Abstract：
:Administration of a single acute intravenous injection of interleukin-15 (IL-15) (100 microg/kg bw) to rats resulted in a significant decrease (22%) in triacylglycerol absorption, as measured by using [14C]-triolein load. The cytokine, however, did not influence the oxidation of the exogenously administered lipid or the tissue uptake of [14C]-triolein; this is in concordance with the lack of effects found in the measurement of the tissue lipoprotein lipase activity. Concerning the mechanism involved in the decreased intestinal absorption associated with IL-15 administration, the results presented clearly demonstrate that changes in gastric emptying and intestinal mobility are not involved, as the effect is specific for triacylglycerols. In conclusion, intestinal absorption may be an additional mechanism to take into consideration to explain the 'anti-fat' effect of this cytokine.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Almendro V,Carbó N,Busquets S,López-Soriano J,Figueras M,Ametller E,Argilés JM,López-Soriano FJsubject
Has Abstractpub_date
2005-06-01 00:00:00pages
963-7issue
6eissn
1107-3756issn
1791-244Xjournal_volume
15pub_type
杂志文章abstract：:Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2019.4073
更新日期：2019-03-01 00:00:00
abstract：:Human immunodeficiency virus type-1 (HIV-1) transcription is dependent on the interaction of host-cell transcription factors with cis-regulatory DNA elements within the viral long terminal repeat (LTR). Much attention has focused on the series of sequence elements upstream of the transcriptional initiation site in the...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：10.3892/ijmm.1.5.875
更新日期：1998-05-01 00:00:00
abstract：:The basic helix loop helix (bHLH) transcription factor DEC2 is associated with the regulation of apoptosis, circadian rhythm and the response to hypoxia. However, the significance of DEC2 in pancreatic cancer remains unknown. Here, we showed for the first time that DEC2 inhibits the...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2012.1037
更新日期：2012-09-01 00:00:00
abstract：:A number of cell-penetrating peptides (CPPs) have been reported, but their transduction efficiencies are too low to be used as intracellular carriers for therapeutic purposes. We conducted a comprehensive search to find novel CPPs using an in vitro virus (IVV) library, which presented random peptides consisting of 15 ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:The human immunodeficiency virus type 1 (HIV-1) epidemic in Brazil is spreading to small municipalities as well as the innermost parts of the country and scarce information has been reported on the frequency of HIV-1 resistance-associated mutations in these areas. To determine the frequency and diversity of the HIV-1 ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：:The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicativ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：10.3892/ijmm_00000232
更新日期：2009-09-01 00:00:00
abstract：:The molecular mechanisms mediating mercury‑induced neurotoxicity are not yet completely understood. Thus, the aim of this study was to investigate whether the severity of MeHg‑ and HgCl2‑mediated cytotoxicity to SH‑SY5Y human dopaminergic neurons can be attenuated by regulating glutamate‑mediated signal‑transmission t...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2017.2937
更新日期：2017-05-01 00:00:00
abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2011.643
更新日期：2011-06-01 00:00:00
abstract：:It is abundantly clear that tumor-derived parathyroid hormone-related protein (PTHrP), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are central contributors in promoting osteolytic process of breast carcinoma bone metastasis. Forcusing on this molecular basis, the study was undertak...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2018.3515
更新日期：2018-06-01 00:00:00
abstract：:We examined whether generation of H2O2 is a critical event for the apoptotic pathway upstream of mitochondrial involvement and caspase-3 protease activation. Perylquinone photosensitizers such as Hypocrellin A (HA), Hypocrellin B (HB) and Hypericin (HY) induced activation of caspase-3 and apoptosis upon photoactivatio...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:The current study aimed to clarify the role of nucleolin in the phenotypic transformation of vascular smooth muscle cells (VSMCs) and to preliminarily explore its underlying mechanism. The spatial and temporal expression patterns of nucleolin, and the effects of angiotensin II (Ang II) on the expression of VSMC phenot...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2019.4090
更新日期：2019-04-01 00:00:00
abstract：:Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology and pathogenesis remain poorly understood. The aberrant expression of T lymphocytes plays an essential role in the progression of UC. This study aimed to evaluate the expression profile of circulating Th17, Th1 and Tc1 cells in...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2013.1287
更新日期：2013-04-01 00:00:00
abstract：:It was previously shown that total saponins extracted from Aralia taibaiensis (sAT) have potent antioxidant activities for treating diabetes mellitus and attenuate d-galactose-induced aging. Since diabetes mellitus and aging are closely associated with cardiac dysfunction, particularly ischemic heart disease, sAT may ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2015.2391
更新日期：2015-12-01 00:00:00
abstract：:We have studied an age-related impairment in angiogenesis and evaluated the effect of overexpressing VEGF in this situation. Polyvinyl alcohol sponges were implanted subcutaneously into aged (24-month), adult (12-month), and young (2-month) rats. Blood vessel ingrowth and proliferative activity in the sponges were ass...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：:Tongue squamous cell carcinoma (TSCC) is highly malignant and poorly differentiated, resulting in a high frequency of local recurrence and distant metastases. Sox2 (Sry‑box2), an important factor in embryonic development and cell differentiation, has been shown to associate with malignant phenotypes and epithelial‑mes...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2018.3742
更新日期：2018-09-01 00:00:00
abstract：:Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of cardiomyocytes during the postnatal period may enhance the current understanding regarding this molecular mechanism. The present study identified the differentially express...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2017.3234
更新日期：2018-01-01 00:00:00
abstract：:We studied the expression of several homeobox genes of the HOX family in the adult human intestinal mucosa. HOX genes are regulatory genes homologous to the homeotic genes controlling the body plan of the fruit fly Drosophila melanogaster. The HOX genes are distributed in four homologous HOX loci termed HOX-A, B, C an...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:An effective therapeutic strategy for suppressing liver fibrosis development should improve the overall prognosis of patients with chronic liver diseases. Despite efforts to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic treatments for humans. An alternative strategy may be to employ a ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2011.658
更新日期：2011-07-01 00:00:00
abstract：:Currently, several therapeutic approaches including surgery, chemotherapy, and radiation therapy are available for the treatment of endometrial cancer. However, endometrial cancer cells may survive, resulting in relapse of the disease, and ultimately causing demise of the patient. Hepsin is a cell surface-expressed ch...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:It is now well established that immune effector mechanisms contribute to cardiac dysfunction in several heart diseases, including myocarditis and the associated dilated cardiomyopathy, heart transplant rejection and Chagas' disease. These and other pathologies, in which cellular immunity plays an important role, contr...
journal_title：International journal of molecular medicine
pub_type： 杂志文章,评审
doi：10.3892/ijmm.6.1.3
更新日期：2000-07-01 00:00:00
abstract：:Accumulating evidence has demonstrated that endometrial stromal cells (ESCs) are responsible for the pathogenesis of endometriosis (Ems), which is characterized by the presence of functional endometrial‑like tissues outside the uterine cavity. Abnormal expression of microRNAs (miRNAs) in ESCs may be implicated in the ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2020.4620
更新日期：2020-08-01 00:00:00
abstract：:The objective of this study was to detect interleukin-17 (IL-17), interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and forkhead/winged helix transcription factor p3 (Foxp3) protein and gene expression of the optic nerve and to further explore the role of T helper cell subsets such as Th1, Th2, Th17 and Treg in the p...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm_00000416
更新日期：2010-06-01 00:00:00
abstract：:Leptin is a 147-amino acid adipose tissue-secreted hormone, which acts via several subtypes of receptors, the main and better known variants of which are named Ob-Ra and Ob-Rb. Structure-activity relationship studies pointed out the importance of the N-terminal and C-terminal amino-acid sequences 22-115 and 116-166, r...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Burn trauma is a clinical condition accompanied by muscle wasting that severely impedes rehabilitation in burn survivors. Mitochondrial uncoupling protein 3 (UCP3) is uniformly expressed in myoskeletal mitochondria and its expression has been found to increase in other clinical syndromes that, like burn trauma, are as...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：:The present study aimed to assess the effects of therapy with adiponectin (APN) gene-modified adipose-derived stem cells (ADSCs) on pulmonary arterial hypertension (PAH) in rats and the underlying cellular and molecular mechanisms. ADSCs were successfully isolated from the rats and characterized. ADSCs were effectivel...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.2017.3226
更新日期：2018-01-01 00:00:00
abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:We investigated the expression and function of laminin and type IV collagen (COL-4) in the human endometrial epithelium throughout the menstrual cycle. Their expression was demonstrated by immunohistochemistry, while cytological analysis of the human endometrial epithelial cell line HHUA cultured on laminin- or COL-4-...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：:The human adrenocortical carcinoma-derived SW-13 cell line is currently used to study the interrelationships occurring between cytokines and growth factors and endothelins (ET) and adrenomedullin (AM). SW-13 cells express either ET-1 and AM or growth factors, and several cytokines stimulate ET-1 and AM release from SW...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：:The expression of thymidylate synthase (TS) in human cancer tissues has been suggested to be a prognostic factor for patients receiving 5-fluorouracil-based chemotherapy. We generated monoclonal antibodies to both recombinant and native TS and analyzed the epitopes on the TS molecule. Two monoclonal antibodies were ob...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm.5.2.133
更新日期：2000-02-01 00:00:00
abstract：:The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), plays an important role in angiotension II (Ang II)-induced hypertensive renal injury associated with pro-inflammatory responses, tubular functional damage and cellular apoptosis. In this study, we report on the role of LOX-1 in Ang II-induced oxidat...
journal_title：International journal of molecular medicine
pub_type： 杂志文章
doi：10.3892/ijmm_00000514
更新日期：2010-11-01 00:00:00
