The potential inhibitory effects of miR‑19b on vulnerable plaque formation via the suppression of STAT3 transcriptional activity.

abstract：:The aim of this study was to evaluate in detail the histopathological characteristics of endarterectomized carotid atherosclerotic lesions in symptomatic versus asymptomatic patients. Twenty carotid lesions, 10 from asymptomatic and 10 from symptomatic patients who underwent carotid endarterectomy were classified acco...

journal_title：International journal of molecular medicine

authors： Hakimi M,Hyhlik-Dürr A,von Au A,Betz M,Demirel S,Dihlmann S,Böckler D,Gross-Weissmann ML

更新日期：2013-08-01 00:00:00

abstract：:Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA in the pre...

journal_title：International journal of molecular medicine

authors： Yang Q,Fu C,Zhang X,Zhang Z,Zou J,Xiao J,Ye Z

更新日期：2019-03-01 00:00:00

abstract：:Sleep deprivation (SD) is an epidemic phenomenon in modern countries, and its harmful effects are well known. SD acts as an aggravating factor in inflammatory bowel disease. Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, t...

journal_title：International journal of molecular medicine

authors： Park YS,Chung SH,Lee SK,Kim JH,Kim JB,Kim TK,Kim DS,Baik HW

更新日期：2015-04-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been increasingly recognized as important immune checkpoints involved in the pathogenesis of autoimmune diseases. However, the exact role of lncRNAs in Hashimoto's thyroiditis (HT) has been rarely studied. The aim of the present study was to investigate the role of lncRNAs and the p...

journal_title：International journal of molecular medicine

authors： Peng H,Xiong S,Ding X,Tang X,Wang X,Wang L,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular carti...

journal_title：International journal of molecular medicine

authors： Albrecht C,Schlegel W,Eckl P,Jagersberger T,Sadeghi K,Berger A,Vécsei V,Marlovits S

更新日期：2009-02-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease in the vessel, and inflammatory cytokines play an important role in the inflammatory process of atherosclerosis. A high level of free fatty acids (FFAs) produced in lipid metabolism disorders are known to participate in the formation of atherosclerosis through multiple...

journal_title：International journal of molecular medicine

authors： Wu D,Liu J,Pang X,Wang S,Zhao J,Zhang X,Feng L

更新日期：2014-12-01 00:00:00

abstract：:We have previously demonstrated the possible growth inhibitory activity of both first generation of the effective microorganism fermentation extract (EM-X) as well as the second generation (EM-X2) on cancer cell lines in vitro. The possible anti-angiogenic potential of EM-X has not been reported. Herein we show that u...

journal_title：International journal of molecular medicine

authors： Chui CH,Gambari R,Lau FY,Hau DK,Wong RS,Cheng GY,Kok SH,Higa T,Ke B,Chan AS,Fong DW,Tang JC

更新日期：2006-11-01 00:00:00

abstract：:Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around the TMJ is involved in the pathogenesis of inflammatory diseases, inc...

journal_title：International journal of molecular medicine

authors： Yokota S,Chosa N,Kyakumoto S,Kimura H,Ibi M,Kamo M,Satoh K,Ishisaki A

更新日期：2017-04-01 00:00:00

abstract：:Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions o...

journal_title：International journal of molecular medicine

authors： Ahmed KM,Shitara Y,Kuwano H,Takenoshita S,Uchimuro K,Shinozawa T

更新日期：2000-09-01 00:00:00

abstract：:Aberrant glycosylation of cell surface glycoprotein due to specific alterations of glycosyltransferase activity is usually associated with invasion and metastasis of cancer, particularly of gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which cata...

journal_title：International journal of molecular medicine

authors： Hua D,Shen L,Xu L,Jiang Z,Zhou Y,Yue A,Zou S,Cheng Z,Wu S

更新日期：2012-12-01 00:00:00

abstract：:The spindle checkpoint proteins (SCPs), which sense the existence of misaligned sister chromatids during mitosis and meiosis, are essential for cell proliferation and differentiation. Therefore, the role of SCPs in carcinogenesis is gaining increased attention. In this study, we ana...

journal_title：International journal of molecular medicine

authors： Liao S,Deng D,Hu X,Wang W,Li L,Li W,Zhou J,Xu G,Meng L,Wang S,Ma D

更新日期：2013-01-01 00:00:00

abstract：:The number of regulatory T cells (Treg cells) and the expression of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1; also known as CD39) and 5'-ectonucleotidase (NT5E; also known as CD73) on the Treg cell surface are increased during sepsis. In this study, to determine the factors leading to the high expressi...

journal_title：International journal of molecular medicine

authors： Bao R,Shui X,Hou J,Li J,Deng X,Zhu X,Yang T

更新日期：2016-09-01 00:00:00

abstract：:A 36 kDa extracellular metalloprotease (designated to as vEP-MO6) was purified and characterized from Vibrio vulnificus sp. strain MO6 24/0. vEP-MO6 cleaved azocasein and a few other proteins such as prothrombin, plasminogen, fibrinogen and Factor Xa, which are associated with the blood coagulation pathway. The enzyme...

journal_title：International journal of molecular medicine

authors： Kwon JY,Chang AK,Park JE,Shin SY,Yoon SM,Lee JS

更新日期：2007-01-01 00:00:00

abstract：:The positive effect of low-magnitude, high‑frequency (LMHF) vibration on implant osseointegration has been demonstrated; however, the underlying cellular and molecular mechanisms remain unknown. The aim of this study was to explore the effect of LMHF vibration on the adhesion and the osteogenic differentiation of bone...

journal_title：International journal of molecular medicine

authors： Chen B,Lin T,Yang X,Li Y,Xie D,Zheng W,Cui H,Deng W,Tan X

更新日期：2016-11-01 00:00:00

abstract：:Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of cancers and correlates with metastasis, chemotherapy resistance and tumor prognosis. The present study demonstrated that suppression of HSP7...

journal_title：International journal of molecular medicine

authors： Sheng L,Tang T,Liu Y,Ma Y,Wang Z,Tao H,Zhang Y,Qi Z

更新日期：2018-10-01 00:00:00

abstract：:Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR/Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibited the MAPK phosphorylation in HUV...

journal_title：International journal of molecular medicine

authors： Igarashi K,Isohara T,Kato T,Takigawa K,Shigeta K,Yamano T,Uno I I

更新日期：1998-08-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:To assess effects of Celecoxib, selective cyclo-oxygenase (COX)-2 inhibitor, on matrix synthesis by chondrocytes under mechanical stress in vitro. Chondrocytes from 7-day-old rat articular cartilage were cultured. Cyclic mechanical stress (0.5 Hz, 7% elongation) was loaded using a Flexercell strain unit in the presenc...

journal_title：International journal of molecular medicine

authors： Iimoto S,Watanabe S,Takahashi T,Shimizu A,Yamamoto H

更新日期：2005-12-01 00:00:00

abstract：:We studied the expression of several homeobox genes of the HOX family in the adult human intestinal mucosa. HOX genes are regulatory genes homologous to the homeotic genes controlling the body plan of the fruit fly Drosophila melanogaster. The HOX genes are distributed in four homologous HOX loci termed HOX-A, B, C an...

journal_title：International journal of molecular medicine

authors： Freschi G,Taddei A,Bechi P,Faiella A,Gulisano M,Cillo C,Bucciarelli G,Boncinelli E

更新日期：2005-10-01 00:00:00

abstract：:The heat shock proteins (hsps) are induced by a variety of stressful stimuli and their overexpression has been shown to protect cells both in vitro and in vivo against such stimuli, as well as against stimuli-inducing apoptosis. The potential therapeutic benefit of elevating hsp levels in individuals with, for example...

journal_title：International journal of molecular medicine

authors： Latchman DS

更新日期：1998-10-01 00:00:00

abstract：:ARHGAP1, ARHGAP2, ARHGAP3, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP7 (DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2004-11-01 00:00:00

abstract：:Although various environmental factors, such as a high-salt diet, a smoking habit, excessive alcohol intake, and physical inactivity, influence the development of hypertension, genetic variation also contributes to an individual's susceptibility to this condition. The purpose of the present study was to identify gene ...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Yoshida T,Yokoi K,Matsuo H,Watanabe S,Ichihara S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Yasunaga A,Park H,Tanaka M,Nozawa Y

更新日期：2008-01-01 00:00:00

abstract：:Imatinib is the therapeutic standard for newly diagnosed patients with chronic myeloid leukemia (CML). In these patients, imatinib has been shown to induce an apoptotic response specifically in cells expressing the oncogenic fusion protein BCR-ABL. Previous studies in our lab revealed that imatinib-induced apoptosis i...

journal_title：International journal of molecular medicine

authors： Liu J,Xiao Y,Xiong HM,Li J,Huang B,Zhang HB,Feng DQ,Chen XM,Wang XZ

更新日期：2012-04-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common, fatal and frequently recurrent disease. Changes in the activity of different coagulation factors serve as a pathophysiological basis for the recurrent risk of VTE. Systems biology approaches provide a better understanding of the pathological mechanisms responsible for recurren...

journal_title：International journal of molecular medicine

authors： Xie R,Li L,Chen L,Li W,Chen B,Jiang J,Huang H,Li Y,He Y,Lv J,He W

更新日期：2017-02-01 00:00:00

abstract：:The aim of the present study was to investigate the role of the angiotensin-converting enzyme (ACE)2-angiotensin‑(Ang)-(1-7)-Mas axis in the pathogenesis of pancreatitis and the association between this axis and the p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor (NF-κB) signaling pathway in pancreatic ...

journal_title：International journal of molecular medicine

authors： Yu X,Cui L,Hou F,Liu X,Wang Y,Wen Y,Chi C,Li C,Liu R,Yin C

更新日期：2018-01-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the clearance of pathogens. In the present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C...

journal_title：International journal of molecular medicine

authors： Bian H,Li F,Wang W,Zhao Q,Gao S,Ma J,Li X,Ren W,Qin C,Qi J

更新日期：2017-11-01 00:00:00

abstract：:Tumor necrosis factor‑α‑mediated (TNF‑α) epithelial‑mesenchymal transition (EMT) is associated with distant metastasis in patients with colorectal cancer with poor prognosis. Although traditional herbal medicines have long been used to treat colorectal cancer, the incidence and mortality in patients with colorectal ca...

journal_title：International journal of molecular medicine

authors： Lee K,Cho SG,Choi YK,Choi YJ,Lee GR,Jeon CY,Ko SG

更新日期：2018-01-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominantly inherited cancer syndrome (OMIM 131100), with tumours in several endocrine glands. In 1997 the responsible tumour suppressor gene was identified and recently it was shown that menin, its encoded protein, represses JunD-activated gene expression. Al...

journal_title：International journal of molecular medicine

authors： Roijers JF,Apel T,Neumann HP,Arnim UV,Lips CJ,Hoppener JW

更新日期：2000-06-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is one of the most common causes of chronic liver disease and is considered to be a causative factor of cryptogenic cirrhosis and hepatocellular carcinoma. microRNAs (miRNAs) are small non-coding RNAs that negatively regulate messenger RNA (mRNA). Recently, it was demonstrated that...

journal_title：International journal of molecular medicine

authors： Katsura A,Morishita A,Iwama H,Tani J,Sakamoto T,Tatsuta M,Toyota Y,Fujita K,Kato K,Maeda E,Nomura T,Miyoshi H,Yoneyama H,Himoto T,Fujiwara S,Kobara H,Mori H,Niki T,Ono M,Hirashima M,Masaki T

更新日期：2015-04-01 00:00:00

abstract：:Excessive expansion of the transit-amplifying (TA) cell compartment is a distinct morphological characteristic of psoriatic epidermal hyperplasia. In order to examine the activation of basal stem cells and how they replenish such an enlarged compartment of TA cells in psoriatic epidermis, we utilized a BrdU labeling m...

journal_title：International journal of molecular medicine

authors： Jia HY,Shi Y,Luo LF,Jiang G,Zhou Q,Xu SZ,Lei TC

更新日期：2016-02-01 00:00:00