Endothelial cells from human cerebral aneurysm and arteriovenous malformation release ET-1 in response to vessel rupture.

abstract：:Telomerase activity and hTERT mRNA expression are upregulated in colorectal cancer. Whether they are inherent in colorectal adenomas, premalignant lesions to cancer, however, remains to be elucidated. We examined telomerase activity by the fluorescence-based telomeric repeat amplification protocol method and analyzed ...

journal_title：International journal of molecular medicine

authors： Kanamaru T,Tanaka K,Kotani J,Ueno K,Yamamoto M,Idei Y,Hisatomi H,Takeyama Y

更新日期：2002-08-01 00:00:00

abstract：:The aim of this study was to investigate the role of microRNAs (miRNAs or miRs) in vascular smooth muscle cell (VSMC) proliferation and to elucidate the underlying molecular mechanisms. In a previous study, using microarray analysis, differentially expressed miRNAs were identified in primary VSMCs isolated from the me...

journal_title：International journal of molecular medicine

authors： Liu K,Ying Z,Qi X,Shi Y,Tang Q

更新日期：2015-09-01 00:00:00

abstract：:Dextromethorphan is a widely used anti-tussive drug with non-competitive antagonistic effects on excitatory amino acid receptors of the N-methyl-D-aspartate (NMDA) type. This study examined the effect of daily dextromethorphan administration on gene expression in rat brain hippocampus and cortex regions using Rat 5K c...

journal_title：International journal of molecular medicine

authors： Lee KH,Ahn JI,Yu DH,Koh HC,Kim SH,Yang BH,Lee YS,Lee YS

更新日期：2003-05-01 00:00:00

abstract：:Metabolic syndrome (MetS), a clustering of components, is closely associated with the development and prognosis of cardiovascular disease and diabetes. Sphingosine 1-phosphate (S1P) is a lysophospholipid with paracrine and autocrine effects, which is associated with obesity, insulin resistance, hyperglycemia, dyslipid...

journal_title：International journal of molecular medicine

authors： Chen W,Lu H,Yang J,Xiang H,Peng H

更新日期：2016-10-01 00:00:00

abstract：:Vitiligo is an acquired and progressive disorder manifested by the selective destruction of melanocytes in the skin. An extremely high level of hydrogen peroxide (H2O2) in plasma as well as in lesional skin has been reported in vitiligo patients. High H2O2 level has been suggested to be responsible for the disappearan...

journal_title：International journal of molecular medicine

authors： Song X,Xu A,Pan W,Wallin B,Kivlin R,Lu S,Cao C,Bi Z,Wan Y

更新日期：2008-07-01 00:00:00

abstract：:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potentia...

journal_title：International journal of molecular medicine

authors： Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

更新日期：2014-01-01 00:00:00

abstract：:The molecular pathogenesis of osteosarcoma is very complicated and associated with chaotic abnormalities on many chromosomal arms. We analyzed 12 cases of osteosarcomas with comparative genomic hybridization (CGH) to identify chromosomal imbalances, and detected highly frequent chromosomal alterations in chromosome 6q...

journal_title：International journal of molecular medicine

authors： Ohata N,Ito S,Yoshida A,Kunisada T,Numoto K,Jitsumori Y,Kanzaki H,Ozaki T,Shimizu K,Ouchida M

更新日期：2006-12-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:About 80% of short children are not deficient in endogenous growth hormone (GH) and termed idiopathic short stature (ISS). The causes of impaired growth in children with ISS are various. Short stature and low insulin-like growth factor-I (IGF-I) concentration despite normal to high GH concentration suggest impaired GH...

journal_title：International journal of molecular medicine

authors： Takahashi Y,Chihara K

更新日期：1998-09-01 00:00:00

abstract：:In the present study, a highly efficient method, referred to as optimized ultrafiltration (OUF), was developed. This method is effective for exosome purification and also facilitates clinical work involving substantial urinary exosome isolation. In the OUF method, 0.22‑µm filters along with a dialysis membrane with a ...

journal_title：International journal of molecular medicine

authors： He L,Zhu D,Wang J,Wu X

更新日期：2019-01-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells. There are quantitative and qualitative changes in expression of gangliosides observed in tumors of a neuroectodermal origin such as neuroblastoma, melanoma and astrocytoma. The presence of large amounts of GD2 ganglioside on neuroblastoma cells, as compare...

journal_title：International journal of molecular medicine

authors： Horwacik I,Czaplicki D,Talarek K,Kowalczyk A,Bolesta E,Kozbor D,Rokita H

更新日期：2007-05-01 00:00:00

abstract：:The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. The myocardial I/R model was established using C57BL/J6 mice. Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. Commercial kits were used ...

journal_title：International journal of molecular medicine

authors： Zhou Y,Li KS,Liu L,Li SL

更新日期：2020-06-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) are a cell population mobilized from bone marrow into the peripheral circulation and recruited into sites of vessel injury to participate in blood vessel formation in both physiological and pathological conditions. Due to the lack of unique surfac...

journal_title：International journal of molecular medicine

authors： Li DW,Liu ZQ,Wei J,Liu Y,Hu LS

更新日期：2012-11-01 00:00:00

abstract：:Acute Achilles tendon (AT) rupture is a common injury with a comparatively high complication rate. Presently, surgical treatments compete with nonoperative treatment modalities. The aim of this study was to elucidate the possible beneficial effects of short-term combinatory application of growth factors on tendon heal...

journal_title：International journal of molecular medicine

authors： Konerding MA,Arlt F,Wellmann A,Li V,Li W

更新日期：2010-02-01 00:00:00

abstract：:The present study aimed to assess the effects of therapy with adiponectin (APN) gene-modified adipose-derived stem cells (ADSCs) on pulmonary arterial hypertension (PAH) in rats and the underlying cellular and molecular mechanisms. ADSCs were successfully isolated from the rats and characterized. ADSCs were effectivel...

journal_title：International journal of molecular medicine

authors： Luo L,Zheng W,Lian G,Chen H,Li L,Xu C,Xie L

更新日期：2018-01-01 00:00:00

abstract：:The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride d...

journal_title：International journal of molecular medicine

authors： Kim JH,Na J,Bak DH,Lee BC,Lee E,Choi MJ,Ryu CH,Lee S,Mun SK,Park BC,Kim BJ,Lee HS

更新日期：2019-06-01 00:00:00

abstract：:Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease...

journal_title：International journal of molecular medicine

authors： Hou X,Du H,Yang R,Qi J,Huang Y,Feng S,Wu Y,Lin S,Liu Z,Jia AQ,Yuan S,Sun L

更新日期：2018-05-01 00:00:00

abstract：:Microglia of the central nervous system serve a variety of functions that may ultimately lead to the development or detriment of neighboring neuronal and vascular cells. These scavengers of the nervous system have been associated with a variety of neurodegenerative disorders, but the toxic potential of microglia is eq...

journal_title：International journal of molecular medicine

authors： Chong ZZ,Li F,Maiese K

更新日期：2007-02-01 00:00:00

abstract：:Poligoni Multiflori Radix (PMR) is a traditional Korean medicinal herb that is known to have various pharmacological effects, including antihyperlipidemic, anticancer, and anti‑inflammatory effects. However, the effects of PMR on bone metabolism have not been elucidated to date. The present study aimed to investigate ...

journal_title：International journal of molecular medicine

authors： Han SY,Lee KH,Kim YK

更新日期：2018-07-01 00:00:00

abstract：:Numerous studies have demonstrated the antioxidant effects of grape seed proanthocyanidin extract (GSPE). The generation of free radicals and the ensuing apoptosis may contribute to the pathogenesis of epilepsy; therefore, in the present study, we examined the effects of GSPE on cognitive impairment and neuronal damag...

journal_title：International journal of molecular medicine

authors： Zhen J,Qu Z,Fang H,Fu L,Wu Y,Wang H,Zang H,Wang W

更新日期：2014-08-01 00:00:00

abstract：:To examine the relationship between pathophysiological effects and molecular features of anti-double-stranded (ds)DNA autoantibodies (Abs), we isolated anti-dsDNA Ab fragments by using the phage-display method. Fd ç and light-chain DNA were PCR amplified from peripheral blood lymphocytes of a patient with systemic lup...

journal_title：International journal of molecular medicine

authors： Suzuki M,Katsube Y,Suzuki H,Takemura H,Sumida T

更新日期：1999-04-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. ...

journal_title：International journal of molecular medicine

authors： Bryukhovetskiy I,Ponomarenko A,Lyakhova I,Zaitsev S,Zayats Y,Korneyko M,Eliseikina M,Mischenko P,Shevchenko V,Shanker Sharma H,Sharma A,Khotimchenko Y

更新日期：2018-08-01 00:00:00

abstract：:The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis plays an important role in regulating oxidative stress in ischemic cardiomyocytes. Targeting Keap1 in order to promote Nrf2 activation is considered a potential method for protecting cardiomyocytes against...

journal_title：International journal of molecular medicine

authors： Sun X,Zuo H,Liu C,Yang Y

更新日期：2016-10-01 00:00:00

abstract：:The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose ...

journal_title：International journal of molecular medicine

authors： Sung HJ,Kim Y,Kang H,Sull JW,Kim YS,Jang SW,Ko J

更新日期：2012-02-01 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63...

journal_title：International journal of molecular medicine

authors： Hara T,Kijima H,Yamamoto S,Kenmochi T,Kise Y,Tanaka H,Chino O,Shimada H,Takazawa K,Tanaka M,Inokuchi S,Makuuchi H

更新日期：2004-08-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and a key element in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Moreover, it is a negative regulator of autophagy and acts as a central regulator in cell growth. For the treatment of cancer, mTOR is a nove...

journal_title：International journal of molecular medicine

authors： Cai Y,Xia Q,Su Q,Luo R,Sun Y,Shi Y,Jiang W

更新日期：2013-04-01 00:00:00

abstract：:To assess effects of Celecoxib, selective cyclo-oxygenase (COX)-2 inhibitor, on matrix synthesis by chondrocytes under mechanical stress in vitro. Chondrocytes from 7-day-old rat articular cartilage were cultured. Cyclic mechanical stress (0.5 Hz, 7% elongation) was loaded using a Flexercell strain unit in the presenc...

journal_title：International journal of molecular medicine

authors： Iimoto S,Watanabe S,Takahashi T,Shimizu A,Yamamoto H

更新日期：2005-12-01 00:00:00

abstract：:Neural stem cell transplantation is a promising new treatment of ischemic or traumatic brain injury. We have now investigated the involvement of the peroxynitrite - poly(ADP-ribose) polymerase (ONOO- - PARP) activation cascade in brain trauma and neural stem cell transplantation. The forelimb motor cortex of adult mal...

journal_title：International journal of molecular medicine

authors： Lacza Z,Horváth EM,Komjáti K,Hortobágyi T,Szabó C,Busija DW

更新日期：2003-08-01 00:00:00

abstract：:Anorectal malformations (ARMs) comprise a broad spectrum of anomalies, including anal atresia, congenital anal fistula and persistence of the cloaca. Research suggests that genetic factors play an important role in ARM development. However, few genetic variants have been identified....

journal_title：International journal of molecular medicine

authors： Draaken M,Prins W,Zeidler C,Hilger A,Mughal SS,Latus J,Boemers TM,Schmidt D,Schmiedeke E,Spychalski N,Bartels E,Nöthen MM,Reutter H,Ludwig M

更新日期：2012-12-01 00:00:00

abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

journal_title：International journal of molecular medicine

authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

更新日期：2018-07-01 00:00:00