Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation.

abstract：:Cerebellin (CER) is a regulatory peptide, originally isolated from rat cerebellum, which derives from the cleavage of precerebellin (Cbln), three types of which (Cbln1-3) have been identified in humans and rats. CER is also expressed in several extra-cerebellar tissues, including adrenal gland, and evidence has been p...

journal_title：International journal of molecular medicine

authors： Rucinski M,Albertin G,Spinazzi R,Ziolkowska A,Nussdorfer GG,Malendowicz LK

更新日期：2005-03-01 00:00:00

abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...

journal_title：International journal of molecular medicine

authors： Wang J,Cui M,Sun F,Zhou K,Fan B,Qiu JH,Chen FQ

更新日期：2020-04-01 00:00:00

abstract：:Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Human umbilical vein endothelial cells (HUVECs) wer...

journal_title：International journal of molecular medicine

authors： Ju Y,Hua J,Sakamoto K,Ogawa H,Nagaoka I

更新日期：2008-12-01 00:00:00

abstract：:The complement system participates in the local immune system of the lung. In this study, we investigated the secretion of complement components of the alternative pathway (C3 and factor B) in the alveolar type II epithelial cell line A549. The levels of C3 and factor B protein in the culture medium were determined by...

journal_title：International journal of molecular medicine

authors： Zhao YX,Andoh A,Shimada M,Takaya H,Hata K,Fujiyama Y,Bamda T

更新日期：2000-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by areas of inflammation, demyelination and axonal damage. The etiology of MS is multifactorial with an interaction between genetic, environmental and geographical factors. The objective of this study was to review the physiopathology and the genetic polym...

journal_title：International journal of molecular medicine

authors： Kallaur AP,Kaimen-Maciel DR,Morimoto HK,Watanabe MA,Georgeto SM,Reiche EM

更新日期：2011-10-01 00:00:00

abstract：:Histone deacetylase inhibitor (HDAI) induces accumulation of highly acetylated histones by inhibiting the activity of histone deacetylase and inhibits cell proliferation, induces differentiation, and promotes apoptosis. TNF-related apoptosis inducing ligand (TRAIL) induces apoptosis in various human cancer cells, a pr...

journal_title：International journal of molecular medicine

authors： Inoue H,Shiraki K,Ohmori S,Sakai T,Deguchi M,Yamanaka T,Okano H,Nakano T

更新日期：2002-05-01 00:00:00

abstract：:It was previously shown that total saponins extracted from Aralia taibaiensis (sAT) have potent antioxidant activities for treating diabetes mellitus and attenuate d-galactose-induced aging. Since diabetes mellitus and aging are closely associated with cardiac dysfunction, particularly ischemic heart disease, sAT may ...

journal_title：International journal of molecular medicine

authors： Yan J,Duan J,Wu X,Guo C,Yin Y,Zhu Y,Hu T,Wei G,Wen A,Xi M

更新日期：2015-12-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1), a member of the serpin super-family, forms a covalent complex with its target proteinases, such as tissue and urokinase plasminogen activators. Thus, PAI-1 controls the physiological and pathological proteolysis. An abnormal expression of PAI-1 has been observed in different ...

journal_title：International journal of molecular medicine

authors： Jankun J,Specht Z,Szkudlarek M,Greenfield R,Gaikwad B,Trifonov L,Vaugeois J,Aleem AM,Basrur V,Selman SH,Zavodszky MI,Skrzypczak-Jankun E

更新日期：2006-03-01 00:00:00

abstract：:Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around the TMJ is involved in the pathogenesis of inflammatory diseases, inc...

journal_title：International journal of molecular medicine

authors： Yokota S,Chosa N,Kyakumoto S,Kimura H,Ibi M,Kamo M,Satoh K,Ishisaki A

更新日期：2017-04-01 00:00:00

abstract：:CDH1, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinoma...

journal_title：International journal of molecular medicine

authors： Ling ZQ,Li P,Ge MH,Zhao X,Hu FJ,Fang XH,Dong ZM,Mao WM

更新日期：2011-05-01 00:00:00

abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We further examined whether genetic variants that confer susceptibility to MI might differ among individuals with low or hig...

journal_title：International journal of molecular medicine

authors： Yoshida T,Kato K,Yokoi K,Oguri M,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

更新日期：2010-04-01 00:00:00

abstract：:Intralesional injection of bleomycin‑A5 (BLE‑A5) is a novel treatment for nasal polyps. Our previous study clarified that BLE‑A5 could induce nasal polyp‑derived fibroblast (NPDF) apoptosis in nasal polyps. However, the detailed mechanisms are still unclear. The present study aimed to determine the effects of BLE‑A5 o...

journal_title：International journal of molecular medicine

authors： Wu F,Ma Y,Wang J,Ou H,Dang H,Zheng Y,Tian P,Zou H

更新日期：2021-01-01 00:00:00

abstract：:The present study aimed to investigate the influence of microRNA-4649-3p on nasopharyngeal carcinoma (NPC) cell proliferation and how it regulated SHP-1 expression. The online software TargetScan was used to predict the microRNAs targeting SHP-1 and identified that miR-4649-3p was one of the possible miRNAs targeting ...

journal_title：International journal of molecular medicine

authors： Pan X,Peng G,Liu S,Sun Z,Zou Z,Wu G

更新日期：2015-08-01 00:00:00

abstract：:Acidic pH is frequently used to inactivate viruses. We have previously shown that arginine synergizes with low pH in enhancing virus inactivation. Considering a potential application of the acid inactivation of viruses for the prevention and treatment of superficial virus infection at body surfaces and fixtures, herei...

journal_title：International journal of molecular medicine

authors： Nishide M,Tsujimoto K,Uozaki M,Ikeda K,Yamasaki H,Koyama AH,Arakawa T

更新日期：2011-06-01 00:00:00

abstract：:Inflammatory genes serve a crucial role in the pathogenesis of inflammation‑associated tumors. However, as recent studies have mainly focused on the effects of single inflammatory genes on colorectal cancer (CRC), but not on the global interactions between genes, the underlying mechanisms between inflammatory genes and...

journal_title：International journal of molecular medicine

authors： Jiang H,Dong L,Gong F,Gu Y,Zhang H,Fan D,Sun Z

更新日期：2018-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) is the major pathological mechanism in anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Extracellular signal-regulated kinase (ERK)1/2 pathway has been reported to play...

journal_title：International journal of molecular medicine

authors： Chen X,Ye S,Xiao W,Wang W,Luo L,Liu Y

更新日期：2014-06-01 00:00:00

abstract：:Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Specific microRNAs (miRNAs/miR) have been described to be associated with DS, altho...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic neurodegenerative disease that often occurs at a slow pace yet deteriorates with time. MicroRNAs (miRs) have been demonstrated to offer novel therapeutic hope for disease treatment. The aim of the present study was to investigate the effect of miR‑98 on amyloid β (Aβ)‑protein prod...

journal_title：International journal of molecular medicine

authors： Chen FZ,Zhao Y,Chen HZ

更新日期：2019-01-01 00:00:00

abstract：:Congenital bicuspid aortic valve (BAV) represents the most common type of cardiac birth defect affecting 0.4‑2% of the general population, and accounts for a markedly increased incidence of life‑threatening complications, including valvulopathy and aortopathy. Accumulating evidence has demonstrated the genetic basis o...

journal_title：International journal of molecular medicine

authors： Wang J,Abhinav P,Xu YJ,Li RG,Zhang M,Qiu XB,Di RM,Qiao Q,Li XM,Huang RT,Xue S,Yang YQ

更新日期：2019-04-01 00:00:00

abstract：:Aromatic turmerone (ar-turmerone) has been reported to have a cytotoxic effect on L-1210 and HL-60 cells. In the present study, we investigated the anticancer responses and immune activities in implanted tumor cells. Our study found that ar-turmerone inhibited the increase in the nu...

journal_title：International journal of molecular medicine

authors： Kim D,Suh Y,Lee H,Lee Y

更新日期：2013-02-01 00:00:00

abstract：:Heparin/heparan sulfate interacting protein (HIP) was initially identified as an adhesion molecule from a human uterine epithelial cell line. It was previously demonstrated that HIP was upregulated in human colorectal cancer. However, its expression was significantly lower in Dukes' D samples compared to earlier Dukes...

journal_title：International journal of molecular medicine

authors： Wang Y,Tan S,Hooi SC

更新日期：2003-04-01 00:00:00

abstract：:One of the most aggressive human malignancies, anaplastic thyroid carcinoma (ATC), has an extremely poor prognosis that may be explained by its genomic instability. We hypothesized that the very rapid cell turnover observed in ATC might accelerate telomere shortening and chromosomal instability associated with tumor c...

journal_title：International journal of molecular medicine

authors： Kammori M,Onoda N,Nakamura K,Izumiyama N,Ogisawa K,Kurabayashi R,Ogawa T,Kaminishi M,Poon SS,Takubo K

更新日期：2006-07-01 00:00:00

abstract：:Microsporum canis (M. canis) is a common pathogen that causes tinea capitis and is present worldwide. The incidence of M. canis infection, particularly tinea capitis, has been increasing in China. In our previous studies, family of serine hydrolases 1 (FSH1) was identified as a potential virulence factor in tinea capi...

journal_title：International journal of molecular medicine

authors： Zhang F,Tan C,Xu Y,Yang G

更新日期：2019-12-01 00:00:00

abstract：:In hepatolithiasis, chronic proliferative cholangitis (CPC), an active and longstanding inflammation of stone‑containing bile ducts with enhanced mucin‑producing activity, not only affects the progression of the disease, it can also induce biliary carcinogenesis. The present study aimed to examine the effect of the ep...

journal_title：International journal of molecular medicine

authors： Liu SH,Chen XF,Xie ZB,Zhou J

更新日期：2019-07-01 00:00:00

abstract：:Excessive expansion of the transit-amplifying (TA) cell compartment is a distinct morphological characteristic of psoriatic epidermal hyperplasia. In order to examine the activation of basal stem cells and how they replenish such an enlarged compartment of TA cells in psoriatic epidermis, we utilized a BrdU labeling m...

journal_title：International journal of molecular medicine

authors： Jia HY,Shi Y,Luo LF,Jiang G,Zhou Q,Xu SZ,Lei TC

更新日期：2016-02-01 00:00:00

abstract：:O6-methylguanin-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups from O6-methylguanine to itself. Alkylation of DNA at the O6 position of guanine is the first step by alkylating agents in inducing DNA mutations in an organism. When MGMT and the mismatch repair (MMR) system are impaired,...

journal_title：International journal of molecular medicine

authors： Kohya N,Kitajima Y,Kitahara K,Miyazaki K

更新日期：2003-01-01 00:00:00

abstract：:Cadmium (Cd) is an industrial pollutant and carcinogenic metal. Most in vitro Cd toxicity studies have been carried out in various cell lines cultured in 10% fetal bovine serum (FBS) containing medium. In this report, we compared the toxic effect of Cd (0-300 microM) on cell growth, total RNA, total proteins, and anti...

journal_title：International journal of molecular medicine

authors： Latinwo LM,Badisa VL,Odewumi CO,Ikediobi CO,Badisa RB,Brooks-Walter A,Lambert AT,Nwoga J

更新日期：2008-07-01 00:00:00

abstract：:A preceding hypoxic insult can sensitize the cells or the organism to a subsequent, second insult. The aim of the present study was to investigate the molecular mechanism of this phenomenon (often termed 'two-hit' injury paradigm), in an in vitro model of hypoxia/oxidative stress injury in A549 epithelial cells, with ...

journal_title：International journal of molecular medicine

authors： Erdélyi K,Pacher P,Virág L,Szabó C

更新日期：2013-08-01 00:00:00

abstract：:Antitumor vaccination therapy approaches using naked plasmid DNA or recombinant viruses encoding tumor-associated antigens are currently in development. In the present study, we examined the therapeutic efficacy of vaccination using the mouse alpha-fetoprotein (AFP) gene in mouse hepatocellular carcinoma (HCC) cells. ...

journal_title：International journal of molecular medicine

authors： Saeki A,Nakao K,Nagayama Y,Yanagi K,Matsumoto K,Hayashi T,Ishikawa H,Hamasaki K,Ishii N,Eguchi K

更新日期：2004-01-01 00:00:00

abstract：:We studied whether feeding pregnant female mice with different fats affects lipid exchange and activity of the splenic lymphoid system in offspring exposed to low doses of carcinogen. Female mice were fed diets with either 7% or 15% corn oil or olive oil. The 4-week-old offspring of these mice were transferred to a ch...

journal_title：International journal of molecular medicine

authors： Zusman I,Ben-Hur H,Budovsky A,Geva D,Gurevich P,Tendler Y,Lavee S,Stark A,Madar Z

更新日期：2000-09-01 00:00:00