Inducible HSP70 antagonizes cisplatin‑induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC‑27 cells.

abstract：:Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type an...

journal_title：International journal of molecular medicine

authors： Yang J,Liu A,Chiou SK,Guzman R,Nandi S

更新日期：2000-03-01 00:00:00

abstract：:Ezrin is a key protein in membrane-cytoskeleton interaction. Expression of ezrin in actin-rich cell surfaces may play a role in the modulation of cell shape and adhesion. The aim of this study was to detect ezrin, actin and cytoskeleton and to explore their relationship in the apoptosis of esophageal epithelial cells ...

journal_title：International journal of molecular medicine

authors： Shen ZY,Xu LY,Li EM,Li JT,Chen MH,Shen J,Zeng Y

更新日期：2003-09-01 00:00:00

abstract：:Type I interferon (IFN) receptor consists of two chains (Hu-IFN-alphaR1 and Hu-IFN-alphaR2), and Hu-IFN-alphaR2 takes a soluble, short, or long form (Hu-IFN-alphaR2a, Hu-IFN-alphaR2b, or Hu-IFN-alphaR2c, respectively). We examined Hu-IFN-alphaR2 expression in hepatocellular carcinoma (HCC) tissues and their correspond...

journal_title：International journal of molecular medicine

authors： Takayama A,Yano H,Ogasawara S,Higaki K,Kojiro M

更新日期：2000-12-01 00:00:00

abstract：:Periplaneta americana extracts (PAEs) play a crucial role in skin wound healing. However, their molecular effects and signaling pathways in regenerating tissues and cells are not clear. In this study, we refined the PAE from Periplaneta americana to investigate the mechanisms underlying skin wound healing. The human k...

journal_title：International journal of molecular medicine

authors： Song Q,Xie Y,Gou Q,Guo X,Yao Q,Gou X

更新日期：2017-08-01 00:00:00

abstract：:Breast cancer accounts for 30-40% of all deaths from cancers in females. In an effort to identify tumor associated antigens that may be useful for immunotherapy, we utilized serological analysis of recombinant cDNA expression libraries (SEREX) technique to identify breast cancer-associated antigens. SEREX screening of...

journal_title：International journal of molecular medicine

authors： Qian F,Odunsi K,Blatt LM,Scanlan MJ,Mannan M,Shah N,Montgomery J,Haddad F,Taylor M

更新日期：2005-01-01 00:00:00

abstract：:Telomerase activity and hTERT mRNA expression are upregulated in colorectal cancer. Whether they are inherent in colorectal adenomas, premalignant lesions to cancer, however, remains to be elucidated. We examined telomerase activity by the fluorescence-based telomeric repeat amplification protocol method and analyzed ...

journal_title：International journal of molecular medicine

authors： Kanamaru T,Tanaka K,Kotani J,Ueno K,Yamamoto M,Idei Y,Hisatomi H,Takeyama Y

更新日期：2002-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. ...

journal_title：International journal of molecular medicine

authors： Bryukhovetskiy I,Ponomarenko A,Lyakhova I,Zaitsev S,Zayats Y,Korneyko M,Eliseikina M,Mischenko P,Shevchenko V,Shanker Sharma H,Sharma A,Khotimchenko Y

更新日期：2018-08-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are a cell population mobilized from bone marrow into the peripheral circulation and recruited into sites of vessel injury to participate in blood vessel formation in both physiological and pathological conditions. Due to the lack of unique surfac...

journal_title：International journal of molecular medicine

authors： Li DW,Liu ZQ,Wei J,Liu Y,Hu LS

更新日期：2012-11-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), which is estrogen receptor (ER)-negative, progesterone receptor‑negative and is also negative for HER2 expression, remains a great clinical challenge due to its strong resistance to chemotherapy at the late stage of treatment and relatively unfavorable prognosis. Gemcitabine has b...

journal_title：International journal of molecular medicine

authors： Chen M,He M,Song Y,Chen L,Xiao P,Wan X,Dai F,Shen P

更新日期：2014-07-01 00:00:00

abstract：:Cell sheet technology is a novel tissue engineering technology that has been rapidly developed in recent years. As a novel technology, cell sheet technology is expected to become one of the preferred methods for cell transplantation. The present study investigated the biological effects of rutin on the formation of pe...

journal_title：International journal of molecular medicine

authors： Zhao B,Zhang Y,Xiong Y,Xu X

更新日期：2019-12-01 00:00:00

abstract：:Excessive expansion of the transit-amplifying (TA) cell compartment is a distinct morphological characteristic of psoriatic epidermal hyperplasia. In order to examine the activation of basal stem cells and how they replenish such an enlarged compartment of TA cells in psoriatic epidermis, we utilized a BrdU labeling m...

journal_title：International journal of molecular medicine

authors： Jia HY,Shi Y,Luo LF,Jiang G,Zhou Q,Xu SZ,Lei TC

更新日期：2016-02-01 00:00:00

abstract：:In the present study, we examined whether Acer okamotoanum (A. okamotoanum) sap decreased the serum alcohol and acetaldehyde levels after acute ethanol treatment in a rat model. Male rats were orally administered 25, 50 or 100% A. okamotoanum sap 30 min prior to oral challenge with 3 ml of ethanol (15 ml/kg of a 20% e...

journal_title：International journal of molecular medicine

authors： Yoo YM,Jung EM,Kang HY,Choi IG,Choi KC,Jeung EB

更新日期：2011-10-01 00:00:00

abstract：:Selenium deficiency is a causative factor in heart failure and microRNAs (known as miRNAs or miRs) play an important role in numerous cardiovascular diseases. However, the changes of miRNA expression during selenium deficiency and whether selenium deficiency is involved in cardiac dysfunction remain unclear. In the pr...

journal_title：International journal of molecular medicine

authors： Xing Y,Liu Z,Yang G,Gao D,Niu X

更新日期：2015-01-01 00:00:00

abstract：:To date, only a few studies have suggested that human embryonic stem cells (hESCs) might effectively immunize against colon and lung cancer. The purpose of this study was to investigate the therapeutic potential of hESCs as a vaccine to induce widespread antitumor effects in differe...

journal_title：International journal of molecular medicine

authors： Zhang Z,Chen X,Chang X,Ye X,Li Y,Cui H

更新日期：2013-01-01 00:00:00

abstract：:In our previous study, the proliferation rate of esophageal squamous cell carcinoma cell lines, which poorly expressed p21Waf1, was found to be regulated by p21Waf1 gene transfection using adenovirus vector. In the present study, in order to examine the effect of p21Waf1 gene therapy in esophageal cancer, we used gene...

journal_title：International journal of molecular medicine

authors： Tanaka Y,Fujii T,Yamana H,Kato S,Morimatsu M,Shirouzu K

更新日期：2004-10-01 00:00:00

abstract：:CDH1, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinoma...

journal_title：International journal of molecular medicine

authors： Ling ZQ,Li P,Ge MH,Zhao X,Hu FJ,Fang XH,Dong ZM,Mao WM

更新日期：2011-05-01 00:00:00

abstract：:To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

journal_title：International journal of molecular medicine

authors： Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

更新日期：2004-10-01 00:00:00

abstract：:β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulator...

journal_title：International journal of molecular medicine

authors： Katoh M

更新日期：2018-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that control key genes involved in fatty acid metabolism and energy homeostasis. Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma. As...

journal_title：International journal of molecular medicine

authors： Kannisto K,Chibalin A,Glinghammar B,Zierath JR,Hamsten A,Ehrenborg E

更新日期：2006-01-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of...

journal_title：International journal of molecular medicine

authors： Huang X,Jin Y,Zhou D,Xu G,Huang J,Shen L

更新日期：2015-05-01 00:00:00

abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

journal_title：International journal of molecular medicine

authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

更新日期：2009-01-01 00:00:00

abstract：:Second generation n3-PUFA-depleted rats represent a good animal model of metabolic syndrome as they display several features of the disease such as liver steatosis, visceral obesity and insulin resistance. The goal of our study was to investigate the influence of n3-PUFA deficiency on hepatic glycerol metabolism. Aqua...

journal_title：International journal of molecular medicine

authors： Portois L,Zhang Y,Ladrière L,Perret J,Louchami K,Gaspard N,Hupkens E,Bolaky N,Delforge V,Beauwens R,Malaisse WJ,Sener A,Carpentier YA,Delporte C

更新日期：2012-06-01 00:00:00

abstract：:Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resve...

journal_title：International journal of molecular medicine

authors： Sun X,Fu P,Xie L,Chai S,Xu Q,Zeng L,Wang X,Jiang N,Sang M

更新日期：2021-01-01 00:00:00

abstract：:Biochemical modification of extracellular matrix (ECM) proteins can alter the function in overlying cells. We tested the hypothesis that metal-catalyzed oxidation of native ECM and individual matrix proteins modulates the activity of inducible nitric oxide synthase (iNOS) in cultured rat mesangial cells (RMC). Oxidize...

journal_title：International journal of molecular medicine

authors： Trachtman H,Futterweit S,Koss E,Bogart M,Mermelstein A

更新日期：1999-03-01 00:00:00

abstract：:Epidemiological studies have indicated that increased consumption of cruciferous vegetables is associated with a statistically significant reduction in the risk for cancers. The major bioactive agent in these vegetables is a class of sulfur-containing glycosides called glucosinolates. Isothiocyanates, derivatives of g...

journal_title：International journal of molecular medicine

authors： Jadhav U,Ezhilarasan R,Vaughn SF,Berhow MA,Mohanam S

更新日期：2007-03-01 00:00:00

abstract：:Orientia tsutsugamushi (O. tsutsugamushi), the causative agent of scrub typhus, is an obligate intracellular pathogen. Recent studies have demonstrated the complete genome of O. tsutsugamushi. However, the route and detailed molecular mechanism for O. tsutsugamushi to get accessed into mammalian cells remains unclear....

journal_title：International journal of molecular medicine

authors： Lin CC,Chou CH,Lin TC,Yang MC,Cho CL,Chang CH,Yu HS,Lai CH,Chen LK,Hong YR

更新日期：2012-07-01 00:00:00

abstract：:Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been frequently used in targeted therapy for lung cancer. However, the widespread use of gefitinib in targeted therapy for patients with lung cancer is hampered by its common skin toxicities. The present study aimed to investigate the mechan...

journal_title：International journal of molecular medicine

authors： Fang H,Wang Y,Xu L,Zhou S,Bai J,Wu Y,Qiao J,Jiang X,Zhu D,Ding Y

更新日期：2019-03-01 00:00:00

abstract：:In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Daly T,Gausas RE

更新日期：2004-05-01 00:00:00

abstract：:Kelch‑like ECH‑associated protein 1 (Keap1)/nuclear factor erythroid 2‑related factor 2 (Nrf2) signaling has a protective effect on normal cells. A number of previous studies demonstrated that Keap1/Nrf2 signaling is associated with drug resistance in numerous tumors. The aim of the present study was to investigate th...

journal_title：International journal of molecular medicine

authors： Huang H,Wu Y,Fu W,Wang X,Zhou L,Xu X,Huang F,Wu Y

更新日期：2019-05-01 00:00:00

abstract：:ARHGAP1, ARHGAP2, ARHGAP3, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP7 (DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2004-11-01 00:00:00