Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement.

abstract：:Cadmium (Cd) is an industrial pollutant and carcinogenic metal. Most in vitro Cd toxicity studies have been carried out in various cell lines cultured in 10% fetal bovine serum (FBS) containing medium. In this report, we compared the toxic effect of Cd (0-300 microM) on cell growth, total RNA, total proteins, and anti...

journal_title：International journal of molecular medicine

authors： Latinwo LM,Badisa VL,Odewumi CO,Ikediobi CO,Badisa RB,Brooks-Walter A,Lambert AT,Nwoga J

更新日期：2008-07-01 00:00:00

abstract：:CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

journal_title：International journal of molecular medicine

authors： Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

更新日期：2008-02-01 00:00:00

abstract：:CDH1, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinoma...

journal_title：International journal of molecular medicine

authors： Ling ZQ,Li P,Ge MH,Zhao X,Hu FJ,Fang XH,Dong ZM,Mao WM

更新日期：2011-05-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:In the present study, a highly efficient method, referred to as optimized ultrafiltration (OUF), was developed. This method is effective for exosome purification and also facilitates clinical work involving substantial urinary exosome isolation. In the OUF method, 0.22‑µm filters along with a dialysis membrane with a ...

journal_title：International journal of molecular medicine

authors： He L,Zhu D,Wang J,Wu X

更新日期：2019-01-01 00:00:00

abstract：:Periodontitis is the main cause of tooth or tissue loss. Human periodontal ligament stem cells (hPDLSCs), which have high proliferative, self‑renewal and multi‑differentiation abilities, are vital for the restoration of periodontitis‑induced injuries. The anti‑inflammatory and anti‑apoptotic agent, tetramethylpyrazine...

journal_title：International journal of molecular medicine

authors： Duan Y,An W,Wu Y,Wang J

更新日期：2020-06-01 00:00:00

abstract：:miR-30a is situated on chromosome 6q.13 and is produced by an intronic transcriptional unit. However, its role in regulating the apoptosis, invasion and metastasis of breast cancer cells is not yet fully understood. The aim of this study was to research the biological function of miR‑30a and its direct target gene in ...

journal_title：International journal of molecular medicine

authors： Zhang HD,Jiang LH,Sun DW,Li J,Tang JH

更新日期：2017-10-01 00:00:00

abstract：:The differentiation of atrial fibroblasts into myofibroblasts is a critical event in atrial fibrosis. One of the most important factors in atrial fibroblast differentiation is transforming growth factor-β1 (TGF-β1). Accumulating evidence indicates that sodium tanshinone IIA sulfonate (STS) possesses antifibrotic prope...

journal_title：International journal of molecular medicine

authors： Yang L,Hu J,Hao HZ,Yin Z,Liu G,Zou XJ

更新日期：2015-04-01 00:00:00

abstract：:The pathologic mechanisms of pulmonary fibrosis (PF), one of the most common chronic pulmonary diseases, remain unclear. Napsin A is an aspartic proteinase that has been regarded as a hallmark of pulmonary adenocarcinoma. The present study aimed to investigate the specific function and molecular mechanisms of Napsin A ...

journal_title：International journal of molecular medicine

authors： Guan S,Wu Y,Zhang Q,Zhou J

更新日期：2020-07-01 00:00:00

abstract：:The volatile anesthetic, sevoflurane, is widely used in surgery. Over the years, there has been a growing interest in the biological effects of sevoflurane on tissue and organ systems and the molecular mechanisms involved. MicroRNAs (miRNAs or miRs) acting as pivotal post‑transcriptional regulators for fine-tuning gen...

journal_title：International journal of molecular medicine

authors： Takeuchi J,Sakamoto A,Takizawa T

更新日期：2014-07-01 00:00:00

abstract：:Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of cardiomyocytes during the postnatal period may enhance the current understanding regarding this molecular mechanism. The present study identified the differentially express...

journal_title：International journal of molecular medicine

authors： Wang R,Su C,Wang X,Fu Q,Gao X,Zhang C,Yang J,Yang X,Wei M

更新日期：2018-01-01 00:00:00

abstract：:Obesity increases mammary tumor development in Zucker rats following a single administration of the procarcinogen 7,12-dimenthylbenz(a)anthracene (DMBA). Fifty-day-old obese and lean female Zucker rats were orally gavaged with 65 mg/kg DMBA and sacrificed 139 days post DMBA treatment. At the end of the experiment, mam...

journal_title：International journal of molecular medicine

authors： Whitehead TL,Holley AW,Korourian S,Shaaf S,Kieber-Emmons T,Hakkak R

更新日期：2007-10-01 00:00:00

abstract：:Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

journal_title：International journal of molecular medicine

authors： Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

更新日期：2010-07-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and inflammation induced by obesity lead to adipocyte dysfunction, with the impairment of the insulin pathway. Recent studies have indicated that understanding the physiological role of autophagy is of great significance. In the present study, an in vitro model was used in which 3T3-L...

journal_title：International journal of molecular medicine

authors： Yin J,Wang Y,Gu L,Fan N,Ma Y,Peng Y

更新日期：2015-04-01 00:00:00

abstract：:Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly underst...

journal_title：International journal of molecular medicine

authors： Altaha R,Liang X,Yu JJ,Reed E

更新日期：2004-12-01 00:00:00

abstract：:Angiogenesis is an important process in several physiological situations and it is also implicated in the development of some diseases such as diabetes and cancer. This study investigated the antiangiogenic potential of Chrysobalanus icaco methanol extract in the chicken embrionary tissue. Clinical trials for cancer t...

journal_title：International journal of molecular medicine

authors： Alves De Paulo S,Teruszkin Balassiano I,Henriques Silva N,Oliveira Castilho R,Coelho Kaplan MA,Currie Cabral M,da Costa Carvalho MG

更新日期：2000-06-01 00:00:00

abstract：:Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studi...

journal_title：International journal of molecular medicine

authors： Chen T,Yang P,Jia Y

更新日期：2021-03-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and a key element in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Moreover, it is a negative regulator of autophagy and acts as a central regulator in cell growth. For the treatment of cancer, mTOR is a nove...

journal_title：International journal of molecular medicine

authors： Cai Y,Xia Q,Su Q,Luo R,Sun Y,Shi Y,Jiang W

更新日期：2013-04-01 00:00:00

abstract：:Sevoflurane (Sevo) is one of the most frequently used volatile anesthetic agents in surgical oncology and has various effects on tumors, including inhibiting tumor growth, recurrence, and metastases; however, the molecular mechanisms are unknown. This study tried to investigate the influence of Sevo on hepatocellular ...

journal_title：International journal of molecular medicine

authors： Cao Y,Lv W,Ding W,Li J

更新日期：2020-07-01 00:00:00

abstract：:Receptor-mediated gene delivery is an attractive method for gene transfer in vitro and shows promise for in vivo gene therapy applications. In the current study, we have selected the cytokine interleukin-2 (IL-2) gene to explore the feasibility of receptor-mediated gene transfer into human hepatocellular carcinoma Hep...

journal_title：International journal of molecular medicine

authors： Junbo H,Li Q,Zaide W,Yunde H

更新日期：1999-06-01 00:00:00

abstract：:Metastasis is a hallmark of malignant neuroblastoma and is the main reason for therapeutic failure and recurrence of the tumor. The CXC chemokine receptor-4 (CXCR4), a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1α (SDF-1α), is expressed in various types of tumor. This receptor mediat...

journal_title：International journal of molecular medicine

authors： Zhi Y,Lu H,Duan Y,Sun W,Guan G,Dong Q,Yang C

更新日期：2015-02-01 00:00:00

abstract：:The opioid growth factor (OGF) is a constitutively expressed negative growth regulator whose action is mediated by the OGF receptor (OGFr). The OGF-OGFr axis tonically regulates the growth of human squamous cell carcinoma of the head and neck (SCCHN). To examine the repercussions of amplifying OGFr in SCCHN, construct...

journal_title：International journal of molecular medicine

authors： McLaughlin PJ,Verderame MF,Hankins JL,Zagon IS

更新日期：2007-03-01 00:00:00

abstract：:The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-κB ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into va...

journal_title：International journal of molecular medicine

authors： Fu YX,Gu JH,Zhang YR,Tong XS,Zhao HY,Yuan Y,Liu XZ,Bian JC,Liu ZP

更新日期：2013-06-01 00:00:00

abstract：:Inflammation and remodeling play a role in the pathogenesis of pulmonary arterial hypertension (PAH). Nuclear factor-κB (NF-κB) and nuclear factor of activated T cells-1 (NFAT-1) participate in inflammation and remodeling in a number of diseases. As a tryptophan hydroxylase inhibitor, 4-chloro-DL-phenylalanine (PCPA) ...

journal_title：International journal of molecular medicine

authors： Bai Y,Li ZX,Wang HL,Lian GC,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of atherosclerosis by promoting vascular smooth muscle cell (VSMC) growth, migration, apoptosis, adhesion and the secretion of matrix components. The osteogenic differentiation of VSMCs is essential in the development of vascular calcif...

journal_title：International journal of molecular medicine

authors： Huang J,Huang H,Wu M,Li J,Xie H,Zhou H,Liao E,Peng Y

更新日期：2013-08-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. Findings indicate that Alzheimer disease (AD) and vascular dementia (VaD) may have common risk factors and/or pathogene...

journal_title：International journal of molecular medicine

authors： Folin M,Baiguera S,Conconi MT,Di Liddo R,De Carlo E,Parnigotto PP,Nussdorfer GG

更新日期：2004-10-01 00:00:00

abstract：:Smoking has deleterious effects on osteoporosis and periodontitis both characterized by bone loss. Smoking also interferes with the protective effect that hormone replacement therapy (HRT) has on bone loss. Our study investigated two mechanisms by which smoking may affect bone metabolism: nicotine-induced proliferatio...

journal_title：International journal of molecular medicine

authors： Kamer AR,El-Ghorab N,Marzec N,Margarone JE 3rd,Dziak R

更新日期：2006-01-01 00:00:00

abstract：:Glioblastoma is one of the most radioresistant tumors. Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. ROS scavengers, therefore, are one of the important factors in protecting cells against ROS injury during ionizing ...

journal_title：International journal of molecular medicine

authors： Lee HC,Kim DW,Jung KY,Park IC,Park MJ,Kim MS,Woo SH,Rhee CH,Yoo H,Lee SH,Hong SI

更新日期：2004-06-01 00:00:00

abstract：:Baicalin, extracted and purified from the Chinese medicinal plant, Scutellaria baicalensis Georgi (Huang qin in Chinese), exhibits potent anti-inflammatory activity against asthma. However, it remains unknown whether baicalin inhibits the activity of CC chemokine receptor 7 (CCR7) and its ligands, which are crucial fo...

journal_title：International journal of molecular medicine

authors： Liu J,Wei Y,Luo Q,Xu F,Zhao Z,Zhang H,Lu L,Sun J,Liu F,Du X,Li M,Wei K,Dong J

更新日期：2016-11-01 00:00:00

abstract：:Although recent reports indicate an increasing incidence of patients with reflux esophagitis, its pathomechanism remains unclear. Cytokines and neutrophils, the latter of which produce reactive oxygen species (ROS), have been implicated in the formation of gastrointestinal diseases. This study investigated the roles o...

journal_title：International journal of molecular medicine

authors： Yamaguchi T,Yoshida N,Tomatsuri N,Takayama R,Katada K,Takagi T,Ichikawa H,Naito Y,Okanoue T,Yoshikawa T

更新日期：2005-07-01 00:00:00