miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells.

abstract：:Obesity contributes to the etiologies of a variety of comorbid conditions, such as type 2 diabetes, hypertension and cardiovascular disease. In the present study, the anti-obesity effects of yellow catfish protein hydrolysate (YPh) were observed in mice fed a 45% kcal high-fat diet (HFD) compared with those of mice tr...

journal_title：International journal of molecular medicine

authors： Kim MR,Kim JW,Park JB,Hong YK,Ku SK,Choi JS

更新日期：2017-09-01 00:00:00

abstract：:Lately, the importance of the communication between different cell types and the understanding of the cell communication pathway has been emphasized, as it may provide a novel therapeutic strategy for the regeneration of damaged tissue. In the present study, we suggest that sonic hedgehog (Shh) is a mediator of cell c...

journal_title：International journal of molecular medicine

authors： Kim WJ,Lee SW,Kim KW

更新日期：2014-07-01 00:00:00

abstract：:Cell replacement and gene therapy using neural stem cells (NSCs) have been widely touted as a promising treatment for CNS diseases including brain tumors. Histone deacetylase (HDAC) inhibitors have been used to explore mechanisms behind the lineage-specific differentiation of NSCs a...

journal_title：International journal of molecular medicine

authors： Khan Z,Akhtar M,Ekström TJ

更新日期：2011-12-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00

abstract：:Leptin is a 147-amino acid adipose tissue-secreted hormone, which acts via several subtypes of receptors, the main and better known variants of which are named Ob-Ra and Ob-Rb. Structure-activity relationship studies pointed out the importance of the N-terminal and C-terminal amino-acid sequences 22-115 and 116-166, r...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Gorska T,Tortorella C,Nowak M,Majchrzak M,Spinazzi R,Nussdorfer GG,Nowak KW

更新日期：2004-06-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) is the major pathological mechanism in anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Extracellular signal-regulated kinase (ERK)1/2 pathway has been reported to play...

journal_title：International journal of molecular medicine

authors： Chen X,Ye S,Xiao W,Wang W,Luo L,Liu Y

更新日期：2014-06-01 00:00:00

abstract：:Human gastric cancer SNU 484 cells express mutant p16, which migrates slower than the wild-type p16. We constructed an expression vector containing human p16 cDNA to evaluate the cytotoxic effects of exogenous p16 expression on SNU 484 cell proliferation and to explore the potential use of p16 in cancer gene therapy. ...

journal_title：International journal of molecular medicine

authors： Jeong YW,Kim KS,Oh JY,Park JC,Baek WK,Suh SI,Suh MH,Lee JC,Cho JW

更新日期：2003-07-01 00:00:00

abstract：:The effect of interferon-alpha (IFN) for chronic myeloid leukemia (CML) in the chronic phase (CP) was retrospectively evaluated in comparison with that of busulfan (BU) or hydroxyurea (HU) given alone. Among 107 patients diagnosed with CML between 1982 and 1997, 72 CP cases evaluable for long-term follow-up included 1...

journal_title：International journal of molecular medicine

authors： Itoh T,Tamura S,Takemoto Y,Kakishita E

更新日期：1999-12-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are...

journal_title：International journal of molecular medicine

authors： Zhu Y,Shui X,Liang Z,Huang Z,Qi Y,He Y,Chen C,Luo H,Lei W

更新日期：2020-09-01 00:00:00

abstract：:New drugs are continuously being developed for the treatment of patients with estrogen receptor-positive breast cancer. Thymoquinone is one of the drugs that exhibits anticancer characteristics based on in vivo and in vitro models. This study further investigates the effects of thymoquinone on human gene expression us...

journal_title：International journal of molecular medicine

authors： Motaghed M,Al-Hassan FM,Hamid SS

更新日期：2014-01-01 00:00:00

abstract：:Claudins (CLDNs) constitute the major transmembrane proteins of tight junctions. It may be hypothesized that changes in or loss of expression of tight junctional proteins such as CLDNs can lead to cellular disorientation and detachment, which is commonly seen in neoplasia. Recent studies have suggested that claudin-1 ...

journal_title：International journal of molecular medicine

authors： Morohashi S,Kusumi T,Sato F,Odagiri H,Chiba H,Yoshihara S,Hakamada K,Sasaki M,Kijima H

更新日期：2007-08-01 00:00:00

abstract：:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potentia...

journal_title：International journal of molecular medicine

authors： Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

更新日期：2014-01-01 00:00:00

abstract：:For a number of years, seaweed has been used as a functional food in Asian countries, particularly in Korea, Japan and China. Pyropia yezoensis is a marine red alga that has potentially beneficial biological activities. In this study, we examined the mechanisms through which a Pyropia yezoensis peptide [PYP1 (1-20)] i...

journal_title：International journal of molecular medicine

authors： Lee MK,Kim IH,Choi YH,Choi JW,Kim YM,Nam TJ

更新日期：2015-04-01 00:00:00

abstract：:Sepsis‑induced cardiomyopathy (SIC) is a complication of severe sepsis and septic shock characterized by an invertible myocardial depression. This study sought to explore the potential effects and mechanism of luteolin, a flavonoid polyphenolic compound, in lipopolysaccharide (LPS)‑induced myocardial injury. Experimen...

journal_title：International journal of molecular medicine

authors： Wu B,Song H,Fan M,You F,Zhang L,Luo J,Li J,Wang L,Li C,Yuan M

更新日期：2020-05-01 00:00:00

abstract：:Differential diagnosis between adrenal cortical and adrenal medullary lesions may be difficult in many cases. Different immunohistochemical, histochemical tools as well as ultrastructural diagnostic techniques have been employed to aid in differentiating between these lesions. Recently, both inhibin-A and BCL-2 have b...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Mulligan N,Vortmeyer AO,Poremba C,Harris CA,Alsaigh N,Tomaszewski JE,Nikulasson ST

更新日期：1999-03-01 00:00:00

abstract：:Human histocompatibility leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule. HLA-G is known to provide tolerance from recognition by natural killer cells. We studied HLA-G expression in 39 human colorectal cancers and 23 extra-neoplastic colon tissue samples by RT-PCR. The ex...

journal_title：International journal of molecular medicine

authors： Fukushima Y,Oshika Y,Nakamura M,Tokunaga T,Hatanaka H,Abe Y,Yamazaki H,Kijima H,Ueyama Y,Tamaoki N

更新日期：1998-09-01 00:00:00

abstract：:Paeonol (2'-hydroxy-4'-methoxyacetophenone) is an active component isolated from the root of Paeonia Suffruticosa Andrews. We previously found that paeonol inhibited vascular cell adhesion molecule-1 (VCAM‑1) expression, and thus may be useful for the prevention and treatment of rabbit atherosclerosis (AS); however, t...

journal_title：International journal of molecular medicine

authors： Yuan X,Chen J,Dai M

更新日期：2016-12-01 00:00:00

abstract：:Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process...

journal_title：International journal of molecular medicine

authors： Yukawa K,Tanaka T,Kishino M,Yoshida K,Takeuchi N,Ito T,Takamatsu H,Kikutani H,Kumanogoh A

更新日期：2010-07-01 00:00:00

abstract：:We have studied how benzyl-N-acetyl-alpha-D-galactosaminide, O-glycosylation inhibitor, affects the polymorphism and shedding of membrane-bound MUC1 mucin, and change in adhesive properties of cancer cells. In endometrial adenocarcinoma cells (Ishikawa line), high molecular weight MUC1 mucin was shed from cellular mem...

journal_title：International journal of molecular medicine

authors： Porowska H,Paszkiewicz-Gadek A,Anchim T,Wolczynski S,Gindzienski A

更新日期：2004-03-01 00:00:00

abstract：:To characterize the changes in global gene expression in the livers of H1/siRNAinsulin-CMV/hIDE transgenic (Tg) mice in response to the reduced bioavailability of insulin, total RNA extracted from the livers of 20-week-old Tg and non-Tg mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide ...

journal_title：International journal of molecular medicine

authors： Jee S,Hwang D,Seo S,Kim Y,Kim C,Kim B,Shim S,Lee S,Sin J,Bae C,Lee B,Jang M,Kim M,Yim S,Jang I,Cho J,Chae K

更新日期：2007-12-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant ...

journal_title：International journal of molecular medicine

authors： Zhao H,Guo M,Zhao G,Ma Q,Ma B,Qiu X,Fan Q

更新日期：2012-11-01 00:00:00

abstract：:Airway remodeling is characterized by airway wall thickening, subepithelial fibrosis, increased smooth muscle mass, angiogenesis and increased mucus secretion, which can lead to chronic and obstinate asthma and can obstruct pulmonary function. In this study, the effects of Bangpungtongseong-san water extract (BPTS) on ...

journal_title：International journal of molecular medicine

authors： Lee MY,Shin IS,Jeon WY,Shin N,Shin HK

更新日期：2014-04-01 00:00:00

abstract：:Dynamin-related peptide 1 (Drpl)-mediated mitochondrial fission is an important process associated with cardiac dysfunction under different pathological conditions. The aim of the present study was to investigate the expression of Drpl during inflammatory myocardial injury. Sprague‑Dawley rats were treated intraperito...

journal_title：International journal of molecular medicine

authors： Shen YL,Shi YZ,Chen GG,Wang LL,Zheng MZ,Jin HF,Chen YY

更新日期：2018-04-01 00:00:00

abstract：:The various associations of motor and non-motor symptoms, the onset of motor complications, the cognitive disorder's appearance and other factors make Parkinson's disease (PD) a heterogeneous syndrome with multiple phenotypes. The necessity of discriminating between different forms of PD could have a role in understan...

journal_title：International journal of molecular medicine

authors： Schillaci O,Chiaravalloti A,Pierantozzi M,Di Pietro B,Koch G,Bruni C,Stanzione P,Stefani A

更新日期：2011-11-01 00:00:00

abstract：:The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride d...

journal_title：International journal of molecular medicine

authors： Kim JH,Na J,Bak DH,Lee BC,Lee E,Choi MJ,Ryu CH,Lee S,Mun SK,Park BC,Kim BJ,Lee HS

更新日期：2019-06-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. ...

journal_title：International journal of molecular medicine

authors： Bryukhovetskiy I,Ponomarenko A,Lyakhova I,Zaitsev S,Zayats Y,Korneyko M,Eliseikina M,Mischenko P,Shevchenko V,Shanker Sharma H,Sharma A,Khotimchenko Y

更新日期：2018-08-01 00:00:00

abstract：:Angioplasty is a principal treatment for occlusive vascular disease but 30-50% of patients show a restenosis of the vessel. There is no clinical effective therapy for this disease. It has been demonstrated, in animal models, that various drugs such as NO-donor, plasminogen inhibitor tranexamic acid and MMP (matrix met...

journal_title：International journal of molecular medicine

authors： Indolfi C,Stabile E,Perrino C,Chiariello M

更新日期：1998-08-01 00:00:00

abstract：:Chronic asthma is characterized by inflammatory cell infiltration and tissue remodeling, leading to subepithelial inflammation. In order to evaluate the anti-asthmatic activity of LX519290, a derivative of L-allo threonine, we performed several in vitro and in vivo anti-asthmatic assays. Using ovalbumin (OVA)-sensitiz...

journal_title：International journal of molecular medicine

authors： Heo JC,Lee SH

更新日期：2013-04-01 00:00:00

abstract：:Needle biopsy is widely used to obtain specimens for physiological, anatomical and biochemical studies of skeletal muscle (SM). We optimized a procedure which we termed tiny percutaneous needle biopsy (TPNB), to efficiently gather good numbers of human satellite cells and single dissociated fibers for the functional s...

journal_title：International journal of molecular medicine

authors： Pietrangelo T,D'Amelio L,Doria C,Mancinelli R,Fulle S,Fanò G

更新日期：2011-03-01 00:00:00

abstract：:We isolated two phytochemical lignans, schisandrin and schisandrin C, from Schizandra chinensis Baill and investigated their anti-cancer effects in human leukemia U937 cells. Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the cell cycle and apopt...

journal_title：International journal of molecular medicine

authors： Park C,Choi YW,Hyun SK,Kwon HJ,Hwang HJ,Kim GY,Choi BT,Kim BW,Choi IW,Moon SK,Kim WJ,Choi YH

更新日期：2009-10-01 00:00:00