Identification of potential drug targets based on a computational biology algorithm for venous thromboembolism.

abstract：:Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed, along with its receptors, in organs and body tissues. ANP is well known to inhibit aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone production is controversial. In vivo experiments showed that prolonged AN...

journal_title：International journal of molecular medicine

authors： Raha D,Tortorella C,Neri G,Prasad A,Raza B,Raskar R,Dubey R,Sen NS,Macchi C,Malendowicz LK,Ahmad MF,Nussdorfer GG

更新日期：2006-04-01 00:00:00

abstract：:The number of pro-α cells is known to increase in response to β cell injury and these cells then generate glucagon-like peptide-1 (GLP-1), thus attenuating the development of diabetes. The aim of the present study was to further examine the role and the mechanisms responsible for intra-islet GLP-1 production as a self...

journal_title：International journal of molecular medicine

authors： Huang C,Yuan L,Cao S

更新日期：2015-07-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., is known to exhibit significant selective cytotoxicity against several human tumor cell lines. In the present study, we investigated the possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured human SK-MEL-2 sk...

journal_title：International journal of molecular medicine

authors： Choi HJ,Bae SJ,Kim ND,Jung JH,Choi YH

更新日期：2004-12-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) participates in cancer invasion and metastasis by decreasing the expression of E-cadherin. However, the molecular mechanisms through which COX-2 regulates E-cadherin expression and function have not yet been fully elucidated. The aim of this study was to investigate the possible molecular mech...

journal_title：International journal of molecular medicine

authors： Chen Z,Liu M,Liu X,Huang S,Li L,Song B,Li H,Ren Q,Hu Z,Zhou Y,Qiao L

更新日期：2013-07-01 00:00:00

abstract：:Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-κB pathway; therefore, suppression of TLR4/NF-κB signaling has become a prom...

journal_title：International journal of molecular medicine

authors： Lan L,Tao J,Chen A,Xie G,Huang J,Lin J,Peng J,Chen L

更新日期：2013-01-01 00:00:00

abstract：:Bel1, a transactivator of the prototype foamy virus (PFV), plays pivotal roles in the replication of PFV. Previous studies have demonstrated that Bel1 bears a nuclear localization signal (NLS); however, its amino acid sequence remains unclear and the corresponding adaptor importins have not yet been identified. In thi...

journal_title：International journal of molecular medicine

authors： Duan J,Tang Z,Mu H,Zhang G

更新日期：2016-08-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are an independent factor predicting cardiovascular events. Visfatin plays an important role in the pathogenesis of various metabolic disorders. In this study, we examined the effects of visfatin on the apoptosis of EPCs and the mechanisms underlying these effects. Cultured EPCs pre...

journal_title：International journal of molecular medicine

authors： Sun L,Chen S,Gao H,Ren L,Song G

更新日期：2017-09-01 00:00:00

abstract：:Although various environmental factors, such as a high-salt diet, a smoking habit, excessive alcohol intake, and physical inactivity, influence the development of hypertension, genetic variation also contributes to an individual's susceptibility to this condition. The purpose of the present study was to identify gene ...

journal_title：International journal of molecular medicine

authors： Yamada Y,Kato K,Yoshida T,Yokoi K,Matsuo H,Watanabe S,Ichihara S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Yasunaga A,Park H,Tanaka M,Nozawa Y

更新日期：2008-01-01 00:00:00

abstract：:Caveolin, the essential structural component of caveolae, serves as a scaffolding protein onto which signaling molecules are assembled, and functions as a negative regulator for signal transduction. Caveolin-1 and -2 are expressed in most cell types, but are not expressed in normal blood cells and cell lines. We previ...

journal_title：International journal of molecular medicine

authors： Tsuji Y,Hatanaka M,Maeda T,Seya T,Takenaka H,Shimizu A

更新日期：2005-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that control key genes involved in fatty acid metabolism and energy homeostasis. Little is known about PPAR activation in vivo and the existence of overlapping functions between PPARalpha, -delta and -gamma. As...

journal_title：International journal of molecular medicine

authors： Kannisto K,Chibalin A,Glinghammar B,Zierath JR,Hamsten A,Ehrenborg E

更新日期：2006-01-01 00:00:00

abstract：:Hypertension impairs the morphological and functional integrity of circulation. Previous research has shown that the loss of endothelial cells (ECs) is a common event in many cardiovascular diseases. p120 catenin (p120ctn) plays an important role in the regulation of inflammatory responses in ECs. However, the functio...

journal_title：International journal of molecular medicine

authors： Zhang Y,Zou C,Yang S,Fu J

更新日期：2016-03-01 00:00:00

abstract：:We studied whether feeding pregnant female mice with different fats affects lipid exchange and activity of the splenic lymphoid system in offspring exposed to low doses of carcinogen. Female mice were fed diets with either 7% or 15% corn oil or olive oil. The 4-week-old offspring of these mice were transferred to a ch...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H,Budovsky A,Geva D,Gurevich P,Tendler Y,Lavee S,Stark A,Madar Z

更新日期：2000-09-01 00:00:00

abstract：:It is not clear whether pseudoallergic reactions are caused by similar mechanisms as type I allergic reactions. 3‑Caffeoylquinic acid (chlorogenic acid) is an active ingredient in traditional Chinese medicines used for antibacterial, anti-inflammatory and cholagogic purposes. It is assumed to be the reason for the hig...

journal_title：International journal of molecular medicine

authors： Li Q,Zhao Y,Zheng X,Chen Q,Zhang X

更新日期：2013-12-01 00:00:00

abstract：:Peritoneal fibrosis is a major complication of continuous ambulatory peritoneal dialysis (CAPD). The present study tested the hypothesis that ADP-ribose polymerase-1 (PARP-1) may play a role in peritoneal epithelial-mesenchymal transition and fibrosis under high glucose conditions. High glucose (126 mmol/l)-induced pe...

journal_title：International journal of molecular medicine

authors： Lei P,Jiang Z,Zhu H,Li X,Su N,Yu X

更新日期：2012-03-01 00:00:00

abstract：:Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the ...

journal_title：International journal of molecular medicine

authors： Tsai YM,Chiang KH,Hung JY,Chang WA,Lin HP,Shieh JM,Chong IW,Hsu YL

更新日期：2018-02-01 00:00:00

abstract：:Chinese medicinal herbs have been consumed for thousands of years for the purpose of healthy aging. Lycium barbarum is valued in Chinese culture for its benefits to anti-aging, vision, kidney and liver. Recent studies showed that extracts from L. barbarum possess biological activities including anti-aging, anti-tumor,...

journal_title：International journal of molecular medicine

authors： Yu MS,Ho YS,So KF,Yuen WH,Chang RC

更新日期：2006-06-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are...

journal_title：International journal of molecular medicine

authors： Zhu Y,Shui X,Liang Z,Huang Z,Qi Y,He Y,Chen C,Luo H,Lei W

更新日期：2020-09-01 00:00:00

abstract：:Rosiglitazone has been found to have anti-atherogenic effects and to increase serum high-density lipoprotein (HDL) cholesterol (HDL-C) levels. However, in vivo studies investigating the regulation of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI) by rosigli...

journal_title：International journal of molecular medicine

authors： Li C,Tu Y,Liu TR,Guo ZG,Xie D,Zhong JK,Fan YZ,Lai WY

更新日期：2015-03-01 00:00:00

abstract：:Tumor necrosis factor‑α‑mediated (TNF‑α) epithelial‑mesenchymal transition (EMT) is associated with distant metastasis in patients with colorectal cancer with poor prognosis. Although traditional herbal medicines have long been used to treat colorectal cancer, the incidence and mortality in patients with colorectal ca...

journal_title：International journal of molecular medicine

authors： Lee K,Cho SG,Choi YK,Choi YJ,Lee GR,Jeon CY,Ko SG

更新日期：2018-01-01 00:00:00

abstract：:Congenital bicuspid aortic valve (BAV) represents the most common type of cardiac birth defect affecting 0.4‑2% of the general population, and accounts for a markedly increased incidence of life‑threatening complications, including valvulopathy and aortopathy. Accumulating evidence has demonstrated the genetic basis o...

journal_title：International journal of molecular medicine

authors： Wang J,Abhinav P,Xu YJ,Li RG,Zhang M,Qiu XB,Di RM,Qiao Q,Li XM,Huang RT,Xue S,Yang YQ

更新日期：2019-04-01 00:00:00

abstract：:The tumor suppressor genes p15INK4B and p16INK4A, located in the chromosomal region 9p21, are frequently inactivated by homo- or hemizygous deletions, point mutation or promotor methylation in various types of cancer. No commercial probe is yet available that allows the detection of such deletions by FISH. Long distan...

journal_title：International journal of molecular medicine

authors： Bleichert A,Fiedler W,Claussen U,Ernst G,Loncarevic IF,Heller A,Liehr T,Kunert C,von Eggeling F

更新日期：2001-06-01 00:00:00

abstract：:Sevoflurane (Sevo) is one of the most frequently used volatile anesthetic agents in surgical oncology and has various effects on tumors, including inhibiting tumor growth, recurrence, and metastases; however, the molecular mechanisms are unknown. This study tried to investigate the influence of Sevo on hepatocellular ...

journal_title：International journal of molecular medicine

authors： Cao Y,Lv W,Ding W,Li J

更新日期：2020-07-01 00:00:00

abstract：:Blood supply plays a crucial role in solid tumour development and leukaemogenesis. It has been suggested that blocking of angiogenesis could be possible in cancer therapy. We have demonstrated the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various human solid tumour cancer cell lines as we...

journal_title：International journal of molecular medicine

authors： Chow LM,Chui CH,Tang JC,Lau FY,Yau MY,Cheng GY,Wong RS,Lai PB,Leung TW,Teo IT,Cheung F,Guo D,Chan AS

更新日期：2003-08-01 00:00:00

abstract：:We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling. The novel rat-specific protein, tentatively named long P...

journal_title：International journal of molecular medicine

authors： Sala A,Scaturro M,Proia P,Schiera G,Balistreri E,Aflalo-Rattenbach R,Créau N,Di Liegro I

更新日期：2007-03-01 00:00:00

abstract：:A preceding hypoxic insult can sensitize the cells or the organism to a subsequent, second insult. The aim of the present study was to investigate the molecular mechanism of this phenomenon (often termed 'two-hit' injury paradigm), in an in vitro model of hypoxia/oxidative stress injury in A549 epithelial cells, with ...

journal_title：International journal of molecular medicine

authors： Erdélyi K,Pacher P,Virág L,Szabó C

更新日期：2013-08-01 00:00:00

abstract：:High-fidelity maintenance of genomic integrity in eukaryotes is ensured by cell cycle checkpoints and DNA repair. The checkpoint kinase, Chk2, has been implicated in both of these responses. In response to DNA damage, Chk2 is initially phosphorylated at Thr-68, which leads to its full activation. The fully activated C...

journal_title：International journal of molecular medicine

authors： Liang X,Reed E,Yu JJ

更新日期：2006-05-01 00:00:00

abstract：:Adrenomedullin (ADM) is a hypotensive peptide, that derives from the proteolytic cleavage of pro(p)ADM and acts through two subtypes of receptors, called L1-receptor (L1-R) and calcitonin receptor-like receptor (CRLR). CRLR may function as a calcitonin gene-related peptide or a selective ADM receptor depending on the ...

journal_title：International journal of molecular medicine

authors： Rebuffat P,Forneris ML,Aragona F,Ziolkowska A,Malendowicz LK,Nussdorfer GG

更新日期：2002-02-01 00:00:00

abstract：:To investigate whether in vivo gene transfer causes leptin-antagonistic effects on food intake, animal body weight and fat tissue weight, the R128Q mutated-leptin gene, an R to Q substitution at position 128 of mouse leptin, was transferred into mouse liver and leg muscle by electroporation and hydrodynamics-based gen...

journal_title：International journal of molecular medicine

authors： Xiang L,Murai A,Muramatsu T

更新日期：2005-12-01 00:00:00

abstract：:Skeletal metastasis is the major problem in the management of prostate cancer (PCa). Even though the regulatory role of microRNAs (miRNAs) in the control of tumor metastases has been well described in numerous types of cancer, the importance in bone metastasis of PCa remains largely unknown. In the present study, the ...

journal_title：International journal of molecular medicine

authors： Fu Q,Liu X,Liu Y,Yang J,Lv G,Dong S

更新日期：2015-11-01 00:00:00

abstract：:Graves' ophthalmopathy (GO) is considered to be an organ-specific autoimmune disease. However, the pathogenesis of GO is incompletely understood at the present time. To clarify the immunological differences between newly diagnosed GO and Graves' disease (GD) without ophthalmopathy or healthy controls (HC), we examined...

journal_title：International journal of molecular medicine

authors： Xia N,Zhou S,Liang Y,Xiao C,Shen H,Pan H,Deng H,Wang N,Li QQ

更新日期：2006-05-01 00:00:00