Abstract:
:Telomerase maintains telomere length and is considered to be necessary for the indefinite proliferation of human cells. Telomerase activity is detected not only in germline and immortal cancer cells, but also in stem/progenitor cells of renewal tissues and activated lymphocytes. While it is generally agreed that telomerase is a useful tumor marker, the utility of telomerase activity in non-cancerous cells should also be considered. In the present study, we quantitatively examined telomerase activity in 56 cytology samples and 106 bronchoalveolar lavage samples obtained from patients with various respiratory diseases. Fourteen of 34 samples obtained from lung cancer patients showed detectable telomerase activity, while only 7 of 128 samples obtained from patients without lung cancer did (p<0.001). Moreover, 12 of 14 telomerase-positive samples with lung cancer showed strong signals, while none without lung cancer did. Among 106 non-cancerous bronchoalveolar lavage samples, 4 telomerase positive samples had increased number of lymphocytes and increased disease progression. These findings indicate that evaluation of telomerase activity may not only be a useful diagnostic test for lung cancer, but may also be a marker of disease aggressiveness for immune-associated lung diseases.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Hiyama K,Ishioka S,Shay JW,Taooka Y,Maeda A,Isobe T,Hiyama E,Maeda H,Yamakido Msubject
Has Abstractpub_date
1998-03-01 00:00:00pages
545-9issue
3eissn
1107-3756issn
1791-244Xjournal_volume
1pub_type
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journal_title:International journal of molecular medicine
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更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:2018-07-01 00:00:00
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更新日期:2015-04-01 00:00:00
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journal_title:International journal of molecular medicine
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doi:10.3892/ijmm.2014.2024
更新日期:2015-02-01 00:00:00
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journal_title:International journal of molecular medicine
pub_type: 杂志文章
doi:10.3892/ijmm.2014.1767
更新日期:2014-07-01 00:00:00
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journal_title:International journal of molecular medicine
pub_type: 杂志文章
doi:10.3892/ijmm.2013.1376
更新日期:2013-07-01 00:00:00
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journal_title:International journal of molecular medicine
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
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journal_title:International journal of molecular medicine
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更新日期:2003-04-01 00:00:00
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journal_title:International journal of molecular medicine
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更新日期:2014-01-01 00:00:00
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journal_title:International journal of molecular medicine
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journal_title:International journal of molecular medicine
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更新日期:1998-01-01 00:00:00
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journal_title:International journal of molecular medicine
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doi:10.3892/ijmm.2013.1302
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journal_title:International journal of molecular medicine
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更新日期:2005-10-01 00:00:00
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journal_title:International journal of molecular medicine
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更新日期:2002-03-01 00:00:00
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journal_title:International journal of molecular medicine
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更新日期:2006-06-01 00:00:00
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