The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma.

abstract：:The aim of the present study was to investigate the biological activity of 20 essential oils (EOs) derived from herbal plants and citrus fruits. The in vitro anti-allergic and anti-inflammatory activities of these oils were investigated, and the EO which was found to have the strongest activity of the 20 EOs examined,...

journal_title：International journal of molecular medicine

authors： Mitoshi M,Kuriyama I,Nakayama H,Miyazato H,Sugimoto K,Kobayashi Y,Jippo T,Kuramochi K,Yoshida H,Mizushina Y

更新日期：2014-06-01 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63...

journal_title：International journal of molecular medicine

authors： Hara T,Kijima H,Yamamoto S,Kenmochi T,Kise Y,Tanaka H,Chino O,Shimada H,Takazawa K,Tanaka M,Inokuchi S,Makuuchi H

更新日期：2004-08-01 00:00:00

abstract：:p107 protein, a member of the retinoblastoma family protein, suppresses growth promotion in cancer cells. We have already reported evidence that calpain, a calcium dependent protease is involved in the cleavage of p107 protein. We show here that p107 protein can also be a substrate for ubiquitination. A negative growt...

journal_title：International journal of molecular medicine

authors： Jang JS,Choi YH

更新日期：1999-11-01 00:00:00

abstract：:Burn trauma is a clinical condition accompanied by muscle wasting that severely impedes rehabilitation in burn survivors. Mitochondrial uncoupling protein 3 (UCP3) is uniformly expressed in myoskeletal mitochondria and its expression has been found to increase in other clinical syndromes that, like burn trauma, are as...

journal_title：International journal of molecular medicine

authors： Zhang Q,Cao H,Astrakas LG,Mintzopoulos D,Mindrinos MN,Schulz J 3rd,Tompkins RG,Rahme LG,Tzika AA

更新日期：2006-12-01 00:00:00

abstract：:The aim of the present study was to investigate whether ciliary neurotrophic factor (CNTF) plays its neuroprotective role following hypoxic injury through the activation of signal transducer and activator of transcription 3 (STAT3) signaling. Firstly, to determine whether CNTF exerts its effects via STAT3 following hy...

journal_title：International journal of molecular medicine

authors： Gu YL,Gao GQ,Ma N,Ye LL,Zhang LW,Gao X,Zhang ZB

更新日期：2016-12-01 00:00:00

abstract：:The transcription factor, forkhead box protein M1 (FoxM1), and the tyrosine kinase receptor, human epidermal growth factor receptor-2 (Her-2), are aberrantly expressed in a number of human malignancies, and are closely associated with the development of cancer. However, their regulatory mechanisms and their involvemen...

journal_title：International journal of molecular medicine

authors： Qi W,Li X,Zhang Y,Yao R,Qiu W,Tang D,Liang J

更新日期：2014-06-01 00:00:00

abstract：:Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-...

journal_title：International journal of molecular medicine

authors： Leonardi GC,Candido S,Carbone M,Colaianni V,Garozzo SF,Cinà D,Libra M

更新日期：2012-11-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common, fatal and frequently recurrent disease. Changes in the activity of different coagulation factors serve as a pathophysiological basis for the recurrent risk of VTE. Systems biology approaches provide a better understanding of the pathological mechanisms responsible for recurren...

journal_title：International journal of molecular medicine

authors： Xie R,Li L,Chen L,Li W,Chen B,Jiang J,Huang H,Li Y,He Y,Lv J,He W

更新日期：2017-02-01 00:00:00

abstract：:DNA microarrays, which are among the most popular genomic tools, are widely applied in biology and medicine. Boutique arrays, which are small, spotted, dedicated microarrays, constitute an inexpensive alternative to whole-genome screening methods. The data extracted from each microarray-based experiment must be transf...

journal_title：International journal of molecular medicine

authors： Uszczyńska B,Zyprych-Walczak J,Handschuh L,Szabelska A,Kaźmierczak M,Woronowicz W,Kozłowski P,Sikorski MM,Komarnicki M,Siatkowski I,Figlerowicz M

更新日期：2013-09-01 00:00:00

abstract：:Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons. Nerve growth fact...

journal_title：International journal of molecular medicine

authors： Ohta M,Chosa N,Kyakumoto S,Yokota S,Okubo N,Nemoto A,Kamo M,Joh S,Satoh K,Ishisaki A

更新日期：2018-09-01 00:00:00

abstract：:Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. ...

journal_title：International journal of molecular medicine

authors： Xiao B,Han F,Shi YX

更新日期：2009-12-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent commonly used as a first‑line treatment for high‑grade glioblastoma. However, TMZ has short half‑life and frequently induces tumor resistance, which can limit its therapeutic efficiency. In the present study, it was hypothesized that combined treatment with TMZ and acteoside h...

journal_title：International journal of molecular medicine

authors： Hwang TW,Kim DH,Kim DB,Jang TW,Kim GH,Moon M,Yoon KA,Choi DE,Park JH,Kim JJ

更新日期：2019-03-01 00:00:00

abstract：:Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein and organelle d...

journal_title：International journal of molecular medicine

authors： Zhao X,Liu G,Shen H,Gao B,Li X,Fu J,Zhou J,Ji Q

更新日期：2015-03-01 00:00:00

abstract：:In our previous study, the proliferation rate of esophageal squamous cell carcinoma cell lines, which poorly expressed p21Waf1, was found to be regulated by p21Waf1 gene transfection using adenovirus vector. In the present study, in order to examine the effect of p21Waf1 gene therapy in esophageal cancer, we used gene...

journal_title：International journal of molecular medicine

authors： Tanaka Y,Fujii T,Yamana H,Kato S,Morimatsu M,Shirouzu K

更新日期：2004-10-01 00:00:00

abstract：:Hirschsprung disease (HSCR), or congenital intestinal aganglionosis, is a common hereditary disorder causing intestinal obstruction, thereby showing considerable phenotypic variation in conjunction with complex inheritance. Moreover, phenotypic assessment of the disease has been complicated since a subset of the obser...

journal_title：International journal of molecular medicine

authors： Pusch CM,Sasiadek MM,Blin N

更新日期：2002-10-01 00:00:00

abstract：:Down syndrome (DS) patients, after the fourth decade of life, display some neurophatological features of the Alzheimer's disease (AD). Several hypotheses suggested that apoE4 protein, an AD risk factor, might promote amyloid formation by stabilizing an aggregated conformation of the beta amyloid protein (Abeta). This ...

journal_title：International journal of molecular medicine

authors： Folin M,Baiguera S,Conconi MT,Pati T,Grandi C,Parnigotto PP,Nussdorfer GG

更新日期：2003-02-01 00:00:00

abstract：:The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), plays an important role in angiotension II (Ang II)-induced hypertensive renal injury associated with pro-inflammatory responses, tubular functional damage and cellular apoptosis. In this study, we report on the role of LOX-1 in Ang II-induced oxidat...

journal_title：International journal of molecular medicine

authors： Xu Y,Ruan S,Xie H,Lin J

更新日期：2010-11-01 00:00:00

abstract：:Human interleukin-15 (hIL15) exerts anticancer effects through the activities of lymphokine-activated killer (LAK) cells. However, its short half-life hinders its clinical application. Recombinant adeno-associated virus serotype 2 (rAAV2) is used for hIL15 gene transfer vectors, bec...

journal_title：International journal of molecular medicine

authors： Yiang GT,Chou PL,Tsai HF,Chen LA,Chang WJ,Yu YL,Wei CW

更新日期：2012-05-01 00:00:00

abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

journal_title：International journal of molecular medicine

authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

更新日期：2009-01-01 00:00:00

abstract：:Orientia tsutsugamushi (O. tsutsugamushi), the causative agent of scrub typhus, is an obligate intracellular pathogen. Recent studies have demonstrated the complete genome of O. tsutsugamushi. However, the route and detailed molecular mechanism for O. tsutsugamushi to get accessed into mammalian cells remains unclear....

journal_title：International journal of molecular medicine

authors： Lin CC,Chou CH,Lin TC,Yang MC,Cho CL,Chang CH,Yu HS,Lai CH,Chen LK,Hong YR

更新日期：2012-07-01 00:00:00

abstract：:After cessation of lactation, the mammary gland undergoes involution, regressing to a state resembling that of a virgin animal. This phase of mammary gland development is characterized by epithelial cell death and tissue remodeling. To understand molecular mechanisms of mammary gland involution, we identified involuti...

journal_title：International journal of molecular medicine

authors： Baik MG,Lee MJ,Choi YJ

更新日期：1998-07-01 00:00:00

abstract：:Celastrol, a natural biologically active compound isolated from Tripterygium wilfordii Hook F root extracts, has been shown to possess antitumor properties and therefore, is an interesting candidate for the development of novel chemotherapeutic cancer agents. In this study, we have demonstrated that Celastrol is a pot...

journal_title：International journal of molecular medicine

authors： Huang L,Zhang Z,Zhang S,Ren J,Zhang R,Zeng H,Li Q,Wu G

更新日期：2011-03-01 00:00:00

abstract：:Cutaneous melanoma is very aggressive and results in high mortality rates for cancer patients. Determining molecular targets is important for developing novel therapies for cutaneous melanoma. Cell division cycle associated 8 (CDCA8) is a putative oncogene that is upregulated in multiple types of cancer. The present s...

journal_title：International journal of molecular medicine

authors： Ci C,Tang B,Lyu D,Liu W,Qiang D,Ji X,Qiu X,Chen L,Ding W

更新日期：2019-01-01 00:00:00

abstract：:In the wide horizon of ophthalmologically rare diseases among retinitis pigmentosa forms, Stargardt disease has gradually assumed a significant role due to its heterogeneity. In the present study, we aimed to support one of two opposite hypotheses concerning the causative or protective role of heterozygous c.1268A>G m...

journal_title：International journal of molecular medicine

authors： D'Angelo R,Donato L,Venza I,Scimone C,Aragona P,Sidoti A

更新日期：2017-04-01 00:00:00

abstract：:One of the most aggressive human malignancies, anaplastic thyroid carcinoma (ATC), has an extremely poor prognosis that may be explained by its genomic instability. We hypothesized that the very rapid cell turnover observed in ATC might accelerate telomere shortening and chromosomal instability associated with tumor c...

journal_title：International journal of molecular medicine

authors： Kammori M,Onoda N,Nakamura K,Izumiyama N,Ogisawa K,Kurabayashi R,Ogawa T,Kaminishi M,Poon SS,Takubo K

更新日期：2006-07-01 00:00:00

abstract：:Bcl-2 family member proteins are differentially expressed in skin and in non-melanoma skin cancer (NMSC). To elucidate the contribution of bcl-2 and bax proteins to epidermal differentiation and skin carcinogenesis, we investigated keratinocyte proliferation, differentiation and tumourigenesis in bcl-2(-/-) and bax(-/...

journal_title：International journal of molecular medicine

authors： Cho SH,Delehedde M,Rodriguez-Villanueva J,Brisbay S,McDonnell TJ

更新日期：2001-03-01 00:00:00

abstract：:The molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein (RGPR) was investigated using rat, mouse and human liver cDNA library with a yeast one-hybrid system and a rapid amplification of cDNA ends (RACE) method. The clone coding an unknown protein was isolated...

journal_title：International journal of molecular medicine

authors： Misawa H,Yamaguchi M

更新日期：2001-11-01 00:00:00

abstract：:Biologic abnormalities in vascular smooth muscle cells (VSMC) may perform a crucial role in the pathogenesis of diabetic vascular disease. The principal aim of this study was to determine the effects of zipper-interacting protein kinase (ZIPK) on human aortic smooth muscle cells (HASMCs) stimulated by high glucose (HG...

journal_title：International journal of molecular medicine

authors： Ye Z,Wu W,He M,Leong M,Hu R,Li Y,Zhang S

更新日期：2014-05-01 00:00:00

abstract：:Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), which was originally isolated from rat stomach. Ghrelin and GHS-R are also expressed in several peripheral tissues, including adrenal glands, and this prompted us to study ghrelin expression and ghrelin-binding site localization in th...

journal_title：International journal of molecular medicine

authors： Tortorella C,Macchi C,Spinazzi R,Malendowicz LK,Trejter M,Nussdorfer GG

更新日期：2003-08-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00