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Estrogen receptor variants are present in many normal human tissues.

Abstract：

:Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type and variant receptors from normal human tissues of various origin using semi-nested PCR and direct automated sequence of the amplified products. We demonstrate that many normal human tissues of various origin contain a number of spliced variants of the estrogen receptor that co-exist with the wild-type receptor. Variants lacking exons 2, 4, 5, and 7 are detected in a variety of normal human tissues.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Yang J,Liu A,Chiou SK,Guzman R,Nandi S

doi

10.3892/ijmm.5.3.223

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

223-7

issue

3

eissn

1107-3756

issn

1791-244X

journal_volume

5

pub_type

杂志文章

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