miR‑6835‑3p regulates the function of pancreatic islet cells by modulating the expression of AdipoR1.

abstract：:Cerebellin (CER) is a regulatory peptide, originally isolated from rat cerebellum, which derives from the cleavage of precerebellin (Cbln), three types of which (Cbln1-3) have been identified in humans and rats. CER is also expressed in several extra-cerebellar tissues, including adrenal gland, and evidence has been p...

journal_title：International journal of molecular medicine

authors： Rucinski M,Albertin G,Spinazzi R,Ziolkowska A,Nussdorfer GG,Malendowicz LK

更新日期：2005-03-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the primary regulator of serum calcium homeostasis and bone metabolism. PTH acts primarily by binding to its receptor, PTH1R, in the bone and kidney. In addition to PTH, PTH1R also recognizes PTH-related peptide (PTHrP), a paracrine/autocrine factor originally described as the hormone resp...

journal_title：International journal of molecular medicine

authors： Müller M,Gagiannis S,Nawroth PP,Brune M,Schilling T

更新日期：2009-09-01 00:00:00

abstract：:The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role ...

journal_title：International journal of molecular medicine

authors： Jang BC,Lim KJ,Choi IH,Suh MH,Park JG,Mun KC,Bae JH,Shin DH,Suh SI

更新日期：2007-05-01 00:00:00

abstract：:Following the publication of the above paper, the authors noted that the first author affiliation was presented incorrectly. Essentially, 'School of Medicine' had been omitted from the address. Therefore, the author and affiliation details for this paper should have been presented as follows (the changes are highlight...

journal_title：International journal of molecular medicine

authors： Jayakumar T,Lin KC,Lu WJ,Lin CY,Pitchairaj G,Li JY,Sheu JR

更新日期：2020-02-01 00:00:00

abstract：:It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) alleviated liver fibrosis. We investigated whether BMSCs transfected with human matrix metalloproteinase 1 (BMSCs/MMP1) would improve their therapeutic effect in liver fibrosis induced by carbon tetrachloride (CCl4) in rats. BMSCs were transf...

journal_title：International journal of molecular medicine

authors： Du C,Jiang M,Wei X,Qin J,Xu H,Wang Y,Zhang Y,Zhou D,Xue H,Zheng S,Zeng W

更新日期：2018-06-01 00:00:00

abstract：:MicroRNA‑23b‑3p (miR‑23b‑3p) has been reported to be involved in the pathogenesis of a number of diseases, including non‑small cell lung cancer and gastric cancer, by acting on different signaling pathways. The present study aimed to understand the association between the miR‑23b‑3p level of intracranial aneurysms (IA...

journal_title：International journal of molecular medicine

authors： Guo D,Wang YW,Yan L,Ma J,Han XW,Shui SF

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to investigate the role of the angiotensin-converting enzyme (ACE)2-angiotensin‑(Ang)-(1-7)-Mas axis in the pathogenesis of pancreatitis and the association between this axis and the p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor (NF-κB) signaling pathway in pancreatic ...

journal_title：International journal of molecular medicine

authors： Yu X,Cui L,Hou F,Liu X,Wang Y,Wen Y,Chi C,Li C,Liu R,Yin C

更新日期：2018-01-01 00:00:00

abstract：:Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

journal_title：International journal of molecular medicine

authors： Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

更新日期：2010-07-01 00:00:00

abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...

journal_title：International journal of molecular medicine

authors： Wang J,Cui M,Sun F,Zhou K,Fan B,Qiu JH,Chen FQ

更新日期：2020-04-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) has been suggested to be a putative tumor promoter gene, and autocrine of TNF-α expression has been found in colon cancer and ovarian cancer. As the role of autocrine TNF-α in human gallbladder cancer has not yet been elucidated, the present study examined the expression of TNF-α in gal...

journal_title：International journal of molecular medicine

authors： Zhu G,Du Q,Wang X,Tang N,She F,Chen Y

更新日期：2014-06-01 00:00:00

abstract：:Astragaloside IV is a monomer isolated from Astragalus membranaceus (Fisch.) Bunge, which is one of the most widely used plant-derived drugs in traditional Chinese medicine for diabetes therapy. In the present study, we aimed to examine the effects of astragaloside IV on glucose in C2C12 myotubes and the underlying mo...

journal_title：International journal of molecular medicine

authors： Zhu R,Zheng J,Chen L,Gu B,Huang S

更新日期：2016-06-01 00:00:00

abstract：:Substantial evidence has indicated that osteoblastic differentiation may be regulated by mechanical loads or bone morphogenetic protein-2 (BMP-2). BMP-2-induced in vivo osteogenesis can be significantly enhanced in the presence of mechanical stimuli, revealing the therapeutic potential of the combined application of B...

journal_title：International journal of molecular medicine

authors： Zeng Z,Yin X,Zhang X,Jing D,Feng X

更新日期：2015-11-01 00:00:00

abstract：:Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type an...

journal_title：International journal of molecular medicine

authors： Yang J,Liu A,Chiou SK,Guzman R,Nandi S

更新日期：2000-03-01 00:00:00

abstract：:The aetiological agent of chronic hepatitis C is the hepatitis C virus. The hepatitis C virus is spread by parenteral transmission of body fluids, primarily blood or blood products. In 1989, after more than a decade of research, HCV was isolated and characterised. The hepatitis C viral genome is a positive-sense, sing...

journal_title：International journal of molecular medicine

authors： Fanning LJ

更新日期：2002-02-01 00:00:00

abstract：:D-mannoheptulose was recently proposed as a tool to label preferentially insulin-producing cells in the pancreatic gland in the perspective of the non-invasive imaging of the endocrine pancreas. In such a perspective, we have now synthesized 1-deoxy-1-[125I]iodo-D-mannoheptulose ([125I]MH) and examined its uptake by d...

journal_title：International journal of molecular medicine

authors： Sener A,Bessieres B,Courtois P,Ladriere L,Louchami K,Jijakli H,Malaisse WJ

更新日期：2001-05-01 00:00:00

abstract：:The miR-200 family was recently identified as a suppressor of epithelial-mesenchymal transition (EMT). The loss or gain of miR-200 family members is associated with cancer invasion. The epidermal growth factor receptor (EGFR) is overexpressed in the majority of anaplastic thyroid cancers (ATCs). The activation of EGFR...

journal_title：International journal of molecular medicine

authors： Zhang Z,Liu ZB,Ren WM,Ye XG,Zhang YY

更新日期：2012-10-01 00:00:00

abstract：:Accumulating evidence has demonstrated that endometrial stromal cells (ESCs) are responsible for the pathogenesis of endometriosis (Ems), which is characterized by the presence of functional endometrial‑like tissues outside the uterine cavity. Abnormal expression of microRNAs (miRNAs) in ESCs may be implicated in the ...

journal_title：International journal of molecular medicine

authors： Wang X,Ren R,Shao M,Lan J

更新日期：2020-08-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) are a major cause of hearing loss. In this study, we performed a systematic mutational screening of the 12S rRNA, tRNA Ser(UCN), tRNA Lys and tRNA Leu(UUR) genes in 227 unrelated patients with nonsyndromic hearing impairment for the first time in a Korean population. We found two...

journal_title：International journal of molecular medicine

authors： Bae JW,Lee KY,Choi SY,Lee SH,Park HJ,Kim UK

更新日期：2008-08-01 00:00:00

abstract：:β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulator...

journal_title：International journal of molecular medicine

authors： Katoh M

更新日期：2018-08-01 00:00:00

abstract：:Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...

journal_title：International journal of molecular medicine

authors： Gao P,Yang X,Mungur L,Kampo S,Wen Q

更新日期：2013-06-01 00:00:00

abstract：:The ectromelia virus (ECTV) is a mouse specific Orthopoxvirus that causes lethal infection in some mouse strains. ECTV infection of these mouse strains has been used as a valuable model for understanding the interplay between Orthopoxvirus species and their hosts, including variola virus in humans. Although poxviruses...

journal_title：International journal of molecular medicine

authors： Cheng W,Jia H,Wang X,He X,Jin Q,Cao J,Jing Z

更新日期：2018-08-01 00:00:00

abstract：:Bcl-2 family member proteins are differentially expressed in skin and in non-melanoma skin cancer (NMSC). To elucidate the contribution of bcl-2 and bax proteins to epidermal differentiation and skin carcinogenesis, we investigated keratinocyte proliferation, differentiation and tumourigenesis in bcl-2(-/-) and bax(-/...

journal_title：International journal of molecular medicine

authors： Cho SH,Delehedde M,Rodriguez-Villanueva J,Brisbay S,McDonnell TJ

更新日期：2001-03-01 00:00:00

abstract：:We have recently demonstrated the antiproliferative and apoptotic activities of herbal traditional Chinese medicines, including the analomous fruit extract of Gleditsia sinensis, the fresh juice of Scutellaria barbata and the warmed water extract of Radix Sophorae Tonkinensis on a series of human carcinoma cells. Here...

journal_title：International journal of molecular medicine

authors： Lau FY,Chui CH,Gambari R,Kok SH,Kan KL,Cheng GY,Wong RS,Teo IT,Cheng CH,Wan TS,Chan AS,Tang JC

更新日期：2005-12-01 00:00:00

abstract：:The deletion mutation of exon 4 in surfactant protein C (SP-C), a lung surfactant protein, has been identified in parent-child cases of familial interstitial pneumonia. It has been shown that this mutation induces endoplasmic reticulum (ER) stress. Synoviolin is an E3 ubiquitin ligase that is localized to the ER and i...

journal_title：International journal of molecular medicine

authors： Nakajima F,Aratani S,Fujita H,Yagishita N,Ichinose S,Makita K,Setoguchi Y,Nakajima T

更新日期：2015-01-01 00:00:00

abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

journal_title：International journal of molecular medicine

authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

更新日期：2009-01-01 00:00:00

abstract：:Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage foll...

journal_title：International journal of molecular medicine

authors： Toth B,Schwacha MG,Kuebler JF,Bland KI,Wang P,Chaudrya IH

更新日期：2003-03-01 00:00:00

abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

journal_title：International journal of molecular medicine

authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

更新日期：2005-02-01 00:00:00

abstract：:Maspin, identified as a 42 kDa unique tumor suppressive serine protease inhibitor (serpin), has multifaceted biological functions by interacting with various target molecules under physiological and pathological conditions including oxidative stress. However, the type of post-translational modification that confers th...

journal_title：International journal of molecular medicine

authors： Nawata S,Shi HY,Sugino N,Zhang M

更新日期：2011-02-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome caused by mutations or deletions within the VHL tumor-suppressor gene, but VHL germline mutations in the Chinese have rarely been studied. To investigate the genetic profile of VHL mutations in the Chinese population, we evaluated the clinical characterist...

journal_title：International journal of molecular medicine

authors： Huang Y,Zhou D,Liu J,Zhou P,Li X,Wang Z

更新日期：2012-01-01 00:00:00

abstract：:Atopic dermatitis (AD) shows an increased susceptibility to Staphylococcus aureus infection partly due to decreased expression of human beta-defensin-2 (HBD-2). Interestingly, it was reported that the nasal carrier S. aureus down-regulates the expression of HBD-2 and -3, thereby the carrier strains of S. aureus retain...

journal_title：International journal of molecular medicine

authors： Cho JW,Cho SY,Lee KS

更新日期：2009-03-01 00:00:00