Abstract:
:The response of living cells to change in cell environment depends on the action of second messenger molecules. The two second messenger molecules cAMP and Ca2+ regulate a large number of eukaryotic cellular events. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1) is one of the key enzymes involved in the complex interaction between cAMP and Ca2+ second messenger systems. Some PDE1 isozymes have similar kinetic and immunological properties but are differentially regulated by Ca2+ and calmodulin. Accumulating evidence suggests that the activity of PDE1 is selectively regulated by cross-talk between Ca2+ and cAMP signalling pathways. These isozymes are also further distinguished by various pharmacological agents. We have demonstrated a potentially novel regulation of PDE1 by calpain. This study suggests that limited proteolysis by calpain could be an alternative mechanism for the activation of PDE1. We have also shown PDE1 activity, expression and effect of calpain in the rat model in vitro of cardiac ischemia-reperfusion.
journal_name
Int J Mol Medjournal_title
International journal of molecular medicineauthors
Sharma RK,Das SB,Lakshmikuttyamma A,Selvakumar P,Shrivastav Asubject
Has Abstractpub_date
2006-07-01 00:00:00pages
95-105issue
1eissn
1107-3756issn
1791-244Xjournal_volume
18pub_type
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journal_title:International journal of molecular medicine
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