Abstract:
:The polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine and reproductive dysfunctional diseases. Recent research for genetic variants has identified genetic influences between the polymorphisms of the adiponectin gene and the metabolic syndromes. The aim of our study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in the adiponectin gene and PCOS. Two SNPs, +45G15G(T/G) and +276(G/T), which are found in exon 2 and intron 2, respectively, of the adiponectin gene, were genotyped by PCR-RFLP. Out of 303 women studied for the +45G15G(T/G) and +276(G/T) SNPs, 144 had PCOS and 159 were healthy controls. No association was found between the +45(T/G) SNP and PCOS (P=0.3558, OR=0.83, 95% confidence interval), per contra to the association between +276(G/T) SNP and PCOS (P=0.0126, OR=0.60, 95% confidence interval). These results indicate that the SNP of +276(G/T) is strongly associated with PCOS. However, the +45(T/G) SNP is not associated with PCOS.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Li L,Yun JH,Lee JH,Song S,Choi BC,Baek KHdoi
10.3892/ijmm.2010.565subject
Has Abstractpub_date
2011-02-01 00:00:00pages
283-7issue
2eissn
1107-3756issn
1791-244Xjournal_volume
27pub_type
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