Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples.

abstract：:Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a lack of potential biomarkers for the diagnosis and treatment of patients with PH...

journal_title：International journal of molecular medicine

authors： Wang J,Zhu MC,Kalionis B,Wu JZ,Wang LL,Ge HY,Chen CC,Tang XD,Song YL,He H,Xia SJ

更新日期：2018-09-01 00:00:00

abstract：:Biologic abnormalities in vascular smooth muscle cells (VSMC) may perform a crucial role in the pathogenesis of diabetic vascular disease. The principal aim of this study was to determine the effects of zipper-interacting protein kinase (ZIPK) on human aortic smooth muscle cells (HASMCs) stimulated by high glucose (HG...

journal_title：International journal of molecular medicine

authors： Ye Z,Wu W,He M,Leong M,Hu R,Li Y,Zhang S

更新日期：2014-05-01 00:00:00

abstract：:Claudins (CLDNs) constitute the major transmembrane proteins of tight junctions. It may be hypothesized that changes in or loss of expression of tight junctional proteins such as CLDNs can lead to cellular disorientation and detachment, which is commonly seen in neoplasia. Recent studies have suggested that claudin-1 ...

journal_title：International journal of molecular medicine

authors： Morohashi S,Kusumi T,Sato F,Odagiri H,Chiba H,Yoshihara S,Hakamada K,Sasaki M,Kijima H

更新日期：2007-08-01 00:00:00

abstract：:Whether or not nutritionally-regulated foreign gene expression in vivo is achievable was examined in mouse liver after in vivo gene transfer by electroporation (EP). Electric pulses were applied to a left liver lobe immediately after injection of a luciferase reporter gene driven by the liver-type phosphoenolpyruvate ...

journal_title：International journal of molecular medicine

authors： Muramatsu T,Ito N,Tamaoki N,Oda H,Park HM

更新日期：2001-01-01 00:00:00

abstract：:(-)-Epigallocatechin gallate [(-)-EGCG] has been implicated in cancer chemoprevention and has been shown as an inhibitor of tumor proteasomal chymotrypsin-like activity in vitro and in vivo. However, EGCG is subjected to rapid biotransforming modifications such as methylation by catechol-Omicron-methyltransferase (COM...

journal_title：International journal of molecular medicine

authors： Kanwar J,Mohammad I,Yang H,Huo C,Chan TH,Dou QP

更新日期：2010-08-01 00:00:00

abstract：:Gap junctions are intercellular channels made of connexin proteins, mediating both electrical and biochemical signals between cells. The ability of gap junction proteins to regulate immune responses, cell proliferation, migration, apoptosis and carcinogenesis makes them attractive therapeutic targets for treating infl...

journal_title：International journal of molecular medicine

authors： Wong P,Laxton V,Srivastava S,Chan YW,Tse G

更新日期：2017-03-01 00:00:00

abstract：:Periodontitis is the main cause of tooth or tissue loss. Human periodontal ligament stem cells (hPDLSCs), which have high proliferative, self‑renewal and multi‑differentiation abilities, are vital for the restoration of periodontitis‑induced injuries. The anti‑inflammatory and anti‑apoptotic agent, tetramethylpyrazine...

journal_title：International journal of molecular medicine

authors： Duan Y,An W,Wu Y,Wang J

更新日期：2020-06-01 00:00:00

abstract：:The prognosis for patients with metastatic bladder cancer (BCa) is poor, and has not been improved by current treatment methods. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including bladder cancer. However, the role of zinc finger E‑box‑binding homeobox 1‑antisense 1 (ZEB1‑AS1) in B...

journal_title：International journal of molecular medicine

authors： Zhao X,Wang D,Ding Y,Zhou J,Liu G,Ji Z

更新日期：2019-07-01 00:00:00

abstract：:The development of new osteoconductive bone substitute materials is expected in medicine. In this study, we attempted to produce new hydroxylapatite (HAP)/collagen (Col) composites using two HAP particles of different sizes and porcine type I collagen. The two HAP particles were either nano-sized (40 nm in average dia...

journal_title：International journal of molecular medicine

authors： Hatakeyama W,Taira M,Chosa N,Kihara H,Ishisaki A,Kondo H

更新日期：2013-12-01 00:00:00

abstract：:Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can im...

journal_title：International journal of molecular medicine

authors： Wang X,Meng H,Chen P,Yang N,Lu X,Wang ZM,Gao W,Zhou N,Zhang M,Xu Z,Chen B,Tao Z,Wang L,Yang Z,Zhu T

更新日期：2014-07-01 00:00:00

abstract：:The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pat...

journal_title：International journal of molecular medicine

authors： Mignini F,Sabbatini M,Mattioli L,Cosenza M,Artico M,Cavallotti C

更新日期：2014-06-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) epidemic in Brazil is spreading to small municipalities as well as the innermost parts of the country and scarce information has been reported on the frequency of HIV-1 resistance-associated mutations in these areas. To determine the frequency and diversity of the HIV-1 ...

journal_title：International journal of molecular medicine

authors： Figueiredo Saad F,Kaminami Morimoto H,Wiechmann SL,Bonametti AM,Ueda LT,Matsuo T,Reiche EM

更新日期：2010-10-01 00:00:00

abstract：:Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a cruc...

journal_title：International journal of molecular medicine

authors： Ding Q,Sun P,Zhou H,Wan B,Yin J,Huang Y,Li Q,Yin G,Fan J

更新日期：2018-07-01 00:00:00

abstract：:Aberrant methylation of promoter CpG islands is known to be responsible for the alteration and silencing of genes in cancer. The data presented here describes that the CpG methylations of ERalpha and ERbeta are found in breast cancer tissues, and methylation exerts a considerable effect on gene silencing, investigated...

journal_title：International journal of molecular medicine

authors： Kim SJ,Kim TW,Lee SY,Park SJ,Kim HS,Chung KW,Lee ES,Kang HS

更新日期：2004-08-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional fermented seasoning of Japan and available throughout the world. Polysaccharides were obtained from dialysate of Shoyu, and these Shoyu polysaccharides (SPS) were examined for anti-allergic activity in vitro and in vivo. The SPS originated from partially-degraded polysaccharides of s...

journal_title：International journal of molecular medicine

authors： Kobayashi M,Matsushita H,Yoshida K,Tsukiyama R,Sugimura T,Yamamoto K

更新日期：2004-11-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) occurs in patients with components of metabolic syndrome such as type 2 diabetes mellitus (T2DM). At present, the central pathophysiological problem in patients afflicted with NAFLD is insulin resistance. In this study, we aimed to determine the effects of a dipeptidyl peptida...

journal_title：International journal of molecular medicine

authors： Nakamura K,Fukunishi S,Yokohama K,Ohama H,Tsuchimoto Y,Asai A,Tsuda Y,Higuchi K

更新日期：2017-04-01 00:00:00

abstract：:The fusion gene of herpes simplex virus thymidine kinase and green fluorescent protein (TK-GFP) was shown to be a versatile tool for examining the features of thymidine kinase/ganciclovir gene therapy in vitro. In this study, we used viral vectors carrying the fusion gene to characterize the aspects of this gene thera...

journal_title：International journal of molecular medicine

authors： Pasanen T,Hakkarainen T,Timonen P,Parkkinen J,Tenhunen A,Loimas S,Wahlfors J

更新日期：2003-10-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important regulatory role during adipogenesis, and have been studied extensively in this regard. Specifically, the switch between the differentiation of mesenchymal stem cells (MSCs) towards adipogenic vs. osteogenic lineages is regulated by miR-204 which controls the expression of R...

journal_title：International journal of molecular medicine

authors： He H,Chen K,Wang F,Zhao L,Wan X,Wang L,Mo Z

更新日期：2015-06-01 00:00:00

abstract：:In contrast to the traditional biochemical study of single proteins or isolated pathways in health and disease, technical advances in the high-throughput screening of peptides by mass spectrometry have established new ways of identifying entire cellular protein populations in one swift analytical approach. This review...

journal_title：International journal of molecular medicine

authors： Doran P,Donoghue P,O'Connell K,Gannon J,Ohlendieck K

更新日期：2007-04-01 00:00:00

abstract：:Selenium deficiency is a causative factor in heart failure and microRNAs (known as miRNAs or miRs) play an important role in numerous cardiovascular diseases. However, the changes of miRNA expression during selenium deficiency and whether selenium deficiency is involved in cardiac dysfunction remain unclear. In the pr...

journal_title：International journal of molecular medicine

authors： Xing Y,Liu Z,Yang G,Gao D,Niu X

更新日期：2015-01-01 00:00:00

abstract：:Type 2 cytokine‑associated immunity may be involved in the pathogenesis of allergic asthma. Although interleukin 27 (IL‑27) has been reported as an initiator and suppressor of T‑helper 1 (Th1) and T‑helper 2 (Th2) responses, respectively, its effects on the development of asthma remain unclear. In the present study, m...

journal_title：International journal of molecular medicine

authors： Lu D,Lu J,Ji X,Ji Y,Zhang Z,Peng H,Sun F,Zhang C

更新日期：2020-08-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by progressive lung scarring and excessive extracellular matrix depositon. When stimulated, alveolar epithelial cells (AECs) are aberrantly activated, the expression of profibrotic molecules is enhanced, and lung fibro...

journal_title：International journal of molecular medicine

authors： Li B,Huang X,Xu X,Ning W,Dai H,Wang C

更新日期：2019-07-01 00:00:00

abstract：:The aim of the present study was to investigate whether ciliary neurotrophic factor (CNTF) plays its neuroprotective role following hypoxic injury through the activation of signal transducer and activator of transcription 3 (STAT3) signaling. Firstly, to determine whether CNTF exerts its effects via STAT3 following hy...

journal_title：International journal of molecular medicine

authors： Gu YL,Gao GQ,Ma N,Ye LL,Zhang LW,Gao X,Zhang ZB

更新日期：2016-12-01 00:00:00

abstract：:A substantial increase in NADH production, arising from accelerated glycolysis, occurs in cardiac hypertrophy and this raises the question of how the NADH is oxidised. We have addressed this problem by reconstructing appropriate mitochondrial shuttles in vitro, using mitochondria from the left ventricles of both normo...

journal_title：International journal of molecular medicine

authors： Atlante A,Seccia TM,De Bari L,Marra E,Passarella S

更新日期：2006-07-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by areas of inflammation, demyelination and axonal damage. The etiology of MS is multifactorial with an interaction between genetic, environmental and geographical factors. The objective of this study was to review the physiopathology and the genetic polym...

journal_title：International journal of molecular medicine

authors： Kallaur AP,Kaimen-Maciel DR,Morimoto HK,Watanabe MA,Georgeto SM,Reiche EM

更新日期：2011-10-01 00:00:00

abstract：:The basic helix loop helix (bHLH) transcription factor DEC2 is associated with the regulation of apoptosis, circadian rhythm and the response to hypoxia. However, the significance of DEC2 in pancreatic cancer remains unknown. Here, we showed for the first time that DEC2 inhibits the...

journal_title：International journal of molecular medicine

authors： Sato F,Kawamura H,Wu Y,Sato H,Jin D,Bhawal UK,Kawamoto T,Fujimoto K,Noshiro M,Seino H,Morohashi S,Kato Y,Kijima H

更新日期：2012-09-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) syndrome is an autosomal dominant neoplastic disorder characterized by hemangioblastomas of the central nervous system and retina, renal cell carcinomas, pheochromocytoma, and islet cell tumors. This syndrome is closely related with the VHL, a tumor suppressor gene, implying that loss of functi...

journal_title：International journal of molecular medicine

authors： Iida K,Okimura Y,Takahashi K,Inomata S,Iguchi G,Kaji H,Chihara K

更新日期：2004-03-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are an independent factor predicting cardiovascular events. Visfatin plays an important role in the pathogenesis of various metabolic disorders. In this study, we examined the effects of visfatin on the apoptosis of EPCs and the mechanisms underlying these effects. Cultured EPCs pre...

journal_title：International journal of molecular medicine

authors： Sun L,Chen S,Gao H,Ren L,Song G

更新日期：2017-09-01 00:00:00

abstract：:The commercial use of epidermal growth factor (EGF) is extensive and has been shown to be effective for skin wound healing in clinical practice. There is evidence to indicate that the topical administration of EGF significantly accelerates re-epithelialization by promoting keratinocyte mitogenesis and migration follow...

journal_title：International journal of molecular medicine

authors： Shen C,Sun L,Zhu N,Qi F

更新日期：2017-04-01 00:00:00