p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study.

abstract：:The mechanisms through which mechanical ventilation causes non-infectious inflammatory diseases and lung injury are poorly understood. Animals models of this type of injury suggest that it involves signaling mediated by Toll‑like receptor (TLR)4 and 9. In this study, in order to gain further insight into the involveme...

journal_title：International journal of molecular medicine

authors： Huang C,Pan L,Lin F,Dai H,Fu R

更新日期：2017-03-01 00:00:00

abstract：:When treating glaucoma, excessive scar tissue reactions reduce the postoperative survival rate of the filtering bleb. Accumulating evidence has demonstrated that the proliferation, migration and extracellular matrix (ECM) synthesis of fibroblasts are important molecular mechanisms underlying scar formation. Recent evi...

journal_title：International journal of molecular medicine

authors： Sun L,Dong Y,Zhao J,Yin Y,Tong B,Zheng Y,Xin H

更新日期：2018-03-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the clearance of pathogens. In the present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C...

journal_title：International journal of molecular medicine

authors： Bian H,Li F,Wang W,Zhao Q,Gao S,Ma J,Li X,Ren W,Qin C,Qi J

更新日期：2017-11-01 00:00:00

abstract：:Cell numbers are regulated by a balance between proliferation and apoptosis (programmed cell death). Recent evidence suggests that proteins regulating cell proliferation also mediate apoptosis. Therefore, cellular fate might be determined by cross talk between regulators of cell cycle progression and apoptosis. Previo...

journal_title：International journal of molecular medicine

authors： An B,Johnson DE,Jin JR,Antoku K,Dou QP

更新日期：1998-01-01 00:00:00

abstract：:Microsatellite instability (MSI) and loss of heterozygosity (LOH) was investigated in paired tumour and normal tissue DNA from 108 predominantly premenopausal breast cancer patients (under age 45 years at presentation) for 25 simple repeat loci interspersed across 11 chromosomes. MSI was observed at a single locus in ...

journal_title：International journal of molecular medicine

authors： Luqmani YA,Mathew M,Lobo S

更新日期：2003-01-01 00:00:00

abstract：:Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma cell lines. The expression of these molecules has been also characterized in human normal ti...

journal_title：International journal of molecular medicine

authors： Takebayashi Y,Nakayama K,Fujioka T,Kanzaki A,Mutho M,Uchida T,Miyazaki K,Ito M,Fukumoto M

更新日期：2001-04-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), which is estrogen receptor (ER)-negative, progesterone receptor‑negative and is also negative for HER2 expression, remains a great clinical challenge due to its strong resistance to chemotherapy at the late stage of treatment and relatively unfavorable prognosis. Gemcitabine has b...

journal_title：International journal of molecular medicine

authors： Chen M,He M,Song Y,Chen L,Xiao P,Wan X,Dai F,Shen P

更新日期：2014-07-01 00:00:00

abstract：:Although recent reports indicate an increasing incidence of patients with reflux esophagitis, its pathomechanism remains unclear. Cytokines and neutrophils, the latter of which produce reactive oxygen species (ROS), have been implicated in the formation of gastrointestinal diseases. This study investigated the roles o...

journal_title：International journal of molecular medicine

authors： Yamaguchi T,Yoshida N,Tomatsuri N,Takayama R,Katada K,Takagi T,Ichikawa H,Naito Y,Okanoue T,Yoshikawa T

更新日期：2005-07-01 00:00:00

abstract：:In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Daly T,Gausas RE

更新日期：2004-05-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a lethal disease due to its high aggressiveness. The aim of the present study was to investigate the role of xeroderma pigmentosum complementation group D (XPD) in the growth and invasion of ESCC and to elucidate the potential underlying molecular mechanisms. Western blot a...

journal_title：International journal of molecular medicine

authors： Jian J,Li S,Liu LZ,Zhen L,Yao L,Gan LH,Huang YQ,Fang N

更新日期：2020-07-01 00:00:00

abstract：:The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicativ...

journal_title：International journal of molecular medicine

authors： Quatresooz P,Pierard GE,Pierard-Franchimont C,Mosan Study Group of Pigmented Tumors.

更新日期：2009-09-01 00:00:00

abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

journal_title：International journal of molecular medicine

authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

更新日期：2012-02-01 00:00:00

abstract：:The family of chromosomal high mobility group I/Y consists of proteins involved in gene regulation and chromatin organization. A common feature of these proteins is the presence of multiple copies of DNA binding domains (DBD), the so-called AT-hooks. Bi- or tridendate interaction of two or three DBDs with appropriatel...

journal_title：International journal of molecular medicine

authors： Wisniewski JR,Schwanbeck R

更新日期：2000-10-01 00:00:00

abstract：:Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage foll...

journal_title：International journal of molecular medicine

authors： Toth B,Schwacha MG,Kuebler JF,Bland KI,Wang P,Chaudrya IH

更新日期：2003-03-01 00:00:00

abstract：:The polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine and reproductive dysfunctional diseases. Recent research for genetic variants has identified genetic influences between the polymorphisms of the adiponectin gene and the metabolic syndromes. The aim of our study was to investigate t...

journal_title：International journal of molecular medicine

authors： Li L,Yun JH,Lee JH,Song S,Choi BC,Baek KH

更新日期：2011-02-01 00:00:00

abstract：:The basic helix loop helix (bHLH) transcription factor DEC2 is associated with the regulation of apoptosis, circadian rhythm and the response to hypoxia. However, the significance of DEC2 in pancreatic cancer remains unknown. Here, we showed for the first time that DEC2 inhibits the...

journal_title：International journal of molecular medicine

authors： Sato F,Kawamura H,Wu Y,Sato H,Jin D,Bhawal UK,Kawamoto T,Fujimoto K,Noshiro M,Seino H,Morohashi S,Kato Y,Kijima H

更新日期：2012-09-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) family of transcription factors have been implicated in the regulation of cell proliferation and differentiation. Here we describe molecular characterization of mesoderm-specific bHLH protein, POD-1/Capsulin. Northern blot analysis showed that POD-1/Capsulin are preferentia...

journal_title：International journal of molecular medicine

authors： Miyagishi M,Nakajima T,Fukamizu A

更新日期：2000-01-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen exerts an effective thera...

journal_title：International journal of molecular medicine

authors： Yao L,Chen H,Wu Q,Xie K

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present study was to elucidate whether extracts of Vigna angularis (EVA) inhibit allergic inflammatory reactions and to elucidate the possible mechanisms of action. For the assessment of allergic inflammatory response, histamine release and the expression of pro-inflammatory cytokines from human mast ce...

journal_title：International journal of molecular medicine

authors： Kim HH,Kim SW,Kim DS,Oh HM,Rho MC,Kim SH

更新日期：2013-09-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) epidemic in Brazil is spreading to small municipalities as well as the innermost parts of the country and scarce information has been reported on the frequency of HIV-1 resistance-associated mutations in these areas. To determine the frequency and diversity of the HIV-1 ...

journal_title：International journal of molecular medicine

authors： Figueiredo Saad F,Kaminami Morimoto H,Wiechmann SL,Bonametti AM,Ueda LT,Matsuo T,Reiche EM

更新日期：2010-10-01 00:00:00

abstract：:In the present study, we examined whether Acer okamotoanum (A. okamotoanum) sap decreased the serum alcohol and acetaldehyde levels after acute ethanol treatment in a rat model. Male rats were orally administered 25, 50 or 100% A. okamotoanum sap 30 min prior to oral challenge with 3 ml of ethanol (15 ml/kg of a 20% e...

journal_title：International journal of molecular medicine

authors： Yoo YM,Jung EM,Kang HY,Choi IG,Choi KC,Jeung EB

更新日期：2011-10-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:The number of regulatory T cells (Treg cells) and the expression of ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1; also known as CD39) and 5'-ectonucleotidase (NT5E; also known as CD73) on the Treg cell surface are increased during sepsis. In this study, to determine the factors leading to the high expressi...

journal_title：International journal of molecular medicine

authors： Bao R,Shui X,Hou J,Li J,Deng X,Zhu X,Yang T

更新日期：2016-09-01 00:00:00

abstract：:Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained ...

journal_title：International journal of molecular medicine

authors： Le HTT,Cho YC,Cho S

更新日期：2018-03-01 00:00:00

abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

journal_title：International journal of molecular medicine

authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

更新日期：2001-03-01 00:00:00

abstract：:Cerebral aneurysms and arteriovenous malformations (AVM) are a common cause of stroke and cerebral hemorrage. Both are often discovered when they rupture, causing subarachnoid hemorrhage (SAH). SAH-induced vasospasm is mediated by enhanced vasoconstriction due to endothelin-1 (ET-1). We investigated whether endothelia...

journal_title：International journal of molecular medicine

authors： Boscolo E,Pavesi G,Zampieri P,Conconi MT,Calore C,Scienza R,Parnigotto PP,Folin M

更新日期：2006-11-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that has been implicated as a positive mediator of apoptosis. However, little is known about the involvement of DAPK in the apoptosis associated with several pathological states, except for cancer. Here, DAPK-mutant mice were...

journal_title：International journal of molecular medicine

authors： Yukawa K,Hoshino K,Kishino M,Mune M,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Tanaka T,Ichinose M,Maeda M,Takeda K,Akira S

更新日期：2004-04-01 00:00:00

abstract：:Altered D-glucose metabolism prevails in the soleus muscle of rats depleted in long-chain polyunsaturated omega3 fatty acids (omega3). In these animals, the prior intravenous injection of an omega3-rich medium-chain triglyceride:fish oil emulsion (omega3-FO rats), as compared to that of an omega3-poor medium-chain tri...

journal_title：International journal of molecular medicine

authors： Malaisse WJ,Portois L,Sener A,Carpentier YA

更新日期：2007-12-01 00:00:00

abstract：:Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a cruc...

journal_title：International journal of molecular medicine

authors： Ding Q,Sun P,Zhou H,Wan B,Yin J,Huang Y,Li Q,Yin G,Fan J

更新日期：2018-07-01 00:00:00

abstract：:The majority of studies on scar formation have mainly focused on the dermis and little is known of the involvement of the epidermis. Previous research has demonstrated that the scar tissue-derived keratinocytes are different from normal cells at both the genetic and cell biological levels; however, the mechanisms resp...

journal_title：International journal of molecular medicine

authors： Yang S,Sun Y,Geng Z,Ma K,Sun X,Fu X

更新日期：2016-05-01 00:00:00