Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egr‑1 and epithelial-mesenchymal transition.

abstract：:Electrical activity of beta-cells and cytosolic Ca2+ concentration ([Ca2+]i) were monitored in mouse pancreatic islets exposed to the pentaacetate esters of alpha-D-glucose, beta-D-galactose and beta-L-glucose, all tested at 1.7 mM concentration. In the presence of 5 mM D-glucose, alpha-D-glucose pentaacetate induced ...

journal_title：International journal of molecular medicine

authors： Pomares R,Ropero AB,Sánchez-Andrés JV,Nadal A,Soria B,Malaisse WJ

更新日期：1999-01-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is a regulatory hormone widely expressed, along with its receptors, in organs and body tissues. ANP is well known to inhibit aldosterone secretion from mammalian adrenals, but its effect on glucocorticoid-hormone production is controversial. In vivo experiments showed that prolonged AN...

journal_title：International journal of molecular medicine

authors： Raha D,Tortorella C,Neri G,Prasad A,Raza B,Raskar R,Dubey R,Sen NS,Macchi C,Malendowicz LK,Ahmad MF,Nussdorfer GG

更新日期：2006-04-01 00:00:00

abstract：:Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in the development and metastasis of tumors. However, the role of miR‑93‑5p in esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on the role of miR‑93‑5p and its downstream ...

journal_title：International journal of molecular medicine

authors： Cai Y,Ruan W,Ding J,Wei N,Wang J,Zhang H,Ma N,Weng G,Su WK,Lin Y,Zhu K

更新日期：2021-03-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is one of the most common causes of chronic liver disease and is considered to be a causative factor of cryptogenic cirrhosis and hepatocellular carcinoma. microRNAs (miRNAs) are small non-coding RNAs that negatively regulate messenger RNA (mRNA). Recently, it was demonstrated that...

journal_title：International journal of molecular medicine

authors： Katsura A,Morishita A,Iwama H,Tani J,Sakamoto T,Tatsuta M,Toyota Y,Fujita K,Kato K,Maeda E,Nomura T,Miyoshi H,Yoneyama H,Himoto T,Fujiwara S,Kobara H,Mori H,Niki T,Ono M,Hirashima M,Masaki T

更新日期：2015-04-01 00:00:00

abstract：:Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid and has been shown to exhibit a diversity of pharmacological properties, including antimicrobial and anticancer activiti...

journal_title：International journal of molecular medicine

authors： Hua F,Li CH,Chen XG,Liu XP

更新日期：2018-06-01 00:00:00

abstract：:Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD-ECGF), has been implicated in bladder cancer angiogenesis and invasion. However, the molecular basis of its role in invasion remains unclear. We investigated the expression of TP and 10 invasion-related genes in bladder can...

journal_title：International journal of molecular medicine

authors： Gotanda T,Haraguchi M,Tachiwada T,Shinkura R,Koriyama C,Akiba S,Kawahara M,Nishiyama K,Sumizawa T,Furukawa T,Mimata H,Nomura Y,Akiyama S,Nakagawa M

更新日期：2006-06-01 00:00:00

abstract：:p57 (Kip2) belongs to the Cip/Kip family and is one of the universal negative regulators of the cell cycle. In this study, we investigated the p57 expression of various types of thyroid neoplasm. p57 overexpression was observed in only 4.2% of normal thyroid tissues. In follicular adenoma and minimally invasive follic...

journal_title：International journal of molecular medicine

authors： Ito Y,Yoshida H,Nakano K,Kobayashi K,Yokozawa T,Hirai K,Matsuzuka F,Matsuura N,Kuma K,Miyauchi A

更新日期：2002-04-01 00:00:00

abstract：:Periodontitis is the main cause of tooth or tissue loss. Human periodontal ligament stem cells (hPDLSCs), which have high proliferative, self‑renewal and multi‑differentiation abilities, are vital for the restoration of periodontitis‑induced injuries. The anti‑inflammatory and anti‑apoptotic agent, tetramethylpyrazine...

journal_title：International journal of molecular medicine

authors： Duan Y,An W,Wu Y,Wang J

更新日期：2020-06-01 00:00:00

abstract：:Stannous ion, as a chloride salt, influenced on the survival and adhesive properties of two toxigenic Corynebacterium diphtheriae of the sucrose-fermenting (241 strain) and non-sucrose-fermenting (CDC-E8392 strain) biotypes. Differences in survival fractions suggested differences in susceptibility of strains to bacter...

journal_title：International journal of molecular medicine

authors： Silva De Souza SM,Hirata R Jr,Moreira LO,Gomes ML,Braga De Andrade AF,Bernardo-Filho M,Mattos-Guaraldi AL

更新日期：2003-10-01 00:00:00

abstract：:The expression of thymidylate synthase (TS) in human cancer tissues has been suggested to be a prognostic factor for patients receiving 5-fluorouracil-based chemotherapy. We generated monoclonal antibodies to both recombinant and native TS and analyzed the epitopes on the TS molecule. Two monoclonal antibodies were ob...

journal_title：International journal of molecular medicine

authors： Okabe H,Koizumi K,Tsujimoto H,Fukushima M

更新日期：2000-02-01 00:00:00

abstract：:The tumor suppressor genes p15INK4B and p16INK4A, located in the chromosomal region 9p21, are frequently inactivated by homo- or hemizygous deletions, point mutation or promotor methylation in various types of cancer. No commercial probe is yet available that allows the detection of such deletions by FISH. Long distan...

journal_title：International journal of molecular medicine

authors： Bleichert A,Fiedler W,Claussen U,Ernst G,Loncarevic IF,Heller A,Liehr T,Kunert C,von Eggeling F

更新日期：2001-06-01 00:00:00

abstract：:Alopecia is known as a symptom of acute radiation, yet little is known concerning the mechanism of this phenomenon and the alteration of hair protein profiles. To examine this, 6-week-old male C57/BL6 mice were exposed to 6 Gy of X-ray irradiation, which caused acute alopecia. Their hair and skin were collected, and h...

journal_title：International journal of molecular medicine

authors： Nanashima N,Ito K,Ishikawa T,Nakano M,Nakamura T

更新日期：2012-09-01 00:00:00

abstract：:One of the most aggressive human malignancies, anaplastic thyroid carcinoma (ATC), has an extremely poor prognosis that may be explained by its genomic instability. We hypothesized that the very rapid cell turnover observed in ATC might accelerate telomere shortening and chromosomal instability associated with tumor c...

journal_title：International journal of molecular medicine

authors： Kammori M,Onoda N,Nakamura K,Izumiyama N,Ogisawa K,Kurabayashi R,Ogawa T,Kaminishi M,Poon SS,Takubo K

更新日期：2006-07-01 00:00:00

abstract：:Reperfusion injury (RI) remains an important limitation of myocardial revascularization. The aim of the present study was to evaluate the influence of the intracoronary injection of adiponectin on RI and cardiomyocyte death in a porcine myocardial infarction model. Acute infarction in 14 Polish domestic pigs was induc...

journal_title：International journal of molecular medicine

authors： Dębiński M,Buszman PP,Milewski K,Wojakowski W,Jackiewicz W,Pająk J,Szurlej D,Fryc-Stanek J,Wiernek S,Jelonek M,Spurlock ME,Martin J,Bochenek A,Buszman PE

更新日期：2011-06-01 00:00:00

abstract：:A decrease in bronchial diameter is designated as bronchoconstriction (BC) and impedes the flow of air through the airway. Asthma is characterized by inflammation of the airways, reversible BC and nonspecific hyperreactivity. These last two symptoms are dependent on airway smooth muscle. Stimuli that trigger contracti...

journal_title：International journal of molecular medicine

authors： Sommer B,Flores-Soto E,Gonzalez-Avila G

更新日期：2017-07-01 00:00:00

abstract：:Glioblastoma is one of the most radioresistant tumors. Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. ROS scavengers, therefore, are one of the important factors in protecting cells against ROS injury during ionizing ...

journal_title：International journal of molecular medicine

authors： Lee HC,Kim DW,Jung KY,Park IC,Park MJ,Kim MS,Woo SH,Rhee CH,Yoo H,Lee SH,Hong SI

更新日期：2004-06-01 00:00:00

abstract：:Although recent reports indicate an increasing incidence of patients with reflux esophagitis, its pathomechanism remains unclear. Cytokines and neutrophils, the latter of which produce reactive oxygen species (ROS), have been implicated in the formation of gastrointestinal diseases. This study investigated the roles o...

journal_title：International journal of molecular medicine

authors： Yamaguchi T,Yoshida N,Tomatsuri N,Takayama R,Katada K,Takagi T,Ichikawa H,Naito Y,Okanoue T,Yoshikawa T

更新日期：2005-07-01 00:00:00

abstract：:Myocyte injury due to myocardial reperfusion injury plays a crucial role in the pathogenesis of acute myocardial infarction even after successful coronary revascularization. Identification of compounds that reduce reperfusion-associated myocyte death is important. Therefore, we developed an in vitro model of myocardia...

journal_title：International journal of molecular medicine

authors： Gerö D,Módis K,Nagy N,Szoleczky P,Tóth ZD,Dormán G,Szabó C

更新日期：2007-11-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the ...

journal_title：International journal of molecular medicine

authors： Li K,Yang M,Yuen PM,Chik KW,Li CK,Shing MM,Lam HK,Fok TF

更新日期：2003-12-01 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology and pathogenesis remain poorly understood. The aberrant expression of T lymphocytes plays an essential role in the progression of UC. This study aimed to evaluate the expression profile of circulating Th17, Th1 and Tc1 cells in...

journal_title：International journal of molecular medicine

authors： Dong Z,Du L,Xu X,Yang Y,Wang H,Qu A,Qu X,Wang C

更新日期：2013-04-01 00:00:00

abstract：:Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bon...

journal_title：International journal of molecular medicine

authors： Moon PD,Kim MH,Oh HA,Nam SY,Han NR,Jeong HJ,Kim HM

更新日期：2015-08-01 00:00:00

abstract：:Genetic alterations occurring in various chromosomes have been described in many human tumors. The DCC gene was originally identified in colorectal cancer and was reported as a tumor suppressor gene that might be related to tumor metastasis. We investigated 10 cell lines and 15 fresh tumors of childhood rhabdomyosarco...

journal_title：International journal of molecular medicine

authors： Choi SH,Kong XT,Taki T,Tsuchida Y,Kawaguchi H,Kato H,Hanada R,Look AT,Hayashi Y

更新日期：2000-10-01 00:00:00

abstract：:Heparanase is an enzyme that degrades extracellular glycoprotein to release heparan sulfate molecules. CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration. Production of CD44v3 and expression of heparanase were detected by immunohistochemistry and in situ hy...

journal_title：International journal of molecular medicine

authors： Kuniyasu H,Chihara Y,Kubozoe T,Takahashi T

更新日期：2002-09-01 00:00:00

abstract：:The prognosis of patients suffering from glioblastoma [also referred to as glioblastoma multiforme (GBM)] is dismal despite multimodal therapy. Chemotherapy with temozolomide may suppress tumor growth for a certain period of time (a few months); however, invariable tumor recurrence suggests that glioblastoma initiatin...

journal_title：International journal of molecular medicine

authors： Cheng ZX,Yin WB,Wang ZY

更新日期：2017-11-01 00:00:00

abstract：:It is not clear whether pseudoallergic reactions are caused by similar mechanisms as type I allergic reactions. 3‑Caffeoylquinic acid (chlorogenic acid) is an active ingredient in traditional Chinese medicines used for antibacterial, anti-inflammatory and cholagogic purposes. It is assumed to be the reason for the hig...

journal_title：International journal of molecular medicine

authors： Li Q,Zhao Y,Zheng X,Chen Q,Zhang X

更新日期：2013-12-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have been discovered to participate in the progression of various types of disease and may be a promising biomarker for atherosclerosis (AS). The present study aimed to investigate the regulatory mechanisms of the lncRNA, small nucleolar RNA host gene 7‑003 (SNHG7‑003), on the proliferat...

journal_title：International journal of molecular medicine

authors： Zheng J,Tan Q,Chen H,Chen K,Wang H,Chen Z,Xi Y,Yin H,Lai K,Liu Y

更新日期：2021-02-01 00:00:00

abstract：:Three human pleural malignant mesothelioma cell cultures (MM) of epithelioid (E1), fibrous (F1) and byphasic (B1) histotype were studied in their synthesis of the extracellular matrix (ECM) components laminin (LM), fibronectin (FN), type IV collagen (cIV), and in their chemotactic and haptotactic migration towards the...

journal_title：International journal of molecular medicine

authors： Scarpa S,Giuffrida A,Fazi M,Coletti A,Palumbo C,Pass HI,Procopio A,Modesti A

更新日期：1999-07-01 00:00:00

abstract：:Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of the immune pathology of periodontal disease. Transforming growth factor-β (TGF-β) and vascular endothelial growth facto...

journal_title：International journal of molecular medicine

authors： Matarese G,Isola G,Anastasi GP,Favaloro A,Milardi D,Vermiglio G,Vita G,Cordasco G,Cutroneo G

更新日期：2012-09-01 00:00:00

abstract：:Gene therapy is becoming an important treatment modality against various diseases including cancer, genetic disorders, infectious diseases and inflammatory diseases. For achieving successful gene therapy, it is extremely important to control the expression of a transduced therapeutic gene. However, there have been few...

journal_title：International journal of molecular medicine

authors： Akahane M,Kuriyama S,Ohgushi H,Akahane T,Kawamura K,Watanabe S,Funakoshi F,Yoshiji H,Ikenaka K,Takakura Y

更新日期：2002-07-01 00:00:00

abstract：:The immunosuppressive effect of triptolide has been associated with suppression of T-cell activation. However, the immunosuppressive effects of triptolide on innate immunity in the epithelial barrier remain to be elucidated. Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide and plays an important role ...

journal_title：International journal of molecular medicine

authors： Jang BC,Lim KJ,Choi IH,Suh MH,Park JG,Mun KC,Bae JH,Shin DH,Suh SI

更新日期：2007-05-01 00:00:00