Abstract:
:Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR/Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibited the MAPK phosphorylation in HUVEC induced by VEGF or basic FGF but not by EGF. 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid might be used as an inhibitor of VEGF and basic FGF signal transduction.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Igarashi K,Isohara T,Kato T,Takigawa K,Shigeta K,Yamano T,Uno I Idoi
10.3892/ijmm.2.2.211subject
Has Abstractpub_date
1998-08-01 00:00:00pages
211-215issue
2eissn
1107-3756issn
1791-244Xjournal_volume
2pub_type
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