The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells.

abstract：:Leptin is a 147-amino acid adipose tissue-secreted hormone, which acts via several subtypes of receptors, the main and better known variants of which are named Ob-Ra and Ob-Rb. Structure-activity relationship studies pointed out the importance of the N-terminal and C-terminal amino-acid sequences 22-115 and 116-166, r...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Gorska T,Tortorella C,Nowak M,Majchrzak M,Spinazzi R,Nussdorfer GG,Nowak KW

更新日期：2004-06-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a common, fatal and frequently recurrent disease. Changes in the activity of different coagulation factors serve as a pathophysiological basis for the recurrent risk of VTE. Systems biology approaches provide a better understanding of the pathological mechanisms responsible for recurren...

journal_title：International journal of molecular medicine

authors： Xie R,Li L,Chen L,Li W,Chen B,Jiang J,Huang H,Li Y,He Y,Lv J,He W

更新日期：2017-02-01 00:00:00

abstract：:Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this ...

journal_title：International journal of molecular medicine

authors： Enjoji M,Kotoh K,Kato M,Higuchi N,Kohjima M,Nakashima M,Nakamuta M

更新日期：2008-10-01 00:00:00

abstract：:Melatonin is known to reduce the growth of endocrine-responsive breast cancers by interacting with estrogen signaling pathways. Estrogens play an important role in breast cancer, but also in various types of tissues, including vascular tissue. Estrogen sulfatase (STS) converts inactive estrogen sulfates into active es...

journal_title：International journal of molecular medicine

authors： González A,Martínez-Campa C,Alonso-González C,Cos S

更新日期：2015-12-01 00:00:00

abstract：:Graves' ophthalmopathy (GO) is considered to be an organ-specific autoimmune disease. However, the pathogenesis of GO is incompletely understood at the present time. To clarify the immunological differences between newly diagnosed GO and Graves' disease (GD) without ophthalmopathy or healthy controls (HC), we examined...

journal_title：International journal of molecular medicine

authors： Xia N,Zhou S,Liang Y,Xiao C,Shen H,Pan H,Deng H,Wang N,Li QQ

更新日期：2006-05-01 00:00:00

abstract：:We aimed to explore the anti-inflammatory effects of total alkaloids inRubus alceifolius Poir [corrected]. (TARAP) on non-alcoholic fatty liver disease, and to investigate the possible molecular mechanisms. A rodent non-alcoholic fatty liver disease (NAFLD) model was established by administration of a modified high-fa...

journal_title：International journal of molecular medicine

authors： Zhao J,Zheng H,Liu Y,Lin J,Zhong X,Xu W,Hong Z,Peng J

更新日期：2013-04-01 00:00:00

abstract：:Prostate-specific antigen (PSA) has been used clinically as a marker for the diagnosis and staging of prostate cancer due to its specific expression in prostate epithelial cells. In addition to its medical importance, its complex hormonal and tissue-specific regulation makes it an attractive model to study gene regula...

journal_title：International journal of molecular medicine

authors： Willis RA,Wei C,Turner MJ,Callahan BP,Pugh AE,Barth RK,Lord EM,Frelinger JG

更新日期：1998-02-01 00:00:00

abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

journal_title：International journal of molecular medicine

authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

更新日期：2005-04-01 00:00:00

abstract：:WNT5A, WNT5B, WNT11, FZD3, FZD6, VANGL1, VANGL2, DVL1, DVL2, DVL3, PRICKLE1, PRICKLE2, ANKRD6, NKD1, NKD2, DAAM1, DAAM2, CELSR1, CELSR2, CELSR3, ROR1 and ROR2 are planar cell polarity (PCP) signaling molecules implicated in the regulation of cellular polarity, convergent extension, and invasion. FAT1, FAT2, FAT3 and F...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2006-09-01 00:00:00

abstract：:Recently we have shown the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various solid tumour and leukaemia cell lines as well as primary cultured bone marrow cells isolated from patients with acute and chronic myelogenous leukaemia. We further studied whether the growth inhibitory effect of ...

journal_title：International journal of molecular medicine

authors： Chui CH,Tang JC,Lau FY,Teo IT,Yau MY,Wong RS,Cheng GY,Ho SK,Leung TW,Hui KS,Wong MM,Fatima S,Cheng CH,Cheung F,Tan WQ,Chow LM,Guo D,Chan AS

更新日期：2004-01-01 00:00:00

abstract：:Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the ...

journal_title：International journal of molecular medicine

authors： Si W,Ye S,Ren Z,Liu X,Wu Z,Li Y,Zhou J,Zhang S,Li Y,Deng R,Chen D

更新日期：2019-03-01 00:00:00

abstract：:Evodiamine is a botanical alkaloid compound extracted from Tetradium plants. Previous studies have reported that evodiamine (Evo) treatment can reduce food uptake and improve insulin resistance in animals . The skeletal muscle comprises about 40% of the body mass of adults and has a vital role in regulating whole body...

journal_title：International journal of molecular medicine

authors： Yao X,Yu T,Zhao C,Li Y,Peng Y,Xi F,Yang G

更新日期：2018-03-01 00:00:00

abstract：:The dysregulation of microRNA‑939‑5p (miR‑939) is involved in the development of multiple types of human cancer. However, the expression and roles of miR‑939 in osteosarcoma (OS) have yet to be clarified. The expression level of miR‑939 in OS was measured using reverse transcription quantitative polymerase chain react...

journal_title：International journal of molecular medicine

authors： Zhao X,Li J,Yu D

更新日期：2019-11-01 00:00:00

abstract：:Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-...

journal_title：International journal of molecular medicine

authors： Leonardi GC,Candido S,Carbone M,Colaianni V,Garozzo SF,Cinà D,Libra M

更新日期：2012-11-01 00:00:00

abstract：:Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesen...

journal_title：International journal of molecular medicine

authors： Liu Q,Zhang X,Jiao Y,Liu X,Wang Y,Li SL,Zhang W,Chen FM,Ding Y,Jiang C,Jin Z

更新日期：2018-02-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a key role in repairing the injured vascular endothelium by differentiating into mature endothelial cells (ECs) or secreting cytokines in a paracrine manner to promote proliferation of existing ECs. However, the mechanisms underlying the proliferation of EPCs were not fully und...

journal_title：International journal of molecular medicine

authors： Zhang L,Yu Y,Xia X,Ma Y,Chen XW,Ni ZH,Wang H

更新日期：2016-05-01 00:00:00

abstract：:With the rapid economic development in recent years, China is facing a great challenge due to heavy metal pollution. The heavy metals may enter the human body through ingestion of aqua products to cause great health risks. In the present study, the inhibitory effects of luteolin on the combined toxicity of multi-heavy...

journal_title：International journal of molecular medicine

authors： Wang Y,Su H,Song X,Fiati Kenston SS,Zhao J,Gu Y

更新日期：2018-01-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resve...

journal_title：International journal of molecular medicine

authors： Sun X,Fu P,Xie L,Chai S,Xu Q,Zeng L,Wang X,Jiang N,Sang M

更新日期：2021-01-01 00:00:00

abstract：:In the present study, high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was applied to live Pseudomonas aeruginosa (PA) bacterial cells to determine the metabolome of this opportunistic Gram-negative human pathogen, and in particular, its response to the volatile aromatic low m...

journal_title：International journal of molecular medicine

authors： Righi V,Constantinou C,Kesarwani M,Rahme LG,Tzika AA

更新日期：2018-10-01 00:00:00

abstract：:The storage period of autologous blood of hemodialysis (HD) patients was investigated with focus on the red blood cell life span. Healthy subjects, HD patients administered recombinant human erythropoietin (rHuEPO) preparation at 4,500 units/week and at 9,000 units/week were classified into 3 groups, respectively. Blo...

journal_title：International journal of molecular medicine

authors： Tsuchida K,Nakatani T,Sugimura K,Yoshimura R,Takemoto Y

更新日期：2003-02-01 00:00:00

abstract：:Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene ...

journal_title：International journal of molecular medicine

authors： Wang J,Cui M,Sun F,Zhou K,Fan B,Qiu JH,Chen FQ

更新日期：2020-04-01 00:00:00

abstract：:The prognosis for patients with metastatic bladder cancer (BCa) is poor, and has not been improved by current treatment methods. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including bladder cancer. However, the role of zinc finger E‑box‑binding homeobox 1‑antisense 1 (ZEB1‑AS1) in B...

journal_title：International journal of molecular medicine

authors： Zhao X,Wang D,Ding Y,Zhou J,Liu G,Ji Z

更新日期：2019-07-01 00:00:00

abstract：:During the development of autoimmune and inflammatory diseases, infiltration by multiple leukocyte types is commonly observed at the site of inflammation. These cells are chemotactically recruited via activated integrins expressed on their cell surfaces. However, the detailed mechanism of integrin activation has not b...

journal_title：International journal of molecular medicine

authors： Ohkuro M,Hishinuma I

更新日期：2010-03-01 00:00:00

abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

journal_title：International journal of molecular medicine

authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

更新日期：2009-01-01 00:00:00

abstract：:We previously identified a six-transmembrane epithelial antigen of the prostate (STEAP) 4 as a novel plasma membrane protein that is downregulated in obese patients and may play a significant role in the development of human obesity. This study was designed to identify the biological characteristics of the STEAP4 gene...

journal_title：International journal of molecular medicine

authors： Chen X,Zhu C,Ji C,Zhao Y,Zhang C,Chen F,Gao C,Zhu J,Qian L,Guo X

更新日期：2010-03-01 00:00:00

abstract：:One of the most aggressive human malignancies, anaplastic thyroid carcinoma (ATC), has an extremely poor prognosis that may be explained by its genomic instability. We hypothesized that the very rapid cell turnover observed in ATC might accelerate telomere shortening and chromosomal instability associated with tumor c...

journal_title：International journal of molecular medicine

authors： Kammori M,Onoda N,Nakamura K,Izumiyama N,Ogisawa K,Kurabayashi R,Ogawa T,Kaminishi M,Poon SS,Takubo K

更新日期：2006-07-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), a tumor arising from the epithelial cells of the nasopharynx, is endemic in Southeast Asia and Taiwan. The prognosis of NPC patients with local recurrence and metastasis is poor. Resistance to anoikis is a primary characteristic of tumor cells that metastasize. However, the mechanism th...

journal_title：International journal of molecular medicine

authors： Lin CH,Chiang MC,Chen YJ

更新日期：2017-11-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, the function of miR‑28‑5p in breast cancer migration has yet to be determined. In the present study, Human MicroRNA Expression Database (HMED) analysis revealed that the expression level of miR‑28‑5p was s...

journal_title：International journal of molecular medicine

authors： Ma L,Zhang Y,Hu F

更新日期：2020-10-01 00:00:00

abstract：:Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained ...

journal_title：International journal of molecular medicine

authors： Le HTT,Cho YC,Cho S

更新日期：2018-03-01 00:00:00