Association study of +45G15G(T/G) and +276(G/T) polymorphisms in the adiponectin gene in patients with polycystic ovary syndrome.

Abstract:

:The polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine and reproductive dysfunctional diseases. Recent research for genetic variants has identified genetic influences between the polymorphisms of the adiponectin gene and the metabolic syndromes. The aim of our study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in the adiponectin gene and PCOS. Two SNPs, +45G15G(T/G) and +276(G/T), which are found in exon 2 and intron 2, respectively, of the adiponectin gene, were genotyped by PCR-RFLP. Out of 303 women studied for the +45G15G(T/G) and +276(G/T) SNPs, 144 had PCOS and 159 were healthy controls. No association was found between the +45(T/G) SNP and PCOS (P=0.3558, OR=0.83, 95% confidence interval), per contra to the association between +276(G/T) SNP and PCOS (P=0.0126, OR=0.60, 95% confidence interval). These results indicate that the SNP of +276(G/T) is strongly associated with PCOS. However, the +45(T/G) SNP is not associated with PCOS.

journal_name

Int J Mol Med

authors

Li L,Yun JH,Lee JH,Song S,Choi BC,Baek KH

doi

10.3892/ijmm.2010.565

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

283-7

issue

2

eissn

1107-3756

issn

1791-244X

journal_volume

27

pub_type

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