Analysis of boutique arrays: a universal method for the selection of the optimal data normalization procedure.

abstract：:Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a cruc...

journal_title：International journal of molecular medicine

authors： Ding Q,Sun P,Zhou H,Wan B,Yin J,Huang Y,Li Q,Yin G,Fan J

更新日期：2018-07-01 00:00:00

abstract：:Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD-ECGF), has been implicated in bladder cancer angiogenesis and invasion. However, the molecular basis of its role in invasion remains unclear. We investigated the expression of TP and 10 invasion-related genes in bladder can...

journal_title：International journal of molecular medicine

authors： Gotanda T,Haraguchi M,Tachiwada T,Shinkura R,Koriyama C,Akiba S,Kawahara M,Nishiyama K,Sumizawa T,Furukawa T,Mimata H,Nomura Y,Akiyama S,Nakagawa M

更新日期：2006-06-01 00:00:00

abstract：:Claudins (CLDNs) constitute the major transmembrane proteins of tight junctions. It may be hypothesized that changes in or loss of expression of tight junctional proteins such as CLDNs can lead to cellular disorientation and detachment, which is commonly seen in neoplasia. Recent studies have suggested that claudin-1 ...

journal_title：International journal of molecular medicine

authors： Morohashi S,Kusumi T,Sato F,Odagiri H,Chiba H,Yoshihara S,Hakamada K,Sasaki M,Kijima H

更新日期：2007-08-01 00:00:00

abstract：:The aim of the present study was to elucidate whether extracts of Vigna angularis (EVA) inhibit allergic inflammatory reactions and to elucidate the possible mechanisms of action. For the assessment of allergic inflammatory response, histamine release and the expression of pro-inflammatory cytokines from human mast ce...

journal_title：International journal of molecular medicine

authors： Kim HH,Kim SW,Kim DS,Oh HM,Rho MC,Kim SH

更新日期：2013-09-01 00:00:00

abstract：:Receptor-mediated gene delivery is an attractive method for gene transfer in vitro and shows promise for in vivo gene therapy applications. In the current study, we have selected the cytokine interleukin-2 (IL-2) gene to explore the feasibility of receptor-mediated gene transfer into human hepatocellular carcinoma Hep...

journal_title：International journal of molecular medicine

authors： Junbo H,Li Q,Zaide W,Yunde H

更新日期：1999-06-01 00:00:00

abstract：:To investigate whether in vivo gene transfer causes leptin-antagonistic effects on food intake, animal body weight and fat tissue weight, the R128Q mutated-leptin gene, an R to Q substitution at position 128 of mouse leptin, was transferred into mouse liver and leg muscle by electroporation and hydrodynamics-based gen...

journal_title：International journal of molecular medicine

authors： Xiang L,Murai A,Muramatsu T

更新日期：2005-12-01 00:00:00

abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...

journal_title：International journal of molecular medicine

authors： Wang J,Cui M,Sun F,Zhou K,Fan B,Qiu JH,Chen FQ

更新日期：2020-04-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of...

journal_title：International journal of molecular medicine

authors： Huang X,Jin Y,Zhou D,Xu G,Huang J,Shen L

更新日期：2015-05-01 00:00:00

abstract：:Rosiglitazone has been found to have anti-atherogenic effects and to increase serum high-density lipoprotein (HDL) cholesterol (HDL-C) levels. However, in vivo studies investigating the regulation of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) by rosigli...

journal_title：International journal of molecular medicine

authors： Li C,Tu Y,Liu TR,Guo ZG,Xie D,Zhong JK,Fan YZ,Lai WY

更新日期：2015-03-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:The purpose of the present study was to investigate whether bone marrow mesenchymal stem cells (BMMSCs) modified by CXC‑chemokine receptor type 3 (CXCR3) and heme oxygenase‑1 (HO‑1) genes can repair damaged intestinal epithelial cells in vitro, and the role of the p38 mitogen‑activated protein kinase (p38‑MAPK) pathwa...

journal_title：International journal of molecular medicine

authors： Yin M,Shen Z,Yang L,Zheng W,Song H

更新日期：2019-05-01 00:00:00

abstract：:The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was investigated and it was demonstrated that transforming growth factor‑β1 (TGF‑β1) s...

journal_title：International journal of molecular medicine

authors： Liu Z,Kuang W,Zhou Q,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

journal_title：International journal of molecular medicine

authors： Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

更新日期：2008-02-01 00:00:00

abstract：:Obesity increases mammary tumor development in Zucker rats following a single administration of the procarcinogen 7,12-dimenthylbenz(a)anthracene (DMBA). Fifty-day-old obese and lean female Zucker rats were orally gavaged with 65 mg/kg DMBA and sacrificed 139 days post DMBA treatment. At the end of the experiment, mam...

journal_title：International journal of molecular medicine

authors： Whitehead TL,Holley AW,Korourian S,Shaaf S,Kieber-Emmons T,Hakkak R

更新日期：2007-10-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is known to sense the cellular energy state and regulates various cellular energy metabolism pathways through its activation by AMP, an indicator of a low-energy state. 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), an activator of AMPK, efficiently inhibited the adipo...

journal_title：International journal of molecular medicine

authors： Lee H,Kang R,Bae S,Yoon Y

更新日期：2011-07-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) family of transcription factors have been implicated in the regulation of cell proliferation and differentiation. Here we describe molecular characterization of mesoderm-specific bHLH protein, POD-1/Capsulin. Northern blot analysis showed that POD-1/Capsulin are preferentia...

journal_title：International journal of molecular medicine

authors： Miyagishi M,Nakajima T,Fukamizu A

更新日期：2000-01-01 00:00:00

abstract：:Antioxidative flavonoids are used to reduce the risk of cardiovascular diseases in humans. However, the precise mechanism for the anti-atherosclerotic actions of flavonoids remains to be elucidated. In the present study, to assess the mechanism for the action of antioxidative flavonoids on atherosclerosis, we investig...

journal_title：International journal of molecular medicine

authors： Sugaya K,Igarashi M,Kojima Y,Tsubata M,Nagaoka I

更新日期：2011-01-01 00:00:00

abstract：:The current study aimed to clarify the role of nucleolin in the phenotypic transformation of vascular smooth muscle cells (VSMCs) and to preliminarily explore its underlying mechanism. The spatial and temporal expression patterns of nucleolin, and the effects of angiotensin II (Ang II) on the expression of VSMC phenot...

journal_title：International journal of molecular medicine

authors： Fang L,Zhang PF,Wang KK,Xiao ZL,Yang M,Yu ZX

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. The myocardial I/R model was established using C57BL/J6 mice. Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. Commercial kits were used ...

journal_title：International journal of molecular medicine

authors： Zhou Y,Li KS,Liu L,Li SL

更新日期：2020-06-01 00:00:00

abstract：:Atherosclerotic plaque growth requires angiogenesis, and acute coronary syndrome (ACS) is usually triggered by the rupture of unstable atherosclerotic plaques. Previous studies have identified typically circulating microRNA (miRNA/miR) profiles in patients with ACS. miRNAs serve important roles in the pathophysiology ...

journal_title：International journal of molecular medicine

authors： Li S,Geng Q,Chen H,Zhang J,Cao C,Zhang F,Song J,Liu C,Liang W

更新日期：2018-02-01 00:00:00

abstract：:Colorectal cancer is the second leading cause of malignant death, and better preventive strategies are needed. The treatment of colonic cancer remains difficult because of the lack of effective chemotherapeutic agents; therefore it is important to continue to search for cellular functions that can be disrupted by chem...

journal_title：International journal of molecular medicine

authors： Selvakumar P,Pasha MK,Ashakumary L,Dimmock JR,Sharma RK

更新日期：2002-10-01 00:00:00

abstract：:Ezrin is a key protein in membrane-cytoskeleton interaction. Expression of ezrin in actin-rich cell surfaces may play a role in the modulation of cell shape and adhesion. The aim of this study was to detect ezrin, actin and cytoskeleton and to explore their relationship in the apoptosis of esophageal epithelial cells ...

journal_title：International journal of molecular medicine

authors： Shen ZY,Xu LY,Li EM,Li JT,Chen MH,Shen J,Zeng Y

更新日期：2003-09-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of atherosclerosis by promoting vascular smooth muscle cell (VSMC) growth, migration, apoptosis, adhesion and the secretion of matrix components. The osteogenic differentiation of VSMCs is essential in the development of vascular calcif...

journal_title：International journal of molecular medicine

authors： Huang J,Huang H,Wu M,Li J,Xie H,Zhou H,Liao E,Peng Y

更新日期：2013-08-01 00:00:00

abstract：:Adrenomedullin (AM) is a hypotensive peptide, which originates from the proteolytic cleavage of pro(p)AM and acts via AM22-52-sensitive receptors. Reverse transcription polymerase chain reaction allowed the detection of the specific mRNAs of pAM in the mononuclear hematopoietic cells of the cord blood and immunocytoch...

journal_title：International journal of molecular medicine

authors： Del Pup L,Belloni AS,Carraro G,De Angeli S,Parnigotto PP,Nussdorfer GG

更新日期：2003-02-01 00:00:00

abstract：:Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMAC1 were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become...

journal_title：International journal of molecular medicine

authors： Wang NM,Chang JG

更新日期：1999-05-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is one of the most common causes of chronic liver disease and is considered to be a causative factor of cryptogenic cirrhosis and hepatocellular carcinoma. microRNAs (miRNAs) are small non-coding RNAs that negatively regulate messenger RNA (mRNA). Recently, it was demonstrated that...

journal_title：International journal of molecular medicine

authors： Katsura A,Morishita A,Iwama H,Tani J,Sakamoto T,Tatsuta M,Toyota Y,Fujita K,Kato K,Maeda E,Nomura T,Miyoshi H,Yoneyama H,Himoto T,Fujiwara S,Kobara H,Mori H,Niki T,Ono M,Hirashima M,Masaki T

更新日期：2015-04-01 00:00:00

abstract：:Anorexia that develops in chronic hepatitis is associated with cytokine expression in the brain. Treatment of mice with concanavalin A (12.5 mg/kg, i.v.) elevated the plasma alanine aminotransferase activity at 8.5 h after treatment. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta mRNA expression was ind...

journal_title：International journal of molecular medicine

authors： Okamoto T,Okabe S

更新日期：2001-02-01 00:00:00

abstract：:Alopecia is known as a symptom of acute radiation, yet little is known concerning the mechanism of this phenomenon and the alteration of hair protein profiles. To examine this, 6-week-old male C57/BL6 mice were exposed to 6 Gy of X-ray irradiation, which caused acute alopecia. Their hair and skin were collected, and h...

journal_title：International journal of molecular medicine

authors： Nanashima N,Ito K,Ishikawa T,Nakano M,Nakamura T

更新日期：2012-09-01 00:00:00

abstract：:Geranylgeranylacetone (GGA) has recently been reported to have a protective effect against ischemic, injurious and apoptotic stress in several tissues. The aim of this study was to determine the effect of GGA on colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. Colitis was induced by intrarectal i...

journal_title：International journal of molecular medicine

authors： Ohkawara T,Nishihira J,Takeda H,Katsurada T,Kato K,Yoshiki T,Sugiyama T,Asaka M

更新日期：2006-02-01 00:00:00

abstract：:Chinese medicinal herbs have been consumed for thousands of years for the purpose of healthy aging. Lycium barbarum is valued in Chinese culture for its benefits to anti-aging, vision, kidney and liver. Recent studies showed that extracts from L. barbarum possess biological activities including anti-aging, anti-tumor,...

journal_title：International journal of molecular medicine

authors： Yu MS,Ho YS,So KF,Yuen WH,Chang RC

更新日期：2006-06-01 00:00:00