Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells.

abstract：:Pyrroloquinoline quinone (PQQ) is a naturally occurring redox co‑factor that functions as an essential nutrient and antioxidant, and has been reported to exert potent anti‑inflammatory effects. However, the therapeutic potential of PQQ for isoproterenol hydrochloride (Iso)‑induced cardiac hypertrophy has not yet been ...

journal_title：International journal of molecular medicine

authors： Wen J,Shen J,Zhou Y,Zhao X,Dai Z,Jin Y

更新日期：2020-03-01 00:00:00

abstract：:It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) alleviated liver fibrosis. We investigated whether BMSCs transfected with human matrix metalloproteinase 1 (BMSCs/MMP1) would improve their therapeutic effect in liver fibrosis induced by carbon tetrachloride (CCl4) in rats. BMSCs were transf...

journal_title：International journal of molecular medicine

authors： Du C,Jiang M,Wei X,Qin J,Xu H,Wang Y,Zhang Y,Zhou D,Xue H,Zheng S,Zeng W

更新日期：2018-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a common age-associated neurodegenerative disorder. To date, stem cell transplantation therapy has been developed to replace lost or damaged neural cells in PD patients, in whom dopaminergic neuron cells are lost. Here, we show that CD44+ human amniotic fluid cells (HuAFCs) can be induced t...

journal_title：International journal of molecular medicine

authors： Liu T,Guo L,Liu Z,Huang Y,Cheng W

更新日期：2011-11-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are...

journal_title：International journal of molecular medicine

authors： Zhu Y,Shui X,Liang Z,Huang Z,Qi Y,He Y,Chen C,Luo H,Lei W

更新日期：2020-09-01 00:00:00

abstract：:The storage period of autologous blood of hemodialysis (HD) patients was investigated with focus on the red blood cell life span. Healthy subjects, HD patients administered recombinant human erythropoietin (rHuEPO) preparation at 4,500 units/week and at 9,000 units/week were classified into 3 groups, respectively. Blo...

journal_title：International journal of molecular medicine

authors： Tsuchida K,Nakatani T,Sugimura K,Yoshimura R,Takemoto Y

更新日期：2003-02-01 00:00:00

abstract：:Hydrogen sulfide (H2S) has antifibrotic activity in the kidneys, heart, lungs, and other organs. The present study investigated the protective activity of exogenous H2S against myocardial fibrosis in a rat model of diabetes. Animals were assigned to normal control, diabetes mellitus (DM), DM + sodium hydrosulfide (NaH...

journal_title：International journal of molecular medicine

authors： Yang R,Jia Q,Ma SF,Wang Y,Mehmood S,Chen Y

更新日期：2019-08-01 00:00:00

abstract：:When treating glaucoma, excessive scar tissue reactions reduce the postoperative survival rate of the filtering bleb. Accumulating evidence has demonstrated that the proliferation, migration and extracellular matrix (ECM) synthesis of fibroblasts are important molecular mechanisms underlying scar formation. Recent evi...

journal_title：International journal of molecular medicine

authors： Sun L,Dong Y,Zhao J,Yin Y,Tong B,Zheng Y,Xin H

更新日期：2018-03-01 00:00:00

abstract：:Sleep deprivation (SD) is an epidemic phenomenon in modern countries, and its harmful effects are well known. SD acts as an aggravating factor in inflammatory bowel disease. Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, t...

journal_title：International journal of molecular medicine

authors： Park YS,Chung SH,Lee SK,Kim JH,Kim JB,Kim TK,Kim DS,Baik HW

更新日期：2015-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) have important effects on cancer occurrence and development by adjusting gene expression. The aim of the present study was to examine the role of miR‑214 in papillary thyroid carcinoma cell proliferation and metastasis, and its molecular mechanisms. miR‑214 was demonstrated to be markedly downregula...

journal_title：International journal of molecular medicine

authors： Liu F,Lou K,Zhao X,Zhang J,Chen W,Qian Y,Zhao Y,Zhu Y,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:Chondrocyte senescence is associated with the aging and degeneration of cartilage, and eventually leads to joint destruction. The aim of this study was to elucidate the mechanisms responsible for the cytoprotective effects of heme oxygenase‑1 (HO‑1) on chondrocytes in cartilage. Chondrocyte senescence was induced usin...

journal_title：International journal of molecular medicine

authors： Kim KM,Park SE,Lee MS,Kim K,Park YC

更新日期：2014-11-01 00:00:00

abstract：:The aim of this study was to elucidate the importance of three tumor markers, alpha-fetoprotein (AFP), Lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP), for detecting and predicting the recurrence of hepatocellular carcinomas (HCCs). A total of 108 patients with in...

journal_title：International journal of molecular medicine

authors： Beppu T,Sugimoto K,Shiraki K,Tameda M,Kusagawa S,Nojiri K,Tanaka J,Yamamoto N,Takei Y,Takaki H,Uraki J,Nakatsuka A,Yamakado K,Takeda K

更新日期：2010-09-01 00:00:00

abstract：:During the development of autoimmune and inflammatory diseases, infiltration by multiple leukocyte types is commonly observed at the site of inflammation. These cells are chemotactically recruited via activated integrins expressed on their cell surfaces. However, the detailed mechanism of integrin activation has not b...

journal_title：International journal of molecular medicine

authors： Ohkuro M,Hishinuma I

更新日期：2010-03-01 00:00:00

abstract：:Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the ...

journal_title：International journal of molecular medicine

authors： Tsai YM,Chiang KH,Hung JY,Chang WA,Lin HP,Shieh JM,Chong IW,Hsu YL

更新日期：2018-02-01 00:00:00

abstract：:We have previously reported that the calcium-sensing receptor (CaSR) plays an important role in modulating lipid metabolism under low calcium conditions. The aim of this study was to identify possible regulators of CaSR and the mechanisms of action of CaSR in obese individuals. Subcutaneous fat samples were obtained f...

journal_title：International journal of molecular medicine

authors： He Y,Perry B,Bi M,Sun H,Zhao T,Li Y,Sun C

更新日期：2013-08-01 00:00:00

abstract：:Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. Transforming growth factor-β1 (TGF-β1) signaling has been considered as a trigger causally contributing to pathological cardiac hypertrophy. Asiatic acid (AA) is a triterpenoid compound extracted from Centella asiatica and exhibits a variety of...

journal_title：International journal of molecular medicine

authors： Si L,Xu J,Yi C,Xu X,Wang F,Gu W,Zhang Y,Wang X

更新日期：2014-08-01 00:00:00

abstract：:Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have demonstrated that AS‑IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studi...

journal_title：International journal of molecular medicine

authors： Chen T,Yang P,Jia Y

更新日期：2021-03-01 00:00:00

abstract：:After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and Allison Piovesan, are located at DIMES at the University of Florence (fourth af...

journal_title：International journal of molecular medicine

authors： Salvi A,Vezzoli M,Busatto S,Paolini L,Faranda T,Abeni E,Caracausi M,Antonaros F,Piovesan A,Locatelli C,Cocchi G,Alvisi G,De Petro G,Ricotta D,Bergese P,Radeghieri A

更新日期：2019-08-01 00:00:00

abstract：:The expression of thymidylate synthase (TS) in human cancer tissues has been suggested to be a prognostic factor for patients receiving 5-fluorouracil-based chemotherapy. We generated monoclonal antibodies to both recombinant and native TS and analyzed the epitopes on the TS molecule. Two monoclonal antibodies were ob...

journal_title：International journal of molecular medicine

authors： Okabe H,Koizumi K,Tsujimoto H,Fukushima M

更新日期：2000-02-01 00:00:00

abstract：:Excessive preadipocyte differentiation/adipogenesis is closely linked to the development of obesity. LY3009120 is a pan‑Raf kinase inhibitor and is known for its anticancer activities. In the present study, the effect of LY3009120 on 3T3‑L1 cell adipogenesis was investigated. The differentiation of 3T3‑L1 preadipocyte...

journal_title：International journal of molecular medicine

authors： Yang SM,Park YK,Kim JI,Lee YH,Lee TY,Jang BC

更新日期：2018-12-01 00:00:00

abstract：:Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a cruc...

journal_title：International journal of molecular medicine

authors： Ding Q,Sun P,Zhou H,Wan B,Yin J,Huang Y,Li Q,Yin G,Fan J

更新日期：2018-07-01 00:00:00

abstract：:Second generation n3-PUFA-depleted rats represent a good animal model of metabolic syndrome as they display several features of the disease such as liver steatosis, visceral obesity and insulin resistance. The goal of our study was to investigate the influence of n3-PUFA deficiency on hepatic glycerol metabolism. Aqua...

journal_title：International journal of molecular medicine

authors： Portois L,Zhang Y,Ladrière L,Perret J,Louchami K,Gaspard N,Hupkens E,Bolaky N,Delforge V,Beauwens R,Malaisse WJ,Sener A,Carpentier YA,Delporte C

更新日期：2012-06-01 00:00:00

abstract：:Exposure to solar ultraviolet B (UV-B) is a known causative factor for many skin complications such as wrinkles, black spots, shedding and inflammation. Within the wavelengths 280‑320 nm, UV-B can penetrate to the epidermal level. This investigation aimed to test whether extracts from the tropical abalone [Haliotis as...

journal_title：International journal of molecular medicine

authors： Kuanpradit C,Jaisin Y,Jungudomjaroen S,Akter Mitu S,Puttikamonkul S,Sobhon P,Cummins SF

更新日期：2017-05-01 00:00:00

abstract：:The increased expression of sialyl-Lewisx (SLex) epitope on the surface of tumor cells has been known for decades. However, genetic manipulation of the expression of SLex and the role of SLex in cancer cell proliferation remains to be fully elucidated. The present study suggested that the monoclonal antibody of SLex (...

journal_title：International journal of molecular medicine

authors： Li D,Sun H,Bai G,Wang W,Liu M,Bao Z,Li J,Liu H

更新日期：2018-11-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the development of vascular diseases. In the present study, we tested the efficacy and the mechanisms of action of gastrodin, a bioactive component of the Chinese herb Gastrodia elata Bl, in relation to platelet-derived growth factor-BB (PDGF-BB...

journal_title：International journal of molecular medicine

authors： Zhu L,Guan H,Cui C,Tian S,Yang D,Wang X,Zhang S,Wang L,Jiang H

更新日期：2012-11-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00

abstract：:Leptin is a 147-amino acid adipose tissue-secreted hormone, which acts via several subtypes of receptors, the main and better known variants of which are named Ob-Ra and Ob-Rb. Structure-activity relationship studies pointed out the importance of the N-terminal and C-terminal amino-acid sequences 22-115 and 116-166, r...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Gorska T,Tortorella C,Nowak M,Majchrzak M,Spinazzi R,Nussdorfer GG,Nowak KW

更新日期：2004-06-01 00:00:00

abstract：:Elevated anxiety symptoms have been reported to be present in many patients with diabetes mellitus. The underlying mechanisms by which diabetes mellitus influences behavior remain to be determined. We assessed feeding and anxiety behaviors in spontaneously diabetic Ins2Akita mice. We measured blood glucose, body weigh...

journal_title：International journal of molecular medicine

authors： Asakawa A,Toyoshima M,Inoue K,Koizumi A

更新日期：2007-04-01 00:00:00

abstract：:In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations d...

journal_title：International journal of molecular medicine

authors： Jin R,Kaneko H,Suzuki H,Arai T,Teramoto T,Fukao T,Kondo N

更新日期：2008-02-01 00:00:00

abstract：:The purpose of this study was to detect the differentially expressed genes between ossified herniated discs and herniated discs without ossification. In addition, we sought to identify a few candidate genes and pathways by using bioinformatics analysis. We analyzed 6 samples each of ossified herniated discs (experimen...

journal_title：International journal of molecular medicine

authors： Shao J,Yu M,Jiang L,Wu F,Liu X

更新日期：2017-01-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is highly malignant and poorly differentiated, resulting in a high frequency of local recurrence and distant metastases. Sox2 (Sry‑box2), an important factor in embryonic development and cell differentiation, has been shown to associate with malignant phenotypes and epithelial‑mes...

journal_title：International journal of molecular medicine

authors： Liu X,Qiao B,Zhao T,Hu F,Lam AK,Tao Q

更新日期：2018-09-01 00:00:00