Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids.

abstract：:Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around the TMJ is involved in the pathogenesis of inflammatory diseases, inc...

journal_title：International journal of molecular medicine

authors： Yokota S,Chosa N,Kyakumoto S,Kimura H,Ibi M,Kamo M,Satoh K,Ishisaki A

更新日期：2017-04-01 00:00:00

abstract：:We have previously reported that the calcium-sensing receptor (CaSR) plays an important role in modulating lipid metabolism under low calcium conditions. The aim of this study was to identify possible regulators of CaSR and the mechanisms of action of CaSR in obese individuals. Subcutaneous fat samples were obtained f...

journal_title：International journal of molecular medicine

authors： He Y,Perry B,Bi M,Sun H,Zhao T,Li Y,Sun C

更新日期：2013-08-01 00:00:00

abstract：:Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The alpha1-subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. F...

journal_title：International journal of molecular medicine

authors： Okamoto T,Jeong SY,Takahashi Y,Baughman KW,Ogata K,Goto J,Kanazawa I

更新日期：2001-10-01 00:00:00

abstract：:The increased expression of sialyl-Lewisx (SLex) epitope on the surface of tumor cells has been known for decades. However, genetic manipulation of the expression of SLex and the role of SLex in cancer cell proliferation remains to be fully elucidated. The present study suggested that the monoclonal antibody of SLex (...

journal_title：International journal of molecular medicine

authors： Li D,Sun H,Bai G,Wang W,Liu M,Bao Z,Li J,Liu H

更新日期：2018-11-01 00:00:00

abstract：:Xuebijing injection (XBJ) has long been used to treat infectious diseases in China. The therapeutic effect of XBJ is probably associated with anti-inflammatory effects. However, the precise mechanisms responsible for the effects of XBJ remain unknown. The present study was conducted in order to evaluate the protective...

journal_title：International journal of molecular medicine

authors： Liu MW,Liu R,Wu HY,Zhang W,Xia J,Dong MN,Yu W,Wang Q,Xie FM,Wang R,Huang YQ,Qian CY

更新日期：2016-11-01 00:00:00

abstract：:Choroidal neovascularization (CNV) can lead to progressive and severe visual loss. Vascular endothelial growth factor (VEGF) promotes the development of CNV. Caffeic acid phenethyl ester (CAPE), a biologically active component of the honeybee (Apis mellifera) propolis, has been demonstrated to have several interesting...

journal_title：International journal of molecular medicine

authors： Paeng SH,Jung WK,Park WS,Lee DS,Kim GY,Choi YH,Seo SK,Jang WH,Choi JS,Lee YM,Park S,Choi IW

更新日期：2015-05-01 00:00:00

abstract：:Reactive oxygen species (ROS), generated either extracellularly or intracellularly through ligand-receptor interactions, can function as signal transduction molecules to activate the chemotactic cytokine interleukin-8 (IL-8) and the cell surface adhesion protein, intercellular adhesion molecule-1 (ICAM-1; CD54). Toget...

journal_title：International journal of molecular medicine

authors： Roebuck KA

更新日期：1999-09-01 00:00:00

abstract：:We determined whether the expression of VEGF-A and -C and their receptors, Flt-1 and Flt-4, are associated with primary tumor size, regional lymph node metastasis, distant metastasis and prognosis in patients with tongue carcinoma. The expression of VEGF-A and -C, and their receptors, Flt-1 and Flt-4, in biopsy specim...

journal_title：International journal of molecular medicine

authors： Tanigaki Y,Nagashima Y,Kitamura Y,Matsuda H,Mikami Y,Tsukuda M

更新日期：2004-09-01 00:00:00

abstract：:The colonic crypt contains highly proliferative cells in its base and differentiated cells on its luminal surface. Carcinogenesis significantly affects this orderly cellular distribution. The aims of this study were: i) to examine the expression of apoptosis-related proteins along the crypt-lumen axis during 1, 2-dime...

journal_title：International journal of molecular medicine

authors： Avivi-Green C,Madar Z,Schwartz B

更新日期：2000-12-01 00:00:00

abstract：:The aim of this study was to examine the anti-obesity effects of boiled tuna extract in C57BL/6N mice with obesity induced by a high-fat diet (HFD). We determined the anti-obesity effects of boiled tuna extract (100, 200, or 400 mg/kg) on the progression of HFD-induced obesity for 10 weeks. The mice were divided into ...

journal_title：International journal of molecular medicine

authors： Kim Y,Kwon MJ,Choi JW,Lee MK,Kim C,Jung J,Aprianita H,Nam H,Nam TJ

更新日期：2016-10-01 00:00:00

abstract：:Peritoneal fibrosis is a major complication of continuous ambulatory peritoneal dialysis (CAPD). The present study tested the hypothesis that ADP-ribose polymerase-1 (PARP-1) may play a role in peritoneal epithelial-mesenchymal transition and fibrosis under high glucose conditions. High glucose (126 mmol/l)-induced pe...

journal_title：International journal of molecular medicine

authors： Lei P,Jiang Z,Zhu H,Li X,Su N,Yu X

更新日期：2012-03-01 00:00:00

abstract：:Aromatic turmerone (ar-turmerone) has been reported to have a cytotoxic effect on L-1210 and HL-60 cells. In the present study, we investigated the anticancer responses and immune activities in implanted tumor cells. Our study found that ar-turmerone inhibited the increase in the nu...

journal_title：International journal of molecular medicine

authors： Kim D,Suh Y,Lee H,Lee Y

更新日期：2013-02-01 00:00:00

abstract：:We investigated the expression and function of laminin and type IV collagen (COL-4) in the human endometrial epithelium throughout the menstrual cycle. Their expression was demonstrated by immunohistochemistry, while cytological analysis of the human endometrial epithelial cell line HHUA cultured on laminin- or COL-4-...

journal_title：International journal of molecular medicine

authors： Tanaka T,Wang C,Umesaki N

更新日期：2009-02-01 00:00:00

abstract：:Acute Achilles tendon (AT) rupture is a common injury with a comparatively high complication rate. Presently, surgical treatments compete with nonoperative treatment modalities. The aim of this study was to elucidate the possible beneficial effects of short-term combinatory application of growth factors on tendon heal...

journal_title：International journal of molecular medicine

authors： Konerding MA,Arlt F,Wellmann A,Li V,Li W

更新日期：2010-02-01 00:00:00

abstract：:Smoking has deleterious effects on osteoporosis and periodontitis both characterized by bone loss. Smoking also interferes with the protective effect that hormone replacement therapy (HRT) has on bone loss. Our study investigated two mechanisms by which smoking may affect bone metabolism: nicotine-induced proliferatio...

journal_title：International journal of molecular medicine

authors： Kamer AR,El-Ghorab N,Marzec N,Margarone JE 3rd,Dziak R

更新日期：2006-01-01 00:00:00

abstract：:Recently a candidate gene for hereditary hemo-chromatosis, HFE, was identified. The finding raises the possibility for genetic testing to provide earlier detection and more complete genotypic evaluation of hemochromatosis affected individuals. We determined the frequency of the HFE polymorphisms, C282Y and H63D, in a ...

journal_title：International journal of molecular medicine

authors： Marshall DS,Linfert DR,Tsongalis GJ

更新日期：1999-10-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome caused by mutations or deletions within the VHL tumor-suppressor gene, but VHL germline mutations in the Chinese have rarely been studied. To investigate the genetic profile of VHL mutations in the Chinese population, we evaluated the clinical characterist...

journal_title：International journal of molecular medicine

authors： Huang Y,Zhou D,Liu J,Zhou P,Li X,Wang Z

更新日期：2012-01-01 00:00:00

abstract：:To date, Korean hinoki cypress (Chamaecyparis obtusa), has been widely used for household and commercial purposes. Although the medicinal efficacy of hinoki cypress essential oil has been observed, that of the essential oil‑derived terpenes, which exhibit a mechanism that acts against lung inflammation, remains to be ...

journal_title：International journal of molecular medicine

authors： Raha S,Kim SM,Lee HJ,Lee SJ,Heo JD,Venkatarame Gowda Saralamma V,Ha SE,Kim EH,Mun SP,Kim GS

更新日期：2019-01-01 00:00:00

abstract：:Astrocyte activation has been described as a multi‑stage defensive response, which is characterized by the morphological alteration of astrocytes and the overexpression of intermediate filament proteins. However, the functional mechanism of the secretion system in activated astroglia remains unclear. It has previously...

journal_title：International journal of molecular medicine

authors： Zhan X,Li F,Chu Q,Pang H

更新日期：2018-12-01 00:00:00

abstract：:Cutaneous melanoma is very aggressive and results in high mortality rates for cancer patients. Determining molecular targets is important for developing novel therapies for cutaneous melanoma. Cell division cycle associated 8 (CDCA8) is a putative oncogene that is upregulated in multiple types of cancer. The present s...

journal_title：International journal of molecular medicine

authors： Ci C,Tang B,Lyu D,Liu W,Qiang D,Ji X,Qiu X,Chen L,Ding W

更新日期：2019-01-01 00:00:00

abstract：:Noise-induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. It has been demonstrated that hair cell loss in the auditory end organ may account for the majority of ear pathological conditions. Previous studies have indicated that histone deacetylases (HDACs) play an important...

journal_title：International journal of molecular medicine

authors： Wen LT,Wang J,Wang Y,Chen FQ

更新日期：2015-08-01 00:00:00

abstract：:Arsenic trioxide (ATO) can regulate many biological functions such as apoptosis and differentiation. We evaluated the effects of ATO on various cell types such as cervical cancer HeLa cells, pulmonary adenocarcinoma Calu-6 and A549 cells, calf pulmonary artery endothelial cells (CPAEC), human umbilical vein endothelia...

journal_title：International journal of molecular medicine

authors： Han YH,Moon HJ,You BR,Kim SZ,Kim SH,Park WH

更新日期：2010-01-01 00:00:00

abstract：:There is much interest in precise functions of amino acids on mammalian growth and development. Some of amino acids play important roles in the control of gene expression by controlling the initiation phase of mRNA translation. The signal induced by leucine or arginine may stimulate cell growth. On the other hand, the...

journal_title：International journal of molecular medicine

authors： Naomoto Y,Yamatsuji T,Shigemitsu K,Ban H,Nakajo T,Shirakawa Y,Motok T,Kobayashi M,Gunduz M,Tanaka N

更新日期：2005-08-01 00:00:00

abstract：:Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the activation of microglia, however, the underlying mechanisms remain elusive. Thus, t...

journal_title：International journal of molecular medicine

authors： Huang W,Bai S,Zuo X,Tang W,Chen P,Chen X,Wang G,Wang H,Xie P

更新日期：2018-06-01 00:00:00

abstract：:The aim of the present study was to examine the protective effect of caveolin‑1 (Cav‑1) in the penehyclidine hydrochloride (PHC)‑based inhibition of lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in vivo and in vitro, in addition to the potential underlying mechanisms. In vivo, an ALI rat model was establish...

journal_title：International journal of molecular medicine

authors： Wu X,Kong Q,Xia Z,Zhan L,Duan W,Song X

更新日期：2019-05-01 00:00:00

abstract：:In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

journal_title：International journal of molecular medicine

authors： Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

更新日期：2018-06-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast trans...

journal_title：International journal of molecular medicine

authors： Qi FH,Cai PP,Liu X,Si GM

更新日期：2018-05-01 00:00:00

abstract：:The DAL-1/41B gene (differentially expressed in adenocarcinoma of the lung), located in the chromosome 18p11.3 region, belongs to the protein family 4.1 (membrane-associated proteins), which includes the product of the NF2 gene (merlin), and the proteins, ezrin, radixin, and moesin. DAL-1/4.1B is normally expressed at...

journal_title：International journal of molecular medicine

authors： Martinez-Glez V,Bello MJ,Franco-Hernandez C,De Campos JM,Isla A,Vaquero J,Rey JA

更新日期：2005-10-01 00:00:00

abstract：:Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein and organelle d...

journal_title：International journal of molecular medicine

authors： Zhao X,Liu G,Shen H,Gao B,Li X,Fu J,Zhou J,Ji Q

更新日期：2015-03-01 00:00:00