Ubiquitous p63 expression in human esophageal squamous cell carcinoma.

abstract：:New drugs are continuously being developed for the treatment of patients with estrogen receptor-positive breast cancer. Thymoquinone is one of the drugs that exhibits anticancer characteristics based on in vivo and in vitro models. This study further investigates the effects of thymoquinone on human gene expression us...

journal_title：International journal of molecular medicine

authors： Motaghed M,Al-Hassan FM,Hamid SS

更新日期：2014-01-01 00:00:00

abstract：:The polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine and reproductive dysfunctional diseases. Recent research for genetic variants has identified genetic influences between the polymorphisms of the adiponectin gene and the metabolic syndromes. The aim of our study was to investigate t...

journal_title：International journal of molecular medicine

authors： Li L,Yun JH,Lee JH,Song S,Choi BC,Baek KH

更新日期：2011-02-01 00:00:00

abstract：:Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...

journal_title：International journal of molecular medicine

authors： Gao P,Yang X,Mungur L,Kampo S,Wen Q

更新日期：2013-06-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

journal_title：International journal of molecular medicine

authors： Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

更新日期：2004-10-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast trans...

journal_title：International journal of molecular medicine

authors： Qi FH,Cai PP,Liu X,Si GM

更新日期：2018-05-01 00:00:00

abstract：:Myocyte injury due to myocardial reperfusion injury plays a crucial role in the pathogenesis of acute myocardial infarction even after successful coronary revascularization. Identification of compounds that reduce reperfusion-associated myocyte death is important. Therefore, we developed an in vitro model of myocardia...

journal_title：International journal of molecular medicine

authors： Gerö D,Módis K,Nagy N,Szoleczky P,Tóth ZD,Dormán G,Szabó C

更新日期：2007-11-01 00:00:00

abstract：:Adrenomedullin (ADM) is a hypotensive peptide, that derives from the proteolytic cleavage of pro(p)ADM and acts through two subtypes of receptors, called L1-receptor (L1-R) and calcitonin receptor-like receptor (CRLR). CRLR may function as a calcitonin gene-related peptide or a selective ADM receptor depending on the ...

journal_title：International journal of molecular medicine

authors： Rebuffat P,Forneris ML,Aragona F,Ziolkowska A,Malendowicz LK,Nussdorfer GG

更新日期：2002-02-01 00:00:00

abstract：:(-)-Epigallocatechin gallate [(-)-EGCG] has been implicated in cancer chemoprevention and has been shown as an inhibitor of tumor proteasomal chymotrypsin-like activity in vitro and in vivo. However, EGCG is subjected to rapid biotransforming modifications such as methylation by catechol-Omicron-methyltransferase (COM...

journal_title：International journal of molecular medicine

authors： Kanwar J,Mohammad I,Yang H,Huo C,Chan TH,Dou QP

更新日期：2010-08-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology with considerable morbidity and mortality. Seeking informative diagnostic markers with greater clinical significance is essential for the early diagnosis of IPF. microRNAs (miRNAs or miRs) have emerged as novel serum diagnostic biomarkers for various...

journal_title：International journal of molecular medicine

authors： Li P,Li J,Chen T,Wang H,Chu H,Chang J,Zang W,Wang Y,Ma Y,Du Y,Zhao G,Zhang G

更新日期：2014-06-01 00:00:00

abstract：:The efficacy of the most commonly used form of suicide gene therapy, the HSV-TK/GCV method, utilizing herpes simplex virus thymidine kinase (HSV-TK) and antiviral drug ganciclovir (GCV) has been demonstrated in clinical trials. However, safer delivery of the therapeutic gene and more controlled regulation of the trans...

journal_title：International journal of molecular medicine

authors： Määttä AM,Korja S,Venhoranta H,Hakkarainen T,Pirinen E,Heikkinen S,Pellinen R,Mäkinen K,Wahlfors J

更新日期：2006-11-01 00:00:00

abstract：:The molecular pathogenesis of osteosarcoma is very complicated and associated with chaotic abnormalities on many chromosomal arms. We analyzed 12 cases of osteosarcomas with comparative genomic hybridization (CGH) to identify chromosomal imbalances, and detected highly frequent chromosomal alterations in chromosome 6q...

journal_title：International journal of molecular medicine

authors： Ohata N,Ito S,Yoshida A,Kunisada T,Numoto K,Jitsumori Y,Kanzaki H,Ozaki T,Shimizu K,Ouchida M

更新日期：2006-12-01 00:00:00

abstract：:Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. The Fas/Fas ligand system is considered to be a key regulator of apoptosis. Recently, we have demonstrated that F...

journal_title：International journal of molecular medicine

authors： Ogawa Y,Nishioka A,Kubonishi I,Inomata T,Yoshida S,Kataoka S

更新日期：1998-10-01 00:00:00

abstract：:A long non‑coding RNA (lncRNA) called prostate cancer‑associated non‑coding RNA 1 (PRNCR1) serves crucial roles in the aggressive phenotypes of colorectal cancer and non‑small cell lung cancer. However, there is little research on the expression profile, clinical value and detailed functions of PRNCR1 in tongue squamo...

journal_title：International journal of molecular medicine

authors： Lin C,Zou Y,Li R,Liu D

更新日期：2020-07-01 00:00:00

abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, is widely used as an anticancer drug. Recently, TSA has been shown to exert a protective effect on ischemia/reperfusion (I/R) injury; however, the underlying mechanisms remain unclear. Forkhead box O3a (FoxO3a), a unique FoxO family member, has been shown to atten...

journal_title：International journal of molecular medicine

authors： Guo Y,Li Z,Shi C,Li J,Yao M,Chen X

更新日期：2017-10-01 00:00:00

abstract：:The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular carti...

journal_title：International journal of molecular medicine

authors： Albrecht C,Schlegel W,Eckl P,Jagersberger T,Sadeghi K,Berger A,Vécsei V,Marlovits S

更新日期：2009-02-01 00:00:00

abstract：:Recently, naringin (NAR; 4',5,7-trihydroxyflavanone-7-rhamnoglucoside) has been shown to have cardioprotective properties. However, the specific mechanisms underlying its cardioprotective effects remain unclear. In this study, we aimed to investigate the cardioprotective effects of NAR and the possible underlying mole...

journal_title：International journal of molecular medicine

authors： Huang H,Wu K,You Q,Huang R,Li S,Wu K

更新日期：2013-08-01 00:00:00

abstract：:Curcumin is an orange-yellow colored, lipophilic polyphenol substance derived from the rhizome of Curcuma longa that is widely used in many countries. Curcumin has many reported functions, including antioxidant and anti‑inflammatory effects. Autophagy removes damaged organelles and protein aggregates in the cell. Howe...

journal_title：International journal of molecular medicine

authors： Wang JL,Wang JJ,Cai ZN,Xu CJ

更新日期：2018-11-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is highly malignant and poorly differentiated, resulting in a high frequency of local recurrence and distant metastases. Sox2 (Sry‑box2), an important factor in embryonic development and cell differentiation, has been shown to associate with malignant phenotypes and epithelial‑mes...

journal_title：International journal of molecular medicine

authors： Liu X,Qiao B,Zhao T,Hu F,Lam AK,Tao Q

更新日期：2018-09-01 00:00:00

abstract：:Osteoporosis is a bone disease that poses a tremendous burden to health care. The receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) have been a major focus of this research field. RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but ...

journal_title：International journal of molecular medicine

authors： Minami A,Ogino M,Nakano N,Ichimura M,Nakanishi A,Murai T,Kitagishi Y,Matsuda S

更新日期：2017-02-01 00:00:00

abstract：:Periodontitis is the main cause of tooth or tissue loss. Human periodontal ligament stem cells (hPDLSCs), which have high proliferative, self‑renewal and multi‑differentiation abilities, are vital for the restoration of periodontitis‑induced injuries. The anti‑inflammatory and anti‑apoptotic agent, tetramethylpyrazine...

journal_title：International journal of molecular medicine

authors： Duan Y,An W,Wu Y,Wang J

更新日期：2020-06-01 00:00:00

abstract：:Oxidative burst provides the mechanism for specialized phagocytes, such as granulocytes or monocytes, to kill invading microorganisms through generation of superoxide anions. However, the oxidants generated during the burst damage DNA of the phagocytes and neighboring cells. Human blood leukocytes treated with phorbol...

journal_title：International journal of molecular medicine

authors： Halicka HD,Mitlitski V,Heeter J,Balazs EA,Darzynkiewicz Z

更新日期：2009-05-01 00:00:00

abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...

journal_title：International journal of molecular medicine

authors： Zhen J,Qu Z,Fang H,Fu L,Wu Y,Wang H,Zang H,Wang W

更新日期：2014-08-01 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ) is a naturally occurring redox co‑factor that functions as an essential nutrient and antioxidant, and has been reported to exert potent anti‑inflammatory effects. However, the therapeutic potential of PQQ for isoproterenol hydrochloride (Iso)‑induced cardiac hypertrophy has not yet been ...

journal_title：International journal of molecular medicine

authors： Wen J,Shen J,Zhou Y,Zhao X,Dai Z,Jin Y

更新日期：2020-03-01 00:00:00

abstract：:Mitogen‑activated protein kinase‑activated protein kinase 2 (MK2) and its mediated inflammation are involved in various diseases, including spinal cord injury (SCI). Ultrashortwave (USW) radiation has previously been reported to exert a protective effect on SCI. In the present study, through a series of reverse transc...

journal_title：International journal of molecular medicine

authors： Wang N,Feng Z,Zhao W,Zhang Z,Zhang L

更新日期：2018-10-01 00:00:00

abstract：:A female patient (64 years of age; body mass index, 26) had a markedly and relatively low low-density lipoprotein-cholesterol (LDL-C) level (97 mg/dl) despite high serum total cholesterol (TC) (331 mg/dl) and triacylglyceride levels (307 mg/dl). Since the expected LDL-C was 222 mg/dl, there was a significant differenc...

journal_title：International journal of molecular medicine

authors： Lee JH,Park JH,Lee SH,Kim JR,Cho KH

更新日期：2010-06-01 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesen...

journal_title：International journal of molecular medicine

authors： Liu Q,Zhang X,Jiao Y,Liu X,Wang Y,Li SL,Zhang W,Chen FM,Ding Y,Jiang C,Jin Z

更新日期：2018-02-01 00:00:00

abstract：:The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride d...

journal_title：International journal of molecular medicine

authors： Kim JH,Na J,Bak DH,Lee BC,Lee E,Choi MJ,Ryu CH,Lee S,Mun SK,Park BC,Kim BJ,Lee HS

更新日期：2019-06-01 00:00:00

abstract：:Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid and has been shown to exhibit a diversity of pharmacological properties, including antimicrobial and anticancer activiti...

journal_title：International journal of molecular medicine

authors： Hua F,Li CH,Chen XG,Liu XP

更新日期：2018-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by progressive lung scarring and excessive extracellular matrix depositon. When stimulated, alveolar epithelial cells (AECs) are aberrantly activated, the expression of profibrotic molecules is enhanced, and lung fibro...

journal_title：International journal of molecular medicine

authors： Li B,Huang X,Xu X,Ning W,Dai H,Wang C

更新日期：2019-07-01 00:00:00