Cardiomyopathy: molecular and immunological aspects (review).

abstract：:After cessation of lactation, the mammary gland undergoes involution, regressing to a state resembling that of a virgin animal. This phase of mammary gland development is characterized by epithelial cell death and tissue remodeling. To understand molecular mechanisms of mammary gland involution, we identified involuti...

journal_title：International journal of molecular medicine

authors： Baik MG,Lee MJ,Choi YJ

更新日期：1998-07-01 00:00:00

abstract：:Acute necrotizing pancreatitis (ANP) is a common severe critical illness with a high mortality rate. Resveratrol, a polyphenol compound derived from various plants such as grape skin, peanut, berry and veratrum, exhibits multiple biological activities, especially potent anti‑inflammatory activity, but its effect on AN...

journal_title：International journal of molecular medicine

authors： Wang N,Zhang F,Yang L,Zou J,Wang H,Liu K,Liu M,Zhang H,Xiao X,Wang K

更新日期：2017-08-01 00:00:00

abstract：:The proliferation and migration of vascular smooth muscle cells (SMC) are important aspects of atherogenesis. Activated growth factor signaling in injured vessels subsequently promotes a number of intracellular events resulting in the phenotypic modulation of SMC. Here, we investigated the role of beta2-chimaerin, a n...

journal_title：International journal of molecular medicine

authors： Maeda M,Kato S,Fukushima S,Kaneyuki U,Fujii T,Kazanietz MG,Oshima K,Shigemori M

更新日期：2006-04-01 00:00:00

abstract：:Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is found to be overexpressed in hepatocellular carcinoma (HCC). The purpose of the present study was to investigate the possible role of GPC3 in the development of HCC. In this study, RNA interference (RNAi) with a GPC3 small hairpin RNA (GPC3 shRNA) wa...

journal_title：International journal of molecular medicine

authors： Ruan J,Liu F,Chen X,Zhao P,Su N,Xie G,Chen J,Zheng D,Luo R

更新日期：2011-10-01 00:00:00

abstract：:We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene...

journal_title：International journal of molecular medicine

authors： Chen X,Zhu C,Ji C,Zhao Y,Zhang C,Chen F,Gao C,Zhu J,Qian L,Guo X

更新日期：2010-03-01 00:00:00

abstract：:Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. The Fas/Fas ligand system is considered to be a key regulator of apoptosis. Recently, we have demonstrated that F...

journal_title：International journal of molecular medicine

authors： Ogawa Y,Nishioka A,Kubonishi I,Inomata T,Yoshida S,Kataoka S

更新日期：1998-10-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:FGF and WNT signaling pathways network together during embryogenesis and carcinogenesis. Among 22 FGF family members within human and rodents genomes, FGF20 orthologs are evolutionarily conserved targets of the WNT/beta-catenin signaling pathway. FGF8, FGF17, and FGF18 constitute one of FGF subfamilies. Here, comparat...

journal_title：International journal of molecular medicine

authors： Katoh M,Katoh M

更新日期：2005-09-01 00:00:00

abstract：:The polyacetate esters of certain non-nutrient monosaccharides, such as L-glucose and 2-deoxy-D-glucose, were recently reported to display positive insulinotropic action and, hence, proposed as possible tools for stimulation of insulin release in non-insulin-dependent diabetes. In the present study, the secretory resp...

journal_title：International journal of molecular medicine

authors： Malaisse WJ,Kadiata MM

更新日期：1998-07-01 00:00:00

abstract：:The existence of at least two distinct alpha 1,2fucosyltransferases has been postulated for many years, and recently confirmed in humans with the cloning of the human and rabbit secretor type alpha 1,2fucosyltransferase. We now describe the cloning and analysis of PFUT2, the pig secretor type alpha 1,2fucosyltransfera...

journal_title：International journal of molecular medicine

authors： Cohney S,Mouhtouris E,McKenzie IF,Sandrin MS

更新日期：1999-02-01 00:00:00

abstract：:High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or actively through secretion by monocytes/macrophages. Extracellular HMGB1 acts as a potent inflammatory agent by promoting the release of cytokines such as tumor necro...

journal_title：International journal of molecular medicine

authors： Kawahara K,Hashiguchi T,Masuda K,Saniabadi AR,Kikuchi K,Tancharoen S,Ito T,Miura N,Morimoto Y,Biswas KK,Nawa Y,Meng X,Oyama Y,Takenouchi K,Shrestha B,Sameshima H,Shimizu T,Adachi T,Adachi M,Maruyama I

更新日期：2009-05-01 00:00:00

abstract：:Angioplasty is a principal treatment for occlusive vascular disease but 30-50% of patients show a restenosis of the vessel. There is no clinical effective therapy for this disease. It has been demonstrated, in animal models, that various drugs such as NO-donor, plasminogen inhibitor tranexamic acid and MMP (matrix met...

journal_title：International journal of molecular medicine

authors： Indolfi C,Stabile E,Perrino C,Chiariello M

更新日期：1998-08-01 00:00:00

abstract：:Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. It can cause adult T cell leukemia (ATL) and other diseases. The HTLV-1 basic leucine zipper (bZIP) factor (HBZ), which is encoded by the minus-strand of the provirus, is expressed in all cases of ATL and involved in T cell proliferation. However,...

journal_title：International journal of molecular medicine

authors： Ma Y,Zhang B,Wang D,Qian L,Song X,Wang X,Yang C,Zhao G

更新日期：2017-03-01 00:00:00

abstract：:Glioblastoma is one of the most radioresistant tumors. Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. ROS scavengers, therefore, are one of the important factors in protecting cells against ROS injury during ionizing ...

journal_title：International journal of molecular medicine

authors： Lee HC,Kim DW,Jung KY,Park IC,Park MJ,Kim MS,Woo SH,Rhee CH,Yoo H,Lee SH,Hong SI

更新日期：2004-06-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) have emerged as key regulators of gene expression in essential cellular processes, such as cell growth, differentiation and development. Recent findings have established that the levels of miRNAs are modulated by cell signaling mechanisms, including the bone morphogenetic protein (BMP) signa...

journal_title：International journal of molecular medicine

authors： Hata A,Kang H

更新日期：2015-03-01 00:00:00

abstract：:The interaction between prostate cancer cells and bone marrow stromal cells (BMSC) is critical for survival and proliferation of metastatic cancer cells in the bone microenvironment. In order to study molecular mechanisms of prostate cancer bone metastasis, we established a novel heterotypic co-culture system, in whic...

journal_title：International journal of molecular medicine

authors： Wang J,Levenson AS,Satcher RL Jr

更新日期：2006-05-01 00:00:00

abstract：:miR-30a is situated on chromosome 6q.13 and is produced by an intronic transcriptional unit. However, its role in regulating the apoptosis, invasion and metastasis of breast cancer cells is not yet fully understood. The aim of this study was to research the biological function of miR‑30a and its direct target gene in ...

journal_title：International journal of molecular medicine

authors： Zhang HD,Jiang LH,Sun DW,Li J,Tang JH

更新日期：2017-10-01 00:00:00

abstract：:S100A4, one of the tandemly arranged S100 genes at chromosome 1q21, has been suggested to play a functional role in cell motility and invasiveness of tumor cell growth. We investigated the expression of S100A4 and the in vitro invasiveness of 4 human bile duct adenocarcinoma cell lines by the Matrigel assay. S100A4 wa...

journal_title：International journal of molecular medicine

authors： Katayama N,Murao S,Ajiki T,Kitazawa S,Onoyama H,Kuroda Y,Maeda S

更新日期：2000-11-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a rare aggressive type of B-cell non-Hodgkin's lymphoma. Response to chemotherapy tends to be short and virtually all patients sooner or later relapse. The prognosis of relapsed patients is extremely poor. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered o...

journal_title：International journal of molecular medicine

authors： Pospisilova J,Vit O,Lorkova L,Klanova M,Zivny J,Klener P,Petrak J

更新日期：2013-05-01 00:00:00

abstract：:Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR/Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibited the MAPK phosphorylation in HUV...

journal_title：International journal of molecular medicine

authors： Igarashi K,Isohara T,Kato T,Takigawa K,Shigeta K,Yamano T,Uno I I

更新日期：1998-08-01 00:00:00

abstract：:Fruits, vegetables, spices and a variety of teas are suggested for the prevention of many diseases. They encompass active, non-nutritional ingredients called nutraceuticals which are defined as food products that provide health benefits. Many nutraceuticals have been tested to identify inhibitors of plasminogen activa...

journal_title：International journal of molecular medicine

authors： Jankun J,Skotnicka M,Łysiak-Szydłowska W,Al-Senaidy A,Skrzypczak-Jankun E

更新日期：2011-04-01 00:00:00

abstract：:ABCA3 is a surfactant lipid transporter in the limiting membrane of lamellar bodies in alveolar type II cells. Mutations in the ATP-binding cassette, sub-family A (ABC1), member 3 (ABCA3) gene cause respiratory distress syndrome in newborns, and chronic interstitial lung disease in children and adults. ABCA3 belongs t...

journal_title：International journal of molecular medicine

authors： Frixel S,Lotz-Havla AS,Kern S,Kaltenborn E,Wittmann T,Gersting SW,Muntau AC,Zarbock R,Griese M

更新日期：2016-08-01 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63...

journal_title：International journal of molecular medicine

authors： Hara T,Kijima H,Yamamoto S,Kenmochi T,Kise Y,Tanaka H,Chino O,Shimada H,Takazawa K,Tanaka M,Inokuchi S,Makuuchi H

更新日期：2004-08-01 00:00:00

abstract：:Current therapy for glioma is suboptimal. The transfer of apoptosis genes to tumors constitutes one of the most promising strategies for cancer gene therapy. We have previously shown that massive apoptosis occurs when wild-type p53 or E2F-1 expression is induced in glioma. However, the mechanism of action and the effi...

journal_title：International journal of molecular medicine

authors： Gomez-Manzano C,Fueyo J,Alameda F,Kyritsis AP,Yung WK

更新日期：1999-01-01 00:00:00

abstract：:Although the upregulation of enhancer of zeste homolog 2 (EZH2) expression and downregulation of long non-coding RNA (lncRNA) LET expression are known to be associated with cell apoptosis and proliferation, little is known about the interaction of EZH2 with lncRNA LET. The present study aimed to investigate the intera...

journal_title：International journal of molecular medicine

authors： Zheng W,Yu A

更新日期：2018-04-01 00:00:00

abstract：:The emergence of colorectal cancer in developed nations can be attributed to dietary habits, smoking, a sedentary lifestyle and obesity. Several treatment regimens are available for primary and metastatic colorectal cancer; however, these treatment options have had limited impact on cure and disease‑free survival, and...

journal_title：International journal of molecular medicine

authors： Ahmad R,Vaali-Mohammed MA,Elwatidy M,Al-Obeed O,Al-Khayal K,Eldehna WM,Abdel-Aziz HA,Alafeefy A,Abdulla M

更新日期：2019-10-01 00:00:00

abstract：:Acidic pH is frequently used to inactivate viruses. We have previously shown that arginine synergizes with low pH in enhancing virus inactivation. Considering a potential application of the acid inactivation of viruses for the prevention and treatment of superficial virus infection at body surfaces and fixtures, herei...

journal_title：International journal of molecular medicine

authors： Nishide M,Tsujimoto K,Uozaki M,Ikeda K,Yamasaki H,Koyama AH,Arakawa T

更新日期：2011-06-01 00:00:00

abstract：:The various associations of motor and non-motor symptoms, the onset of motor complications, the cognitive disorder's appearance and other factors make Parkinson's disease (PD) a heterogeneous syndrome with multiple phenotypes. The necessity of discriminating between different forms of PD could have a role in understan...

journal_title：International journal of molecular medicine

authors： Schillaci O,Chiaravalloti A,Pierantozzi M,Di Pietro B,Koch G,Bruni C,Stanzione P,Stefani A

更新日期：2011-11-01 00:00:00

abstract：:About 80% of short children are not deficient in endogenous growth hormone (GH) and termed idiopathic short stature (ISS). The causes of impaired growth in children with ISS are various. Short stature and low insulin-like growth factor-I (IGF-I) concentration despite normal to high GH concentration suggest impaired GH...

journal_title：International journal of molecular medicine

authors： Takahashi Y,Chihara K

更新日期：1998-09-01 00:00:00

abstract：:We evaluated the postoperative adjuvant chemotherapy by UFT using the primary tumor amputation-pulmonary metastasis model. When Lewis lung carcinoma (LLC) primary tumors on the hind foot pad grew palpable, they were amputated on two different days. In experiment (A) (earlier amputation model), micrometastases were det...

journal_title：International journal of molecular medicine

authors： Uchida J,Sato K,Okabe H,Saito H,Nakano K,Fujioka A,Takechi T,Takeda S,Unemi N,Fukushima M

更新日期：2000-04-01 00:00:00