当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE期刊下所有文献 > Expression of genes involved with cell cycle control, cell growth and chromatin modification are altered in hepatoblastomas.

Expression of genes involved with cell cycle control, cell growth and chromatin modification are altered in hepatoblastomas.

Abstract：

:Hepatoblastoma is a rare pediatric liver tumor. While much progress has been made in the treatment of the disease, very little is known about the moleculer events underlying the pathogenesis of this disease. We sought to investigate a series of hepatoblastomas for alterations in gene expression patterns with emphasis on important cell regulatory genes, including chromatin modifying enzymes, cyclin dependent kinase inhibitors, growth factors, oncogenes and cell cycle regulators. Total RNA was extracted from a series of sporadic hepatoblastomas with matched normal liver, some unmatched tumors and fetal livers, and gene expression was measured for various genes using RNase Protection Analysis (RPA). The results of this analysis show that the expression of many important regulatory genes are distinctly altered in these tumors, and a subset of tumors can be distinguished on the basis of these gene expression differences and histopathological features. Because the molecular events underlying the pathogenesis of this rare tumor are so poorly understood, this study represents a first step in determining some of the possible mechanisms involved which may provide future avenues of research.

journal_name

Int J Mol Med

journal_title

International journal of molecular medicine

authors

Gray SG,Hartmann W,Eriksson T,Ekstrom C,Holm S,Kytola S,von Schweinitz D,Pietsch T,Larsson C,Kogner P,Sandstedt B,Ekstrom TJ

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

161-9

issue

2

eissn

1107-3756

issn

1791-244X

journal_volume

6

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE文献大全
  • Identification of a novel Rac3-interacting protein C1D.

    abstract：:Rac3 is a small GTPase of the Rho family, members of which have been implicated in tumorigenesis, cell growth/death and organization of the actin cytoskeleton. Many Rac-interacting proteins or effectors identified to date have a role in cytoskeletal organization. Using the yeast two-hybrid system, we have isolated a n...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.1.4.665

    authors： Haataja L,Groffen J,Heisterkamp N

    更新日期：1998-04-01 00:00:00

  • Microarray analysis of insulin-regulated gene expression in the liver: the use of transgenic mice co-expressing insulin-siRNA and human IDE as an animal model.

    abstract：:To characterize the changes in global gene expression in the livers of H1/siRNAinsulin-CMV/hIDE transgenic (Tg) mice in response to the reduced bioavailability of insulin, total RNA extracted from the livers of 20-week-old Tg and non-Tg mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Jee S,Hwang D,Seo S,Kim Y,Kim C,Kim B,Shim S,Lee S,Sin J,Bae C,Lee B,Jang M,Kim M,Yim S,Jang I,Cho J,Chae K

    更新日期：2007-12-01 00:00:00

  • In silico-initiated cloning and molecular characterization of cortexin 3, a novel human gene specifically expressed in the kidney and brain, and well conserved in vertebrates.

    abstract：:We report on the in silico-initiated cloning and molecular characterization of CTXN3 (cortexin 3), a new human gene that was specifically expressed in the kidney and brain due to tissue-specific alternative exon 1 usage, on chromosome 5q23.2 using digital gene expression displayer (DGED) and a novel in silico cloning ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Wang HT,Chang JW,Guo Z,Li BG

    更新日期：2007-10-01 00:00:00

  • Interleukin-10 does not affect IL-1-induced interleukin-6 and metalloproteinase production in human chondrosarcoma cells, SW1353.

    abstract：:Cartilage repair by transplantation of autologous chondrocytes is an option when restoring functional joints. Control of chondrocyte function is thus required. Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine affecting the expression of a wide range of immune mediators in hematopoietic and non-hematopoiet...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Radons J,Falk W,Schubert TE

    更新日期：2006-02-01 00:00:00

  • Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.

    abstract：:The pathogenesis of inflammatory bowel disease (IBD) is believed to be associated with the abnormal expression of inflammatory factors. The aryl hydrocarbon receptor (AhR) is a ligand‑dependent transcription factor, which can suppress the inflammatory response and attenuate experimental colitis. However, the detailed ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2017.3262

    authors： Wang Q,Yang K,Han B,Sheng B,Yin J,Pu A,Li L,Sun L,Yu M,Qiu Y,Xiao W,Yang H

    更新日期：2018-02-01 00:00:00

  • Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer.

    abstract：:Heparanase is an enzyme that degrades extracellular glycoprotein to release heparan sulfate molecules. CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration. Production of CD44v3 and expression of heparanase were detected by immunohistochemistry and in situ hy...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kuniyasu H,Chihara Y,Kubozoe T,Takahashi T

    更新日期：2002-09-01 00:00:00

  • AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in 3T3-L1 adipocytes.

    abstract：:AMP-activated protein kinase (AMPK) is known to sense the cellular energy state and regulates various cellular energy metabolism pathways through its activation by AMP, an indicator of a low-energy state. 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), an activator of AMPK, efficiently inhibited the adipo...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2011.674

    authors： Lee H,Kang R,Bae S,Yoon Y

    更新日期：2011-07-01 00:00:00

  • A technique for capturing broad subtypes and circulating recombinant forms of HIV-1 based on anionic polymer-coated magnetic beads.

    abstract：:Magnetic beads coated with an anionic polymer, poly(methyl vinyl ether-maleic anhydrate) [poly(MVE-MA)], were used in a method to capture human immunodeficiency virus type-1 (HIV-1). The beads were incubated with either HIV-1-infected cell culture medium or plasma from HIV-1 infecte...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2012.1009

    authors： Sakudo A,Ikuta K

    更新日期：2012-08-01 00:00:00

  • Excision repair cross complementing-group 1: gene expression and platinum resistance.

    abstract：:Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly underst...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,评审

    doi：

    authors： Altaha R,Liang X,Yu JJ,Reed E

    更新日期：2004-12-01 00:00:00

  • miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke.

    abstract：:Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2019.4073

    authors： Si W,Ye S,Ren Z,Liu X,Wu Z,Li Y,Zhou J,Zhang S,Li Y,Deng R,Chen D

    更新日期：2019-03-01 00:00:00

  • Human chondrocytes differentially express matrix modulators during in vitro expansion for tissue engineering.

    abstract：:Cartilage tissue engineering plays an important role in the generation of grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. Dedifferentiated cells produce matrix of less quality, and the molecular basis is still not well understood. Theref...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Goessler UR,Bieback K,Bugert P,Naim R,Schafer C,Sadick H,Hormann K,Riedel F

    更新日期：2005-10-01 00:00:00

  • Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

    abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of abnormal liver dysfunction, and its prevalence has markedly increased. We previously evaluated the expression of fatty acid metabolism-related genes in NAFLD and reported changes in expression that could contribute to increased fatty acid s...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kohjima M,Enjoji M,Higuchi N,Kato M,Kotoh K,Yoshimoto T,Fujino T,Yada M,Yada R,Harada N,Takayanagi R,Nakamuta M

    更新日期：2007-09-01 00:00:00

  • Modulation of TNF-alpha-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide.

    abstract：:Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Human umbilical vein endothelial cells (HUVECs) wer...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Ju Y,Hua J,Sakamoto K,Ogawa H,Nagaoka I

    更新日期：2008-12-01 00:00:00

  • Melatonin affects the dynamic steady-state equilibrium of estrogen sulfates in human umbilical vein endothelial cells by regulating the balance between estrogen sulfatase and sulfotransferase.

    abstract：:Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active es...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2360

    authors： González A,Martínez-Campa C,Alonso-González C,Cos S

    更新日期：2015-12-01 00:00:00

  • Induction of apoptotic cell death by mycelium extracts of Phellinus linteus in human neuroblastoma cells.

    abstract：:Phellinus linteus is a well-known Oriental medicinal fungus that has various biological activities, including immunomodulatory and anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we investigated the effects of mycelium extracts of P. linteus (MEPL) on the growth of human neu...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Choi YH,Huh MK,Ryu CH,Choi BT,Jeong YK

    更新日期：2004-08-01 00:00:00

  • The metabolic syndrome of omega3-depleted rats. III. Brain phospholipids.

    abstract：:Rats exposed from 7 weeks after birth and for the ensuing 3 to 7 months to a diet depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a new animal model for the metabolic syndrome. The present study aimed mainly at investigating whether, in this new model, the perturbation of the fatty ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Portois L,Hacquebard M,Malaisse WJ,Carpentier YA

    更新日期：2009-08-01 00:00:00

  • Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-β1-Smad-ILK pathway in unilateral ureteral obstruction rats.

    abstract：:Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast trans...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2018.3485

    authors： Qi FH,Cai PP,Liu X,Si GM

    更新日期：2018-05-01 00:00:00

  • Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines.

    abstract：:Oral squamous cell carcinomas (OSCCs), a major public health problem worldwide, are the most common neoplasms of the head and neck. The most important prognostic indicator for patients with OSCC is metastasis to cervical lymph nodes or distant organs. Galectin-9 is correlated with cellular adhesion and aggregation in ...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Kasamatsu A,Uzawa K,Nakashima D,Koike H,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

    更新日期：2005-08-01 00:00:00

  • Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer.

    abstract：:The present study aimed to investigate the diagnostic and prognostic values of contrast‑enhanced ultrasound (CEUS) combined with diffusion‑weighted magnetic resonance imaging (DW‑MRI) in different subtypes of breast cancer (BC). CEUS and DW‑MRI were conducted in 232 patients with BC prior to surgical treatment. Patien...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章,收录出版

    doi：10.3892/ijmm.2018.3591

    authors： Liu GF,Wang ZQ,Zhang SH,Li XF,Liu L,Miao YY,Yu SN

    更新日期：2018-07-01 00:00:00

  • Neuro-immune modulation of the thymus microenvironment (review).

    abstract：:The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pat...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1709

    authors： Mignini F,Sabbatini M,Mattioli L,Cosenza M,Artico M,Cavallotti C

    更新日期：2014-06-01 00:00:00

  • Effect of the harvest procedure and tissue site on the osteogenic function of and gene expression in human mesenchymal stem cells.

    abstract：:Evidence has indicated that mesenchymal stem cells (MSCs) harvested with the Reamer/Irrigator/Aspirator (RIA) procedure exhibited an improved osteogenic differentiation capability compared with MSCs obtained by bone marrow aspiration from the iliac crest. In the present study, we hypothesized that the harvest procedur...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2016.2489

    authors： Henrich D,Nau C,Kraft SB,Zollfrank M,Kontradowitz K,Oppermann E,Schultheiss J,Meier S,Frank J,Marzi I,Seebach C

    更新日期：2016-04-01 00:00:00

  • Assessment by D-[(3)H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats.

    abstract：:The uptake of D-[3H]mannoheptulose by isolated pancreatic islets was recently proposed as a tool to assess the relative contribution of insulin-producing cells to the total mass of the islets. In the present study, the uptake of the tritiated heptose over 60 min incubation at 37 degrees C was about 21% lower in islets...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Sener A,Ladriere L,Malaisse WJ

    更新日期：2001-08-01 00:00:00

  • Migration of mesothelioma cells correlates with histotype-specific synthesis of extracellular matrix.

    abstract：:Three human pleural malignant mesothelioma cell cultures (MM) of epithelioid (E1), fibrous (F1) and byphasic (B1) histotype were studied in their synthesis of the extracellular matrix (ECM) components laminin (LM), fibronectin (FN), type IV collagen (cIV), and in their chemotactic and haptotactic migration towards the...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.4.1.67

    authors： Scarpa S,Giuffrida A,Fazi M,Coletti A,Palumbo C,Pass HI,Procopio A,Modesti A

    更新日期：1999-07-01 00:00:00

  • Bleomycin A5 suppresses Drp1‑mediated mitochondrial fission and induces apoptosis in human nasal polyp‑derived fibroblasts.

    abstract：:Intralesional injection of bleomycin‑A5 (BLE‑A5) is a novel treatment for nasal polyps. Our previous study clarified that BLE‑A5 could induce nasal polyp‑derived fibroblast (NPDF) apoptosis in nasal polyps. However, the detailed mechanisms are still unclear. The present study aimed to determine the effects of BLE‑A5 o...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2020.4797

    authors： Wu F,Ma Y,Wang J,Ou H,Dang H,Zheng Y,Tian P,Zou H

    更新日期：2021-01-01 00:00:00

  • TNF-α promotes gallbladder cancer cell growth and invasion through autocrine mechanisms.

    abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2014.1711

    authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

    更新日期：2014-06-01 00:00:00

  • Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells.

    abstract：:Induction of apoptosis is one of the mechanisms of chemotherapeutic agents against breast cancer. In addition, recent studies have shown that diets containing polyphenolic components possess anticancer activities either in vitro or in vivo by inhibiting cell proliferation and inducing apoptosis. The aim of our study w...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：

    authors： Ye W,Chang HL,Wang LS,Huang YW,Shu S,Sugimoto Y,Dowd MK,Wan PJ,Lin YC

    更新日期：2010-07-01 00:00:00

  • Effects of platelet-derived growth factor, vitamin D and parathyroid hormone on osteoblasts derived from cancer patients on chronic bisphosphonate therapy.

    abstract：:Bisphosphonates consist of a family of pyrophosphate analogues that are currently being used to treat metastatic bone diseases as well as systemic bone diseases such as osteoporosis. There is accumulating evidence suggesting that patients treated with these bisphosphonates can develop, particularly with invasive denta...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm_00000145

    authors： Rao MV,Berk J,Almojaly SA,Goodloe Iii S,Margarone Iii J,Sullivan M,Dziak R

    更新日期：2009-03-01 00:00:00

  • MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase.

    abstract：:A variety of microRNAs (miRNAs) have been reported to be significantly be involved in the regulation of vascular smooth muscle cell (VSMC) proliferation, which is an essential process for the formation of atherosclerotic plaque. The objective of the present study was to explore the role of microRNA-155 (miR-155) in th...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2015.2181

    authors： Zhang J,Zhao F,Yu X,Lu X,Zheng G

    更新日期：2015-06-01 00:00:00

  • GATA binding protein 3 overexpression and suppression significantly contribute to the regulation of allergic skin inflammation.

    abstract：:GATA binding protein 3 (GATA3) is a key molecule regulating the balance in the ratio of type 1 helper T (Th1) cells to type 2 helper T (Th2) cells, which is thought to be indicative of the pathogenesis of allergic diseases such as asthma and atopic dermatitis. The aim of this study was to investigate the role of GATA3...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2011.685

    authors： Bae CJ,Lee JW,Shim SB,Jee SW,Lee SH,Woo JM,Lee CK,Hwang DY

    更新日期：2011-08-01 00:00:00

  • Tiny percutaneous needle biopsy: An efficient method for studying cellular and molecular aspects of skeletal muscle in humans.

    abstract：:Needle biopsy is widely used to obtain specimens for physiological, anatomical and biochemical studies of skeletal muscle (SM). We optimized a procedure which we termed tiny percutaneous needle biopsy (TPNB), to efficiently gather good numbers of human satellite cells and single dissociated fibers for the functional s...

    journal_title：International journal of molecular medicine

    pub_type： 杂志文章

    doi：10.3892/ijmm.2010.582

    authors： Pietrangelo T,D'Amelio L,Doria C,Mancinelli R,Fulle S,Fanò G

    更新日期：2011-03-01 00:00:00