Abstract:
:We studied the expression of several homeobox genes of the HOX family in the adult human intestinal mucosa. HOX genes are regulatory genes homologous to the homeotic genes controlling the body plan of the fruit fly Drosophila melanogaster. The HOX genes are distributed in four homologous HOX loci termed HOX-A, B, C and D, located on four different chromosomes. They have been found to be expressed in many embryonic tissues and axial structures like the central nervous system, the spine and in selected adult cells. The expression of 39 HOX genes belonging to HOX-A, B, C and D was studied by in situ hybridization on specimens of mucosa from normal adult colon. All the genes studied were shown to be expressed in these tissues, but the genes belonging to the four loci showed different localization within the colonic mucosa: HOX-A genes are expressed in undifferentiated proliferating cells at the base of the crypts, HOX-C genes in differentiated cells at the apex of the crypts and HOX-B and HOX-D genes are weakly expressed along the entire crypt length. Expression of some of these genes was also studied in differentiating CaCo-2 cells and tumoral tissues. In particular, in colonic adenocarcinomatous cells, some HOX-A genes appear to be abundantly expressed confirming the presence of these gene products in normal.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Freschi G,Taddei A,Bechi P,Faiella A,Gulisano M,Cillo C,Bucciarelli G,Boncinelli Esubject
Has Abstractpub_date
2005-10-01 00:00:00pages
581-7issue
4eissn
1107-3756issn
1791-244Xjournal_volume
16pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of molecular medicine
pub_type: 临床试验,杂志文章
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