Abstract:
:Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung cancer cell lines (NCI-H446). Then we examined the effects of ABCE1 knockdown in cancer cells, including proliferation, invasiveness, apoptosis, and gene expression. We found that ABCE1 could be efficiently knocked down by siRNA, and the ABCE1 silence inhibited the proliferation, invasiveness of small cell lung cancer cell lines NCI-H446. In conclusion, our results suggest that ABCE1 play an important role in the pathogenesis of human small cell lung cancer cell. ABCE1 may be used as a potential target of gene therapy for small cell lung cancer in future.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Huang B,Gao Y,Tian D,Zheng Msubject
Has Abstractpub_date
2010-05-01 00:00:00pages
687-93issue
5eissn
1107-3756issn
1791-244Xjournal_volume
25pub_type
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journal_title:International journal of molecular medicine
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