Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs.

abstract：:Rac3 is a small GTPase of the Rho family, members of which have been implicated in tumorigenesis, cell growth/death and organization of the actin cytoskeleton. Many Rac-interacting proteins or effectors identified to date have a role in cytoskeletal organization. Using the yeast two-hybrid system, we have isolated a n...

journal_title：International journal of molecular medicine

authors： Haataja L,Groffen J,Heisterkamp N

更新日期：1998-04-01 00:00:00

abstract：:The emergence of colorectal cancer in developed nations can be attributed to dietary habits, smoking, a sedentary lifestyle and obesity. Several treatment regimens are available for primary and metastatic colorectal cancer; however, these treatment options have had limited impact on cure and disease‑free survival, and...

journal_title：International journal of molecular medicine

authors： Ahmad R,Vaali-Mohammed MA,Elwatidy M,Al-Obeed O,Al-Khayal K,Eldehna WM,Abdel-Aziz HA,Alafeefy A,Abdulla M

更新日期：2019-10-01 00:00:00

abstract：:Akt1/protein kinase Bα (Akt1/PKBα) is a downstream mediator of the insulin signaling system. In this study we explored mechanism(s) for its role in burn injury. Akt1/PKBα in liver extracts from mice with burn injury fed with (2H7)-L-Leu was immunoprecipitated and isolated with SDS-PAGE. Two tryptic peptides, one in th...

journal_title：International journal of molecular medicine

authors： Lu XM,Tompkins RG,Fischman AJ

更新日期：2012-03-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Molecular analysis are useful for diagnosis, prognosis and follow-up of the patients, as well as for addressing therapeutic choices. Most of the molecular methods are based on the analysis of nucleic acids. The DNA and RNA methodologies of routine applicability include Southern and Northern hybridizations and polymera...

journal_title：International journal of molecular medicine

authors： Scarpa A,Tognon M

更新日期：1998-06-01 00:00:00

abstract：:Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine ...

journal_title：International journal of molecular medicine

authors： Seya T,Nomura M,Murakami Y,Begum NA,Matsumoto M,Nagasawa S

更新日期：1998-05-01 00:00:00

abstract：:Biologically well-tolerated materials are at the core of intense research. In this study, we report both the intrinsic features of formic acid (FA)-crosslinked three-dimensional (3D) nonwoven scaffolds consisting of sericin-deprived, Bombyx mori silk fibroin (SF) in beta-sheet form and the long-term co-culture of adul...

journal_title：International journal of molecular medicine

authors： Dal Pra I,Chiarini A,Boschi A,Freddi G,Armato U

更新日期：2006-08-01 00:00:00

abstract：:Caveolin, the essential structural component of caveolae, serves as a scaffolding protein onto which signaling molecules are assembled, and functions as a negative regulator for signal transduction. Caveolin-1 and -2 are expressed in most cell types, but are not expressed in normal blood cells and cell lines. We previ...

journal_title：International journal of molecular medicine

authors： Tsuji Y,Hatanaka M,Maeda T,Seya T,Takenaka H,Shimizu A

更新日期：2005-11-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:Many viruses have been investigated for their oncolytic properties and potential use as therapeutic agents for cancer treatment. Most of these replication-competent viruses are human pathogens. We investigated the oncolytic properties of an animal virus which is non pathogenic for both its natural host and humans. Bov...

journal_title：International journal of molecular medicine

authors： Smyth M,Symonds A,Brazinova S,Martin J

更新日期：2002-07-01 00:00:00

abstract：:Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

journal_title：International journal of molecular medicine

authors： Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

更新日期：2014-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a common age-associated neurodegenerative disorder. To date, stem cell transplantation therapy has been developed to replace lost or damaged neural cells in PD patients, in whom dopaminergic neuron cells are lost. Here, we show that CD44+ human amniotic fluid cells (HuAFCs) can be induced t...

journal_title：International journal of molecular medicine

authors： Liu T,Guo L,Liu Z,Huang Y,Cheng W

更新日期：2011-11-01 00:00:00

abstract：:Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) control...

journal_title：International journal of molecular medicine

authors： Chen JL,Niu XL,Gao YL,Ma L,Gao XH,Chen HD,Qi RQ

更新日期：2020-08-01 00:00:00

abstract：:Recently, naringin (NAR; 4',5,7-trihydroxyflavanone-7-rhamnoglucoside) has been shown to have cardioprotective properties. However, the specific mechanisms underlying its cardioprotective effects remain unclear. In this study, we aimed to investigate the cardioprotective effects of NAR and the possible underlying mole...

journal_title：International journal of molecular medicine

authors： Huang H,Wu K,You Q,Huang R,Li S,Wu K

更新日期：2013-08-01 00:00:00

abstract：:DNA vaccines raise immune responses by expressing proteins in vaccinated hosts. Responses are raised by nanogram levels of protein expression. Popular methods of DNA delivery include intramuscular (i. m.) injections of DNA in saline and gene gun delivery of DNA-coated gold beads to the epidermis. Professional antigen-...

journal_title：International journal of molecular medicine

authors： Robinson HL

更新日期：1999-11-01 00:00:00

abstract：:Chronic hepatitis B (CHB) virus infection is caused by compromised host immunity, but the precise underlying mechanism remains unclear. Retinoic acid-inducible gene I (RIG-I) triggers antiviral immunity by inducing interferon-β (IFN-β) production following viral infection. To investigate the role of the RIG-I-IFN-β si...

journal_title：International journal of molecular medicine

authors： Zhao G,An B,Zhou H,Wang H,Xu Y,Xiang X,Dong Z,An F,Yu D,Wang W,Bao S,Xie Q

更新日期：2012-12-01 00:00:00

abstract：:p107 protein, a member of the retinoblastoma family protein, suppresses growth promotion in cancer cells. We have already reported evidence that calpain, a calcium dependent protease is involved in the cleavage of p107 protein. We show here that p107 protein can also be a substrate for ubiquitination. A negative growt...

journal_title：International journal of molecular medicine

authors： Jang JS,Choi YH

更新日期：1999-11-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the primary regulator of serum calcium homeostasis and bone metabolism. PTH acts primarily by binding to its receptor, PTH1R, in the bone and kidney. In addition to PTH, PTH1R also recognizes PTH-related peptide (PTHrP), a paracrine/autocrine factor originally described as the hormone resp...

journal_title：International journal of molecular medicine

authors： Müller M,Gagiannis S,Nawroth PP,Brune M,Schilling T

更新日期：2009-09-01 00:00:00

abstract：:The interaction between prostate cancer cells and bone marrow stromal cells (BMSC) is critical for survival and proliferation of metastatic cancer cells in the bone microenvironment. In order to study molecular mechanisms of prostate cancer bone metastasis, we established a novel heterotypic co-culture system, in whic...

journal_title：International journal of molecular medicine

authors： Wang J,Levenson AS,Satcher RL Jr

更新日期：2006-05-01 00:00:00

abstract：:Bisphosphonates consist of a family of pyrophosphate analogues that are currently being used to treat metastatic bone diseases as well as systemic bone diseases such as osteoporosis. There is accumulating evidence suggesting that patients treated with these bisphosphonates can develop, particularly with invasive denta...

journal_title：International journal of molecular medicine

authors： Rao MV,Berk J,Almojaly SA,Goodloe Iii S,Margarone Iii J,Sullivan M,Dziak R

更新日期：2009-03-01 00:00:00

abstract：:Epidermal growth factor (EGF) plays a critical role in fibroblasts by stimulating the production of collagen and supports cell renewal through the interaction between keratinocytes and fibroblasts. It is well known that the contractile activity of fibroblasts is required for the remodeling of the extracellular matrix ...

journal_title：International journal of molecular medicine

authors： Kim D,Kim SY,Mun SK,Rhee S,Kim BJ

更新日期：2015-04-01 00:00:00

abstract：:The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-κB ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into va...

journal_title：International journal of molecular medicine

authors： Fu YX,Gu JH,Zhang YR,Tong XS,Zhao HY,Yuan Y,Liu XZ,Bian JC,Liu ZP

更新日期：2013-06-01 00:00:00

abstract：:Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by...

journal_title：International journal of molecular medicine

authors： Zhu H,Cao W,Zhao P,Wang J,Qian Y,Li Y

更新日期：2018-12-01 00:00:00

abstract：:Claudins (CLDNs) constitute the major transmembrane proteins of tight junctions. It may be hypothesized that changes in or loss of expression of tight junctional proteins such as CLDNs can lead to cellular disorientation and detachment, which is commonly seen in neoplasia. Recent studies have suggested that claudin-1 ...

journal_title：International journal of molecular medicine

authors： Morohashi S,Kusumi T,Sato F,Odagiri H,Chiba H,Yoshihara S,Hakamada K,Sasaki M,Kijima H

更新日期：2007-08-01 00:00:00

abstract：:The development of diabetes mellitus (DM) is accompanied by hyperglycemia-induced oxidative stress. Hyperoside is a major bioactive component in Zanthoxylum bungeanum leaves (HZL) and is a natural antioxidant. However, the effects of HZL on DM and its mechanisms of action remain undefined. The present study evaluated ...

journal_title：International journal of molecular medicine

authors： Zhang Y,Wang M,Dong H,Yu X,Zhang J

更新日期：2018-01-01 00:00:00

abstract：:Choroidal neovascularization (CNV) can lead to progressive and severe visual loss. Vascular endothelial growth factor (VEGF) promotes the development of CNV. Caffeic acid phenethyl ester (CAPE), a biologically active component of the honeybee (Apis mellifera) propolis, has been demonstrated to have several interesting...

journal_title：International journal of molecular medicine

authors： Paeng SH,Jung WK,Park WS,Lee DS,Kim GY,Choi YH,Seo SK,Jang WH,Choi JS,Lee YM,Park S,Choi IW

更新日期：2015-05-01 00:00:00

abstract：:Clinical situations with release of proteinases from blood cells or tissues into the circulation may result in a marked decrease of blood proteinase inhibitor content which in turn may result in a capillary leak syndrome, shock and even in exitus letalis. Replenishment of blood proteinase inhibitors is of benefit in s...

journal_title：International journal of molecular medicine

authors： Langner J,Thiem M,Bohning V

更新日期：1999-12-01 00:00:00

abstract：:Many lines of evidence have shown that preproglucagon-derived peptides affect steroid secretion from dispersed adrenocortical cells, and that streptozotocin (STZ)-induced experimental diabetes alters adrenocortical-cell function. Hence, we compared the effects of glucagon, glucagon-like peptide (GLP)-1 and GLP-2 on ba...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Spinazzi R,Nussdorfer GG,Trejter M

更新日期：2003-07-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. Findings indicate that Alzheimer disease (AD) and vascular dementia (VaD) may have common risk factors and/or pathogene...

journal_title：International journal of molecular medicine

authors： Folin M,Baiguera S,Conconi MT,Di Liddo R,De Carlo E,Parnigotto PP,Nussdorfer GG

更新日期：2004-10-01 00:00:00

abstract：:We have previously reported comparative genomics analyses on FGF3, FGF4, FGF6, FGF7, FGF8, FGF10, FGF11, FGF17, FGF18, FGF19, FGF20, FGF22 and FGF23 genes. Here, we performed comparative genomics analyses on FGF1, FGF2, FGF5, FGF9, FGF12, FGF13, FGF14, FGF16 and FGF21 genes, and further characterized the FGF16 gene. C...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2005-11-01 00:00:00