miR-30a inhibits the biological function of breast cancer cells by targeting Notch1.

abstract：:Hyposalivation is an intractable side‑effect of radiotherapy for head and neck cancer. It is caused by the irreversible loss of acinar cells and decreased saliva secretion. However, this situation severely compromises the quality of life of affected patients. Currently, there is no effective treatment for this conditi...

journal_title：International journal of molecular medicine

authors： Xiong X,Shi X,Chen F

更新日期：2014-09-01 00:00:00

abstract：:Colon cancer stem cells (CCSCs) are involved in colon cancer and promote tumor progression and recurrence. LGR5, a marker for intestinal stem cells (ISCs), is also considered to serve as a marker for CCSCs. However, the precise function of LGR5 in CCSCs is unclear. In this study, we demonstrated that LGR5 was highly e...

journal_title：International journal of molecular medicine

authors： Chen X,Wei B,Han X,Zheng Z,Huang J,Liu J,Huang Y,Wei H

更新日期：2014-07-01 00:00:00

abstract：:The active fraction of the extract of Asiasari radix, the 60% methanol chromatographic fraction from the ethyl acetate layer (PPAR), was used to investigate the melanogenesis signal pathway in B16F10 melanoma cells. PPAR led to significantly decreased melanin synthesis and tyrosinase activity in a dose-dependent manne...

journal_title：International journal of molecular medicine

authors： Jang JY,Lee JH,Shin HK,Choi YH,Lee JD,Choi BT

更新日期：2010-02-01 00:00:00

abstract：:A long non‑coding RNA (lncRNA) called prostate cancer‑associated non‑coding RNA 1 (PRNCR1) serves crucial roles in the aggressive phenotypes of colorectal cancer and non‑small cell lung cancer. However, there is little research on the expression profile, clinical value and detailed functions of PRNCR1 in tongue squamo...

journal_title：International journal of molecular medicine

authors： Lin C,Zou Y,Li R,Liu D

更新日期：2020-07-01 00:00:00

abstract：:Recently, naringin (NAR; 4',5,7-trihydroxyflavanone-7-rhamnoglucoside) has been shown to have cardioprotective properties. However, the specific mechanisms underlying its cardioprotective effects remain unclear. In this study, we aimed to investigate the cardioprotective effects of NAR and the possible underlying mole...

journal_title：International journal of molecular medicine

authors： Huang H,Wu K,You Q,Huang R,Li S,Wu K

更新日期：2013-08-01 00:00:00

abstract：:Congenital bicuspid aortic valve (BAV) represents the most common type of cardiac birth defect affecting 0.4‑2% of the general population, and accounts for a markedly increased incidence of life‑threatening complications, including valvulopathy and aortopathy. Accumulating evidence has demonstrated the genetic basis o...

journal_title：International journal of molecular medicine

authors： Wang J,Abhinav P,Xu YJ,Li RG,Zhang M,Qiu XB,Di RM,Qiao Q,Li XM,Huang RT,Xue S,Yang YQ

更新日期：2019-04-01 00:00:00

abstract：:A large number of p53-transcribed proteins have been shown to mediate growth arrest and/or apoptosis in vitro, whereas their in vivo roles remain largely unclear. p53 is capable of initiating apoptosis without transcription of apoptosis inducer genes, although the underlying mechanism is unknown. p53 is present in the...

journal_title：International journal of molecular medicine

authors： Chang NS

更新日期：2002-01-01 00:00:00

abstract：:Porphyra yezoensis (P. yezoensis) is the most noteworthy red alga and is mainly consumed in China, Japan and Korea. In the present study, the effects of a P. yezoensis peptide (PY‑PE) on cell proliferation and the associated signaling pathways were examined in IEC‑6 rat intestinal epithelial cells. First, the MTS assa...

journal_title：International journal of molecular medicine

authors： Lee MK,Kim IH,Choi YH,Nam TJ

更新日期：2015-02-01 00:00:00

abstract：:Akt1/protein kinase Bα (Akt1/PKBα) is a downstream mediator of the insulin signaling system. In this study we explored mechanism(s) for its role in burn injury. Akt1/PKBα in liver extracts from mice with burn injury fed with (2H7)-L-Leu was immunoprecipitated and isolated with SDS-PAGE. Two tryptic peptides, one in th...

journal_title：International journal of molecular medicine

authors： Lu XM,Tompkins RG,Fischman AJ

更新日期：2012-03-01 00:00:00

abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...

journal_title：International journal of molecular medicine

authors： Dębiński M,Buszman PP,Milewski K,Wojakowski W,Jackiewicz W,Pająk J,Szurlej D,Fryc-Stanek J,Wiernek S,Jelonek M,Spurlock ME,Martin J,Bochenek A,Buszman PE

更新日期：2011-06-01 00:00:00

abstract：:We reviewed the effectiveness of commercial serological markers for the early detection of cancer and monitoring cancer patients. Parameters, such as specificity and variability of tumor markers were compared with a new approach for cancer detection which was recently developed in our laboratory. We demonstrate that t...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H

更新日期：2001-05-01 00:00:00

abstract：:Prostate cancer is among the most common tumors in industrialized nations. However, little is known about the molecular events underlying its development. In the present study we used suppressive subtraction hybridization (SSH) in combination with laser-assisted microdissection in order to compare gene expression betw...

journal_title：International journal of molecular medicine

authors： Ko Y,Hahn T,Lu H,Ma ZL,Chen J,Rothe M,Florin A,Fronhoffs S,Albers P,Sachinidis A,Vetter H,Kaminski A,Behrens P,Wellmann A,Wernert N

更新日期：2005-02-01 00:00:00

abstract：:The prevalence of psoriasis is increasing, and poses a serious risk to human health and quality of life. Psoriasis, a chronic immune‑mediated skin disease with epidermal hyperkeratosis and parakeratosis, is associated with numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via...

journal_title：International journal of molecular medicine

authors： Fan X,Yan K,Meng Q,Sun R,Yang X,Yuan D,Li F,Deng H

更新日期：2019-07-01 00:00:00

abstract：:Nail-Patella syndrome, or osteo-onychodysplasia, is an autosomal dominant disorder characterized by nail dysplasia, absent or hypoplastic patellae, iliac horns and nephropathy. Previous studies have demonstrated linkage of the Nail-Patella locus with polymorphic markers on human chromosome 9q34. Recently, point mutati...

journal_title：International journal of molecular medicine

authors： Seri M,Melchionda S,Dreyer S,Marini M,Carella M,Cusano R,Piemontese MR,Caroli F,Silengo M,Zelante L,Romeo G,Ravazzolo R,Gasparini P,Lee B

更新日期：1999-09-01 00:00:00

abstract：:Evidence has been recently provided that beacon, an ubiquitin-like protein overexpressed in the hypothalamus of Israeli sand rat, is also expressed in several endocrine glands of the Wistar rat, including adrenal cortex. Moreover, it has been shown that the in vivo administration of beacon[47-73] (hereinafter, beacon)...

journal_title：International journal of molecular medicine

authors： Ziolkowska A,Carraro G,Rebuffat P,Spinazzi R,Nussdorfer GG,Rucinski M,Malendowicz LK

更新日期：2004-09-01 00:00:00

abstract：:Promoter methylation‑associated silencing of cancer‑associated microRNAs (miRNAs) is a common epigenetic mechanism during tumorigenesis in various types of human cancer. However, this has not been comprehensively examined in endometrial carcinoma (EC). In the present study, an miRNA microarray consisting of 1,347 comm...

journal_title：International journal of molecular medicine

authors： Ni J,Liang S,Shan B,Tian W,Wang H,Ren Y

更新日期：2020-06-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:Kelch‑like ECH‑associated protein 1 (Keap1)/nuclear factor erythroid 2‑related factor 2 (Nrf2) signaling has a protective effect on normal cells. A number of previous studies demonstrated that Keap1/Nrf2 signaling is associated with drug resistance in numerous tumors. The aim of the present study was to investigate th...

journal_title：International journal of molecular medicine

authors： Huang H,Wu Y,Fu W,Wang X,Zhou L,Xu X,Huang F,Wu Y

更新日期：2019-05-01 00:00:00

abstract：:Second generation n3-PUFA-depleted rats represent a good animal model of metabolic syndrome as they display several features of the disease such as liver steatosis, visceral obesity and insulin resistance. The goal of our study was to investigate the influence of n3-PUFA deficiency on hepatic glycerol metabolism. Aqua...

journal_title：International journal of molecular medicine

authors： Portois L,Zhang Y,Ladrière L,Perret J,Louchami K,Gaspard N,Hupkens E,Bolaky N,Delforge V,Beauwens R,Malaisse WJ,Sener A,Carpentier YA,Delporte C

更新日期：2012-06-01 00:00:00

abstract：:The increased proliferation and decreased apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the main causes of hypoxic pulmonary hypertension. In this study, we investigated the role of troglitazone [peroxisome proliferator-activated receptor γ (PPARγ) agonist] in the regulation of phosphatase and tensin ...

journal_title：International journal of molecular medicine

authors： Pi WF,Guo XJ,Su LP,Xu WG

更新日期：2013-11-01 00:00:00

abstract：:Human skin fibroblasts may be the target cells for estrogens. The aim of present study was to confirm the presence of both isoforms of estrogen receptors (ER) in these cells. Experiments were carried out in primary cultures of human skin fibroblasts. ER-alpha and ER-beta mRNAs were measured by quantitative assays base...

journal_title：International journal of molecular medicine

authors： Haczynski J,Tarkowski R,Jarzabek K,Slomczynska M,Wolczynski S,Magoffin DA,Jakowicki JA,Jakimiuk AJ

更新日期：2002-08-01 00:00:00

abstract：:S100A4, one of the tandemly arranged S100 genes at chromosome 1q21, has been suggested to play a functional role in cell motility and invasiveness of tumor cell growth. We investigated the expression of S100A4 and the in vitro invasiveness of 4 human bile duct adenocarcinoma cell lines by the Matrigel assay. S100A4 wa...

journal_title：International journal of molecular medicine

authors： Katayama N,Murao S,Ajiki T,Kitazawa S,Onoyama H,Kuroda Y,Maeda S

更新日期：2000-11-01 00:00:00

abstract：:Arl4D is a developmentally-regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/Arl) family of Ras-related GTPases. Although Arl4 protein is reported to be expressed in adipose tissue, the function of Arl4D is unknown. To investigate the potential role of Arl4D in adipogenesis, we examined Arl4D expre...

journal_title：International journal of molecular medicine

authors： Yu J,Ka SO,Kwon KB,Lee SM,Park JW,Park BH

更新日期：2011-11-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is recognized as a main regulator of energy homeostasis. Osteocalcin (OC), which is produced specifically by mature osteoblasts, is stored in bone matrix, strongly binds to hydroxyapatite and is released into the circulation, has been recognized as a marker of bone metabolism. It ha...

journal_title：International journal of molecular medicine

authors： Kondo A,Otsuka T,Kato K,Matsushima-Nishiwaki R,Kuroyanagi G,Mizutani J,Tokuda H,Kozawa O

更新日期：2013-06-01 00:00:00

abstract：:Tuberculous meningitis (TBM) is a serious complication of tuberculosis that affects the central nervous system. As TBM may result in permanent sequelae and death, rapid, accurate diagnostic tests using novel biomarkers are required for the early diagnosis and treatment of TBM. A quantitative proteomic study was theref...

journal_title：International journal of molecular medicine

authors： Yang Y,Mu J,Chen G,Zhan Y,Zhong J,Wei Y,Cheng K,Qin B,You H,Xie P

更新日期：2015-05-01 00:00:00

abstract：:The introduction of bortezomib has resulted in a paradigm shift in the treatment of multiple myeloma (MM) and has contributed to the improved survival of patients with MM. Inevitably, resistance to therapy develops, and thus the clinical efficacy of bortezomib is hampered by drug resistance. The oncogene B-cell‑specif...

journal_title：International journal of molecular medicine

authors： Wu SQ,Xu ZZ,Niu WY,Huang HB,Zhan R

更新日期：2014-08-01 00:00:00

abstract：:An early insulin regimen ameliorates glucotoxicity but also lipotoxicity in type 2 diabetes; however, the underlying mechanism remains elusive. In the present study, we investigated the role of mitochondria in lipid regulation following early insulin administration in insulin-resistant skeletal muscle cells. Male C57B...

journal_title：International journal of molecular medicine

authors： Tang W,Tang S,Wang H,Ge Z,Zhu D,Bi Y

更新日期：2017-12-01 00:00:00

abstract：:Exposure to solar ultraviolet B (UV-B) is a known causative factor for many skin complications such as wrinkles, black spots, shedding and inflammation. Within the wavelengths 280‑320 nm, UV-B can penetrate to the epidermal level. This investigation aimed to test whether extracts from the tropical abalone [Haliotis as...

journal_title：International journal of molecular medicine

authors： Kuanpradit C,Jaisin Y,Jungudomjaroen S,Akter Mitu S,Puttikamonkul S,Sobhon P,Cummins SF

更新日期：2017-05-01 00:00:00

abstract：:Fibrosarcoma is an aggressive and highly metastatic cancer of the connective tissue, for which effective therapeutic methods are limited. Recently, there has been a renewed interest in small molecular compounds from natural products in the treatment of cancer. In the present study, we investigated the compound, scutel...

journal_title：International journal of molecular medicine

authors： Shi X,Chen G,Liu X,Qiu Y,Yang S,Zhang Y,Fang X,Zhang C,Liu X

更新日期：2015-01-01 00:00:00

abstract：:We describe a novel spontaneous autosomal recessive mutation, cervelet-4 (crv4), which arose in a BALB/c strain. Mice homozygous for the mutation exhibit principally a reduced body size, a congenital neurological phenotype characterized by ataxic gait and intention tremor, with no gross anomalies observed in brain or ...

journal_title：International journal of molecular medicine

authors： Conti V,Aghaie A,Cilli M,Martin N,Caridi G,Musante L,Candiano G,Castagna M,Fairen A,Ravazzolo R,Guenet JL,Puliti A

更新日期：2006-10-01 00:00:00