Comparative integromics on FAT1, FAT2, FAT3 and FAT4.

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by microthrombocytopenia, eczema, immunodeficiency, and susceptibility to lymphoid malignancy. Loss-of-function mutations in WAS gene have been identified to cause disorders with platelet defects including WAS and X-linked thrombocytopenia....

journal_title：International journal of molecular medicine

authors： Chatchatee P,Srichomthong C,Chewatavorn A,Shotelersuk V

更新日期：2003-12-01 00:00:00

abstract：:Tissue engineering represents a promising method for generating chondrogenic grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. Stem cells, however, displaying unlimited self-renewal and the capacity to differentiate towards chondrocytes, m...

journal_title：International journal of molecular medicine

authors： Goessler UR,Bieback K,Bugert P,Heller T,Sadick H,Hörmann K,Riedel F

更新日期：2006-02-01 00:00:00

abstract：:Microtraumata often lead to articular cartilage lesions. Due to the bradytrophic character of hyaline cartilage, these lesions are hardly repaired by the organism. Autologous chondrocyte implantation (ACI) was established for restoring isolated structural cartilage defects in knee joints. However, results are not alwa...

journal_title：International journal of molecular medicine

authors： Schubert T,Anders S,Neumann E,Schölmerich J,Hofstädter F,Grifka J,Müller-Ladner U,Libera J,Schedel J

更新日期：2009-04-01 00:00:00

abstract：:In the present study, the effects of erlotinib on mouse tear function and corneal epithelial tissue structure were investigated. Throughout the 3 weeks of treatment, no notable differences were observed in the body, eye or lacrimal gland weights of the control and experimental mice. However, in the experimental group,...

journal_title：International journal of molecular medicine

authors： Yang QC,Bao J,Li C,Tan G,Wu AH,Ye L,Ye LH,Zhou Q,Shao Y

更新日期：2018-03-01 00:00:00

abstract：:The response of living cells to change in cell environment depends on the action of second messenger molecules. The two second messenger molecules cAMP and Ca2+ regulate a large number of eukaryotic cellular events. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1) is one of the key enzymes involved in ...

journal_title：International journal of molecular medicine

authors： Sharma RK,Das SB,Lakshmikuttyamma A,Selvakumar P,Shrivastav A

更新日期：2006-07-01 00:00:00

abstract：:Inflammatory genes serve a crucial role in the pathogenesis of inflammation‑associated tumors. However, as recent studies have mainly focused on the effects of single inflammatory genes on colorectal cancer (CRC), but not on the global interactions between genes, the underlying mechanisms between inflammatory genes and...

journal_title：International journal of molecular medicine

authors： Jiang H,Dong L,Gong F,Gu Y,Zhang H,Fan D,Sun Z

更新日期：2018-07-01 00:00:00

abstract：:A number of cell-penetrating peptides (CPPs) have been reported, but their transduction efficiencies are too low to be used as intracellular carriers for therapeutic purposes. We conducted a comprehensive search to find novel CPPs using an in vitro virus (IVV) library, which presented random peptides consisting of 15 ...

journal_title：International journal of molecular medicine

authors： Kamide K,Nakakubo H,Uno S,Fukamizu A

更新日期：2010-01-01 00:00:00

abstract：:Kelch‑like ECH‑associated protein 1 (Keap1)/nuclear factor erythroid 2‑related factor 2 (Nrf2) signaling has a protective effect on normal cells. A number of previous studies demonstrated that Keap1/Nrf2 signaling is associated with drug resistance in numerous tumors. The aim of the present study was to investigate th...

journal_title：International journal of molecular medicine

authors： Huang H,Wu Y,Fu W,Wang X,Zhou L,Xu X,Huang F,Wu Y

更新日期：2019-05-01 00:00:00

abstract：:The aim of the present study was to examine the protective effect of caveolin‑1 (Cav‑1) in the penehyclidine hydrochloride (PHC)‑based inhibition of lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in vivo and in vitro, in addition to the potential underlying mechanisms. In vivo, an ALI rat model was establish...

journal_title：International journal of molecular medicine

authors： Wu X,Kong Q,Xia Z,Zhan L,Duan W,Song X

更新日期：2019-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is mainly associated with myosin, heavy chain 7 (MYH7) and myosin binding protein C, cardiac (MYBPC3) mutations. In order to better explain the clinical and genetic heterogeneity in HCM patients, in this study, we implemented a target-next generation sequencing (NGS) assay. An Ion Amp...

journal_title：International journal of molecular medicine

authors： Cecconi M,Parodi MI,Formisano F,Spirito P,Autore C,Musumeci MB,Favale S,Forleo C,Rapezzi C,Biagini E,Davì S,Canepa E,Pennese L,Castagnetta M,Degiorgio D,Coviello DA

更新日期：2016-10-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of abnormal liver dysfunction, and its prevalence has markedly increased. We previously evaluated the expression of fatty acid metabolism-related genes in NAFLD and reported changes in expression that could contribute to increased fatty acid s...

journal_title：International journal of molecular medicine

authors： Kohjima M,Enjoji M,Higuchi N,Kato M,Kotoh K,Yoshimoto T,Fujino T,Yada M,Yada R,Harada N,Takayanagi R,Nakamuta M

更新日期：2007-09-01 00:00:00

abstract：:There is clinical evidence that patients with heart failure and concomitant iron deficiency have increased skeletal muscle fatigability and impaired exercise tolerance. It was expected that a skeletal muscle cell line subjected to different degrees of iron availability and/or concomitant hypoxia would demonstrate chan...

journal_title：International journal of molecular medicine

authors： Kobak K,Kasztura M,Dziegala M,Bania J,Kapuśniak V,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2018-05-01 00:00:00

abstract：:Recently a candidate gene for hereditary hemo-chromatosis, HFE, was identified. The finding raises the possibility for genetic testing to provide earlier detection and more complete genotypic evaluation of hemochromatosis affected individuals. We determined the frequency of the HFE polymorphisms, C282Y and H63D, in a ...

journal_title：International journal of molecular medicine

authors： Marshall DS,Linfert DR,Tsongalis GJ

更新日期：1999-10-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical cancer HeLa cells and the possible mechanism involved. Immunohistochemistry was us...

journal_title：International journal of molecular medicine

authors： Sun R,Guan H,Liu W,Liang J,Wang F,Li C

更新日期：2020-05-01 00:00:00

abstract：:Evidence has been recently provided that beacon, an ubiquitin-like protein overexpressed in the hypothalamus of Israeli sand rat, is also expressed in several endocrine glands of the Wistar rat, including adrenal cortex. Moreover, it has been shown that the in vivo administration of beacon[47-73] (hereinafter, beacon)...

journal_title：International journal of molecular medicine

authors： Ziolkowska A,Carraro G,Rebuffat P,Spinazzi R,Nussdorfer GG,Rucinski M,Malendowicz LK

更新日期：2004-09-01 00:00:00

abstract：:Krüppel‑like family (KLF) members are important regulators of proinflammatory activation in the vasculature. A transcriptome study involving RNA sequencing (RNA‑seq) and quantitative PCR (qPCR) was performed to investigate Klf15 and Klf15‑regulated gene levels in C57BL/6 mice with inferior vena cava thrombi and in con...

journal_title：International journal of molecular medicine

authors： Zhou J,Zhao X,Xie S,Zhou R

更新日期：2020-06-01 00:00:00

abstract：:Stannous ion, as a chloride salt, influenced on the survival and adhesive properties of two toxigenic Corynebacterium diphtheriae of the sucrose-fermenting (241 strain) and non-sucrose-fermenting (CDC-E8392 strain) biotypes. Differences in survival fractions suggested differences in susceptibility of strains to bacter...

journal_title：International journal of molecular medicine

authors： Silva De Souza SM,Hirata R Jr,Moreira LO,Gomes ML,Braga De Andrade AF,Bernardo-Filho M,Mattos-Guaraldi AL

更新日期：2003-10-01 00:00:00

abstract：:Trastuzumab has efficacy to improve the effect of cytotoxic drugs, such as paclitaxel and anthracyclin, against HER2-overexpressing breast cancer cells. Sodium butyrate (NaB), a histone deacetylase inhibitor, is known to have antitumoral properties. However, whether and how trastuzumab possesses the potential to syner...

journal_title：International journal of molecular medicine

authors： Chen W,Wei F,Xu J,Wang Y,Chen L,Wang J,Guan X

更新日期：2011-12-01 00:00:00

abstract：:Atopic dermatitis (AD) shows an increased susceptibility to Staphylococcus aureus infection partly due to decreased expression of human beta-defensin-2 (HBD-2). Interestingly, it was reported that the nasal carrier S. aureus down-regulates the expression of HBD-2 and -3, thereby the carrier strains of S. aureus retain...

journal_title：International journal of molecular medicine

authors： Cho JW,Cho SY,Lee KS

更新日期：2009-03-01 00:00:00

abstract：:Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of cancers and correlates with metastasis, chemotherapy resistance and tumor prognosis. The present study demonstrated that suppression of HSP7...

journal_title：International journal of molecular medicine

authors： Sheng L,Tang T,Liu Y,Ma Y,Wang Z,Tao H,Zhang Y,Qi Z

更新日期：2018-10-01 00:00:00

abstract：:The number of patients suffering from diabetes mellitus is constantly rising worldwide, and diabetic retinopathy (DR) has become the most frequent cause of postnatal blindness. Vascular endothelial growth factor (VEGF) is known to play a central role during DR development. Thus, inhibiting the effects of VEGF may hamp...

journal_title：International journal of molecular medicine

authors： Ideno J,Mizukami H,Kakehashi A,Saito Y,Okada T,Urabe M,Kume A,Kuroki M,Kawakami M,Ishibashi S,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:Neuropathic pain is one of most intense types of chronic pain. Numerous studies investigating neuropathic pain have described the critical involvement of microglia in the spinal cord. Previous studies have indicated that activation of large conductance Ca2+‑activated K+ (BK) channels contributes to microglial activati...

journal_title：International journal of molecular medicine

authors： Imari K,Harada Y,Zhang J,Mori Y,Hayashi Y

更新日期：2019-10-01 00:00:00

abstract：:Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study i...

journal_title：International journal of molecular medicine

authors： Pei W,Zou Y,Wang W,Wei L,Zhao Y,Li L

更新日期：2018-12-01 00:00:00

abstract：:MicroRNA‑23b‑3p (miR‑23b‑3p) has been reported to be involved in the pathogenesis of a number of diseases, including non‑small cell lung cancer and gastric cancer, by acting on different signaling pathways. The present study aimed to understand the association between the miR‑23b‑3p level of intracranial aneurysms (IA...

journal_title：International journal of molecular medicine

authors： Guo D,Wang YW,Yan L,Ma J,Han XW,Shui SF

更新日期：2018-09-01 00:00:00

abstract：:Psoriasis is an inflammatory skin disease with or without joint involvement. In this disease, the thickened epidermis and impaired barrier are associated with altered calcium gradients. Calcium and vitamin D are known to play important roles in keratinocyte differentiation and bone metabolism. Intracellular calcium is...

journal_title：International journal of molecular medicine

authors： Cubillos S,Norgauer J

更新日期：2016-10-01 00:00:00

abstract：:Three human pleural malignant mesothelioma cell cultures (MM) of epithelioid (E1), fibrous (F1) and byphasic (B1) histotype were studied in their synthesis of the extracellular matrix (ECM) components laminin (LM), fibronectin (FN), type IV collagen (cIV), and in their chemotactic and haptotactic migration towards the...

journal_title：International journal of molecular medicine

authors： Scarpa S,Giuffrida A,Fazi M,Coletti A,Palumbo C,Pass HI,Procopio A,Modesti A

更新日期：1999-07-01 00:00:00

abstract：:The ectromelia virus (ECTV) is a mouse specific Orthopoxvirus that causes lethal infection in some mouse strains. ECTV infection of these mouse strains has been used as a valuable model for understanding the interplay between Orthopoxvirus species and their hosts, including variola virus in humans. Although poxviruses...

journal_title：International journal of molecular medicine

authors： Cheng W,Jia H,Wang X,He X,Jin Q,Cao J,Jing Z

更新日期：2018-08-01 00:00:00

abstract：:Mycobacterium tuberculosis (MTB), one of the major bacterial pathogens for lethal infectious diseases, is capable of surviving within the phagosomes of host alveolar macrophages; therefore, host genetic variations may alter the susceptibility to MTB. In this study, to identify host genes exploited by MTB during infect...

journal_title：International journal of molecular medicine

authors： Bao Z,Chen R,Zhang P,Lu S,Chen X,Yao Y,Jin X,Sun Y,Zhou J

更新日期：2016-09-01 00:00:00

abstract：:Substantial evidence has indicated that osteoblastic differentiation may be regulated by mechanical loads or bone morphogenetic protein-2 (BMP-2). BMP-2-induced in vivo osteogenesis can be significantly enhanced in the presence of mechanical stimuli, revealing the therapeutic potential of the combined application of B...

journal_title：International journal of molecular medicine

authors： Zeng Z,Yin X,Zhang X,Jing D,Feng X

更新日期：2015-11-01 00:00:00

abstract：:The increased expression of sialyl-Lewisx (SLex) epitope on the surface of tumor cells has been known for decades. However, genetic manipulation of the expression of SLex and the role of SLex in cancer cell proliferation remains to be fully elucidated. The present study suggested that the monoclonal antibody of SLex (...

journal_title：International journal of molecular medicine

authors： Li D,Sun H,Bai G,Wang W,Liu M,Bao Z,Li J,Liu H

更新日期：2018-11-01 00:00:00