Microarray analysis of insulin-regulated gene expression in the liver: the use of transgenic mice co-expressing insulin-siRNA and human IDE as an animal model.

abstract：:Immortalized cloned human chondrocytes isolated from a normal (Ch-4, 8, N) and an osteoarthritis patient (Ch-8-OA) were established by introduction of recombinant SV40-adenovirus vector containing SV40 early gene. These cells exhibited continuous proliferative capacity in monolayer culture and showed chondrocytic char...

journal_title：International journal of molecular medicine

authors： Yoshimatsu T,Saitoh A,Ryu JN,Shima D,Handa H,Hiramoto M,Kawakami Y,Aizawa S

更新日期：2001-10-01 00:00:00

abstract：:Current therapy for glioma is suboptimal. The transfer of apoptosis genes to tumors constitutes one of the most promising strategies for cancer gene therapy. We have previously shown that massive apoptosis occurs when wild-type p53 or E2F-1 expression is induced in glioma. However, the mechanism of action and the effi...

journal_title：International journal of molecular medicine

authors： Gomez-Manzano C,Fueyo J,Alameda F,Kyritsis AP,Yung WK

更新日期：1999-01-01 00:00:00

abstract：:Human gastric cancer SNU 484 cells express mutant p16, which migrates slower than the wild-type p16. We constructed an expression vector containing human p16 cDNA to evaluate the cytotoxic effects of exogenous p16 expression on SNU 484 cell proliferation and to explore the potential use of p16 in cancer gene therapy. ...

journal_title：International journal of molecular medicine

authors： Jeong YW,Kim KS,Oh JY,Park JC,Baek WK,Suh SI,Suh MH,Lee JC,Cho JW

更新日期：2003-07-01 00:00:00

abstract：:Tuberculous meningitis (TBM) is a serious complication of tuberculosis that affects the central nervous system. As TBM may result in permanent sequelae and death, rapid, accurate diagnostic tests using novel biomarkers are required for the early diagnosis and treatment of TBM. A quantitative proteomic study was theref...

journal_title：International journal of molecular medicine

authors： Yang Y,Mu J,Chen G,Zhan Y,Zhong J,Wei Y,Cheng K,Qin B,You H,Xie P

更新日期：2015-05-01 00:00:00

abstract：:We describe a novel spontaneous autosomal recessive mutation, cervelet-4 (crv4), which arose in a BALB/c strain. Mice homozygous for the mutation exhibit principally a reduced body size, a congenital neurological phenotype characterized by ataxic gait and intention tremor, with no gross anomalies observed in brain or ...

journal_title：International journal of molecular medicine

authors： Conti V,Aghaie A,Cilli M,Martin N,Caridi G,Musante L,Candiano G,Castagna M,Fairen A,Ravazzolo R,Guenet JL,Puliti A

更新日期：2006-10-01 00:00:00

abstract：:Protein phosphorylation/dephosphorylation on tyrosine residues are regulated by tyrosine kinases/phosphatases. The tyrosine phosphatase SH-PTP2 (PTP1D, PTP2C) interacts physically through its SH2 domain with phosphorylated epidermal growth factor receptor (EGFR). In KB cells, an oral epidermoid carcinoma, high epiderm...

journal_title：International journal of molecular medicine

authors： Kamer AR,Hoghooghi SA,Liebow C

更新日期：1998-04-01 00:00:00

abstract：:The root of Cynanchum wilfordii (C. wilfordii) contains several biologically active compounds which have been used as traditional medicines in Asia. In the present study, we evaluated the anti-inflammatory effects of an ethanol root extract of C. wilfordii (CWE) on tumor necrosis factor (TNF)-α-stimulated human aortic...

journal_title：International journal of molecular medicine

authors： Koo HJ,Sohn EH,Pyo S,Woo HG,Park DW,Ham YM,Jang SA,Park SY,Kang SC

更新日期：2015-04-01 00:00:00

abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

journal_title：International journal of molecular medicine

authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

更新日期：2005-02-01 00:00:00

abstract：:The miR-200 family was recently identified as a suppressor of epithelial-mesenchymal transition (EMT). The loss or gain of miR-200 family members is associated with cancer invasion. The epidermal growth factor receptor (EGFR) is overexpressed in the majority of anaplastic thyroid cancers (ATCs). The activation of EGFR...

journal_title：International journal of molecular medicine

authors： Zhang Z,Liu ZB,Ren WM,Ye XG,Zhang YY

更新日期：2012-10-01 00:00:00

abstract：:Tumor necrosis factor‑α‑mediated (TNF‑α) epithelial‑mesenchymal transition (EMT) is associated with distant metastasis in patients with colorectal cancer with poor prognosis. Although traditional herbal medicines have long been used to treat colorectal cancer, the incidence and mortality in patients with colorectal ca...

journal_title：International journal of molecular medicine

authors： Lee K,Cho SG,Choi YK,Choi YJ,Lee GR,Jeon CY,Ko SG

更新日期：2018-01-01 00:00:00

abstract：:Formalin-fixed, paraffin-embedded (FFPE) tissues are one of the popular sources of diagnostic materials, the easiest to store and transport. They are often used as the source of nucleic acids for retrospective molecular analyses based on DNA amplification by polymerase chain reaction (PCR). However, it is known that n...

journal_title：International journal of molecular medicine

authors： Bielawski K,Zaczek A,Lisowska U,Dybikowska A,Kowalska A,Falkiewicz B

更新日期：2001-11-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a lethal disease due to its high aggressiveness. The aim of the present study was to investigate the role of xeroderma pigmentosum complementation group D (XPD) in the growth and invasion of ESCC and to elucidate the potential underlying molecular mechanisms. Western blot a...

journal_title：International journal of molecular medicine

authors： Jian J,Li S,Liu LZ,Zhen L,Yao L,Gan LH,Huang YQ,Fang N

更新日期：2020-07-01 00:00:00

abstract：:The activation of the classical angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 receptor (AT1R) axis of the renin-angiotensin system (RAS) has been associated with islet dysfunction and insulin resistance. Hyperglycaemia, hypertension and obesity, major components of metabolic syndrome, are all associat...

journal_title：International journal of molecular medicine

authors： Härdtner C,Mörke C,Walther R,Wolke C,Lendeckel U

更新日期：2013-10-01 00:00:00

abstract：:In hypercholesterolemia increased lipid and lipoprotein peroxidation occurs. The renin-angiotensin system plays an important role in atherogenesis. Angiotensin II induces smooth muscle cells proliferation and stimulates oxidation of LDL particles and foam cell accumulation. Inhibition of ang II production leads to dec...

journal_title：International journal of molecular medicine

authors： Wojakowski W,Gminski J,Siemianowicz K,Goss M,Machalski M

更新日期：2000-11-01 00:00:00

abstract：:Hyposalivation is an intractable side‑effect of radiotherapy for head and neck cancer. It is caused by the irreversible loss of acinar cells and decreased saliva secretion. However, this situation severely compromises the quality of life of affected patients. Currently, there is no effective treatment for this conditi...

journal_title：International journal of molecular medicine

authors： Xiong X,Shi X,Chen F

更新日期：2014-09-01 00:00:00

abstract：:The inhibition of the Smad2/3 pathway is a key step involved in the downregulation of type I collagen synthesis, thus preventing keloid formation in tissue. In this study, we investigated the effect of silibinin on the proliferation of human skin fibroblasts (HSFs), as well as its effect on the expression of type I co...

journal_title：International journal of molecular medicine

authors： Cho JW,Il KJ,Lee KS

更新日期：2013-05-01 00:00:00

abstract：:The presence of cells positive for cytokeratins or prostate-specific antigen (PSA) in bone marrow aspirates (BMAs) has been used to indicate the presence of micrometastasis. The aim of this prospective study of prostate cancer patients was to determine the presence of prostate cells in blood and BMAs and to compare th...

journal_title：International journal of molecular medicine

authors： Murray NP,Reyes E,Tapia P,Badinez L,Orellana N,Fuentealba C,Olivares R,Porcell J,Dueñas R

更新日期：2012-10-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome caused by mutations or deletions within the VHL tumor-suppressor gene, but VHL germline mutations in the Chinese have rarely been studied. To investigate the genetic profile of VHL mutations in the Chinese population, we evaluated the clinical characterist...

journal_title：International journal of molecular medicine

authors： Huang Y,Zhou D,Liu J,Zhou P,Li X,Wang Z

更新日期：2012-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), which is estrogen receptor (ER)-negative, progesterone receptor‑negative and is also negative for HER2 expression, remains a great clinical challenge due to its strong resistance to chemotherapy at the late stage of treatment and relatively unfavorable prognosis. Gemcitabine has b...

journal_title：International journal of molecular medicine

authors： Chen M,He M,Song Y,Chen L,Xiao P,Wan X,Dai F,Shen P

更新日期：2014-07-01 00:00:00

abstract：:Oxidative stress-induced apoptosis is associated with neuronal cell death and ischemia. The NOL3 [nucleolar protein 3 (apoptosis repressor with CARD domain)] protein protects against oxidative stress-induced cell death. However, the protective mechanism responsible for this effect as well as the effects of NOL3 agains...

journal_title：International journal of molecular medicine

authors： Sohn EJ,Shin MJ,Eum WS,Kim DW,Yong JI,Ryu EJ,Park JH,Cho SB,Cha HJ,Kim SJ,Yeo HJ,Yeo EJ,Choi YJ,Im SK,Kweon HY,Kim DS,Yu YH,Cho SW,Park M,Park J,Cho YJ,Choi SY

更新日期：2016-07-01 00:00:00

abstract：:Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...

journal_title：International journal of molecular medicine

authors： Gao P,Yang X,Mungur L,Kampo S,Wen Q

更新日期：2013-06-01 00:00:00

abstract：:The efficacy of the most commonly used form of suicide gene therapy, the HSV-TK/GCV method, utilizing herpes simplex virus thymidine kinase (HSV-TK) and antiviral drug ganciclovir (GCV) has been demonstrated in clinical trials. However, safer delivery of the therapeutic gene and more controlled regulation of the trans...

journal_title：International journal of molecular medicine

authors： Määttä AM,Korja S,Venhoranta H,Hakkarainen T,Pirinen E,Heikkinen S,Pellinen R,Mäkinen K,Wahlfors J

更新日期：2006-11-01 00:00:00

abstract：:Anorectal malformations (ARMs) comprise a broad spectrum of anomalies, including anal atresia, congenital anal fistula and persistence of the cloaca. Research suggests that genetic factors play an important role in ARM development. However, few genetic variants have been identified....

journal_title：International journal of molecular medicine

authors： Draaken M,Prins W,Zeidler C,Hilger A,Mughal SS,Latus J,Boemers TM,Schmidt D,Schmiedeke E,Spychalski N,Bartels E,Nöthen MM,Reutter H,Ludwig M

更新日期：2012-12-01 00:00:00

abstract：:Phellinus linteus is a well-known Oriental medicinal fungus that has various biological activities, including immunomodulatory and anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we investigated the effects of mycelium extracts of P. linteus (MEPL) on the growth of human neu...

journal_title：International journal of molecular medicine

authors： Choi YH,Huh MK,Ryu CH,Choi BT,Jeong YK

更新日期：2004-08-01 00:00:00

abstract：:The aim of this study was to identify key genes associated with coronary artery disease (CAD) and to explore the related signaling pathways. Gene expression profiles of 110 CAD and 112 non-CAD, healthy patients [CAD index (CADi) >23 and =0, respectively] were downloaded from the Gene Expression Omnibus (GEO) database ...

journal_title：International journal of molecular medicine

authors： Zhang X,Cheng X,Liu H,Zheng C,Rao K,Fang Y,Zhou H,Xiong S

更新日期：2014-09-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00

abstract：:Betulinic acid (BA), a potential anticancer compound, could induce apoptosis in human cervical cancer (HeLa) cells, but its mechanism has yet to be fully elucidated. The present study was focused on deciphering the detailed molecular mechanism of BA-induced apoptosis. In the present study, results indicated that BA wa...

journal_title：International journal of molecular medicine

authors： Xu T,Pang Q,Wang Y,Yan X

更新日期：2017-12-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells. There are quantitative and qualitative changes in expression of gangliosides observed in tumors of a neuroectodermal origin such as neuroblastoma, melanoma and astrocytoma. The presence of large amounts of GD2 ganglioside on neuroblastoma cells, as compare...

journal_title：International journal of molecular medicine

authors： Horwacik I,Czaplicki D,Talarek K,Kowalczyk A,Bolesta E,Kozbor D,Rokita H

更新日期：2007-05-01 00:00:00

abstract：:Gene therapy is becoming an important treatment modality against various diseases including cancer, genetic disorders, infectious diseases and inflammatory diseases. For achieving successful gene therapy, it is extremely important to control the expression of a transduced therapeutic gene. However, there have been few...

journal_title：International journal of molecular medicine

authors： Akahane M,Kuriyama S,Ohgushi H,Akahane T,Kawamura K,Watanabe S,Funakoshi F,Yoshiji H,Ikenaka K,Takakura Y

更新日期：2002-07-01 00:00:00

abstract：:A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect...

journal_title：International journal of molecular medicine

authors： Sancho V,Nuche B,Arnés L,Cancelas J,González N,Díaz-Miguel M,Martín-Duce A,Valverde I,Villanueva-Peñacarrillo ML

更新日期：2007-06-01 00:00:00