, the pathogenesis of GO is incompletely understood at the present time. To clarify the immunological differences between newly diagnosed GO and Graves' disease (GD) without ophthalmopathy or healthy controls (HC), we examined...

journal_title：International journal of molecular medicine

authors： Xia N,Zhou S,Liang Y,Xiao C,Shen H,Pan H,Deng H,Wang N,Li QQ

更新日期：2006-05-01 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesen...

journal_title：International journal of molecular medicine

authors： Liu Q,Zhang X,Jiao Y,Liu X,Wang Y,Li SL,Zhang W,Chen FM,Ding Y,Jiang C,Jin Z

更新日期：2018-02-01 00:00:00

abstract：:Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that ...

journal_title：International journal of molecular medicine

authors： Nakajima K,Wu G,Takeyama N,Sakudo A,Sugiura K,Yukawa M,Onodera T

更新日期：2009-07-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung ...

journal_title：International journal of molecular medicine

authors： Huang B,Gao Y,Tian D,Zheng M

更新日期：2010-05-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMCs) are involved in all stages of the progression of human atherosclerosis (AS). MicroRNAs (miRNAs or miRs) are non‑coding, small RNAs that regulate gene expression at the post‑transcriptional level through translational repression or messenger RNA (mRNA) decay. Recently, a variety of ...

journal_title：International journal of molecular medicine

authors： Yu X,Li Z

更新日期：2014-10-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Despite the improvement in gastric cancer (GC) treatment, multidrug resistance (MDR) is still a significant reason for chemotherapy failure. Our previous studies have demonstrated that miR-19a/b upregulation directly promoted MDR in GC cells. However, the exact regulation and the potential molecule mechanisms have not...

journal_title：International journal of molecular medicine

authors： Zhu F,Wu Q,Ni Z,Lei C,Li T,Shi Y

更新日期：2018-07-01 00:00:00

abstract：:It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) alleviated liver fibrosis. We investigated whether BMSCs transfected with human matrix metalloproteinase 1 (BMSCs/MMP1) would improve their therapeutic effect in liver fibrosis induced by carbon tetrachloride (CCl4) in rats. BMSCs were transf...

journal_title：International journal of molecular medicine

authors： Du C,Jiang M,Wei X,Qin J,Xu H,Wang Y,Zhang Y,Zhou D,Xue H,Zheng S,Zeng W

更新日期：2018-06-01 00:00:00

abstract：:When treating glaucoma, excessive scar tissue reactions reduce the postoperative survival rate of the filtering bleb. Accumulating evidence has demonstrated that the proliferation, migration and extracellular matrix (ECM) synthesis of fibroblasts are important molecular mechanisms underlying scar formation. Recent evi...

journal_title：International journal of molecular medicine

authors： Sun L,Dong Y,Zhao J,Yin Y,Tong B,Zheng Y,Xin H

更新日期：2018-03-01 00:00:00

abstract：:In the present study, the effects of erlotinib on mouse tear function and corneal epithelial tissue structure were investigated. Throughout the 3 weeks of treatment, no notable differences were observed in the body, eye or lacrimal gland weights of the control and experimental mice. However, in the experimental group,...

journal_title：International journal of molecular medicine

authors： Yang QC,Bao J,Li C,Tan G,Wu AH,Ye L,Ye LH,Zhou Q,Shao Y

更新日期：2018-03-01 00:00:00

abstract：:A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect...

journal_title：International journal of molecular medicine

authors： Sancho V,Nuche B,Arnés L,Cancelas J,González N,Díaz-Miguel M,Martín-Duce A,Valverde I,Villanueva-Peñacarrillo ML

更新日期：2007-06-01 00:00:00

abstract：:Microsatellite instability (MSI) and loss of heterozygosity (LOH) was investigated in paired tumour and normal tissue DNA from 108 predominantly premenopausal breast cancer patients (under age 45 years at presentation) for 25 simple repeat loci interspersed across 11 chromosomes. MSI was observed at a single locus in ...

journal_title：International journal of molecular medicine

authors： Luqmani YA,Mathew M,Lobo S

更新日期：2003-01-01 00:00:00

abstract：:We have recently demonstrated the antiproliferative and apoptotic activities of herbal traditional Chinese medicines, including the analomous fruit extract of Gleditsia sinensis, the fresh juice of Scutellaria barbata and the warmed water extract of Radix Sophorae Tonkinensis on a series of human carcinoma cells. Here...

journal_title：International journal of molecular medicine

authors： Lau FY,Chui CH,Gambari R,Kok SH,Kan KL,Cheng GY,Wong RS,Teo IT,Cheng CH,Wan TS,Chan AS,Tang JC

更新日期：2005-12-01 00:00:00

abstract：:Biologically well-tolerated materials are at the core of intense research. In this study, we report both the intrinsic features of formic acid (FA)-crosslinked three-dimensional (3D) nonwoven scaffolds consisting of sericin-deprived, Bombyx mori silk fibroin (SF) in beta-sheet form and the long-term co-culture of adul...

journal_title：International journal of molecular medicine

authors： Dal Pra I,Chiarini A,Boschi A,Freddi G,Armato U

更新日期：2006-08-01 00:00:00

abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

journal_title：International journal of molecular medicine

authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

更新日期：2005-02-01 00:00:00

abstract：:We studied whether feeding pregnant female mice with different fats affects lipid exchange and activity of the splenic lymphoid system in offspring exposed to low doses of carcinogen. Female mice were fed diets with either 7% or 15% corn oil or olive oil. The 4-week-old offspring of these mice were transferred to a ch...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H,Budovsky A,Geva D,Gurevich P,Tendler Y,Lavee S,Stark A,Madar Z

更新日期：2000-09-01 00:00:00

abstract：:The tree shrew (Tupaia belangeri) diverges from the primate order (Primates) and is classified as a separate taxonomic group of mammals - Scandentia. It has been suggested that the tree shrew can be used as an animal model for studying human diseases; however, the genomic sequence of the tree shrew is largely unidenti...

journal_title：International journal of molecular medicine

authors： Zheng Y,Yun C,Wang Q,Smith WW,Leng J

更新日期：2015-02-01 00:00:00

abstract：:Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease...

journal_title：International journal of molecular medicine

authors： Hou X,Du H,Yang R,Qi J,Huang Y,Feng S,Wu Y,Lin S,Liu Z,Jia AQ,Yuan S,Sun L

更新日期：2018-05-01 00:00:00

abstract：:Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and ...

journal_title：International journal of molecular medicine

authors： Zhou Q,Cao J,Chen L

更新日期：2016-05-01 00:00:00

abstract：:Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requireme...

journal_title：International journal of molecular medicine

authors： Wang Z,Wang N,Liu X,Wang Q,Xu B,Liu P,Zhu H,Chen J,Situ H,Lin Y

更新日期：2018-01-01 00:00:00

abstract：:In the present study, human umbilical cord-derived mesenchymal stem cells (hUMSCs) were investigated for their potential to be induced to differentiate in vitro into neuron-like cells by monosialoteterahexosyl ganglioside (GM1). Mononuclear cells obtained from umbilical cords from women with full-term pregnancies whos...

journal_title：International journal of molecular medicine

authors： Nan C,Shi Y,Zhao Z,Ma S,Liu J,Yan D,Song G,Liu H

更新日期：2015-10-01 00:00:00

abstract：:Tuberculous meningitis (TBM) is a serious complication of tuberculosis that affects the central nervous system. As TBM may result in permanent sequelae and death, rapid, accurate diagnostic tests using novel biomarkers are required for the early diagnosis and treatment of TBM. A quantitative proteomic study was theref...

journal_title：International journal of molecular medicine

authors： Yang Y,Mu J,Chen G,Zhan Y,Zhong J,Wei Y,Cheng K,Qin B,You H,Xie P

更新日期：2015-05-01 00:00:00

abstract：:Dental pulp cells (DPCs), including dental pulp (DP) stem cells, play a role in dentine repair under certain conditions caused by bacterial infections associated with caries, tooth fracture and injury. Mesenchymal stem cells (MSCs) have also been shown to be involved in this process of repair. However, the mechanisms ...

journal_title：International journal of molecular medicine

authors： Akazawa Y,Hasegawa T,Yoshimura Y,Chosa N,Asakawa T,Ueda K,Sugimoto A,Kitamura T,Nakagawa H,Ishisaki A,Iwamoto T

更新日期：2015-08-01 00:00:00

abstract：:Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this ...

journal_title：International journal of molecular medicine

authors： Enjoji M,Kotoh K,Kato M,Higuchi N,Kohjima M,Nakashima M,Nakamuta M

更新日期：2008-10-01 00:00:00

abstract：:The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular carti...

journal_title：International journal of molecular medicine

authors： Albrecht C,Schlegel W,Eckl P,Jagersberger T,Sadeghi K,Berger A,Vécsei V,Marlovits S

更新日期：2009-02-01 00:00:00

abstract：:Thioredoxin (TRX), which is a stress-inducible protein with redox-active disulfide structures, has various biological activities by regulating DNA binding of transcription factors in cells. In Graves' disease that is among the common diseases of the thyroid, endogenous stresses that are induced by excess thyroid hormo...

journal_title：International journal of molecular medicine

authors： Kihara M,Kontani K,Yamauchi A,Miyauchi A,Nakamura H,Yodoi J,Yokomise H

更新日期：2005-05-01 00:00:00

abstract：:CDH1, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinoma...

journal_title：International journal of molecular medicine

authors： Ling ZQ,Li P,Ge MH,Zhao X,Hu FJ,Fang XH,Dong ZM,Mao WM

更新日期：2011-05-01 00:00:00

abstract：:The inhibition of elements of the plasminogen activator system [urokinase (uPA), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)] plays an important role in human diseases. PAI-1 is overexpressed in obesity and diabetes, and the inhibition of this protein has been postulated to allevia...

journal_title：International journal of molecular medicine

authors： Jankun J,Kondray V,Skrzypczak-Jankun E

更新日期：2013-05-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome caused by mutations or deletions within the VHL tumor-suppressor gene, but VHL germline mutations in the Chinese have rarely been studied. To investigate the genetic profile of VHL mutations in the Chinese population, we evaluated the clinical characterist...

journal_title：International journal of molecular medicine

authors： Huang Y,Zhou D,Liu J,Zhou P,Li X,Wang Z

更新日期：2012-01-01 00:00:00