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Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome.

Abstract：

:Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase release and propidium iodide penetration. Stimulation by Der f1 enhances interleukin (IL)‑1β cleavage and release, which is associated with caspase‑1 activation. In addition, the NOD‑like receptor family pyrin domain‑containing 3 (NLRP3), is required for the activation of caspase‑1 through increasing the formation of the inflammasome complex. Consistent with these findings, pre‑treatment of HBECs with a caspase‑1 inhibitor, or silencing of NLRP3 by siRNA transfection, reduced Der f1‑mediated IL‑1β and pyroptosis. Therefore, the common allergen Der f1 was not only found to induce allergy, but also led to pyroptosis and IL‑1β secretion via the NLRP3‑caspase‑1 inflammasome in HBECs. This newly identified connection of the Der f1 allergen with BEC damage and inflammation may play an important role in the pathogenesis of asthma.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Tsai YM,Chiang KH,Hung JY,Chang WA,Lin HP,Shieh JM,Chong IW,Hsu YL

doi

10.3892/ijmm.2017.3310

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

757-764

issue

2

eissn

1107-3756

issn

1791-244X

journal_volume

41

pub_type

杂志文章

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