Analysis of boutique arrays: a universal method for the selection of the optimal data normalization procedure.

abstract：:The present study aimed to assess the effects of therapy with adiponectin (APN) gene-modified adipose-derived stem cells (ADSCs) on pulmonary arterial hypertension (PAH) in rats and the underlying cellular and molecular mechanisms. ADSCs were successfully isolated from the rats and characterized. ADSCs were effectivel...

journal_title：International journal of molecular medicine

authors： Luo L,Zheng W,Lian G,Chen H,Li L,Xu C,Xie L

更新日期：2018-01-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:The human adrenocortical carcinoma-derived SW-13 cell line is currently used to study the interrelationships occurring between cytokines and growth factors and endothelins (ET) and adrenomedullin (AM). SW-13 cells express either ET-1 and AM or growth factors, and several cytokines stimulate ET-1 and AM release from SW...

journal_title：International journal of molecular medicine

authors： Albertin G,Carraro G,Petrelli L,Guidolin D,Neri G,Nussdorfer GG

更新日期：2005-03-01 00:00:00

abstract：:The direction of mesenchymal stem cell (MSC) differentiation is regulated by stimulation with various growth factors and cytokines. We recently established MSC lines, [transforming growth factor-β (TGF-β)-responsive SG‑2 cells, bone morphogenetic protein (BMP)-responsive SG‑3 cells, and TGF-β/BMP-non-responsive SG‑5 c...

journal_title：International journal of molecular medicine

authors： Igarashi Y,Chosa N,Sawada S,Kondo H,Yaegashi T,Ishisaki A

更新日期：2016-04-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent commonly used as a first‑line treatment for high‑grade glioblastoma. However, TMZ has short half‑life and frequently induces tumor resistance, which can limit its therapeutic efficiency. In the present study, it was hypothesized that combined treatment with TMZ and acteoside h...

journal_title：International journal of molecular medicine

authors： Hwang TW,Kim DH,Kim DB,Jang TW,Kim GH,Moon M,Yoon KA,Choi DE,Park JH,Kim JJ

更新日期：2019-03-01 00:00:00

abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

journal_title：International journal of molecular medicine

authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

更新日期：2012-02-01 00:00:00

abstract：:Astrocytes are major components of the adult neurogenic niche and play a crucial role in regulating neural stem cell proliferation and differentiation. Following brain injury, astrocytes become reactive and release high-mobility group box 1 (HMGB1), which plays a crucial role in the inflammatory process. However, alth...

journal_title：International journal of molecular medicine

authors： Li M,Sun L,Luo Y,Xie C,Pang Y,Li Y

更新日期：2014-09-01 00:00:00

abstract：:Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease....

journal_title：International journal of molecular medicine

authors： Yim SY,Chae KR,Shim SB,Hong JT,Park JY,Lee CY,Son HJ,Sheen YY,Hwang DY

更新日期：2009-07-01 00:00:00

abstract：:The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride d...

journal_title：International journal of molecular medicine

authors： Kim JH,Na J,Bak DH,Lee BC,Lee E,Choi MJ,Ryu CH,Lee S,Mun SK,Park BC,Kim BJ,Lee HS

更新日期：2019-06-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Cancer stem cells (CSCs) have recently been linked to new treatment strategies for gastric cancer due to the critical role which they play as the 'heartbeat' of cancer. In the present study, we explored the effects of quercetin, an anti-inflammatory and antiviral compound, on gastric CSCs (GCSCs). We noted that quercet...

journal_title：International journal of molecular medicine

authors： Shen X,Si Y,Wang Z,Wang J,Guo Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

journal_title：International journal of molecular medicine

authors： Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

更新日期：2018-06-01 00:00:00

abstract：:The number of patients suffering from diabetes mellitus is constantly rising worldwide, and diabetic retinopathy (DR) has become the most frequent cause of postnatal blindness. Vascular endothelial growth factor (VEGF) is known to play a central role during DR development. Thus, inhibiting the effects of VEGF may hamp...

journal_title：International journal of molecular medicine

authors： Ideno J,Mizukami H,Kakehashi A,Saito Y,Okada T,Urabe M,Kume A,Kuroki M,Kawakami M,Ishibashi S,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manne...

journal_title：International journal of molecular medicine

authors： Jang JY,Lee JH,Shin HK,Choi YH,Lee JD,Choi BT

更新日期：2010-02-01 00:00:00

abstract：:Immortalized cloned human chondrocytes isolated from a normal (Ch-4, 8, N) and an osteoarthritis patient (Ch-8-OA) were established by introduction of recombinant SV40-adenovirus vector containing SV40 early gene. These cells exhibited continuous proliferative capacity in monolayer culture and showed chondrocytic char...

journal_title：International journal of molecular medicine

authors： Yoshimatsu T,Saitoh A,Ryu JN,Shima D,Handa H,Hiramoto M,Kawakami Y,Aizawa S

更新日期：2001-10-01 00:00:00

abstract：:The aim of the present study was to investigate the biological activity of 20 essential oils (EOs) derived from herbal plants and citrus fruits. The in vitro anti-allergic and anti-inflammatory activities of these oils were investigated, and the EO which was found to have the strongest activity of the 20 EOs examined,...

journal_title：International journal of molecular medicine

authors： Mitoshi M,Kuriyama I,Nakayama H,Miyazato H,Sugimoto K,Kobayashi Y,Jippo T,Kuramochi K,Yoshida H,Mizushina Y

更新日期：2014-06-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ) is a naturally occurring redox co‑factor that functions as an essential nutrient and antioxidant, and has been reported to exert potent anti‑inflammatory effects. However, the therapeutic potential of PQQ for isoproterenol hydrochloride (Iso)‑induced cardiac hypertrophy has not yet been ...

journal_title：International journal of molecular medicine

authors： Wen J,Shen J,Zhou Y,Zhao X,Dai Z,Jin Y

更新日期：2020-03-01 00:00:00

abstract：:Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis. As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP a...

journal_title：International journal of molecular medicine

authors： Cong M,Zhao W,Liu T,Wang P,Fan X,Zhai Q,Bao X,Zhang D,You H,Kisseleva T,Brenner DA,Jia J,Zhuang H

更新日期：2017-08-01 00:00:00

abstract：:The adenomatous polyposis coli gene (APC gene) originally was identified as a tumor suppressor gene in colon cancer. We reported previously that APC is mutated and/or deleted in primary oral squamous cell carcinoma (OSCC) tissues and suggested that loss of APC function contributes to carcinogenesis in the oral region....

journal_title：International journal of molecular medicine

authors： Uesugi H,Uzawa K,Kawasaki K,Shimada K,Moriya T,Tada A,Shiiba M,Tanzawa H

更新日期：2005-04-01 00:00:00

abstract：:Elevated anxiety symptoms have been reported to be present in many patients with diabetes mellitus. The underlying mechanisms by which diabetes mellitus influences behavior remain to be determined. We assessed feeding and anxiety behaviors in spontaneously diabetic Ins2Akita mice. We measured blood glucose, body weigh...

journal_title：International journal of molecular medicine

authors： Asakawa A,Toyoshima M,Inoue K,Koizumi A

更新日期：2007-04-01 00:00:00

abstract：:Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around the TMJ is involved in the pathogenesis of inflammatory diseases, inc...

journal_title：International journal of molecular medicine

authors： Yokota S,Chosa N,Kyakumoto S,Kimura H,Ibi M,Kamo M,Satoh K,Ishisaki A

更新日期：2017-04-01 00:00:00

abstract：:We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

journal_title：International journal of molecular medicine

authors： Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

更新日期：2008-10-01 00:00:00

abstract：:Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and ...

journal_title：International journal of molecular medicine

authors： Zhou Q,Cao J,Chen L

更新日期：2016-05-01 00:00:00

abstract：:Synovial membrane consists of fibroblasts and macrophages forming the synovial lining supported by vascularized subsynovium. Each of these components may specifically react to a particular stimulus. Thus, reactions of isolated synovial cells may not correspond to that of intact tissue. We characterized the production ...

journal_title：International journal of molecular medicine

authors： Hyc A,Osiecka-Iwan A,Niderla-Bielinska J,Jankowska-Steifer E,Moskalewski S

更新日期：2009-10-01 00:00:00

abstract：:Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

journal_title：International journal of molecular medicine

authors： Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

更新日期：2014-02-01 00:00:00

abstract：:Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly underst...

journal_title：International journal of molecular medicine

authors： Altaha R,Liang X,Yu JJ,Reed E

更新日期：2004-12-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

journal_title：International journal of molecular medicine

authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

更新日期：2003-12-01 00:00:00

abstract：:Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), which was originally isolated from rat stomach. Ghrelin and GHS-R are also expressed in several peripheral tissues, including adrenal glands, and this prompted us to study ghrelin expression and ghrelin-binding site localization in th...

journal_title：International journal of molecular medicine

authors： Tortorella C,Macchi C,Spinazzi R,Malendowicz LK,Trejter M,Nussdorfer GG

更新日期：2003-08-01 00:00:00

abstract：:Annexin A9 (ANXA9), a member of annexin family, has been reported be associated with colorectal cancer (CRC) carcinogenesis. However, the clinical significance of ANXA9 in CRC, particularly its correlation to invasion and metastasis remains ambiguous. The aim of the present study was to investigate the significance of...

journal_title：International journal of molecular medicine

authors： Yu S,Bian H,Gao X,Gui L

更新日期：2018-04-01 00:00:00