Expression of thioredoxin in patients with Graves' disease.


:Thioredoxin (TRX), which is a stress-inducible protein with redox-active disulfide structures, has various biological activities by regulating DNA binding of transcription factors in cells. In Graves' disease that is among the common diseases of the thyroid, endogenous stresses that are induced by excess thyroid hormones or antibodies against thyroid stimulating hormone (TSH) receptors are responsible for the pathogenesis. The objective of this study was to examine the expression of TRX and to determine whether TRX is responsible for the pathogenesis of Graves' disease. The thyroid follicular cells were shown to express both TRX and vascular cell growth factors (VEGF) in all of the patients with Graves' disease by immunohistochemistry. In contrast, the expression of TRX or VEGF was not found in any of the normal thyroids. Serum levels of TRX were significantly elevated in patients with Graves' disease regardless of their thyroid function compared to those in healthy donors (122+/-16 versus 37+/-5 ng/ml, p<0.0001). Consecutive administration of iodine resulted in not only a reduction in serum levels of free triiodothyronine (T3) but also an increase in serum levels of TRX in the patients. These findings suggest that release of intracellular TRX from thyroid follicular cells in response to iodine resulted in suppression of T3 production. Taken together, TRX is highly produced under stress in Graves' disease and involved in regulating production of thyroid hormones. The investigation of biological behavior of this molecule may greatly help to understand pathogenesis of Graves' disease functions.


Int J Mol Med


Kihara M,Kontani K,Yamauchi A,Miyauchi A,Nakamura H,Yodoi J,Yokomise H


Has Abstract


2005-05-01 00:00:00












  • Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development.

    abstract::Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of cardiomyocytes during the postnatal period may enhance the current understanding regarding this molecular mechanism. The present study identified the differentially express...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Wang R,Su C,Wang X,Fu Q,Gao X,Zhang C,Yang J,Yang X,Wei M

    更新日期:2018-01-01 00:00:00

  • Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO.

    abstract::Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Gao P,Yang X,Mungur L,Kampo S,Wen Q

    更新日期:2013-06-01 00:00:00

  • Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway.

    abstract::Recently, naringin (NAR; 4',5,7-trihydroxyflavanone-7-rhamnoglucoside) has been shown to have cardioprotective properties. However, the specific mechanisms underlying its cardioprotective effects remain unclear. In this study, we aimed to investigate the cardioprotective effects of NAR and the possible underlying mole...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Huang H,Wu K,You Q,Huang R,Li S,Wu K

    更新日期:2013-08-01 00:00:00

  • Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats.

    abstract::It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) alleviated liver fibrosis. We investigated whether BMSCs transfected with human matrix metalloproteinase 1 (BMSCs/MMP1) would improve their therapeutic effect in liver fibrosis induced by carbon tetrachloride (CCl4) in rats. BMSCs were transf...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Du C,Jiang M,Wei X,Qin J,Xu H,Wang Y,Zhang Y,Zhou D,Xue H,Zheng S,Zeng W

    更新日期:2018-06-01 00:00:00

  • Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.

    abstract::Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis. As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP a...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Cong M,Zhao W,Liu T,Wang P,Fan X,Zhai Q,Bao X,Zhang D,You H,Kisseleva T,Brenner DA,Jia J,Zhuang H

    更新日期:2017-08-01 00:00:00

  • The effect of curcumin on the differentiation, apoptosis and cell cycle of neural stem cells is mediated through inhibiting autophagy by the modulation of Atg7 and p62.

    abstract::Curcumin is an orange-yellow colored, lipophilic polyphenol substance derived from the rhizome of Curcuma longa that is widely used in many countries. Curcumin has many reported functions, including antioxidant and anti‑inflammatory effects. Autophagy removes damaged organelles and protein aggregates in the cell. Howe...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Wang JL,Wang JJ,Cai ZN,Xu CJ

    更新日期:2018-11-01 00:00:00

  • Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia.

    abstract::The circulating concentrations of triglycerides, high density lipoprotein (HDL)‑cholesterol, and low density lipoprotein (LDL)‑cholesterol have a substantial genetic component, and the heritability of early‑onset dyslipidemia might be expected to be higher compared with late‑onset forms. In the present study, exome‑wi...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Yamada Y,Kato K,Oguri M,Horibe H,Fujimaki T,Yasukochi Y,Takeuchi I,Sakuma J

    更新日期:2019-01-01 00:00:00

  • Effects of a small, volatile bacterial molecule on Pseudomonas aeruginosa bacteria using whole cell high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and genomics.

    abstract::In the present study, high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was applied to live Pseudomonas aeruginosa (PA) bacterial cells to determine the metabolome of this opportunistic Gram-negative human pathogen, and in particular, its response to the volatile aromatic low m...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Righi V,Constantinou C,Kesarwani M,Rahme LG,Tzika AA

    更新日期:2018-10-01 00:00:00

  • Cardiomyopathy: molecular and immunological aspects (review).

    abstract::Idiopathic cardiomyopathy is reviewed from molecular standpoint. About a half of all patients with hypertrophic cardiomyopathy show intra-familial occurrence. In familial hypertrophic cardiomyopathy, nine gene abnormalities have been discovered in the sarcomere, i.e. the genes of beta cardiac myosin heavy chain, cardi...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Takeda N

    更新日期:2003-01-01 00:00:00

  • TBX20 loss-of-function mutation contributes to double outlet right ventricle.

    abstract::Congenital heart disease (CHD), the most prevalent birth defect in humans worldwide, is still a leading non‑infectious cause of infant morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of CHD, and more than 50 genes have been linked to various types...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Pan Y,Geng R,Zhou N,Zheng GF,Zhao H,Wang J,Zhao CM,Qiu XB,Yang YQ,Liu XY

    更新日期:2015-04-01 00:00:00

  • Personalized regulation of glioblastoma cancer stem cells based on biomedical technologies: From theory to experiment (Review).

    abstract::Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Bryukhovetskiy I,Ponomarenko A,Lyakhova I,Zaitsev S,Zayats Y,Korneyko M,Eliseikina M,Mischenko P,Shevchenko V,Shanker Sharma H,Sharma A,Khotimchenko Y

    更新日期:2018-08-01 00:00:00

  • Gene and protein expression profile of naive and osteo-chondrogenically differentiated rat bone marrow-derived mesenchymal progenitor cells.

    abstract::Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Grässel S,Ahmed N,Göttl C,Grifka J

    更新日期:2009-06-01 00:00:00

  • MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase.

    abstract::A variety of microRNAs (miRNAs) have been reported to be significantly be involved in the regulation of vascular smooth muscle cell (VSMC) proliferation, which is an essential process for the formation of atherosclerotic plaque. The objective of the present study was to explore the role of microRNA-155 (miR-155) in th...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Zhang J,Zhao F,Yu X,Lu X,Zheng G

    更新日期:2015-06-01 00:00:00

  • Therapeutic immune response induced by intratumoral expression of the fusogenic membrane protein of vesicular stomatitis virus and cytokines encoded by adenoviral vectors.

    abstract::We assessed whether intratumoral expression of the fusogenic membrane protein of vesicular stomatitis virus (VSV-G), encoded by a replication-defective adenovirus vector (Ad.VSV-G), alone or in combination with local coexpression of cytokines induces tumor-specific immune responses in a syngeneic murine colon cancer m...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Hoffmann D,Bayer W,Wildner O

    更新日期:2007-11-01 00:00:00

  • DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.

    abstract::DJ-1 plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in the onset of Parkinson's disease. DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 pr...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Koide-Yoshida S,Niki T,Ueda M,Himeno S,Taira T,Iguchi-Ariga SM,Ando Y,Ariga H

    更新日期:2007-06-01 00:00:00

  • Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay.

    abstract::Preclinical studies have suggested that paracrine factors from adipose-derived stem cells (ASCs) promote the healing of chronic wounds, and that the exposure of ASCs to hypoxia enhances their wound healing effect. To aid the translation of these findings into clinical use, robust wound models are necessary to explore ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Riis S,Newman R,Ipek H,Andersen JI,Kuninger D,Boucher S,Vemuri MC,Pennisi CP,Zachar V,Fink T

    更新日期:2017-03-01 00:00:00

  • Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review).

    abstract::Post-transcriptional control of mRNA trafficking and metabolism plays a critical role in the actualization and fine tuning of the genetic program of cells, both in development and in differentiated tissues. Cis-acting signals, responsible for post-transcriptional regulation, reside in the RNA message itself, usually i...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章,评审


    authors: Di Liegro CM,Schiera G,Di Liegro I

    更新日期:2014-04-01 00:00:00

  • Mitochondria as a therapeutic target for cardiac ischemia‑reperfusion injury (Review).

    abstract::Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue generates irreversible damage to the myocardium, which is termed 'cardiac ischemia‑reperfusion (IR) injury'. Due to the large number of mito...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Marin W,Marin D,Ao X,Liu Y

    更新日期:2021-02-01 00:00:00

  • Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin.

    abstract::We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

    更新日期:2008-10-01 00:00:00

  • Loss of immunogenecity of liver dendritic cells from mouse with chronic hepatitis.

    abstract::Antigen presenting cells, especially the antigen presenting dendritic cells (DC) in the tissue, regulate the magnitude of antigen-specific immune response. A role of impaired and narrowly focused specific immune response has been implicated in the pathogenesis of chronic hepatitis due to hepatitis B virus and hepatiti...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Abe M,Kajino K,Akbar SM,Yamamura K,Onji M,Hino O

    更新日期:2002-01-01 00:00:00

  • The opioid growth factor receptor in human head and neck squamous cell carcinoma.

    abstract::Carcinoma of the head and neck is the sixth leading cause of cancer in the world, and the third most common neoplasia in developing countries. More than 90% of head and neck cancers are squamous cell carcinomas (SCCHN). Approximately half of the patients afflicted die within 5 years of diagnosis and survival rates for...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: McLaughlin PJ,Levin RJ,Zagon IS

    更新日期:2000-02-01 00:00:00

  • Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy.

    abstract::Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen exerts an effective thera...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Yao L,Chen H,Wu Q,Xie K

    更新日期:2019-09-01 00:00:00

  • Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway.

    abstract::Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study i...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Pei W,Zou Y,Wang W,Wei L,Zhao Y,Li L

    更新日期:2018-12-01 00:00:00

  • A small interfering ABCE1-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer.

    abstract::Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung ...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Huang B,Gao Y,Tian D,Zheng M

    更新日期:2010-05-01 00:00:00

  • Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids.

    abstract::The inhibition of the Smad2/3 pathway is a key step involved in the downregulation of type I collagen synthesis, thus preventing keloid formation in tissue. In this study, we investigated the effect of silibinin on the proliferation of human skin fibroblasts (HSFs), as well as its effect on the expression of type I co...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Cho JW,Il KJ,Lee KS

    更新日期:2013-05-01 00:00:00

  • ATP inhibition of proliferation of immortalized human fibroblasts is greater than that of normal human diploid fibroblasts.

    abstract::It is known that cancers develop by a multi-step process. Normal cells are first immortalized, and then transformed into tumorigenic cells. Normal human cells are very rarely immortalized, but once they are, they are relatively easily transformed into tumorigenic cells. This indicates that the immortalization step pla...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Katayama B,Sakaguchi M,Li JW,Pu H,Inoue Y,Namba M

    更新日期:1998-11-01 00:00:00

  • Effects of a Rho kinase inhibitor on the sequential expression of ICAM-1, HIF-1α, Bcl-2 and caspase-3 in the retina of rats with oxygen-induced retinopathy.

    abstract::The aim of the present study was to evaluate the effects of blocking the Rho kinase pathway on non-perfused regions and angiogenesis in the retina of rats using a rat model of oxygen-induced retinopathy (OIR) by observing the sequential expression of intercellular adhesion molecule-1 (ICAM-1), hypoxia-inducible factor...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Wang H,Chen X

    更新日期:2013-08-01 00:00:00

  • Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases.

    abstract::Telomerase maintains telomere length and is considered to be necessary for the indefinite proliferation of human cells. Telomerase activity is detected not only in germline and immortal cancer cells, but also in stem/progenitor cells of renewal tissues and activated lymphocytes. While it is generally agreed that telom...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Hiyama K,Ishioka S,Shay JW,Taooka Y,Maeda A,Isobe T,Hiyama E,Maeda H,Yamakido M

    更新日期:1998-03-01 00:00:00

  • A novel retinoic acid analog, 4-amino-2-trifluoromethyl-phenyl retinate, inhibits gastric cancer cell growth.

    abstract::Retinoic acid (RA) analogs have been used in the treatment of a variety of cancers; however, their application is limited due to serious therapy-related sequelae. In the present study, the effects of a novel RA analog, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), on the growth of gastric cancer cells were evaluat...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Hu KW,Pan XH,Chen FH,Qin R,Wu LM,Zhu HG,Wu FR,Ge JF,Han WX,Yin CL,Li HJ

    更新日期:2014-02-01 00:00:00

  • High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem/progenitor cells.

    abstract::Astrocytes are major components of the adult neurogenic niche and play a crucial role in regulating neural stem cell proliferation and differentiation. Following brain injury, astrocytes become reactive and release high-mobility group box 1 (HMGB1), which plays a crucial role in the inflammatory process. However, alth...

    journal_title:International journal of molecular medicine

    pub_type: 杂志文章


    authors: Li M,Sun L,Luo Y,Xie C,Pang Y,Li Y

    更新日期:2014-09-01 00:00:00