Abstract:
:The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pathways occur, performing strict control on the maturation and selection processes of T lymphocytes. In this review, the main morphological characteristics of the thymus microenvironment, with particular emphasis on nerve fibers and neuropeptides were assessed, as both are responsible for neuro-immune‑modulation functions. Among several neurotransmitters that affect thymus function, we highlight the dopaminergic system as only recently has its importance on thymus function and lymphocyte physiology come to light.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Mignini F,Sabbatini M,Mattioli L,Cosenza M,Artico M,Cavallotti Cdoi
10.3892/ijmm.2014.1709subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1392-400issue
6eissn
1107-3756issn
1791-244Xjournal_volume
33pub_type
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