The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells.

abstract：:In hypercholesterolemia increased lipid and lipoprotein peroxidation occurs. The renin-angiotensin system plays an important role in atherogenesis. Angiotensin II induces smooth muscle cells proliferation and stimulates oxidation of LDL particles and foam cell accumulation. Inhibition of ang II production leads to dec...

journal_title：International journal of molecular medicine

authors： Wojakowski W,Gminski J,Siemianowicz K,Goss M,Machalski M

更新日期：2000-11-01 00:00:00

abstract：:The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role ...

journal_title：International journal of molecular medicine

authors： Jang BC,Lim KJ,Choi IH,Suh MH,Park JG,Mun KC,Bae JH,Shin DH,Suh SI

更新日期：2007-05-01 00:00:00

abstract：:Inflammatory genes serve a crucial role in the pathogenesis of inflammation‑associated tumors. However, as recent studies have mainly focused on the effects of single inflammatory genes on colorectal cancer (CRC), but not on the global interactions between genes, the underlying mechanisms between inflammatory genes and...

journal_title：International journal of molecular medicine

authors： Jiang H,Dong L,Gong F,Gu Y,Zhang H,Fan D,Sun Z

更新日期：2018-07-01 00:00:00

abstract：:p38 has been shown to be involved in TGF-beta-induced gene expression, but the upstream of the signaling pathway leading to the activation of p38 is left undefined. We investigated the pathway in cultured human keratinocytes (HaCat cells). Western blot analysis revealed that TGF-beta induced the activation of p38 with...

journal_title：International journal of molecular medicine

authors： Chiu C,Maddock DA,Zhang Q,Souza KP,Townsend AR,Wan Y

更新日期：2001-09-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2), a multifunctional member of the transforming growth factor (TGF)-beta, superfamily, has powerful osteoinductive effects and causes cell cycle arrest in a variety of transformed cell lines. We have observed BMP-2-induced inhibition of cell proliferation in an androgen-dependent hum...

journal_title：International journal of molecular medicine

authors： Tomari K,Kumagai T,Shimizu T,Takeda K

更新日期：2005-02-01 00:00:00

abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

journal_title：International journal of molecular medicine

authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

更新日期：2005-04-01 00:00:00

abstract：:We evaluated the mechanism of antitumor effects of buserelin, which is one of LH-RH agonists, on a hormone dependent breast cancer model, using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer. Rats developing solid mammary tumors within 5-7 weeks following the DMBA administration were divided into gro...

journal_title：International journal of molecular medicine

authors： Koibuchi Y,Sugamata N,Iino Y,Yokoe T,Andoh T,Maemura M,Takei H,Horiguchi J,Matsumoto H,Morishita Y

更新日期：1999-08-01 00:00:00

abstract：:Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. In the present study, human PTECs were incubated with 100 µg/ml soluble (S) UA in the pre...

journal_title：International journal of molecular medicine

authors： Yang Q,Fu C,Zhang X,Zhang Z,Zou J,Xiao J,Ye Z

更新日期：2019-03-01 00:00:00

abstract：:Cardiac fibroblast (CF) proliferation and transformation into myofibroblasts play important roles in cardiac fibrosis during pathological myocardial remodeling. In this study, we demonstrate that hepatocyte growth factor (HGF), an antifibrotic factor in the process of pulmonary, renal and liver fibrosis, is a negative...

journal_title：International journal of molecular medicine

authors： Yi X,Li X,Zhou Y,Ren S,Wan W,Feng G,Jiang X

更新日期：2014-08-01 00:00:00

abstract：:Free radicals derived from the reaction of iron and oxygen are thought to be one of the causes of tissue injury. In order to identify whether oxygen concentrations are an important factor in iron-mediated damage to cells, cytotoxic effects of Fe(3+)-NTA on human fibroblasts (KMST-6 line) were studied under the conditi...

journal_title：International journal of molecular medicine

authors： Pu H,Sakaguchi M,Kondo T,Kondo A,Kawabata T,Namba M

更新日期：2001-03-01 00:00:00

abstract：:Most peptidic growth factors (GFs) that act as mitogens for different cell types bind to tyrosine kinase receptors (RTKs) and trigger complex intracellular signal transduction pathways finally leading to cell proliferation. Among the early events induced by GFs, cytosolic calcium increase plays a key role, and in part...

journal_title：International journal of molecular medicine

authors： Munaron L

更新日期：2002-12-01 00:00:00

abstract：:POU domain proteins are a family of critical regulators of development and differentiation due to their transcriptional activity in the nucleus. Skn‑1a, a member of the POU domain protein family, appears to be expressed predominantly in epidermal keratinocytes and is thought to play a critical role in keratinocyte dif...

journal_title：International journal of molecular medicine

authors： Moritsugu R,Tamai K,Nakano H,Aizu T,Nakajima K,Yamazaki T,Sawamura D

更新日期：2014-08-01 00:00:00

abstract：:Orexins are hypothalamic peptides that regulate food intake, wakefulness, the reward system and energy metabolism. Recent studies have demonstrated the ability of orexins to promote a robust apoptosis and subsequent inhibition of cell growth in various types of cancer cells. The present study was conducted to investig...

journal_title：International journal of molecular medicine

authors： Liu Y,Zhao Y,Ju S,Guo L

更新日期：2015-02-01 00:00:00

abstract：:Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this ...

journal_title：International journal of molecular medicine

authors： Enjoji M,Kotoh K,Kato M,Higuchi N,Kohjima M,Nakashima M,Nakamuta M

更新日期：2008-10-01 00:00:00

abstract：:Serum response factor (SRF) is a transcription factor that has important roles in tumor progression. However, its role in cervical cancer cell proliferation and invasion remains unclear. The present study revealed that SRF silencing constrained cervical cancer cell proliferation and invasion via controlling early grow...

journal_title：International journal of molecular medicine

authors： Ma L,Yu Y,Qu X

更新日期：2019-01-01 00:00:00

abstract：:Mostotrin (MT), a novel compound, at least five orders of magnitude more soluble in water than its mother substance, was designed and synthesised from tryptanthrin (TR). Its structure was established by nuclear magnetic resonance and mass spectrometry data and confirmed by X‑ray analysis, revealing that MT is a pentac...

journal_title：International journal of molecular medicine

authors： Popov A,Klimovich A,Styshova O,Moskovkina T,Shchekotikhin A,Grammatikova N,Dezhenkova L,Kaluzhny D,Deriabin P,Gerasimenko A,Udovenko A,Stonik V

更新日期：2020-10-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant ...

journal_title：International journal of molecular medicine

authors： Zhao H,Guo M,Zhao G,Ma Q,Ma B,Qiu X,Fan Q

更新日期：2012-11-01 00:00:00

abstract：:The low survival rate of patients with colorectal cancer (CRC) is mainly due to the drug resistance of tumor cells to chemotherapeutic agents. It has been reported that basic fibroblast growth factor (bFGF) is an essential factor involved in the epigenetic mechanisms of drug resistance, which provides a novel potentia...

journal_title：International journal of molecular medicine

authors： Luo W,Yu Y,Wang R,He D,Wang C,Zeng X,Chen X,Tan X,Huang T,Wu X

更新日期：2014-01-01 00:00:00

abstract：:Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

journal_title：International journal of molecular medicine

authors： Grässel S,Ahmed N,Göttl C,Grifka J

更新日期：2009-06-01 00:00:00

abstract：:The prognosis for patients with metastatic bladder cancer (BCa) is poor, and has not been improved by current treatment methods. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including bladder cancer. However, the role of zinc finger E‑box‑binding homeobox 1‑antisense 1 (ZEB1‑AS1) in B...

journal_title：International journal of molecular medicine

authors： Zhao X,Wang D,Ding Y,Zhou J,Liu G,Ji Z

更新日期：2019-07-01 00:00:00

abstract：:Dietary fat is an important factor involved in the pathogenesis of inflammatory bowel disease (IBD). It remains unclear how n-3 and n-6 fatty acids modulate intestinal inflammation. In this study, we investigated the effects of n-3 and n-6 fatty acid-rich diets on trinitrobenzene sulfonic acid (TNBS)-induced enteritis...

journal_title：International journal of molecular medicine

authors： Andoh A,Tsujikawa T,Ishizuka I,Araki Y,Sasaki M,Koyama S,Fujiyama Y

更新日期：2003-11-01 00:00:00

abstract：:The aim of this study was to evaluate in detail the histopathological characteristics of endarterectomized carotid atherosclerotic lesions in symptomatic versus asymptomatic patients. Twenty carotid lesions, 10 from asymptomatic and 10 from symptomatic patients who underwent carotid endarterectomy were classified acco...

journal_title：International journal of molecular medicine

authors： Hakimi M,Hyhlik-Dürr A,von Au A,Betz M,Demirel S,Dihlmann S,Böckler D,Gross-Weissmann ML

更新日期：2013-08-01 00:00:00

abstract：:Preclinical studies have suggested that paracrine factors from adipose-derived stem cells (ASCs) promote the healing of chronic wounds, and that the exposure of ASCs to hypoxia enhances their wound healing effect. To aid the translation of these findings into clinical use, robust wound models are necessary to explore ...

journal_title：International journal of molecular medicine

authors： Riis S,Newman R,Ipek H,Andersen JI,Kuninger D,Boucher S,Vemuri MC,Pennisi CP,Zachar V,Fink T

更新日期：2017-03-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00

abstract：:Second generation n3-PUFA-depleted rats represent a good animal model of metabolic syndrome as they display several features of the disease such as liver steatosis, visceral obesity and insulin resistance. The goal of our study was to investigate the influence of n3-PUFA deficiency on hepatic glycerol metabolism. Aqua...

journal_title：International journal of molecular medicine

authors： Portois L,Zhang Y,Ladrière L,Perret J,Louchami K,Gaspard N,Hupkens E,Bolaky N,Delforge V,Beauwens R,Malaisse WJ,Sener A,Carpentier YA,Delporte C

更新日期：2012-06-01 00:00:00

abstract：:We have studied how benzyl-N-acetyl-alpha-D-galactosaminide, O-glycosylation inhibitor, affects the polymorphism and shedding of membrane-bound MUC1 mucin, and change in adhesive properties of cancer cells. In endometrial adenocarcinoma cells (Ishikawa line), high molecular weight MUC1 mucin was shed from cellular mem...

journal_title：International journal of molecular medicine

authors： Porowska H,Paszkiewicz-Gadek A,Anchim T,Wolczynski S,Gindzienski A

更新日期：2004-03-01 00:00:00

abstract：:Evodiamine is a botanical alkaloid compound extracted from Tetradium plants. Previous studies have reported that evodiamine (Evo) treatment can reduce food uptake and improve insulin resistance in animals . The skeletal muscle comprises about 40% of the body mass of adults and has a vital role in regulating whole body...

journal_title：International journal of molecular medicine

authors： Yao X,Yu T,Zhao C,Li Y,Peng Y,Xi F,Yang G

更新日期：2018-03-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:MicroRNAs (miRNAs) have important effects on cancer occurrence and development by adjusting gene expression. The aim of the present study was to examine the role of miR‑214 in papillary thyroid carcinoma cell proliferation and metastasis, and its molecular mechanisms. miR‑214 was demonstrated to be markedly downregula...

journal_title：International journal of molecular medicine

authors： Liu F,Lou K,Zhao X,Zhang J,Chen W,Qian Y,Zhao Y,Zhu Y,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMAC1 were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become...

journal_title：International journal of molecular medicine

authors： Wang NM,Chang JG

更新日期：1999-05-01 00:00:00