Characterization of immortalized human chondrocytes originated from osteoarthritis cartilage.

abstract：:The human immunodeficiency virus type 1 (HIV-1) epidemic in Brazil is spreading to small municipalities as well as the innermost parts of the country and scarce information has been reported on the frequency of HIV-1 resistance-associated mutations in these areas. To determine the frequency and diversity of the HIV-1 ...

journal_title：International journal of molecular medicine

authors： Figueiredo Saad F,Kaminami Morimoto H,Wiechmann SL,Bonametti AM,Ueda LT,Matsuo T,Reiche EM

更新日期：2010-10-01 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesen...

journal_title：International journal of molecular medicine

authors： Liu Q,Zhang X,Jiao Y,Liu X,Wang Y,Li SL,Zhang W,Chen FM,Ding Y,Jiang C,Jin Z

更新日期：2018-02-01 00:00:00

abstract：:Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine ...

journal_title：International journal of molecular medicine

authors： Seya T,Nomura M,Murakami Y,Begum NA,Matsumoto M,Nagasawa S

更新日期：1998-05-01 00:00:00

abstract：:The current study aimed to clarify the role of nucleolin in the phenotypic transformation of vascular smooth muscle cells (VSMCs) and to preliminarily explore its underlying mechanism. The spatial and temporal expression patterns of nucleolin, and the effects of angiotensin II (Ang II) on the expression of VSMC phenot...

journal_title：International journal of molecular medicine

authors： Fang L,Zhang PF,Wang KK,Xiao ZL,Yang M,Yu ZX

更新日期：2019-04-01 00:00:00

abstract：:The emergence of colorectal cancer in developed nations can be attributed to dietary habits, smoking, a sedentary lifestyle and obesity. Several treatment regimens are available for primary and metastatic colorectal cancer; however, these treatment options have had limited impact on cure and disease‑free survival, and...

journal_title：International journal of molecular medicine

authors： Ahmad R,Vaali-Mohammed MA,Elwatidy M,Al-Obeed O,Al-Khayal K,Eldehna WM,Abdel-Aziz HA,Alafeefy A,Abdulla M

更新日期：2019-10-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is known to be an important regulator for feeding and energy balance. MCH was recently reported to stimulate water intake independent of food intake. The purpose of the present study is to examine the dipsogenic response of MCH with special emphasis on sweetened beverages, the prefe...

journal_title：International journal of molecular medicine

authors： Sakamaki R,Uemoto M,Inui A,Asakawa A,Ueno N,Ishibashi C,Hirono S,Yukioka H,Kato A,Shinfuku N,Kasuga M,Katsuura G

更新日期：2005-06-01 00:00:00

abstract：:In hypercholesterolemia increased lipid and lipoprotein peroxidation occurs. The renin-angiotensin system plays an important role in atherogenesis. Angiotensin II induces smooth muscle cells proliferation and stimulates oxidation of LDL particles and foam cell accumulation. Inhibition of ang II production leads to dec...

journal_title：International journal of molecular medicine

authors： Wojakowski W,Gminski J,Siemianowicz K,Goss M,Machalski M

更新日期：2000-11-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of bone morphogenetic protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration and epithelial‑mesenchymal transition (EMT) of cervical cancer HeLa cells and the possible mechanism involved. Immunohistochemistry was us...

journal_title：International journal of molecular medicine

authors： Sun R,Guan H,Liu W,Liang J,Wang F,Li C

更新日期：2020-05-01 00:00:00

abstract：:The complement system participates in the local immune system of the lung. In this study, we investigated the secretion of complement components of the alternative pathway (C3 and factor B) in the alveolar type II epithelial cell line A549. The levels of C3 and factor B protein in the culture medium were determined by...

journal_title：International journal of molecular medicine

authors： Zhao YX,Andoh A,Shimada M,Takaya H,Hata K,Fujiyama Y,Bamda T

更新日期：2000-04-01 00:00:00

abstract：:After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and Allison Piovesan, are located at DIMES at the University of Florence (fourth af...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-08-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. Three different PPARs; alpha (PPARA), gamma (PPARG) and delta (PPARD) have been characterized and they are distinguished from each other by tissue distribution and cell...

journal_title：International journal of molecular medicine

authors： Skogsberg J,Kannisto K,Roshani L,Gagne E,Hamsten A,Larsson C,Ehrenborg E

更新日期：2000-07-01 00:00:00

abstract：:The mechanisms through which mechanical ventilation causes non-infectious inflammatory diseases and lung injury are poorly understood. Animals models of this type of injury suggest that it involves signaling mediated by Toll‑like receptor (TLR)4 and 9. In this study, in order to gain further insight into the involveme...

journal_title：International journal of molecular medicine

authors： Huang C,Pan L,Lin F,Dai H,Fu R

更新日期：2017-03-01 00:00:00

abstract：:In the present study, the effects of erlotinib on mouse tear function and corneal epithelial tissue structure were investigated. Throughout the 3 weeks of treatment, no notable differences were observed in the body, eye or lacrimal gland weights of the control and experimental mice. However, in the experimental group,...

journal_title：International journal of molecular medicine

authors： Yang QC,Bao J,Li C,Tan G,Wu AH,Ye L,Ye LH,Zhou Q,Shao Y

更新日期：2018-03-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease in the vessel, and inflammatory cytokines play an important role in the inflammatory process of atherosclerosis. A high level of free fatty acids (FFAs) produced in lipid metabolism disorders are known to participate in the formation of atherosclerosis through multiple...

journal_title：International journal of molecular medicine

authors： Wu D,Liu J,Pang X,Wang S,Zhao J,Zhang X,Feng L

更新日期：2014-12-01 00:00:00

abstract：:Evidence has indicated that mesenchymal stem cells (MSCs) harvested with the Reamer/Irrigator/Aspirator (RIA) procedure exhibited an improved osteogenic differentiation capability compared with MSCs obtained by bone marrow aspiration from the iliac crest. In the present study, we hypothesized that the harvest procedur...

journal_title：International journal of molecular medicine

authors： Henrich D,Nau C,Kraft SB,Zollfrank M,Kontradowitz K,Oppermann E,Schultheiss J,Meier S,Frank J,Marzi I,Seebach C

更新日期：2016-04-01 00:00:00

abstract：:Breast cancer accounts for 30-40% of all deaths from cancers in females. In an effort to identify tumor associated antigens that may be useful for immunotherapy, we utilized serological analysis of recombinant cDNA expression libraries (SEREX) technique to identify breast cancer-associated antigens. SEREX screening of...

journal_title：International journal of molecular medicine

authors： Qian F,Odunsi K,Blatt LM,Scanlan MJ,Mannan M,Shah N,Montgomery J,Haddad F,Taylor M

更新日期：2005-01-01 00:00:00

abstract：:Overconsumption of fats and sugars is a major cause of development of non‑alcoholic fatty liver disease (NAFLD). The main objectives of the present study were to explore the pathways sustaining the interfering metabolic effects of excess fructose and fatty acids in hepatocytes, and to clarify the mechanisms through wh...

journal_title：International journal of molecular medicine

authors： Grasselli E,Baldini F,Vecchione G,Oliveira PJ,Sardão VA,Voci A,Portincasa P,Vergani L

更新日期：2019-08-01 00:00:00

abstract：:Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the activation of microglia, however, the underlying mechanisms remain elusive. Thus, t...

journal_title：International journal of molecular medicine

authors： Huang W,Bai S,Zuo X,Tang W,Chen P,Chen X,Wang G,Wang H,Xie P

更新日期：2018-06-01 00:00:00

abstract：:Cervical cancer is one of the most common types of female malignant tumor. It is well established that radiotherapy (RT) is the first‑line treatment of cervical cancer; however, radioresistance is a substantial obstacle to cervical cancer RT. At present, the mechanism underlying radioresistance remains unclear. Emergi...

journal_title：International journal of molecular medicine

authors： Fan L,Huang C,Li J,Gao T,Lin Z,Yao T

更新日期：2018-10-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is one of the most important causes of drug-resistant epilepsy in paediatric patients, particularly in those below the age of 3. Even though over 40 years have passed since the first description of the entity by Taylor, the exact mechanisms causing these cortical abnormalities remain une...

journal_title：International journal of molecular medicine

authors： Siedlecka M,Grajkowska W,Galus R,Dembowska-Bagińska B,Jóźwiak J

更新日期：2016-11-01 00:00:00

abstract：:Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

journal_title：International journal of molecular medicine

authors： Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

更新日期：2010-07-01 00:00:00

abstract：:Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of i...

journal_title：International journal of molecular medicine

authors： Cervello M,Giannitrapani L,La Rosa M,Notarbartolo M,Labbozzetta M,Poma P,Montalto G,D'Alessandro N

更新日期：2004-05-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are a cell population mobilized from bone marrow into the peripheral circulation and recruited into sites of vessel injury to participate in blood vessel formation in both physiological and pathological conditions. Due to the lack of unique surfac...

journal_title：International journal of molecular medicine

authors： Li DW,Liu ZQ,Wei J,Liu Y,Hu LS

更新日期：2012-11-01 00:00:00

abstract：:We examined whether generation of H2O2 is a critical event for the apoptotic pathway upstream of mitochondrial involvement and caspase-3 protease activation. Perylquinone photosensitizers such as Hypocrellin A (HA), Hypocrellin B (HB) and Hypericin (HY) induced activation of caspase-3 and apoptosis upon photoactivatio...

journal_title：International journal of molecular medicine

authors： Ali SM,Chee SK,Yuen GY,Olivo M

更新日期：2002-05-01 00:00:00

abstract：:Gene therapy is becoming an important treatment modality against various diseases including cancer, genetic disorders, infectious diseases and inflammatory diseases. For achieving successful gene therapy, it is extremely important to control the expression of a transduced therapeutic gene. However, there have been few...

journal_title：International journal of molecular medicine

authors： Akahane M,Kuriyama S,Ohgushi H,Akahane T,Kawamura K,Watanabe S,Funakoshi F,Yoshiji H,Ikenaka K,Takakura Y

更新日期：2002-07-01 00:00:00

abstract：:Biologically well-tolerated materials are at the core of intense research. In this study, we report both the intrinsic features of formic acid (FA)-crosslinked three-dimensional (3D) nonwoven scaffolds consisting of sericin-deprived, Bombyx mori silk fibroin (SF) in beta-sheet form and the long-term co-culture of adul...

journal_title：International journal of molecular medicine

authors： Dal Pra I,Chiarini A,Boschi A,Freddi G,Armato U

更新日期：2006-08-01 00:00:00

abstract：:The present study aimed to develop a tumor necrosis factor‑α (TNF‑α) B‑cell epitope/IL‑1β helper T lymphocyte epitope complex MAP vaccine for the alleviation of ulcerative colitis (UC) in mice. The B cell epitopes of murine TNF‑α (mTNF‑α) were predicted in silico and coupled with the universal interleukin 1β (IL‑1β) h...

journal_title：International journal of molecular medicine

authors： Sun Y,Pan W,Zhang J,Cui Y,Wang H,Ru G,Chen L

更新日期：2019-09-01 00:00:00

abstract：:Aberrant glycosylation of cell surface glycoprotein due to specific alterations of glycosyltransferase activity is usually associated with invasion and metastasis of cancer, particularly of gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which cata...

journal_title：International journal of molecular medicine

authors： Hua D,Shen L,Xu L,Jiang Z,Zhou Y,Yue A,Zou S,Cheng Z,Wu S

更新日期：2012-12-01 00:00:00

abstract：:Neuromedin-U (NMU) is a brain-gut peptide, which has been previously found to stimulate hypothalamic-pituitary-adrenal axis in the rat. Enucleation-induced adrenal regeneration in rats with contralateral adrenalectomy is a well-established model of adrenal growth, that not only depends on the compensatory ACTH hyperse...

journal_title：International journal of molecular medicine

authors： Trejter M,Neri G,Rucinski M,Majchrzak M,Nussdorfer GG,Malendowicz LK

更新日期：2008-06-01 00:00:00

abstract：:Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-κB pathway; therefore, suppression of TLR4/NF-κB signaling has become a prom...

journal_title：International journal of molecular medicine

authors： Lan L,Tao J,Chen A,Xie G,Huang J,Lin J,Peng J,Chen L

更新日期：2013-01-01 00:00:00