Gene therapy for gliomas: p53 and E2F-1 proteins and the target of apoptosis.

abstract：:GINS2 has been found to be closely related to cell proliferation, survival and maintenance of genomic integrity in addition to the induction of polyploidy. However, the molecular mechanisms of GINS2-mediated tumor regression have not been fully elucidated. Our study showed that GINS2 interacted with PML-C (a structura...

journal_title：International journal of molecular medicine

authors： Gao Y,Wang S,Liu B,Zhong L

更新日期：2013-06-01 00:00:00

abstract：:Dextromethorphan is a widely used anti-tussive drug with non-competitive antagonistic effects on excitatory amino acid receptors of the N-methyl-D-aspartate (NMDA) type. This study examined the effect of daily dextromethorphan administration on gene expression in rat brain hippocampus and cortex regions using Rat 5K c...

journal_title：International journal of molecular medicine

authors： Lee KH,Ahn JI,Yu DH,Koh HC,Kim SH,Yang BH,Lee YS,Lee YS

更新日期：2003-05-01 00:00:00

abstract：:Arl4D is a developmentally-regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/Arl) family of Ras-related GTPases. Although Arl4 protein is reported to be expressed in adipose tissue, the function of Arl4D is unknown. To investigate the potential role of Arl4D in adipogenesis, we examined Arl4D expre...

journal_title：International journal of molecular medicine

authors： Yu J,Ka SO,Kwon KB,Lee SM,Park JW,Park BH

更新日期：2011-11-01 00:00:00

abstract：:The adenomatous polyposis coli gene (APC gene) originally was identified as a tumor suppressor gene in colon cancer. We reported previously that APC is mutated and/or deleted in primary oral squamous cell carcinoma (OSCC) tissues and suggested that loss of APC function contributes to carcinogenesis in the oral region....

journal_title：International journal of molecular medicine

authors： Uesugi H,Uzawa K,Kawasaki K,Shimada K,Moriya T,Tada A,Shiiba M,Tanzawa H

更新日期：2005-04-01 00:00:00

abstract：:Administration of a single acute intravenous injection of interleukin-15 (IL-15) (100 microg/kg bw) to rats resulted in a significant decrease (22%) in triacylglycerol absorption, as measured by using [14C]-triolein load. The cytokine, however, did not influence the oxidation of the exogenously administered lipid or t...

journal_title：International journal of molecular medicine

authors： Almendro V,Carbó N,Busquets S,López-Soriano J,Figueras M,Ametller E,Argilés JM,López-Soriano FJ

更新日期：2005-06-01 00:00:00

abstract：:Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the provirus, is expressed in all cases of ATL and involved in T cell proliferation. However,...

journal_title：International journal of molecular medicine

authors： Ma Y,Zhang B,Wang D,Qian L,Song X,Wang X,Yang C,Zhao G

更新日期：2017-03-01 00:00:00

abstract：:Intermedin (IMD) is a recently discovered peptide closely related to adrenomedullin. Its principal physiological activity is its role in the regulation of the cardiovascular system, where it exerts a potent hypotensive effect. In addition, data were recently provided showing that this peptide is able to exert a clearc...

journal_title：International journal of molecular medicine

authors： Albertin G,Sorato E,Oselladore B,Mascarin A,Tortorella C,Guidolin D

更新日期：2010-08-01 00:00:00

abstract：:Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of the immune pathology of periodontal disease. Transforming growth factor-β (TGF-β) and vascular endothelial growth facto...

journal_title：International journal of molecular medicine

authors： Matarese G,Isola G,Anastasi GP,Favaloro A,Milardi D,Vermiglio G,Vita G,Cordasco G,Cutroneo G

更新日期：2012-09-01 00:00:00

abstract：:Studies have shown that an overproduction of mitochondrial reactive oxygen species (ROS) is an initiating cause in the pathogenesis of diabetic complications. However, uncoupling protein 2 (UCP2) can protect retinal vascular endothelial cells from damage by inhibiting the overproduction of mitochondrial ROS, although ...

journal_title：International journal of molecular medicine

authors： He Y,Wang N,Shen Y,Zheng Z,Xu X

更新日期：2014-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic neurodegenerative disease that often occurs at a slow pace yet deteriorates with time. MicroRNAs (miRs) have been demonstrated to offer novel therapeutic hope for disease treatment. The aim of the present study was to investigate the effect of miR‑98 on amyloid β (Aβ)‑protein prod...

journal_title：International journal of molecular medicine

authors： Chen FZ,Zhao Y,Chen HZ

更新日期：2019-01-01 00:00:00

abstract：:To gain a better understanding of the mechanisms that underpin aortic calcification, rodent models have been previously utilised. Regions of calcium and phosphate deposition are commonly visualised using labor-intensive two-dimensional histomorphometric techniques. In this study, we developed a novel micro-computed to...

journal_title：International journal of molecular medicine

authors： Huesa C,Millán JL,van 't Hof RJ,MacRae VE

更新日期：2013-11-01 00:00:00

abstract：:Protein phosphorylation/dephosphorylation on tyrosine residues are regulated by tyrosine kinases/phosphatases. The tyrosine phosphatase SH-PTP2 (PTP1D, PTP2C) interacts physically through its SH2 domain with phosphorylated epidermal growth factor receptor (EGFR). In KB cells, an oral epidermoid carcinoma, high epiderm...

journal_title：International journal of molecular medicine

authors： Kamer AR,Hoghooghi SA,Liebow C

更新日期：1998-04-01 00:00:00

abstract：:Influenza is the most common infectious disease and is caused by influenza A virus (IAV) infection. Hemagglutinin (HA) is an important viral protein of influenza A and is a major component of current IAV vaccines. The side effects associated with IAV vaccination are well studied; however, the HA‑induced immunopatholog...

journal_title：International journal of molecular medicine

authors： Li Y,Hu H,Qi Z,Sun J,Li Y,Feng Q,Guo C,Wang H,Zhao P,Liu Y,Zhao X,Wang G,Zhang H,Liu L,Hu J

更新日期：2018-03-01 00:00:00

abstract：:Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), which was originally isolated from rat stomach. Ghrelin and GHS-R are also expressed in several peripheral tissues, including adrenal glands, and this prompted us to study ghrelin expression and ghrelin-binding site localization in th...

journal_title：International journal of molecular medicine

authors： Tortorella C,Macchi C,Spinazzi R,Malendowicz LK,Trejter M,Nussdorfer GG

更新日期：2003-08-01 00:00:00

abstract：:Orientia tsutsugamushi (O. tsutsugamushi), the causative agent of scrub typhus, is an obligate intracellular pathogen. Recent studies have demonstrated the complete genome of O. tsutsugamushi. However, the route and detailed molecular mechanism for O. tsutsugamushi to get accessed into mammalian cells remains unclear....

journal_title：International journal of molecular medicine

authors： Lin CC,Chou CH,Lin TC,Yang MC,Cho CL,Chang CH,Yu HS,Lai CH,Chen LK,Hong YR

更新日期：2012-07-01 00:00:00

abstract：:Psoriasis is an inflammatory skin disease with or without joint involvement. In this disease, the thickened epidermis and impaired barrier are associated with altered calcium gradients. Calcium and vitamin D are known to play important roles in keratinocyte differentiation and bone metabolism. Intracellular calcium is...

journal_title：International journal of molecular medicine

authors： Cubillos S,Norgauer J

更新日期：2016-10-01 00:00:00

abstract：:Baicalin, extracted and purified from the Chinese medicinal plant, Scutellaria baicalensis Georgi (Huang qin in Chinese), exhibits potent anti-inflammatory activity against asthma. However, it remains unknown whether baicalin inhibits the activity of CC chemokine receptor 7 (CCR7) and its ligands, which are crucial fo...

journal_title：International journal of molecular medicine

authors： Liu J,Wei Y,Luo Q,Xu F,Zhao Z,Zhang H,Lu L,Sun J,Liu F,Du X,Li M,Wei K,Dong J

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to elucidate whether extracts of Vigna angularis (EVA) inhibit allergic inflammatory reactions and to elucidate the possible mechanisms of action. For the assessment of allergic inflammatory response, histamine release and the expression of pro-inflammatory cytokines from human mast ce...

journal_title：International journal of molecular medicine

authors： Kim HH,Kim SW,Kim DS,Oh HM,Rho MC,Kim SH

更新日期：2013-09-01 00:00:00

abstract：:The advanced glycation end‑product (AGE)‑receptor for AGE (RAGE) axis induces transforming growth factor‑β (TGF‑β) expression, cell hypertrophy and increases extracellular matrices that are indicated in the pathogenesis of diabetic nephropathy (DN). RAGE binds to numerous ligands besides AGE, including S100B. In the p...

journal_title：International journal of molecular medicine

authors： Chuang CT,Guh JY,Lu CY,Chen HC,Chuang LY

更新日期：2015-02-01 00:00:00

abstract：:Peritoneal fibrosis is a major complication of continuous ambulatory peritoneal dialysis (CAPD). The present study tested the hypothesis that ADP-ribose polymerase-1 (PARP-1) may play a role in peritoneal epithelial-mesenchymal transition and fibrosis under high glucose conditions. High glucose (126 mmol/l)-induced pe...

journal_title：International journal of molecular medicine

authors： Lei P,Jiang Z,Zhu H,Li X,Su N,Yu X

更新日期：2012-03-01 00:00:00

abstract：:The aim of the present study was to examine the protective effect of caveolin‑1 (Cav‑1) in the penehyclidine hydrochloride (PHC)‑based inhibition of lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in vivo and in vitro, in addition to the potential underlying mechanisms. In vivo, an ALI rat model was establish...

journal_title：International journal of molecular medicine

authors： Wu X,Kong Q,Xia Z,Zhan L,Duan W,Song X

更新日期：2019-05-01 00:00:00

abstract：:There is clinical evidence that patients with heart failure and concomitant iron deficiency have increased skeletal muscle fatigability and impaired exercise tolerance. It was expected that a skeletal muscle cell line subjected to different degrees of iron availability and/or concomitant hypoxia would demonstrate chan...

journal_title：International journal of molecular medicine

authors： Kobak K,Kasztura M,Dziegala M,Bania J,Kapuśniak V,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2018-05-01 00:00:00

abstract：:As hyperprolactinemia is observed in patients with bromocriptine‑resistant prolactinoma, prolactin (PRL) has been implicated in the development of bromocriptine resistance. Since PRL primarily mediates cell survival and drug resistance via the Janus kinase‑2 (JAK2)/signal transducer and activator of transcription 5A (...

journal_title：International journal of molecular medicine

authors： Xiao Z,Liang J,Deng Q,Song C,Yang X,Liu Z,Shao Z,Zhang K,Wang X,Li Z

更新日期：2021-01-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

journal_title：International journal of molecular medicine

authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

更新日期：2014-06-01 00:00:00

abstract：:In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

journal_title：International journal of molecular medicine

authors： Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

更新日期：2018-06-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. We have shown that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation. DA...

journal_title：International journal of molecular medicine

authors： Yukawa K,Kishino M,Hoshino K,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Bai T,Tanaka T,Ueyama T,Ichinose M,Takeda K,Akira S,Maeda M

更新日期：2005-01-01 00:00:00

abstract：:Apoptosis may limit the utility of cell-based therapies for articular cartilage disorders. We tested the hypothesis that chondrocyte apoptosis can be reduced by optimizing the conditions employed to expand chondrocyte numbers in culture. Chondrocyte apoptosis was examined in monolayer and suspension culture, in the pr...

journal_title：International journal of molecular medicine

authors： Takahashi T,Yamamoto H,Ogawa Y,Yoshida S,Kataoka S,Majumdar M,Morris E,Tripple SB

更新日期：2003-03-01 00:00:00

abstract：:We are interested in the possibility of a new prostate cancer therapy that would control tumor malignancy via induction of terminal cell differentiation. We previously reported that 12-O-tetra-decanoylphorbol-13-acetate (TPA) induces differentiation into cells with characteristics of microglia and decreases the malign...

journal_title：International journal of molecular medicine

authors： Suzuki T,Shimizu T,Satoh K,Sugibayashi R,Takeda K

更新日期：2002-12-01 00:00:00

abstract：:Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can im...

journal_title：International journal of molecular medicine

authors： Wang X,Meng H,Chen P,Yang N,Lu X,Wang ZM,Gao W,Zhou N,Zhang M,Xu Z,Chen B,Tao Z,Wang L,Yang Z,Zhu T

更新日期：2014-07-01 00:00:00

abstract：:Following the publication of the above paper, the authors noted that the first author affiliation was presented incorrectly. Essentially, 'School of Medicine' had been omitted from the address. Therefore, the author and affiliation details for this paper should have been presented as follows (the changes are highlight...

journal_title：International journal of molecular medicine

authors： Jayakumar T,Lin KC,Lu WJ,Lin CY,Pitchairaj G,Li JY,Sheu JR

更新日期：2020-02-01 00:00:00