当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE期刊下所有文献 > Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: a role of these biomarkers in the pathogenesis of scleroderma and periodontal disease.

Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: a role of these biomarkers in the pathogenesis of scleroderma and periodontal disease.

Abstract：

:Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of the immune pathology of periodontal disease. Transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) represent a family of polypeptide proteins involved in the inflammation and regulation of immune responses, especially in rheumatic disease. The relationship between these growth factors and periodontitis has resulted in a new field of osteoimmunology and provides a context for better understanding the pathogenesis of periodontal disease. Therefore, the aim of this study was to compare the protein expression profile of these inflammatory mediators in 90 patients divided in three groups: healthy control, chronic periodontitis and in rheumatic disease, scleroderma. The findings presented here highlight that biomarkers, such as TGF-β1 and VEGF, play a key role in the evolution of the immune response, which in turn influences the outcome of disease establishment.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Matarese G,Isola G,Anastasi GP,Favaloro A,Milardi D,Vermiglio G,Vita G,Cordasco G,Cutroneo G

doi

10.3892/ijmm.2012.1024

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

502-8

issue

3

eissn

1107-3756

issn

1791-244X

journal_volume

30

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE文献大全
  • The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma.

    abstract：:We determined whether the expression of VEGF-A and -C and their receptors, Flt-1 and Flt-4, are associated with primary tumor size, regional lymph node metastasis, distant metastasis and prognosis in patients with tongue carcinoma. The expression of VEGF-A and -C, and their receptors, Flt-1 and Flt-4, in biopsy specim...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Tanigaki Y,Nagashima Y,Kitamura Y,Matsuda H,Mikami Y,Tsukuda M

    更新日期：2004-09-01 00:00:00

  • Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer.

    abstract：:Aberrant glycosylation of cell surface glycoprotein due to specific alterations of glycosyltransferase activity is usually associated with invasion and metastasis of cancer, particularly of gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which cata...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2012.1130

    authors： Hua D,Shen L,Xu L,Jiang Z,Zhou Y,Yue A,Zou S,Cheng Z,Wu S

    更新日期：2012-12-01 00:00:00

  • Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis.

    abstract：:Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Specific microRNAs (miRNAs/miR) have been described to be associated with DS, altho...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4158

    authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

    更新日期：2019-06-01 00:00:00

  • A novel NOTCH3 mutation identified in patients with oral cancer by whole exome sequencing.

    abstract：:Oral cancer is a serious disease caused by environmental factors and/or susceptible genes. In the present study, in order to identify useful genetic biomarkers for cancer prediction and prevention, and for personalized treatment, we detected somatic mutations in 5 pairs of oral cancer tissues and blood samples using w...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.2965

    authors： Yi Y,Tian Z,Ju H,Ren G,Hu J

    更新日期：2017-06-01 00:00:00

  • Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.

    abstract：:The mechanistic significance of oxidative stress to fibrogenesis in the methionine and choline-deficient (MCD) diet-induced model of steatohepatitis was evaluated by antioxidant intervention, using either vitamin E or L-2-oxothiazolidine-4-carboxylate (OTC), a cysteine precursor that promotes glutathione synthesis. Si...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000220

    authors： Phung N,Pera N,Farrell G,Leclercq I,Hou JY,George J

    更新日期：2009-08-01 00:00:00

  • Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis.

    abstract：:Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. Howe...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4772

    authors： Xiao J,Wang R,Zhou W,Cai X,Ye Z

    更新日期：2021-01-01 00:00:00

  • Roles of SEA-expressing Staphylococcus aureus, isolated from an atopic dermatitis patient, on expressions of human beta-defensin-2 and inflammatory cytokines in HaCaT cells.

    abstract：:Atopic dermatitis (AD) shows an increased susceptibility to Staphylococcus aureus infection partly due to decreased expression of human beta-defensin-2 (HBD-2). Interestingly, it was reported that the nasal carrier S. aureus down-regulates the expression of HBD-2 and -3, thereby the carrier strains of S. aureus retain...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000135

    authors： Cho JW,Cho SY,Lee KS

    更新日期：2009-03-01 00:00:00

  • Connective tissue growth factor induces osteogenic differentiation of vascular smooth muscle cells through ERK signaling.

    abstract：:Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of atherosclerosis by promoting vascular smooth muscle cell (VSMC) growth, migration, apoptosis, adhesion and the secretion of matrix components. The osteogenic differentiation of VSMCs is essential in the development of vascular calcif...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1398

    authors： Huang J,Huang H,Wu M,Li J,Xie H,Zhou H,Liao E,Peng Y

    更新日期：2013-08-01 00:00:00

  • Influence of stannous chloride on the adhesive properties of Corynebacterium diphtheriae strains.

    abstract：:Stannous ion, as a chloride salt, influenced on the survival and adhesive properties of two toxigenic Corynebacterium diphtheriae of the sucrose-fermenting (241 strain) and non-sucrose-fermenting (CDC-E8392 strain) biotypes. Differences in survival fractions suggested differences in susceptibility of strains to bacter...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Silva De Souza SM,Hirata R Jr,Moreira LO,Gomes ML,Braga De Andrade AF,Bernardo-Filho M,Mattos-Guaraldi AL

    更新日期：2003-10-01 00:00:00

  • Ouabain chronic infusion enhances the growth and steroidogenic capacity of rat adrenal zona glomerulosa: the possible involvement of the endothelin system.

    abstract：:Ouabain, an inhibitor of the Na+/K+-ATPase, has been reported to affect the secretory activity of the adrenal cortex, and especially of zona glomerulosa (ZG). However, conflicting results were obtained, depending on the experimental condition used since ouabain appears to interact with angiotensin-II (Ang-II) and its ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Neri G,De Toni R,Tortorella C,Rebuffat P,Bova S,Cargnelli G,Petrelli L,Spinazzi R,Nussdorfer GG

    更新日期：2006-08-01 00:00:00

  • Triticum aestivum sprout-derived polysaccharide exerts hepatoprotective effects against ethanol-induced liver damage by enhancing the antioxidant system in mice.

    abstract：:Triticum aestivum sprout-derived polysaccharide (TASP) has anti-diabetic properties, but no information is available in regards to its protective effect against ethanol-induced hepatic injury. This study aimed to investigate the mechanism behind the protective role of TASP against ethanol-induced liver injury in vivo....

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3095

    authors： Nepali S,Ki HH,Lee JH,Cha JY,Lee YM,Kim DK

    更新日期：2017-10-01 00:00:00

  • Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway.

    abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, is widely used as an anticancer drug. Recently, TSA has been shown to exert a protective effect on ischemia/reperfusion (I/R) injury; however, the underlying mechanisms remain unclear. Forkhead box O3a (FoxO3a), a unique FoxO family member, has been shown to atten...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3101

    authors： Guo Y,Li Z,Shi C,Li J,Yao M,Chen X

    更新日期：2017-10-01 00:00:00

  • Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: the 'Power Rehabilitation' program.

    abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

    更新日期：2009-01-01 00:00:00

  • Involvement of the nuclear factor-κB signaling pathway in the regulation of CXC chemokine receptor-4 expression in neuroblastoma cells induced by tumor necrosis factor-α.

    abstract：:Metastasis is a hallmark of malignant neuroblastoma and is the main reason for therapeutic failure and recurrence of the tumor. The CXC chemokine receptor-4 (CXCR4), a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1α (SDF-1α), is expressed in various types of tumor. This receptor mediat...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.2032

    authors： Zhi Y,Lu H,Duan Y,Sun W,Guan G,Dong Q,Yang C

    更新日期：2015-02-01 00:00:00

  • Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck.

    abstract：:The opioid growth factor (OGF) is a constitutively expressed negative growth regulator whose action is mediated by the OGF receptor (OGFr). The OGF-OGFr axis tonically regulates the growth of human squamous cell carcinoma of the head and neck (SCCHN). To examine the repercussions of amplifying OGFr in SCCHN, construct...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： McLaughlin PJ,Verderame MF,Hankins JL,Zagon IS

    更新日期：2007-03-01 00:00:00

  • Leiomyoma phosphoproteins involved in inhibition of oxidative stress and synthesis of reactive oxygen species.

    abstract：:Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4377

    authors： Ura B,Monasta L,Arrigoni G,Licastro D,Di Lorenzo G,Romano F,Gaita B,Scrimin F,Ricci G

    更新日期：2019-12-01 00:00:00

  • Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease.

    abstract：:Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a fa...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Peros E,Geroldi D,D'Angelo A,Falcone C,Montagna L,Carabela M,Emanuele E

    更新日期：2004-02-01 00:00:00

  • Induction of ROS‑mediated cell death and activation of the JNK pathway by a sulfonamide derivative.

    abstract：:The emergence of colorectal cancer in developed nations can be attributed to dietary habits, smoking, a sedentary lifestyle and obesity. Several treatment regimens are available for primary and metastatic colorectal cancer; however, these treatment options have had limited impact on cure and disease‑free survival, and...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4284

    authors： Ahmad R,Vaali-Mohammed MA,Elwatidy M,Al-Obeed O,Al-Khayal K,Eldehna WM,Abdel-Aziz HA,Alafeefy A,Abdulla M

    更新日期：2019-10-01 00:00:00

  • Involvement of NF-kappaB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma.

    abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

    更新日期：2005-04-01 00:00:00

  • MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma.

    abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3124

    authors： Cheng ZX,Yin WB,Wang ZY

    更新日期：2017-11-01 00:00:00

  • Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions.

    abstract：:The increased proliferation and decreased apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the main causes of hypoxic pulmonary hypertension. In this study, we investigated the role of troglitazone [peroxisome proliferator-activated receptor γ (PPARγ) agonist] in the regulation of phosphatase and tensin ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1487

    authors： Pi WF,Guo XJ,Su LP,Xu WG

    更新日期：2013-11-01 00:00:00

  • Plasminogen activator inhibitor-1 in kidney pathology (Review).

    abstract：:Plasminogen activator inhibitor type-1 (PAI-1) inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which convert plasminogen to plasmin, a strong proteolytic enzyme. Thus, PAI-1 is a primary and negative regulator of plasmin-driven proteolysis. In ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：10.3892/ijmm.2013.1234

    authors： Małgorzewicz S,Skrzypczak-Jankun E,Jankun J

    更新日期：2013-03-01 00:00:00

  • Bradykinin-induced inhibition of cell proliferation and tyrosine kinase activity in rat mesangial cells.

    abstract：:The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation s...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.5.1.85

    authors： Alric C,Pecher C,Schanstra JP,Bascands JL,Girolami JP

    更新日期：2000-01-01 00:00:00

  • Artemisinin inhibits monocyte adhesion to HUVECs through the NF-κB and MAPK pathways in vitro.

    abstract：:The adhesion of monocytes to human umbilical vein endothelial cells (HUVECs) plays a crucial role in the initiation of atherosclerosis. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are two important molecules involved in the adhesion of monocytes to HUVECs. Previous studies...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2016.2579

    authors： Wang Y,Cao J,Fan Y,Xie Y,Xu Z,Yin Z,Gao L,Wang C

    更新日期：2016-06-01 00:00:00

  • Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement.

    abstract：:Psoriasis is an inflammatory skin disease with or without joint involvement. In this disease, the thickened epidermis and impaired barrier are associated with altered calcium gradients. Calcium and vitamin D are known to play important roles in keratinocyte differentiation and bone metabolism. Intracellular calcium is...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2016.2718

    authors： Cubillos S,Norgauer J

    更新日期：2016-10-01 00:00:00

  • Effects of apatite particle size in two apatite/collagen composites on the osteogenic differentiation profile of osteoblastic cells.

    abstract：:The development of new osteoconductive bone substitute materials is expected in medicine. In this study, we attempted to produce new hydroxylapatite (HAP)/collagen (Col) composites using two HAP particles of different sizes and porcine type I collagen. The two HAP particles were either nano-sized (40 nm in average dia...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1516

    authors： Hatakeyama W,Taira M,Chosa N,Kihara H,Ishisaki A,Kondo H

    更新日期：2013-12-01 00:00:00

  • Cysteine induces longitudinal bone growth in mice by upregulating IGF-I.

    abstract：:Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bon...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2257

    authors： Moon PD,Kim MH,Oh HA,Nam SY,Han NR,Jeong HJ,Kim HM

    更新日期：2015-08-01 00:00:00

  • Nardostachys chinensis induces the differentiation of human promyelocytic leukemic cells through the activation of the protein kinase C-dependent extracellular signal-regulated kinase signaling pathway.

    abstract：:The underground parts of Nardostachys chinensis (N. chinensis), which belongs the genus Valerianaceae, have been used as sedative and analgesic agents in traditional Korean medicine for centuries. The mitogen-activated protein kinases (MAPKs) are serine/threonine kinases involved in the regulation of various cellular ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2013.1596

    authors： Ju SM,Kang JG,Pae HO,Lee GS,Kim WS,Lyu YS,Jeon BH

    更新日期：2014-03-01 00:00:00

  • A novel component of the ubiquitin pathway, ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer.

    abstract：:Prostate cancer is among the most common tumors in industrialized nations. However, little is known about the molecular events underlying its development. In the present study we used suppressive subtraction hybridization (SSH) in combination with laser-assisted microdissection in order to compare gene expression betw...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Ko Y,Hahn T,Lu H,Ma ZL,Chen J,Rothe M,Florin A,Fronhoffs S,Albers P,Sachinidis A,Vetter H,Kaminski A,Behrens P,Wellmann A,Wernert N

    更新日期：2005-02-01 00:00:00

  • Effects of oxygen concentrations on human fibroblasts treated with Fe(3+)-NTA.

    abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

    更新日期：2001-03-01 00:00:00