Gene expression during involution of mammary gland (review).

abstract：:The development of angiogenesis within a tumor brings on a sequence of extremely complex molecular events. We have developed a methodology which enables a wide set of biological parameters to be quantitatively determined in the field of anti-angiogenesis pharmacology. This methodology which includes a video cell track...

journal_title：International journal of molecular medicine

authors： Farinelle S,Dehauwer C,Darro F,Decaestecker C,Fontaine J,Pasteels JL,Van Ham P,Atassi G,Kiss R

更新日期：1998-11-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:A substantial increase in NADH production, arising from accelerated glycolysis, occurs in cardiac hypertrophy and this raises the question of how the NADH is oxidised. We have addressed this problem by reconstructing appropriate mitochondrial shuttles in vitro, using mitochondria from the left ventricles of both normo...

journal_title：International journal of molecular medicine

authors： Atlante A,Seccia TM,De Bari L,Marra E,Passarella S

更新日期：2006-07-01 00:00:00

abstract：:Electrical activity of beta-cells and cytosolic Ca2+ concentration ([Ca2+]i) were monitored in mouse pancreatic islets exposed to the pentaacetate esters of alpha-D-glucose, beta-D-galactose and beta-L-glucose, all tested at 1.7 mM concentration. In the presence of 5 mM D-glucose, alpha-D-glucose pentaacetate induced ...

journal_title：International journal of molecular medicine

authors： Pomares R,Ropero AB,Sánchez-Andrés JV,Nadal A,Soria B,Malaisse WJ

更新日期：1999-01-01 00:00:00

abstract：:About 80% of short children are not deficient in endogenous growth hormone (GH) and termed idiopathic short stature (ISS). The causes of impaired growth in children with ISS are various. Short stature and low insulin-like growth factor-I (IGF-I) concentration despite normal to high GH concentration suggest impaired GH...

journal_title：International journal of molecular medicine

authors： Takahashi Y,Chihara K

更新日期：1998-09-01 00:00:00

abstract：:Apoptosis may limit the utility of cell-based therapies for articular cartilage disorders. We tested the hypothesis that chondrocyte apoptosis can be reduced by optimizing the conditions employed to expand chondrocyte numbers in culture. Chondrocyte apoptosis was examined in monolayer and suspension culture, in the pr...

journal_title：International journal of molecular medicine

authors： Takahashi T,Yamamoto H,Ogawa Y,Yoshida S,Kataoka S,Majumdar M,Morris E,Tripple SB

更新日期：2003-03-01 00:00:00

abstract：:Cell numbers are regulated by a balance between proliferation and apoptosis (programmed cell death). Recent evidence suggests that proteins regulating cell proliferation also mediate apoptosis. Therefore, cellular fate might be determined by cross talk between regulators of cell cycle progression and apoptosis. Previo...

journal_title：International journal of molecular medicine

authors： An B,Johnson DE,Jin JR,Antoku K,Dou QP

更新日期：1998-01-01 00:00:00

abstract：:Chondrocyte senescence is associated with the aging and degeneration of cartilage, and eventually leads to joint destruction. The aim of this study was to elucidate the mechanisms responsible for the cytoprotective effects of heme oxygenase‑1 (HO‑1) on chondrocytes in cartilage. Chondrocyte senescence was induced usin...

journal_title：International journal of molecular medicine

authors： Kim KM,Park SE,Lee MS,Kim K,Park YC

更新日期：2014-11-01 00:00:00

abstract：:Neuropathic pain is one of most intense types of chronic pain. Numerous studies investigating neuropathic pain have described the critical involvement of microglia in the spinal cord. Previous studies have indicated that activation of large conductance Ca2+‑activated K+ (BK) channels contributes to microglial activati...

journal_title：International journal of molecular medicine

authors： Imari K,Harada Y,Zhang J,Mori Y,Hayashi Y

更新日期：2019-10-01 00:00:00

abstract：:Neural stem cell transplantation is a promising new treatment of ischemic or traumatic brain injury. We have now investigated the involvement of the peroxynitrite - poly(ADP-ribose) polymerase (ONOO- - PARP) activation cascade in brain trauma and neural stem cell transplantation. The forelimb motor cortex of adult mal...

journal_title：International journal of molecular medicine

authors： Lacza Z,Horváth EM,Komjáti K,Hortobágyi T,Szabó C,Busija DW

更新日期：2003-08-01 00:00:00

abstract：:Human bladder exstrophy-epispadias complex (BEEC) comprises a spectrum of urogenital anomalies in which part or all of the distal urinary tract fails to close. Several lines of evidence implicate genetic factors in the formation of BEEC. Among them a murine p63+/+ knockout model showed the full picture of classic exst...

journal_title：International journal of molecular medicine

authors： Ching BJ,Wittler L,Proske J,Yagnik G,Qi L,Draaken M,Reutter H,Gearhart JP,Ludwig M,Boyadjiev SA

更新日期：2010-12-01 00:00:00

abstract：:Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genomic DNA from the members o...

journal_title：International journal of molecular medicine

authors： Horiuchi T,Tsukamoto H,Mitoma H,Miyagawa H,Tamimoto Y,Yoshizawa S,Harada M,Hayashi K,Hashimura C,Oribe M,Okamura S

更新日期：2004-11-01 00:00:00

abstract：:Promoter methylation‑associated silencing of cancer‑associated microRNAs (miRNAs) is a common epigenetic mechanism during tumorigenesis in various types of human cancer. However, this has not been comprehensively examined in endometrial carcinoma (EC). In the present study, an miRNA microarray consisting of 1,347 comm...

journal_title：International journal of molecular medicine

authors： Ni J,Liang S,Shan B,Tian W,Wang H,Ren Y

更新日期：2020-06-01 00:00:00

abstract：:Dextromethorphan is a widely used anti-tussive drug with non-competitive antagonistic effects on excitatory amino acid receptors of the N-methyl-D-aspartate (NMDA) type. This study examined the effect of daily dextromethorphan administration on gene expression in rat brain hippocampus and cortex regions using Rat 5K c...

journal_title：International journal of molecular medicine

authors： Lee KH,Ahn JI,Yu DH,Koh HC,Kim SH,Yang BH,Lee YS,Lee YS

更新日期：2003-05-01 00:00:00

abstract：:Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of cancers and correlates with metastasis, chemotherapy resistance and tumor prognosis. The present study demonstrated that suppression of HSP7...

journal_title：International journal of molecular medicine

authors： Sheng L,Tang T,Liu Y,Ma Y,Wang Z,Tao H,Zhang Y,Qi Z

更新日期：2018-10-01 00:00:00

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:Myocyte injury due to myocardial reperfusion injury plays a crucial role in the pathogenesis of acute myocardial infarction even after successful coronary revascularization. Identification of compounds that reduce reperfusion-associated myocyte death is important. Therefore, we developed an in vitro model of myocardia...

journal_title：International journal of molecular medicine

authors： Gerö D,Módis K,Nagy N,Szoleczky P,Tóth ZD,Dormán G,Szabó C

更新日期：2007-11-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Non‑small cell lung carcinoma (NSCLC) is a life‑threatening malignancy. The level of the cell growth regulator mitogen‑activated protein kinase kinase kinase kinase 3 (MAP4K3) has been shown to be correlated with a high risk of NSCLC recurrence and poor recurrence‑free survival rate. The present study examined the eff...

journal_title：International journal of molecular medicine

authors： Zhou Y,Hong T,Tong L,Liu W,Yang X,Luo J,Wang F,Li J,Yan L

更新日期：2018-12-01 00:00:00

abstract：:Noise-induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. It has been demonstrated that hair cell loss in the auditory end organ may account for the majority of ear pathological conditions. Previous studies have indicated that histone deacetylases (HDACs) play an important...

journal_title：International journal of molecular medicine

authors： Wen LT,Wang J,Wang Y,Chen FQ

更新日期：2015-08-01 00:00:00

abstract：:Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard approaches used in the treatment of nasopharyngeal carcinoma (NPC). However, resistance to chemotherapy has recently become more common, resulting in the failure of this combination therapy for NPC. The aim of the present study was to assess the cellu...

journal_title：International journal of molecular medicine

authors： Zhang P,Liu H,Xia F,Zhang QW,Zhang YY,Zhao Q,Chao ZH,Jiang ZW,Jiang CC

更新日期：2014-01-01 00:00:00

abstract：:Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active es...

journal_title：International journal of molecular medicine

authors： González A,Martínez-Campa C,Alonso-González C,Cos S

更新日期：2015-12-01 00:00:00

abstract：:Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the provirus, is expressed in all cases of ATL and involved in T cell proliferation. However,...

journal_title：International journal of molecular medicine

authors： Ma Y,Zhang B,Wang D,Qian L,Song X,Wang X,Yang C,Zhao G

更新日期：2017-03-01 00:00:00

abstract：:Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Human umbilical vein endothelial cells (HUVECs) wer...

journal_title：International journal of molecular medicine

authors： Ju Y,Hua J,Sakamoto K,Ogawa H,Nagaoka I

更新日期：2008-12-01 00:00:00

abstract：:Cutaneous melanoma is very aggressive and results in high mortality rates for cancer patients. Determining molecular targets is important for developing novel therapies for cutaneous melanoma. Cell division cycle associated 8 (CDCA8) is a putative oncogene that is upregulated in multiple types of cancer. The present s...

journal_title：International journal of molecular medicine

authors： Ci C,Tang B,Lyu D,Liu W,Qiang D,Ji X,Qiu X,Chen L,Ding W

更新日期：2019-01-01 00:00:00

abstract：:Telomerase maintains telomere length and is considered to be necessary for the indefinite proliferation of human cells. Telomerase activity is detected not only in germline and immortal cancer cells, but also in stem/progenitor cells of renewal tissues and activated lymphocytes. While it is generally agreed that telom...

journal_title：International journal of molecular medicine

authors： Hiyama K,Ishioka S,Shay JW,Taooka Y,Maeda A,Isobe T,Hiyama E,Maeda H,Yamakido M

更新日期：1998-03-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

journal_title：International journal of molecular medicine

authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

更新日期：2003-12-01 00:00:00

abstract：:Fruits, vegetables, spices and a variety of teas are suggested for the prevention of many diseases. They encompass active, non-nutritional ingredients called nutraceuticals which are defined as food products that provide health benefits. Many nutraceuticals have been tested to identify inhibitors of plasminogen activa...

journal_title：International journal of molecular medicine

authors： Jankun J,Skotnicka M,Łysiak-Szydłowska W,Al-Senaidy A,Skrzypczak-Jankun E

更新日期：2011-04-01 00:00:00

abstract：:Cartilage tissue engineering plays an important role in the generation of grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. Dedifferentiated cells produce matrix of less quality, and the molecular basis is still not well understood. Theref...

journal_title：International journal of molecular medicine

authors： Goessler UR,Bieback K,Bugert P,Naim R,Schafer C,Sadick H,Hormann K,Riedel F

更新日期：2005-10-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) the simplest of the water-soluble phospholipids, is produced by activated platelets, macrophage and endothelial cells. It also evokes various biological responses. When LPA concentrations reach high levels, brain injury, including stroke and intracerebral hemorrhage (ICH), occurs. Previous ...

journal_title：International journal of molecular medicine

authors： Yu Y,Qin J,Liu M,Ruan Q,Li Y,Zhang Z

更新日期：2014-03-01 00:00:00